REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | IER3 | Radiation-inducible immediate-early gene IEX-1 | [1] | -0.70[2] | -1.18[3] | -4.08[4] | -1.69[5] | -1.86[6] | -6.20[7] |
2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [8] | -1.14[9] | -1.55[10] | -0.88[11] | -0.54[12] | -0.69[13] | -1.92[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.67[16] | -0.98[17] | -2.10[18] | -0.60[19] | -0.72[20] | -1.20[21] |
4 | TRIB3 | Tribbles homolog 3 | [22] | 0.16[23] | 0.37[24] | -0.78[25] | -2.57[26] | -2.19[27] | -1.38[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 0.05[29] | -0.20[30] | -0.32[31] | 0.66[32] | -0.15[33] | -0.81[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | -0.48[35] | -0.46[36] | -1.14[37] | 0.19[38] | 0.17[39] | -1.06[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | -1.14[41] | -1.56[42] | -1.52[43] | -1.01[44] | -1.25[45] | -1.94[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | -0.30[48] | 0.05[49] | -0.04[50] | 0.34[51] | 0.83[52] | 0.30[53] |
9 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [54] | 0.67[55] | -0.02[56] | -1.08[57] | 0.24[58] | 0.48[59] | -1.64[60] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [61] | 0.45[62] | 0.21[63] | 0.29[64] | 0.00[65] | -0.22[66] | -0.66[67] |
11 | FGFR4 | Fibroblast growth factor receptor 4 | [68] | 1.21[69] | 1.47[70] | 2.01[71] | -4.79[72] | -5.05[73] | -0.46[74] |
12 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | -1.87[75] | -1.06[76] | -0.38[77] | -0.80[78] | -2.06[79] | -0.32[80] | |
13 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isofor | -1.05[81] | -0.26[82] | -0.60[83] | 0.39[84] | 0.06[85] | -1.15[86] | |
14 | PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 | [87] | -3.53[88] | -1.25[89] | -0.67[90] | -3.48[91] | -8.45[92] | 1.54[93] |
15 | MET | Hepatocyte growth factor receptor | [94] | -0.66[95] | -0.71[96] | -0.12[97] | 0.98[98] | -0.43[99] | 0.01[100] |
16 | MYD88 | Myeloid differentiation primary response protein MyD88 | [101] | -0.93[102] | -0.96[103] | -1.56[104] | -1.59[105] | -1.43[106] | -0.16[107] |
17 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | -0.30[108] | -0.90[109] | -0.53[110] | -0.28[111] | -0.63[112] | 1.98[113] | |
18 | IL1RAP | Interleukin-1 receptor accessory protein | [114] | -2.25[115] | -0.10[116] | -0.50[117] | -2.02[118] | -1.07[119] | 1.23[120] |
19 | MAPK1 | Mitogen-activated protein kinase 1 | [121] | 0.96[122] | 1.02[123] | 0.81[124] | 1.30[125] | 0.81[126] | 0.82[127] |
20 | AKT2 | RAC-beta serine/threonine-protein kinase | [128] | 0.21[129] | 0.41[130] | 0.50[131] | 0.31[132] | -0.04[133] | 0.18[134] |
21 | KLB | Beta-klotho | [135] | -0.15[136] | -0.40[137] | 1.01[138] | -6.52[139] | -7.29[140] | 0.59[141] |
22 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | [142] | 1.26[143] | 2.56[144] | 1.56[145] | -6.42[146] | -6.31[147] | 1.35[148] |
23 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 0.50[149] | 0.18[150] | -0.30[151] | 0.74[152] | 0.49[153] | -1.22[154] | |
24 | FGFR3 | Fibroblast growth factor receptor 3 | [155] | 1.98[156] | 1.81[157] | 2.10[158] | -3.85[159] | -2.63[160] | -0.51[161] |
25 | RHOG | Rho-related GTP-binding protein RhoG | [162] | -0.48[163] | -1.74[164] | -1.85[165] | -0.53[166] | -1.09[167] | -1.66[168] |
26 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [169] | -1.22[170] | -1.18[171] | -0.13[172] | 1.51[173] | 0.88[174] | 2.05[175] |
27 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -1.29[176] | 0.03[177] | 0.18[178] | -1.12[179] | 0.00[180] | 1.52[181] | |
