REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.51[2] -0.71[3] -0.75[4] -0.90[5] -0.51[6] -0.23[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.07[16] 0.04[17] -0.39[18] -0.05[19] -0.13[20] 0.22[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.37[23] 2.28[24] 3.12[25] 1.35[26] 2.10[27] 0.99[28]
5 GRB2 Growth factor receptor-bound protein 2 [29] 2.88[30] 2.72[31] 2.65[32] 2.43[33] 2.28[34] 1.94[35]
6 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate [36] 2.58[37] 2.09[38] 1.37[39] 2.37[40] 2.23[41] 0.87[42]
7 MET Hepatocyte growth factor receptor [43] 1.77[44] 1.80[45] 2.24[46] 3.41[47] 2.07[48] 2.61[49]
8 SH3GL1 Endophilin-A2 [50] 2.76[51] 3.15[52] 2.12[53] 2.41[54] 2.69[55] 1.21[56]
9 PTPN1 Tyrosine-protein phosphatase non-receptor type 1 [57] 2.81[58] 2.47[59] 1.80[60] 3.70[61] 2.93[62] 1.34[63]
10 PTPN2 Tyrosine-protein phosphatase non-receptor type 2 [64] 0.83[65] 2.14[66] 2.33[67] 1.32[68] 1.40[69] 1.39[70]
11 USP8 Ubiquitin carboxyl-terminal hydrolase 8 [71] 1.52[72] 2.63[73] 2.43[74] 3.01[75] 2.69[76] 3.08[77]
12 LRIG1 Leucine-rich repeats and immunoglobulin-like domains protein 1 [78] 0.46[79] 1.83[80] 2.46[81] -1.03[82] 0.80[83] 3.14[84]
13 EPS15 Epidermal growth factor receptor substrate 15 [85] 1.83[86] 2.71[87] 2.80[88] 3.47[89] 2.93[90] 3.89[91]
14 STAM Signal transducing adapter molecule 1 [92] 2.74[93] 3.19[94] 2.04[95] 3.57[96] 2.81[97] 1.40[98]
15 STAM2 Signal transducing adapter molecule 2 [99] 1.95[100] 2.73[101] 1.66[102] 3.44[103] 2.65[104] 2.84[105]
16 SH3KBP1 SH3 domain-containing kinase-binding protein 1 [106] 3.28[107] 3.15[108] 3.69[109] 3.67[110] 4.09[111] 2.12[112]
17 PTPRJ Receptor-type tyrosine-protein phosphatase eta [113] 0.61[114] 2.24[115] 3.36[116] 3.34[117] 3.31[118] 3.60[119]
18 CBL E3 ubiquitin-protein ligase CBL [120] 6.14[121] 5.08[122] 5.11[123] 7.01[124] 6.43[125] 5.40[126]
19 SH3GL2 Endophilin-A1 [127] -0.57[128] [129] -3.55[130] 2.89[131] 1.60[132] 1.83[133]
20 HGF Hepatocyte growth factor [134] [135] [136] -0.15[137] 6.47[138] 3.44[139] 10.54[140]
21 SH3GL3 Endophilin-A3 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[30]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[31]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[32]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[33]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[34]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[35]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[36]
ref_hepatocyte HGS
Mean 16.6
Standard deviation 15
Values 6.9 15 42 11 8.1
[37]
HepG2 HGS
Mean 68.4
Standard deviation 17
Values 80 57
[38]
HepG2.C3A HGS
Mean 43.2
Standard deviation 8
Values 49 38
[39]
HuH.7 HGS
Mean 28.9
Standard deviation 4.1
Values 30 24 32
[40]
SNU475 HGS
Mean 43.1
Standard deviation 3.7
Values 40 46
[41]
THLE HGS
Mean 45.7
Standard deviation 2.6
Values 44 48
[42]
liver HGS
Mean 13.8
Standard deviation 3.3
Values 17 9.3 16 14
[43]
ref_hepatocyte MET
Mean 12.9
Standard deviation 12
Values 6.9 32 16 3.7 5.7
[44]
HepG2 MET
Mean 30.2
Standard deviation 2.7
Values 32 28
[45]
HepG2.C3A MET
Mean 27.5
Standard deviation 6.5
Values 23 32
[46]
HuH.7 MET
Mean 40.8
Standard deviation 7.3
Values 43 47 33
[47]
SNU475 MET
Mean 68.7
Standard deviation 7.1
Values 64 74
[48]
THLE MET
Mean 31.7
Standard deviation 2
Values 33 30
[49]
liver MET
Mean 35.9
