REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.89[2] -1.17[3] -0.95[4] -1.00[5] -0.69[6] -0.82[7]
2 PEBP1 Phosphatidylethanolamine-binding protein 1 [8] -0.54[9] -0.26[10] -1.20[11] -3.01[12] -2.58[13] 0.34[14]
3 RPS27A Ubiquitin-40S ribosomal protein S27a [15] [16] [17] [18] [19] [20] [21]
4 UBC Polyubiquitin-C [22] -0.45[23] -0.42[24] -0.59[25] -0.15[26] -0.31[27] -0.36[28]
5 DUSP1 Dual specificity protein phosphatase 1 [29] -1.67[30] -2.07[31] -2.62[32] -3.01[33] 0.79[34] 0.94[35]
6 UBA52 Ubiquitin-60S ribosomal protein L40 [36] 1.99[37] 1.81[38] 2.93[39] 1.25[40] 1.91[41] 0.40[42]
7 YWHAB 14-3-3 protein beta/alpha [43] 2.35[44] 1.97[45] 1.33[46] 3.08[47] 2.37[48] 0.96[49]
8 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [50] 0.38[51] -0.03[52] 0.62[53] 1.24[54] 1.59[55] -0.13[56]
9 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 2.11[57] 1.85[58] 1.85[59] 2.99[60] 2.17[61] 1.21[62]
10 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [63] 1.36[64] 0.96[65] 1.90[66] 0.94[67] 1.27[68] -0.64[69]
11 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1.58[70] 1.59[71] 1.03[72] 2.52[73] 2.49[74] 0.96[75]
12 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.91[76] 0.49[77] 0.64[78] 1.32[79] 1.07[80] 0.07[81]
13 RAF1 RAF proto-oncogene serine/threonine-protein kinase [82] 1.24[83] 1.57[84] 2.91[85] 1.59[86] 2.31[87] 2.16[88]
14 DUSP6 Dual specificity protein phosphatase 6 [89] 0.82[90] 2.82[91] 2.17[92] -2.13[93] 1.51[94] 1.31[95]
15 DUSP5 Dual specificity protein phosphatase 5 [96] 0.05[97] -3.89[98] 1.39[99] 0.24[100] -0.60[101] -1.39[102]
16 NRAS GTPase NRas [103] 1.94[104] 2.29[105] 2.77[106] 2.78[107] 2.20[108] 0.81[109]
17 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform 0.19[110] 0.99[111] 1.79[112] 1.53[113] 0.25[114] 1.70[115]
18 PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 1.00[116] 1.79[117] 1.57[118] 2.72[119] 2.38[120] 0.86[121]
19 ARAF Serine/threonine-protein kinase A-Raf [122] 0.85[123] 0.46[124] 0.81[125] 1.68[126] 1.57[127] 1.94[128]
20 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1.76[129] 1.15[130] 1.64[131] 2.05[132] 1.68[133] 3.99[134]
21 PPP5C Serine/threonine-protein phosphatase 5 [135] 1.36[136] 1.12[137] 1.64[138] 1.93[139] 2.36[140] 0.82[141]
22 HRAS GTPase HRas [142] 0.30[143] -0.49[144] -1.21[145] 0.83[146] 0.47[147] -1.60[148]
23 MAPK1 Mitogen-activated protein kinase 1 [149] 3.02[150] 3.07[151] 2.97[152] 3.63[153] 3.13[154] 2.84[155]
24 KRAS GTPase KRas [156] 0.79[157] 0.69[158] 2.36[159] 2.58[160] 2.09[161] 1.74[162]
25 MARK3 MAP/microtubule affinity-regulating kinase 3 [163] 1.23[164] 1.41[165] 1.47[166] 2.91[167] 2.45[168] 1.33[169]
26 DUSP9 Dual specificity protein phosphatase 9 [170] 4.77[171] 5.04[172] 3.59[173] -3.24[174] -3.55[175] -3.22[176]
27 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 2.56[177] 2.23[178] 1.87[179] 3.07[180] 2.80[181] 0.79[182]
28 DUSP16 Dual specificity protein phosphatase 16 [183] 2.87[184] 2.81[185] 2.62[186] 0.38[187] 1.13[188] 2.51[189]
29 DUSP10 Dual specificity protein phosphatase 10 [190] -1.69[191] -2.52[192] -1.00[193] 0.98[194] -0.16[195] 1.06[196]
30 PTPN3 Tyrosine-protein phosphatase non-receptor type 3 [197] 1.71[198] 1.90[199] 2.21[200] 1.49[201] 2.26[202] 3.62[203]
31 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1.42[204] 1.52[205] 1.12[206] 2.64[207] 2.28[208] 1.25[209]
