REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 LRP5 Low-density lipoprotein receptor-related protein 5 [1] -0.88[2] 0.04[3] -0.03[4] -0.40[5] -2.57[6] -0.34[7]
2 KREMEN1 Kremen protein 1 [8] 0.03[9] 0.03[10] -0.59[11] -0.57[12] -1.50[13] -2.15[14]
3 DKK1 Dickkopf-related protein 1 [15] 2.29[16] -0.15[17] -0.39[18] -0.80[19] 1.25[20] -7.93[21]
4 LRP6 Low-density lipoprotein receptor-related protein 6 [22] -1.17[23] 0.71[24] 1.36[25] -0.28[26] -0.44[27] 2.29[28]
5 SFRP2 Secreted frizzled-related protein 2 [29] [30] [31] [32] -6.02[33] -9.74[34] -9.06[35]
6 SFRP1 Secreted frizzled-related protein 1 [36] -8.67[37] [38] [39] -1.44[40] -3.09[41] -1.43[42]
7 WNT4 Protein Wnt-4 [43] -6.68[44] -4.61[45] -6.42[46] -3.50[47] -5.53[48] -2.28[49]
8 WNT5A Protein Wnt-5a [50] -6.18[51] -4.96[52] -4.49[53] 4.46[54] 5.32[55] -1.18[56]
9 DKK4 Dickkopf-related protein 4 [57] -1.42[58] -0.10[59] [60] [61] -10.04[62] -5.68[63]
10 WNT9A Protein Wnt-9a [64] -2.94[65] -4.86[66] -6.33[67] -0.90[68] -3.82[69] -5.12[70]
11 KREMEN2 Kremen protein 2 [71] 4.91[72] 5.15[73] 4.67[74] 0.87[75] 2.46[76] -3.30[77]
12 WNT3A Protein Wnt-3a [78] [79] [80] [81] [82] [83] [84]
13 SOST Sclerostin [85] [86] [87] [88] [89] [90] [91]
14 WIF1 Wnt inhibitory factor 1 [92] [93] [94] [95] [96] [97] [98]
15 DKK2 Dickkopf-related protein 2 [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte LRP5
Mean 11.4
Standard deviation 3.9
Values 8.8 10 7.3 17 13
[2]
HepG2 LRP5
Mean 108
Standard deviation 24
Values 1.3e+02 91
[3]
HepG2.C3A LRP5
Mean 79.2
Standard deviation 20
Values 93 65
[4]
HuH.7 LRP5
Mean 117
Standard deviation 36
Values 1.5e+02 81 1.2e+02
[5]
SNU475 LRP5
Mean 69.8
Standard deviation 26
Values 88 52
[6]
THLE LRP5
Mean 28.3
Standard deviation 7.2
Values 23 33
[7]
liver LRP5
Mean 71.8
Standard deviation 33
Values 39 93 50 1.1e+02
[8]
ref_hepatocyte KREMEN1
Mean 2.07
Standard deviation 2.5
Values 6.3 2.3 0.9 0.26 0.59
[9]
HepG2 KREMEN1
Mean 37.1
Standard deviation 7.2
Values 42 32
[10]
HepG2.C3A KREMEN1
Mean 14.3
Standard deviation 0.73
Values 15 14
[11]
HuH.7 KREMEN1
Mean 14.4
Standard deviation 4.7
Values 19 9.5 15
[12]
SNU475 KREMEN1
Mean 11.2
Standard deviation 4.3
Values 14 8.2
[13]
THLE KREMEN1
Mean 10.8
Standard deviation 1.1
Values 10 12
[14]
liver KREMEN1
Mean 3.73
Standard deviation 1.9
Values 3.3 4.2 1.4 6.1
[15]
ref_hepatocyte DKK1
Mean 2
Standard deviation 4.1
Values 9.3 0.59 0 0 0.089
[16]
HepG2 DKK1
Mean 172
Standard deviation 31
Values 1.5e+02 1.9e+02
[17]
HepG2.C3A DKK1
Mean 12.2
Standard deviation 9
Values 5.8 19
[18]
HuH.7 DKK1
Mean 16.1
Standard deviation 6.9
Values 19 8.2 21
[19]
SNU475 DKK1
Mean 9.29
Standard deviation 1.1
Values 8.5 10
[20]
THLE DKK1
Mean 70.4
Standard deviation 23
Values 54 87
[21]
liver DKK1
Mean 0.0656
Standard deviation 0.079
Values 0 0.043 0.18 0.04
[22]
ref_hepatocyte LRP6
Mean 1.95
Standard deviation 0.83
Values 2.8 2.6 0.7 1.7 1.9