28 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [182] | 1.62[183] | 0.37[184] | 1.49[185] | 0.70[186] | 0.17[187] | -0.80[188] |
29 | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | [189] | 0.35[190] | 0.32[191] | 0.40[192] | 1.74[193] | 1.29[194] | -1.04[195] |
30 | INSR | Insulin receptor | [196] | -0.29[197] | 0.28[198] | 1.67[199] | -3.63[200] | -1.17[201] | 3.05[202] |
31 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isofor | -0.63[203] | -0.53[204] | -1.04[205] | 0.31[206] | -0.04[207] | -0.76[208] | |
32 | EGFR | Epidermal growth factor receptor | [209] | -1.45[210] | -1.90[211] | 0.94[212] | -0.12[213] | 0.36[214] | 1.70[215] |
33 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [216] | 1.13[217] | 1.27[218] | 1.84[219] | 0.16[220] | 0.58[221] | -1.25[222] |
34 | AREG | Amphiregulin | [223] | -3.61[224] | -6.93[225] | -8.73[226] | -10.25[227] | -0.08[228] | -11.26[229] |
35 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | [230] | 0.54[231] | 0.39[232] | -0.29[233] | 0.01[234] | -0.16[235] | -1.00[236] |
36 | MAPK3 | Mitogen-activated protein kinase 3 | [237] | 1.10[238] | 1.07[239] | 1.07[240] | -0.13[241] | -0.24[242] | -2.00[243] |
37 | FGF2 | Fibroblast growth factor 2 | [244] | -7.43[245] | -7.26[246] | -3.15[247] | 0.38[248] | 1.83[249] | -2.62[250] |
38 | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | [251] | 1.79[252] | 1.28[253] | 1.52[254] | 1.89[255] | 1.06[256] | 0.21[257] |
39 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [258] | -2.46[259] | -8.53[260] | -9.18[261] | -1.94[262] | 1.73[263] | -2.19[264] |
40 | SRC | Proto-oncogene tyrosine-protein kinase Src | [265] | 2.28[266] | 2.18[267] | 1.14[268] | 1.85[269] | 0.89[270] | -1.81[271] |
41 | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | [272] | 0.89[273] | 0.08[274] | 0.10[275] | 1.70[276] | 0.53[277] | 0.35[278] |
42 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.46[279] | 0.89[280] | 1.01[281] | 0.50[282] | 0.52[283] | 0.20[284] | |
43 | IRS1 | Insulin receptor substrate 1 | [285] | 1.34[286] | 0.71[287] | 2.09[288] | 1.15[289] | 0.60[290] | 1.16[291] |
44 | PHLPP1 | PH domain leucine-rich repeat-containing protein phosphatase 1 | [292] | 0.72[293] | 0.69[294] | -0.02[295] | -0.61[296] | -0.35[297] | 1.32[298] |
45 | IRS2 | Insulin receptor substrate 2 | [299] | -6.40[300] | [301] | -3.66[302] | -1.22[303] | 2.47[304] | 1.43[305] |
46 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | 0.03[306] | -0.29[307] | -0.97[308] | -0.26[309] | 0.77[310] | -0.86[311] | |
47 | FYN | Tyrosine-protein kinase Fyn | [312] | 0.20[313] | -8.48[314] | 0.04[315] | 0.92[316] | 2.31[317] | 0.01[318] |
48 | TGFA | Protransforming growth factor alpha | [319] | 1.04[320] | 2.03[321] | -9.06[322] | -1.51[323] | -2.87[324] | -1.35[325] |
49 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.13[326] | 0.43[327] | 0.58[328] | 0.58[329] | 0.64[330] | 0.96[331] | |
50 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.14[332] | 2.15[333] | -1.71[334] | -0.27[335] | 0.36[336] | -0.66[337] | |
51 | THEM4 | Acyl-coenzyme A thioesterase THEM4 | [338] | -0.10[339] | 0.27[340] | 0.77[341] | 1.45[342] | 0.74[343] | 0.13[344] |
52 | HBEGF | Proheparin-binding EGF-like growth factor | [345] | -1.74[346] | -2.63[347] | -3.74[348] | -0.25[349] | -0.70[350] | -3.39[351] |
53 | FLT3LG | Fms-related tyrosine kinase 3 ligand | [352] | -3.00[353] | -2.99[354] | -2.57[355] | -2.89[356] | -1.94[357] | -3.11[358] |
54 | PDGFA | Platelet-derived growth factor subunit A | [359] | -1.75[360] | -1.62[361] | 0.42[362] | -0.89[363] | -1.94[364] | -1.71[365] |