32 MAPK3 Mitogen-activated protein kinase 3 [210] 3.16[211] 3.12[212] 3.23[213] 2.20[214] 2.07[215] 0.02[216]
33 BRAP BRCA1-associated protein [217] 1.66[218] 1.78[219] 1.94[220] 2.66[221] 2.62[222] 1.80[223]
34 PPP2R5B Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform 2.08[224] 1.76[225] 1.19[226] 2.07[227] 3.08[228] 1.16[229]
35 PAQR3 Progestin and adipoQ receptor family member 3 [230] 2.78[231] 2.29[232] 2.85[233] 2.84[234] 4.05[235] 2.10[236]
36 DUSP8 Dual specificity protein phosphatase 8 [237] 2.45[238] 1.80[239] 1.06[240] 0.35[241] 0.78[242] -2.76[243]
37 DUSP7 Dual specificity protein phosphatase 7 [244] 2.86[245] 1.86[246] 3.19[247] 1.35[248] 3.59[249] 1.09[250]
38 BRAF Serine/threonine-protein kinase B-raf [251] 1.56[252] 1.20[253] 3.31[254] 2.52[255] 2.06[256] 2.91[257]
39 MAPK12 Mitogen-activated protein kinase 12 [258] 4.13[259] 3.71[260] 4.89[261] 3.26[262] 4.37[263] 0.16[264]
40 DUSP2 Dual specificity protein phosphatase 2 [265] -1.45[266] [267] -6.19[268] 1.50[269] 1.40[270] 1.11[271]
41 KSR1 Kinase suppressor of Ras 1 [272] 4.57[273] 4.19[274] 1.18[275] 3.83[276] 4.17[277] 1.79[278]
42 PTPN7 Tyrosine-protein phosphatase non-receptor type 7 [279] -0.57[280] [281] [282] -1.77[283] [284] 3.67[285]
43 DUSP4 Dual specificity protein phosphatase 4 [286] 6.81[287] 3.72[288] 9.69[289] 9.51[290] 7.30[291] 4.89[292]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte PEBP1
Mean 629
Standard deviation 4.9e+02
Values 1.1e+03 1.7e+02 63 7.4e+02 1.1e+03
[9]
HepG2 PEBP1
Mean 387
Standard deviation 1.1e+02
Values 3.1e+02 4.7e+02
[10]
HepG2.C3A PEBP1
Mean 441
Standard deviation 17
Values 4.3e+02 4.5e+02
[11]
HuH.7 PEBP1
Mean 209
Standard deviation 28
Values 2e+02 1.9e+02 2.4e+02
[12]
SNU475 PEBP1
Mean 41.7
Standard deviation 11
Values 49 34
[13]
THLE PEBP1
Mean 69.9
Standard deviation 7.3
Values 65 75
[14]
liver PEBP1
Mean 541
Standard deviation 4.8e+02
Values 1.1e+03 1.4e+02 7.1e+02 1.7e+02
[15]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[16]
HepG2 RPS27A
Missing
[17]
HepG2.C3A RPS27A
Missing
[18]
HuH.7 RPS27A
Missing
[19]
SNU475 RPS27A
Missing
[20]
THLE RPS27A
Missing
[21]
liver RPS27A
Missing
[22]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[23]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[24]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[25]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[26]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[27]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[28]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[29]
ref_hepatocyte DUSP1
Mean 86.9
Standard deviation 80
Values 13 43 1.2e+02 2.1e+02 49
[30]
HepG2 DUSP1
Mean 24.4
Standard deviation 17
Values 36 12
[31]
HepG2.C3A DUSP1
Mean 17.4
Standard deviation 9.2
Values 24 11
[32]
HuH.7 DUSP1
Mean 10.9
Standard deviation 8.1
Values 5.7 20 6.7
[33]
SNU475 DUSP1
Mean 5.79
Standard deviation 1.2
Values 5 6.6
[34]
THLE DUSP1
Mean 100
Standard deviation 2.2
Values 1e+02 98
[35]
liver DUSP1
Mean 114
Standard deviation 83
Values 2.2e+02 62 1.3e+02 38