Standard deviation 13
Values 27 46 22 48
[50]
ref_hepatocyte SH3GL1
Mean 12.4
Standard deviation 7.5
Values 7.4 8.5 25 13 8.1
[51]
HepG2 SH3GL1
Mean 57.7
Standard deviation 6.8
Values 63 53
[52]
HepG2.C3A SH3GL1
Mean 67.2
Standard deviation 9.8
Values 74 60
[53]
HuH.7 SH3GL1
Mean 36.1
Standard deviation 5.8
Values 39 29 40
[54]
SNU475 SH3GL1
Mean 33.1
Standard deviation 3.1
Values 35 31
[55]
THLE SH3GL1
Mean 46.9
Standard deviation 4
Values 44 50
[56]
liver SH3GL1
Mean 13
Standard deviation 6.5
Values 17 6.7 20 8.4
[57]
ref_hepatocyte PTPN1
Mean 8.72
Standard deviation 6.8
Values 20 10 6.8 4.1 2.6
[58]
HepG2 PTPN1
Mean 41.8
Standard deviation 5
Values 38 45
[59]
HepG2.C3A PTPN1
Mean 29.5
Standard deviation 3
Values 27 32
[60]
HuH.7 PTPN1
Mean 20.4
Standard deviation 3.4
Values 24 18 19
[61]
SNU475 PTPN1
Mean 56.7
Standard deviation 1.9
Values 55 58
[62]
THLE PTPN1
Mean 39.1
Standard deviation 7.5
Values 34 44
[63]
liver PTPN1
Mean 10
Standard deviation 0.98
Values 11 10 11 8.6
[64]
ref_hepatocyte PTPN2
Mean 8.27
Standard deviation 3
Values 5 6 9.1 13 8.8
[65]
HepG2 PTPN2
Mean 10.1
Standard deviation 2.9
Values 8 12
[66]
HepG2.C3A PTPN2
Mean 22.3
Standard deviation 0.11
Values 22 22
[67]
HuH.7 PTPN2
Mean 28
Standard deviation 2.9
Values 28 25 31
[68]
SNU475 PTPN2
Mean 10.3
Standard deviation 2
Values 8.9 12
[69]
THLE PTPN2
Mean 12.7
Standard deviation 0.75
Values 12 13
[70]
liver PTPN2
Mean 9.84
Standard deviation 1.6
Values 11 8.1 12 8.9
[71]
ref_hepatocyte USP8
Mean 6.73
Standard deviation 4.3
Values 12 10 3.2 3.5 4.3
[72]
HepG2 USP8
Mean 13.2
Standard deviation 5.6
Values 9.2 17
[73]
HepG2.C3A USP8
Mean 25.5
Standard deviation 2.2
Values 24 27
[74]
HuH.7 USP8
Mean 24.3
Standard deviation 2.7
Values 26 26 21
[75]
SNU475 USP8
Mean 27.1
Standard deviation 1.4
Values 26 28
[76]
THLE USP8
Mean 25.4
Standard deviation 6.5
Values 30 21
[77]
liver USP8
Mean 25.8
Standard deviation 2.7
Values 29 26 25 23
[78]
ref_hepatocyte LRIG1
Mean 5.62
Standard deviation 3.3
Values 1.3 5 4.1 8.3 9.5
[79]
HepG2 LRIG1
Mean 5.32
Standard deviation 1.1
Values 6.1 4.5
[80]
HepG2.C3A LRIG1
Mean 12.2
Standard deviation 2.2
Values 14 11
[81]
HuH.7 LRIG1
Mean 20.8
Standard deviation 1.2
Values 22 20 21
[82]
SNU475 LRIG1
Mean 1.37
Standard deviation 0.75
Values 0.84 1.9
[83]
THLE LRIG1
Mean 5.73
Standard deviation 0.44
Values 5.4 6
[84]
liver LRIG1
Mean 22.5
Standard deviation 14
Values 14 23 11 42
[85]
ref_hepatocyte EPS15
Mean 4.89
Standard deviation 1.8
Values 5.6 6.8 2.8 3.1 6.2
[86]
HepG2 EPS15
Mean 11.9
Standard deviation 1.7
Values 11 13
[87]
HepG2.C3A EPS15
Mean 19.5
Standard deviation 2.6
Values 21 18
[88]
HuH.7 EPS15
Mean 22.8
Standard deviation 3.3
Values 24 25 19
[89]
SNU475 EPS15
Mean 27.1
Standard deviation 6.2
Values 31 23
[90]
THLE EPS15
Mean 21.8
Standard deviation 0.2
Values 22 22
[91]
liver EPS15
Mean 32.9
Standard deviation 7.3
Values 27 42 27 36
[92]
ref_hepatocyte STAM
Mean 4.67
Standard deviation 4.3
Values 3.4 4.5 12 1.7 1.7
[93]
HepG2 STAM
Mean 21.4
Standard deviation 0.48
Values 22 21
[94]
HepG2.C3A STAM
Mean 26
Standard deviation 1.5
Values 25 27
[95]
HuH.7 STAM
Mean 12.8
Standard deviation 1.6
Values 15 11 13
[96]
SNU475 STAM
Mean 27.6
Standard deviation 1.8
Values 26 29
[97]
THLE STAM
Mean 19.2
Standard deviation 2.2
Values 18 21
[98]
liver STAM
Mean 5.6
Standard deviation 0.77
Values 5.9 5.8 6.3 4.5