55 | GAB2 | GRB2-associated-binding protein 2 | [366] | 0.82[367] | 0.53[368] | 0.73[369] | 0.37[370] | 0.32[371] | -0.41[372] |
56 | ESR1 | Estrogen receptor | [373] | -8.05[374] | [375] | -6.66[376] | -4.72[377] | -7.12[378] | 1.44[379] |
57 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [380] | -0.49[381] | 0.79[382] | 1.03[383] | 0.87[384] | 0.49[385] | 0.82[386] |
58 | FGFR2 | Fibroblast growth factor receptor 2 | [387] | -3.26[388] | -2.13[389] | 1.77[390] | 0.90[391] | -4.07[392] | 2.47[393] |
59 | NRG1 | Pro-neuregulin-1, membrane-bound isoform | [394] | -0.41[395] | -6.63[396] | -3.78[397] | 1.50[398] | -6.11[399] | -0.19[400] |
60 | FRS2 | Fibroblast growth factor receptor substrate 2 | [401] | 0.54[402] | 1.55[403] | 2.01[404] | 2.35[405] | 1.84[406] | 2.39[407] |
61 | IL1RL1 | Interleukin-1 receptor-like 1 | [408] | -6.10[409] | -4.94[410] | -6.54[411] | -5.86[412] | 5.36[413] | 0.41[414] |
62 | STRN | Striatin | [415] | 1.22[416] | 2.10[417] | 1.68[418] | 2.77[419] | 2.53[420] | 1.94[421] |
63 | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | [422] | 2.01[423] | 1.17[424] | 1.46[425] | 2.07[426] | 2.50[427] | 0.51[428] |
64 | TRAF6 | TNF receptor-associated factor 6 | [429] | 0.34[430] | 0.15[431] | 0.68[432] | 1.11[433] | 0.43[434] | 1.95[435] |
65 | BTC | Probetacellulin | [436] | -8.89[437] | -9.36[438] | -5.18[439] | -3.43[440] | -3.59[441] | -3.87[442] |
66 | PHLPP2 | PH domain leucine-rich repeat-containing protein phosphatase 2 | [443] | 1.58[444] | 2.10[445] | 1.60[446] | 2.64[447] | 1.80[448] | 1.46[449] |
67 | FGFR1 | Fibroblast growth factor receptor 1 | [450] | 3.83[451] | 2.06[452] | 3.67[453] | 4.50[454] | 3.64[455] | 0.71[456] |
68 | GAB1 | GRB2-associated-binding protein 1 | [457] | 0.55[458] | 1.56[459] | 1.64[460] | 1.38[461] | 1.11[462] | 1.92[463] |
69 | PDGFB | Platelet-derived growth factor subunit B | [464] | 2.31[465] | 2.09[466] | -0.76[467] | -0.49[468] | -1.05[469] | -0.58[470] |
70 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | [471] | -0.31[472] | 2.02[473] | 1.51[474] | -4.38[475] | -6.10[476] | -3.85[477] |
71 | NRG4 | Pro-neuregulin-4, membrane-bound isoform | [478] | -4.84[479] | -2.04[480] | -2.14[481] | -0.27[482] | -2.60[483] | -1.89[484] |
72 | FGF7 | Fibroblast growth factor 7 | [485] | -10.04[486] | -6.42[487] | [488] | -5.93[489] | -1.79[490] | -2.41[491] |
73 | PDGFRA | Platelet-derived growth factor receptor alpha | [492] | -4.37[493] | -5.43[494] | 2.17[495] | -0.03[496] | 4.51[497] | 4.36[498] |
74 | PDGFRB | Platelet-derived growth factor receptor beta | [499] | 0.55[500] | 0.87[501] | -1.63[502] | 1.30[503] | 1.73[504] | 2.46[505] |
75 | VAV1 | Proto-oncogene vav | [506] | -9.25[507] | -4.50[508] | -6.25[509] | -6.64[510] | -8.04[511] | 0.23[512] |
76 | IL33 | Interleukin-33 | [513] | -3.68[514] | -8.33[515] | -0.63[516] | -3.73[517] | 5.22[518] | 3.70[519] |
77 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [520] | 0.97[521] | 0.90[522] | 1.71[523] | 2.61[524] | 1.50[525] | 1.72[526] |
78 | CD86 | T-lymphocyte activation antigen CD86 | [527] | [528] | [529] | -5.58[530] | -4.65[531] | -6.81[532] | 0.39[533] |
79 | AKT3 | RAC-gamma serine/threonine-protein kinase | [534] | -2.59[535] | -5.23[536] | -4.58[537] | 5.29[538] | 4.11[539] | 2.65[540] |
80 | LCK | Tyrosine-protein kinase Lck | [541] | 2.03[542] | 2.03[543] | -8.01[544] | -5.64[545] | -5.97[546] | 0.28[547] |
81 | KL | Klotho | [548] | -6.80[549] | [550] | [551] | -1.94[552] | -7.33[553] | -0.71[554] |