[36]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[37]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[38]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[39]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[40]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[41]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[42]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[43]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[44]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[45]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[46]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[47]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[48]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[49]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[50]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[51]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[52]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[53]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[54]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[55]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[56]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[57]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[58]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[59]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[60]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[61]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[62]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[63]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[64]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[65]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[66]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[67]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[68]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[69]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[70]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[71]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[72]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[73]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[74]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[75]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[76]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[77]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[78]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[79]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[80]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[81]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[82]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[83]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[84]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[85]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 6 14 20 20 17
[86]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 29 36
[87]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 41 37
[88]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 85 93 89
[89]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 22 28
[90]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[91]
liver RAF1
Mean 47
Standard deviation 3.6
Values 51 42 49 46
[92]
ref_hepatocyte DUSP6
Mean 15.3
Standard deviation 12
Values 1.5 4.5 29 26 15
[93]
HepG2 DUSP6
Mean 24.2
Standard deviation 10
Values 31 17
[94]
HepG2.C3A DUSP6
Mean 91
Standard deviation 18
Values 1e+02 78
[95]
HuH.7 DUSP6
Mean 52.9
Standard deviation 18
Values 62 32 65
[96]
SNU475 DUSP6
Mean 1.87
Standard deviation 2.3
Values 0.26 3.5
[97]
THLE DUSP6
Mean 28.9
Standard deviation 3.7
Values 26 32
[98]
liver DUSP6
Mean 25.9
Standard deviation 9.5
Values 38 19 28 18
[99]
ref_hepatocyte DUSP5
Mean 14.8
Standard deviation 22
Values 0 16 52 3.6 2
[100]
HepG2 DUSP5
Mean 13.7
Standard deviation 10