[23]
HepG2 LRP6
Mean 15.2
Standard deviation 4.8
Values 12 19
[24]
HepG2.C3A LRP6
Mean 21.5
Standard deviation 0.56
Values 21 22
[25]
HuH.7 LRP6
Mean 52.6
Standard deviation 14
Values 58 64 37
[26]
SNU475 LRP6
Mean 13
Standard deviation 2
Values 14 12
[27]
THLE LRP6
Mean 21.2
Standard deviation 0.26
Values 21 21
[28]
liver LRP6
Mean 76.1
Standard deviation 40
Values 42 1.1e+02 40 1.1e+02
[29]
ref_hepatocyte SFRP2
Mean 0.665
Standard deviation 1.1
Values 0 0 2.4 0 0.89
[30]
HepG2 SFRP2
Mean 0
Standard deviation 0
Values 0 0
[31]
HepG2.C3A SFRP2
Mean 0
Standard deviation 0
Values 0 0
[32]
HuH.7 SFRP2
Mean 0
Standard deviation 0
Values 0 0 0
[33]
SNU475 SFRP2
Mean 0.0827
Standard deviation 0.012
Values 0.074 0.091
[34]
THLE SFRP2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[35]
liver SFRP2
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[36]
ref_hepatocyte SFRP1
Mean 0.401
Standard deviation 0.61
Values 0.054 0.052 1.4 0 0.46
[37]
HepG2 SFRP1
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[38]
HepG2.C3A SFRP1
Mean 0
Standard deviation 0
Values 0 0
[39]
HuH.7 SFRP1
Mean 0
Standard deviation 0
Values 0 0 0
[40]
SNU475 SFRP1
Mean 1.19
Standard deviation 1.1
Values 0.41 2
[41]
THLE SFRP1
Mean 0.696
Standard deviation 0.19
Values 0.56 0.83
[42]
liver SFRP1
Mean 1.19
Standard deviation 0.31
Values 1.4 1.3 1.3 0.71
[43]
ref_hepatocyte WNT4
Mean 0.276
Standard deviation 0.47
Values 0 0 0.3 1.1 0
[44]
HepG2 WNT4
Mean 0.0472
Standard deviation 0.0061
Values 0.052 0.043
[45]
HepG2.C3A WNT4
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[46]
HuH.7 WNT4
Mean 0.034
Standard deviation 0.022
Values 0.033 0.013 0.056
[47]
SNU475 WNT4
Mean 0.197
Standard deviation 0.1
Values 0.13 0.27
[48]
THLE WNT4
Mean 0.0881
Standard deviation 0.034
Values 0.11 0.064
[49]
liver WNT4
Mean 0.454
Standard deviation 0.67
Values 0.024 0.3 0.051 1.4
[50]
ref_hepatocyte WNT5A
Mean 0.261
Standard deviation 0.17
Values 0 0.4 0.23 0.25 0.43
[51]
HepG2 WNT5A
Mean 0.063
Standard deviation 0.041
Values 0.092 0.034
[52]
HepG2.C3A WNT5A
Mean 0.0565
Standard deviation 0.011
Values 0.049 0.064
[53]
HuH.7 WNT5A
Mean 0.122
Standard deviation 0.062
Values 0.18 0.13 0.056
[54]
SNU475 WNT5A
Mean 46.2
Standard deviation 6.6
Values 51 42
[55]
THLE WNT5A
Mean 154
Standard deviation 20
Values 1.7e+02 1.4e+02
[56]
liver WNT5A
Mean 0.919
Standard deviation 0.41
Values 0.54 1.3 0.59 1.2
[57]
ref_hepatocyte DKK4
Mean 0.21
Standard deviation 0.38
Values 0.88 0 0 0.17 0
[58]
HepG2 DKK4
Mean 1.37
Standard deviation 1.4
Values 0.41 2.3
[59]
HepG2.C3A DKK4
Mean 1.32
Standard deviation 1.1
Values 0.57 2.1
[60]
HuH.7 DKK4
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 DKK4
Mean 0
Standard deviation 0
Values 0 0
[62]
THLE DKK4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[63]
liver DKK4
Mean 0.0328
Standard deviation 0.049
Values 0 0.029 0.1 0
[64]