[99]
ref_hepatocyte STAM2
Mean 3.7
Standard deviation 1.9
Values 6 5.1 3.6 1.5 2.3
[100]
HepG2 STAM2
Mean 9.81
Standard deviation 3.1
Values 7.6 12
[101]
HepG2.C3A STAM2
Mean 15
Standard deviation 2.6
Values 13 17
[102]
HuH.7 STAM2
Mean 7.81
Standard deviation 2.2
Values 7.1 10 6.1
[103]
SNU475 STAM2
Mean 20
Standard deviation 2.9
Values 22 18
[104]
THLE STAM2
Mean 13.6
Standard deviation 0.034
Values 14 14
[105]
liver STAM2
Mean 12
Standard deviation 2.6
Values 10 16 10 12
[106]
ref_hepatocyte SH3KBP1
Mean 3.69
Standard deviation 0.65
Values 3.7 4 4.6 3 3.1
[107]
HepG2 SH3KBP1
Mean 24.6
Standard deviation 3.6
Values 27 22
[108]
HepG2.C3A SH3KBP1
Mean 20
Standard deviation 1.3
Values 21 19
[109]
HuH.7 SH3KBP1
Mean 31.8
Standard deviation 7.3
Values 39 24 33
[110]
SNU475 SH3KBP1
Mean 23.4
Standard deviation 3.2
Values 21 26
[111]
THLE SH3KBP1
Mean 36.7
Standard deviation 7.1
Values 32 42
[112]
liver SH3KBP1
Mean 7.31
Standard deviation 4.4
Values 13 4.4 8.2 3.5
[113]
ref_hepatocyte PTPRJ
Mean 3.68
Standard deviation 1.9
Values 1.8 6.2 5 2 3.4
[114]
HepG2 PTPRJ
Mean 3.86
Standard deviation 2.6
Values 5.7 2
[115]
HepG2.C3A PTPRJ
Mean 10.6
Standard deviation 4.9
Values 14 7.2
[116]
HuH.7 PTPRJ
Mean 25.4
Standard deviation 13
Values 20 40 16
[117]
SNU475 PTPRJ
Mean 18.6
Standard deviation 4.4
Values 16 22
[118]
THLE PTPRJ
Mean 21.4
Standard deviation 4.2
Values 18 24
[119]
liver PTPRJ
Mean 20.4
Standard deviation 13
Values 12 28 7.1 34
[120]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[121]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[122]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[123]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[124]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[125]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[126]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14
[127]
ref_hepatocyte SH3GL2
Mean 0.0479
Standard deviation 0.06
Values 0 0.041 0 0.052 0.15
[128]
HepG2 SH3GL2
Mean 0.0222
Standard deviation 0.023
Values 0.0057 0.039
[129]
HepG2.C3A SH3GL2
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 SH3GL2
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[131]
SNU475 SH3GL2
Mean 0.178
Standard deviation 0.19
Values 0.046 0.31
[132]
THLE SH3GL2
Mean 0.0849
Standard deviation 0.022
Values 0.1 0.069
[133]
liver SH3GL2
Mean 0.0774
Standard deviation 0.058
Values 0.047 0.014 0.1 0.15
[134]
ref_hepatocyte HGF
Mean 0.0217
Standard deviation 0.03
Values 0 0 0 0.052 0.057
[135]
HepG2 HGF
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A HGF
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 HGF
Mean 0.0131
Standard deviation 0.017
Values 0.033 0.0064 0
[138]
SNU475 HGF
Mean 0.963
Standard deviation 0.42
Values 1.3 0.67
[139]
THLE HGF
Mean 0.138
Standard deviation 0.061
Values 0.095 0.18
[140]
liver HGF
Mean 14.7
Standard deviation 7.2
Values 9.2 24 9.5 16
[141]
ref_hepatocyte SH3GL3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 SH3GL3
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A SH3GL3
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 SH3GL3
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 SH3GL3
Mean 0.281
Standard deviation 0.0029
Values 0.28 0.28
[146]
THLE SH3GL3
Mean 0.451
Standard deviation 0.0062
Values 0.46 0.45
[147]
liver SH3GL3
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0