Values 21 6.5
[101]
HepG2.C3A DUSP5
Mean 0.842
Standard deviation 0.16
Values 0.73 0.95
[102]
HuH.7 DUSP5
Mean 29.8
Standard deviation 5.2
Values 24 34 31
[103]
SNU475 DUSP5
Mean 9.32
Standard deviation 4.3
Values 6.3 12
[104]
THLE DUSP5
Mean 6.48
Standard deviation 0.82
Values 7.1 5.9
[105]
liver DUSP5
Mean 3.85
Standard deviation 1.1
Values 2.4 5 3.8 4.2
[106]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[107]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[108]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[109]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[110]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[111]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[112]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[113]
ref_hepatocyte PPP2R5A
Mean 14.2
Standard deviation 11
Values 8.7 5.8 6.2 21 30
[114]
HepG2 PPP2R5A
Mean 14.4
Standard deviation 0.58
Values 14 15
[115]
HepG2.C3A PPP2R5A
Mean 23.8
Standard deviation 5
Values 27 20
[116]
HuH.7 PPP2R5A
Mean 37.7
Standard deviation 14
Values 28 54 31
[117]
SNU475 PPP2R5A
Mean 21.9
Standard deviation 3
Values 24 20
[118]
THLE PPP2R5A
Mean 11.3
Standard deviation 0.33
Values 12 11
[119]
liver PPP2R5A
Mean 31.4
Standard deviation 5.3
Values 33 37 24 32
[120]
ref_hepatocyte PPP2R5C
Mean 14.1
Standard deviation 2.7
Values 15 17 10 13 15
[121]
HepG2 PPP2R5C
Mean 25.2
Standard deviation 5.7
Values 21 29
[122]
HepG2.C3A PPP2R5C
Mean 41.3
Standard deviation 0.87
Values 41 42
[123]
HuH.7 PPP2R5C
Mean 32.2
Standard deviation 4.1
Values 31 37 29
[124]
SNU475 PPP2R5C
Mean 49.7
Standard deviation 5.7
Values 54 46
[125]
THLE PPP2R5C
Mean 48.8
Standard deviation 6.3
Values 44 53
[126]
liver PPP2R5C
Mean 17.5
Standard deviation 1.8
Values 18 20 16 16
[127]
ref_hepatocyte ARAF
Mean 12.3
Standard deviation 8
Values 4.1 4 13 21 19
[128]
HepG2 ARAF
Mean 19.8
Standard deviation 1.6
Values 21 19
[129]
HepG2.C3A ARAF
Mean 14.3
Standard deviation 2.2
Values 16 13
[130]
HuH.7 ARAF
Mean 16.5
Standard deviation 1.9
Values 18 14 17
[131]
SNU475 ARAF
Mean 21.1
Standard deviation 1.4
Values 22 20
[132]
THLE ARAF
Mean 24.2
Standard deviation 1.6
Values 23 25
[133]
liver ARAF
Mean 32.1
Standard deviation 23
Values 50 11 54 13
[134]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[135]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[136]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[137]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[138]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[139]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[140]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[141]
ref_hepatocyte PPP5C
Mean 11.7
Standard deviation 4.1
Values 6.7 18 10 13 11
[142]
HepG2 PPP5C
Mean 26.8
Standard deviation 1.3
Values 28 26
[143]
HepG2.C3A PPP5C
Mean 21.4
Standard deviation 2.5
Values 20 23
[144]
HuH.7 PPP5C
Mean 28
Standard deviation 11
Values 28 17 39
[145]
SNU475 PPP5C
Mean 23.9
Standard deviation 1
Values 23 25
[146]
THLE PPP5C
Mean 39.9
Standard deviation 5.8
Values 36 44
[147]
liver PPP5C
Mean 14.1
Standard deviation 1.2
Values 16 13 13 14