ref_hepatocyte WNT9A
Mean 0.115
Standard deviation 0.17
Values 0 0.19 0.38 0 0
[65]
HepG2 WNT9A
Mean 0.263
Standard deviation 0.0014
Values 0.26 0.26
[66]
HepG2.C3A WNT9A
Mean 0.0268
Standard deviation 0.038
Values 0 0.054
[67]
HuH.7 WNT9A
Mean 0.015
Standard deviation 0.026
Values 0 0.045 0
[68]
SNU475 WNT9A
Mean 0.497
Standard deviation 0.065
Values 0.54 0.45
[69]
THLE WNT9A
Mean 0.12
Standard deviation 0.0028
Values 0.12 0.12
[70]
liver WNT9A
Mean 0.0264
Standard deviation 0.036
Values 0 0.029 0.077 0
[71]
ref_hepatocyte KREMEN2
Mean 0.00813
Standard deviation 0.018
Values 0 0 0 0 0.041
[72]
HepG2 KREMEN2
Mean 4.27
Standard deviation 2.5
Values 6.1 2.5
[73]
HepG2.C3A KREMEN2
Mean 1.95
Standard deviation 0.63
Values 1.5 2.4
[74]
HuH.7 KREMEN2
Mean 2.17
Standard deviation 0.96
Values 2.1 1.3 3.2
[75]
SNU475 KREMEN2
Mean 0.12
Standard deviation 0.031
Values 0.097 0.14
[76]
THLE KREMEN2
Mean 0.662
Standard deviation 0.026
Values 0.68 0.64
[77]
liver KREMEN2
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[78]
ref_hepatocyte WNT3A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 WNT3A
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[80]
HepG2.C3A WNT3A
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 WNT3A
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 WNT3A
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[83]
THLE WNT3A
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[84]
liver WNT3A
Mean 0.0165
Standard deviation 0.033
Values 0 0 0 0.066
[85]
ref_hepatocyte SOST
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 SOST
Mean 0.0143
Standard deviation 0.02
Values 0.029 0
[87]
HepG2.C3A SOST
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 SOST
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 SOST
Mean 4.38
Standard deviation 2.7
Values 6.3 2.5
[90]
THLE SOST
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[91]
liver SOST
Mean 0
Standard deviation 0
Values 0 0 0 0
[92]
ref_hepatocyte WIF1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 WIF1
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A WIF1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 WIF1
Mean 0.33
Standard deviation 0.13
Values 0.48 0.24 0.27
[96]
SNU475 WIF1
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[97]
THLE WIF1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[98]
liver WIF1
Mean 0.0128
Standard deviation 0.026
Values 0 0 0.051 0
[99]
ref_hepatocyte DKK2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 DKK2
Mean 0.0258
Standard deviation 0.012
Values 0.017 0.034
[101]
HepG2.C3A DKK2
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 DKK2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 DKK2
Mean 0.137
Standard deviation 0.05
Values 0.1 0.17
[104]
THLE DKK2
Mean 0.026
Standard deviation 0.022
Values 0.041 0.011
[105]
liver DKK2
Mean 0.0557
Standard deviation 0.044
Values 0.12 0.014 0.051 0.04