REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.81[2] | -1.00[3] | -1.09[4] | -1.02[5] | -0.70[6] | -0.37[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.36[16] | -0.25[17] | -0.73[18] | -0.16[19] | -0.32[20] | 0.08[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.07[23] | 1.99[24] | 2.78[25] | 1.23[26] | 1.90[27] | 0.85[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 2.19[29] | 2.02[30] | 1.70[31] | 2.97[32] | 2.15[33] | 1.65[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.66[35] | 1.77[36] | 0.89[37] | 2.50[38] | 2.47[39] | 1.41[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 1.00[41] | 0.66[42] | 0.50[43] | 1.31[44] | 1.06[45] | 0.52[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | 1.84[48] | 2.28[49] | 1.99[50] | 2.65[51] | 3.14[52] | 2.77[53] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [54] | 2.59[55] | 2.43[56] | 2.31[57] | 2.32[58] | 2.09[59] | 1.81[60] |
10 | FGFR4 | Fibroblast growth factor receptor 4 | [61] | 3.35[62] | 3.70[63] | 4.03[64] | -2.47[65] | -2.74[66] | 2.01[67] |
11 | MAPK1 | Mitogen-activated protein kinase 1 | [68] | 3.10[69] | 3.25[70] | 2.83[71] | 3.61[72] | 3.12[73] | 3.29[74] |
12 | KLB | Beta-klotho | [75] | 1.99[76] | 1.83[77] | 3.03[78] | -4.20[79] | -4.99[80] | 3.06[81] |
13 | MAPK3 | Mitogen-activated protein kinase 3 | [82] | 3.24[83] | 3.30[84] | 3.09[85] | 2.19[86] | 2.06[87] | 0.47[88] |
14 | FGF2 | Fibroblast growth factor 2 | [89] | -5.29[90] | -5.03[91] | -1.13[92] | 2.70[93] | 4.13[94] | -0.15[95] |
15 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [96] | 1.76[97] | 1.39[98] | 1.66[99] | 2.11[100] | 1.56[101] | 2.21[102] |
16 | SRC | Proto-oncogene tyrosine-protein kinase Src | [103] | 4.42[104] | 4.41[105] | 3.16[106] | 4.16[107] | 3.19[108] | 0.66[109] |
17 | SPRY2 | Protein sprouty homolog 2 | [110] | 0.79[111] | 0.95[112] | 3.13[113] | -0.51[114] | 1.37[115] | 1.68[116] |
18 | FRS2 | Fibroblast growth factor receptor substrate 2 | [117] | 2.68[118] | 3.78[119] | 4.03[120] | 4.67[121] | 4.15[122] | 4.85[123] |
19 | BRAF | Serine/threonine-protein kinase B-raf | [124] | 1.64[125] | 1.38[126] | 3.16[127] | 2.50[128] | 2.05[129] | 3.36[130] |
20 | CBL | E3 ubiquitin-protein ligase CBL | [131] | 5.84[132] | 4.79[133] | 4.77[134] | 6.90[135] | 6.24[136] | 5.27[137] |
21 | FGF1 | Fibroblast growth factor 1 | [138] | -1.37[139] | -0.58[140] | -5.28[141] | 2.35[142] | 3.78[143] | 1.55[144] |
22 | FGF19 | Fibroblast growth factor 19 | [145] | -0.67[146] | 0.49[147] | 6.99[148] | 2.59[149] | -1.02[150] | [151] |
23 | FGF8 | Fibroblast growth factor 8 | [152] | -1.94[153] | -1.58[154] | 2.67[155] | -0.15[156] | [157] | 4.20[158] |
24 | FGF18 | Fibroblast growth factor 18 | [159] | 3.17[160] | -0.94[161] | 0.99[162] | 2.38[163] | 2.83[164] | 2.09[165] |
25 | FGF9 | Fibroblast growth factor 9 | [166] | 3.65[167] | 0.00[168] | [169] | 4.55[170] | -0.71[171] | 1.61[172] |
26 | FGF16 | Fibroblast growth factor 16 | [173] | [174] | [175] | [176] | [177] | [178] | [179] |
27 | FGF4 | Fibroblast growth factor 4 | [180] | [181] | [182] | [183] | [184] | [185] | [186] |
28 | FGF17 | Fibroblast growth factor 17 | [187] | [188] | [189] | [190] | [191] | [192] | [193] |
29 | FGF23 | Fibroblast growth factor 23 | [194] | [195] | [196] | [197] | [198] | [199] | [200] |
30 | FGF20 | Fibroblast growth factor 20 | [201] | [202] | [203] | [204] | [205] | [206] | [207] |
31 | FGF6 | Fibroblast growth factor 6 | [208] | [209] | [210] | [211] | [212] | [213] | [214] |