[148]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[149]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[150]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[151]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[152]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[153]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[154]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[155]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[156]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[157]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[158]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[159]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[160]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[161]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[162]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[163]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[164]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[165]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[166]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[167]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[168]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[169]
ref_hepatocyte MARK3
Mean 8.81
Standard deviation 4
Values 6.9 13 14 6.1 4.9
[170]
HepG2 MARK3
Mean 18.5
Standard deviation 2.2
Values 17 20
[171]
HepG2.C3A MARK3
Mean 19.8
Standard deviation 0.88
Values 20 19
[172]
HuH.7 MARK3
Mean 18.8
Standard deviation 1.9
Values 18 17 21
[173]
SNU475 MARK3
Mean 35.5
Standard deviation 3.7
Values 33 38
[174]
THLE MARK3
Mean 32
Standard deviation 0.32
Values 32 32
[175]
liver MARK3
Mean 15.1
Standard deviation 6.7
Values 11 22 8.1 20
[176]
ref_hepatocyte DUSP9
Mean 8.55
Standard deviation 19
Values 42 0 0.022 0.06 0.16
[177]
HepG2 DUSP9
Mean 207
Standard deviation 22
Values 2.2e+02 1.9e+02
[178]
HepG2.C3A DUSP9
Mean 236
Standard deviation 24
Values 2.5e+02 2.2e+02
[179]
HuH.7 DUSP9
Mean 79
Standard deviation 11
Values 67 87 83
[180]
SNU475 DUSP9
Mean 0.485
Standard deviation 0.1
Values 0.41 0.56
[181]
THLE DUSP9
Mean 0.487
Standard deviation 0.019
Values 0.47 0.5
[182]
liver DUSP9
Mean 0.625
Standard deviation 0.59
Values 0.82 0.2 0.1 1.4
[183]
ref_hepatocyte PPP2R5D
Mean 7.67
Standard deviation 1.8
Values 11 7.4 6.7 6.6 6.7
[184]
HepG2 PPP2R5D
Mean 40.3
Standard deviation 5.9
Values 36 44
[185]
HepG2.C3A PPP2R5D
Mean 30.4
Standard deviation 4.1
Values 27 33
[186]
HuH.7 PPP2R5D
Mean 21.5
Standard deviation 4.4
Values 26 17 22
[187]
SNU475 PPP2R5D
Mean 34.4
Standard deviation 4.8
Values 38 31
[188]
THLE PPP2R5D
Mean 35.6
Standard deviation 5.6
Values 32 40
[189]
liver PPP2R5D
Mean 9.05
Standard deviation 4.1
Values 11 5.8 14 5.4
[190]
ref_hepatocyte DUSP16
Mean 7.61
Standard deviation 4
Values 4.7 12 12 6.1 3.5
[191]
HepG2 DUSP16
Mean 49.8
Standard deviation 0.41
Values 50 50
[192]
HepG2.C3A DUSP16
Mean 44.8
Standard deviation 6.7
Values 50 40
[193]
HuH.7 DUSP16
Mean 35.9
Standard deviation 14
Values 33 51 24
[194]
SNU475 DUSP16
Mean 5.29
Standard deviation 0.16
Values 5.4 5.2
[195]
THLE DUSP16
Mean 11.1
Standard deviation 0.034
Values 11 11
[196]
liver DUSP16
Mean 29.5
Standard deviation 18
Values 14 47 14 43
[197]
ref_hepatocyte DUSP10
Mean 7.44
Standard deviation 3.9
Values 1.9 7.2 5.9 12 10
[198]
HepG2 DUSP10
Mean 2.05
Standard deviation 0.45
Values 2.4 1.7
[199]
HepG2.C3A DUSP10
Mean 1.09
Standard deviation 0.49
Values 1.4 0.74
[200]
HuH.7 DUSP10
Mean 2.85
Standard deviation 1.9
Values 1.8 5.1 1.6
[201]
SNU475 DUSP10
Mean 7.88
Standard deviation 4.2
Values 11 4.9
[202]
THLE DUSP10
Mean 4.44
Standard deviation 0.4
Values 4.2 4.7
[203]
liver DUSP10
Mean 10.6
Standard deviation 2.1
Values 14 8.9 10 9.7
[204]
ref_hepatocyte PTPN3
Mean 6.09