82 | FGF5 | Fibroblast growth factor 5 | [555] | -1.74[556] | -0.50[557] | -0.61[558] | 0.93[559] | 0.48[560] | 2.18[561] |
83 | EREG | Proepiregulin | [562] | 1.01[563] | 0.85[564] | -3.60[565] | -2.12[566] | 2.99[567] | -2.43[568] |
84 | FGF1 | Fibroblast growth factor 1 | [569] | -3.51[570] | -2.80[571] | -7.31[572] | 0.03[573] | 1.48[574] | -0.91[575] |
85 | FGF19 | Fibroblast growth factor 19 | [576] | -2.81[577] | -1.74[578] | 4.96[579] | 0.28[580] | -3.33[581] | [582] |
86 | KITLG | Kit ligand | [583] | 4.70[584] | 0.84[585] | 6.53[586] | 6.18[587] | 4.23[588] | 2.08[589] |
87 | CD28 | T-cell-specific surface glycoprotein CD28 | [590] | -4.75[591] | -3.96[592] | -3.97[593] | -2.90[594] | -3.09[595] | 0.16[596] |
88 | KIT | Mast/stem cell growth factor receptor Kit | [597] | -3.74[598] | -5.70[599] | [600] | 1.95[601] | -3.72[602] | 2.68[603] |
89 | CD19 | B-lymphocyte antigen CD19 | [604] | 1.36[605] | 2.98[606] | -1.90[607] | -2.02[608] | [609] | 0.11[610] |
90 | CD80 | T-lymphocyte activation antigen CD80 | [611] | [612] | [613] | -6.13[614] | -1.71[615] | -2.91[616] | 1.67[617] |
91 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [618] | [619] | [620] | -4.37[621] | -3.34[622] | [623] | 1.96[624] |
92 | ESR2 | Estrogen receptor beta | [625] | -1.31[626] | -1.02[627] | -1.04[628] | 0.08[629] | 0.04[630] | 1.57[631] |
93 | TRAT1 | T-cell receptor-associated transmembrane adapter 1 | [632] | [633] | [634] | [635] | [636] | [637] | 1.83[638] |
94 | ICOS | Inducible T-cell costimulator | [639] | [640] | -4.20[641] | [642] | [643] | [644] | -1.51[645] |
95 | HGF | Hepatocyte growth factor | [646] | [647] | [648] | -2.52[649] | 4.04[650] | 0.94[651] | 7.94[652] |
96 | FGF8 | Fibroblast growth factor 8 | [653] | -4.08[654] | -3.81[655] | 0.64[656] | -2.47[657] | [658] | 1.74[659] |
97 | FGF18 | Fibroblast growth factor 18 | [660] | 1.03[661] | -3.17[662] | -1.03[663] | 0.06[664] | 0.52[665] | -0.37[666] |
98 | FGF9 | Fibroblast growth factor 9 | [667] | 1.51[668] | -2.22[669] | [670] | 2.23[671] | -3.02[672] | -0.85[673] |
99 | EGF | Pro-epidermal growth factor | [674] | 1.22[675] | 2.93[676] | 6.50[677] | 8.47[678] | 5.76[679] | 0.62[680] |
100 | FGF10 | Fibroblast growth factor 10 | [681] | [682] | [683] | [684] | [685] | [686] | [687] |
101 | FGF22 | Fibroblast growth factor 22 | [688] | [689] | [690] | [691] | [692] | [693] | [694] |
102 | FGF17 | Fibroblast growth factor 17 | [695] | [696] | [697] | [698] | [699] | [700] | [701] |
103 | FGF3 | Fibroblast growth factor 3 | [702] | [703] | [704] | [705] | [706] | [707] | [708] |
104 | FGF23 | Fibroblast growth factor 23 | [709] | [710] | [711] | [712] | [713] | [714] | [715] |
105 | FGF20 | Fibroblast growth factor 20 | [716] | [717] | [718] | [719] | [720] | [721] | [722] |
106 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | [723] | [724] | [725] | [726] | [727] | [728] | [729] |
107 | FGF16 | Fibroblast growth factor 16 | [730] | [731] | [732] | [733] | [734] | [735] | [736] |
108 | NRG3 | Pro-neuregulin-3, membrane-bound isoform | [737] | [738] | [739] | [740] | [741] | [742] | [743] |
109 | FGF4 | Fibroblast growth factor 4 | [744] | [745] | [746] | [747] | [748] | [749] | [750] |
110 | FGF6 | Fibroblast growth factor 6 | [751] | [752] | [753] | [754] | [755] | [756] | [757] |
111 | NRG2 | Pro-neuregulin-2, membrane-bound isoform | [758] | [759] | [760] | [761] | [762] | [763] | [764] |
112 | EPGN | Epigen | [765] | [766] | [767] | [768] | [769] | [770] | [771] |
113 | INS | Insulin | [772] | [773] | [774] | [775] | [776] | [777] | [778] |