Standard deviation 3.4
Values 2 3.5 6.4 10 8.5
[205]
HepG2 PTPN3
Mean 17.8
Standard deviation 1.5
Values 19 17
[206]
HepG2.C3A PTPN3
Mean 19.1
Standard deviation 3.7
Values 22 17
[207]
HuH.7 PTPN3
Mean 21.6
Standard deviation 1.3
Values 23 22 20
[208]
SNU475 PTPN3
Mean 9.15
Standard deviation 0.66
Values 9.6 8.7
[209]
THLE PTPN3
Mean 19.4
Standard deviation 0.74
Values 20 19
[210]
liver PTPN3
Mean 51.2
Standard deviation 8.7
Values 56 60 41 47
[211]
ref_hepatocyte PPP2R5E
Mean 5.64
Standard deviation 2
Values 6.5 7.7 6.9 3.9 3.2
[212]
HepG2 PPP2R5E
Mean 13.5
Standard deviation 2.7
Values 12 15
[213]
HepG2.C3A PPP2R5E
Mean 13.6
Standard deviation 2.9
Values 11 16
[214]
HuH.7 PPP2R5E
Mean 9.42
Standard deviation 2.1
Values 12 9.4 7.3
[215]
SNU475 PPP2R5E
Mean 18.8
Standard deviation 1.2
Values 20 18
[216]
THLE PPP2R5E
Mean 18.2
Standard deviation 0.7
Values 18 19
[217]
liver PPP2R5E
Mean 9.17
Standard deviation 1.5
Values 11 9.6 9.4 7
[218]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[219]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[220]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[221]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[222]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[223]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[224]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[225]
ref_hepatocyte BRAP
Mean 3.21
Standard deviation 1.1
Values 4.5 3 3.9 2.8 1.8
[226]
HepG2 BRAP
Mean 9.06
Standard deviation 1.2
Values 8.2 9.9
[227]
HepG2.C3A BRAP
Mean 9.29
Standard deviation 2
Values 7.9 11
[228]
HuH.7 BRAP
Mean 9.44
Standard deviation 0.52
Values 9.4 8.9 10
[229]
SNU475 BRAP
Mean 10.8
Standard deviation 1.1
Values 10 12
[230]
THLE BRAP
Mean 13.2
Standard deviation 0.98
Values 12 14
[231]
liver BRAP
Mean 7.63
Standard deviation 0.83
Values 7.1 8.6 8 6.8
[232]
ref_hepatocyte PPP2R5B
Mean 2.1
Standard deviation 0.85
Values 1.5 2.2 2.4 3.3 1.2
[233]
HepG2 PPP2R5B
Mean 7.95
Standard deviation 0.71
Values 7.4 8.5
[234]
HepG2.C3A PPP2R5B
Mean 6.01
Standard deviation 3.4
Values 8.4 3.6
[235]
HuH.7 PPP2R5B
Mean 3.69
Standard deviation 1.6
Values 2.4 5.5 3.2
[236]
SNU475 PPP2R5B
Mean 4.72
Standard deviation 0.053
Values 4.8 4.7
[237]
THLE PPP2R5B
Mean 11.9
Standard deviation 2.7
Values 14 10
[238]
liver PPP2R5B
Mean 3.19
Standard deviation 1.1
Values 3.5 2 4.5 2.8
[239]
ref_hepatocyte PAQR3
Mean 1.67
Standard deviation 1.3
Values 1.4 3.8 1.5 0.45 1.1
[240]
HepG2 PAQR3
Mean 10.2
Standard deviation 0.76
Values 11 9.7
[241]
HepG2.C3A PAQR3
Mean 6.85
Standard deviation 1.1
Values 6.1 7.6
[242]
HuH.7 PAQR3
Mean 9.22
Standard deviation 1.8
Values 11 8.3 8
[243]
SNU475 PAQR3
Mean 6.4
Standard deviation 0.019
Values 6.4 6.4
[244]
THLE PAQR3
Mean 18.3
Standard deviation 1
Values 18 19
[245]
liver PAQR3
Mean 4.87
Standard deviation 0.49
Values 4.2 5.2 4.8 5.3
[246]
ref_hepatocyte DUSP8
Mean 1.65
Standard deviation 1.8
Values 1.4 1.4 4.7 0.78 0
[247]
HepG2 DUSP8
Mean 8.05
Standard deviation 3
Values 10 5.9
[248]
HepG2.C3A DUSP8
Mean 4.84
Standard deviation 3.1
Values 7.1 2.6
[249]
HuH.7 DUSP8
Mean 2.64
Standard deviation 2.5
Values 1.2 5.5 1.2
[250]
SNU475 DUSP8
Mean 1.13
Standard deviation 0.22
Values 1.3 0.97
[251]
THLE DUSP8
Mean 1.88
Standard deviation 0.61
Values 2.3 1.5
[252]
liver DUSP8
Mean 0.165
Standard deviation 0.085
Values 0.12 0.086 0.18 0.28
[253]
ref_hepatocyte DUSP7
Mean 1.21
Standard deviation 1.1
Values 1.2 0.72 3.1 0.56 0.45
[254]
HepG2 DUSP7
Mean 7.84
Standard deviation 0.41
Values 8.1 7.6
[255]
HepG2.C3A DUSP7
Mean 3.71
Standard deviation 0.37
Values 3.5 4
[256]
HuH.7 DUSP7
Mean 8.47
Standard deviation 1.7
Values 9.6 6.5 9.2
[257]
SNU475 DUSP7
Mean 1.66
Standard deviation 0.53
Values 1.3 2
[258]
THLE DUSP7
Mean 9.74
Standard deviation 1.7
Values 8.5 11
[259]
liver DUSP7
Mean 1.76
Standard deviation 0.63
Values 2.3 1.3 1.2 2.3
[260]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 0.56 1.2 2.3 0.67 0.67
[261]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 2.4 3.2
[262]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 1.6 2.5
[263]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 6.4 15 3.4
[264]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.2 3.4
[265]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[266]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 3.1 8 2.9 7.9
[267]
ref_hepatocyte MAPK12
Mean 0.743
Standard deviation 0.94
Values 2.4 0.4 0.21 0.41 0.28
[268]
HepG2 MAPK12
Mean 11.6
Standard deviation 3.6
Values 14 9
[269]
HepG2.C3A MAPK12
Mean 8.16
Standard deviation 0.15
Values 8.1 8.3
[270]
HuH.7 MAPK12
Mean 16.9
Standard deviation 6.7
Values 18 9.7 23
[271]
SNU475 MAPK12
Mean 3.82
Standard deviation 1.9
Values 5.2 2.5
[272]
THLE MAPK12
Mean 10.2
Standard deviation 1.3
Values 9.2 11
[273]
liver MAPK12
Mean 0.564
Standard deviation 0.13
Values 0.47 0.43 0.67 0.69
[274]
ref_hepatocyte DUSP2
Mean 0.519
Standard deviation 0.46
Values 0 0.14 0.5 1 0.95
[275]
HepG2 DUSP2
Mean 0.169
Standard deviation 0.24
Values 0.34 0
[276]
HepG2.C3A DUSP2
Mean 0
Standard deviation 0
Values 0 0
[277]
HuH.7 DUSP2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[278]
SNU475 DUSP2
Mean 0.788
Standard deviation 0.35
Values 0.54 1
[279]
THLE DUSP2
Mean 0.913
Standard deviation 0.065
Values 0.96 0.87
[280]
liver DUSP2
Mean 0.762
Standard deviation 0.25
Values 0.75 0.74 1.1 0.48
[281]
ref_hepatocyte KSR1
Mean 0.387
Standard deviation 0.39
Values 1 0.34 0.38 0.06 0.11
[282]
HepG2 KSR1
Mean 8.21
Standard deviation 0.63
Values 8.7 7.8
[283]
HepG2.C3A KSR1
Mean 5.95
Standard deviation 0.11
Values 6 5.9
[284]
HuH.7 KSR1
Mean 0.672
Standard deviation 0.25
Values 0.6 0.95 0.47
[285]
SNU475 KSR1
Mean 2.94
Standard deviation 0.81
Values 2.4 3.5
[286]
THLE KSR1
Mean 4.65
Standard deviation 0.57
Values 4.2 5
[287]
liver KSR1
Mean 0.913
Standard deviation 0.48
Values 0.49 1.4 0.51 1.2
[288]
ref_hepatocyte PTPN7
Mean 0.0927
Standard deviation 0.21
Values 0 0 0 0 0.46
[289]
HepG2 PTPN7
Mean 0.0558
Standard deviation 0.018
Values 0.069 0.043
[290]
HepG2.C3A PTPN7
Mean 0
Standard deviation 0
Values 0 0
[291]
HuH.7 PTPN7
Mean 0
Standard deviation 0
Values 0 0 0
[292]
SNU475 PTPN7
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[293]
THLE PTPN7
Mean 0
Standard deviation 0
Values 0 0
[294]
liver PTPN7
Mean 0.805
Standard deviation 0.34
Values 0.85 0.41 1.2 0.73
[295]
ref_hepatocyte DUSP4
Mean 0.0303
Standard deviation 0.044
Values 0 0 0 0.095 0.057
[296]
HepG2 DUSP4
Mean 3.05
Standard deviation 2.7
Values 4.9 1.2
[297]
HepG2.C3A DUSP4
Mean 0.336
Standard deviation 0.0055
Values 0.34 0.33
[298]
HuH.7 DUSP4
Mean 19.3
Standard deviation 5.6
Values 23 13 22
[299]
SNU475 DUSP4
Mean 11.8
Standard deviation 7.2
Values 6.8 17
[300]
THLE DUSP4
Mean 3.18
Standard deviation 0.19
Values 3 3.3
[301]
liver DUSP4
Mean 0.614
Standard deviation 0.19
Values 0.45 0.73 0.46 0.82