REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.77[2] | -0.93[3] | -0.94[4] | -1.03[5] | -0.72[6] | -0.30[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.33[16] | -0.18[17] | -0.58[18] | -0.18[19] | -0.34[20] | 0.15[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.11[23] | 2.05[24] | 2.93[25] | 1.22[26] | 1.89[27] | 0.92[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 2.23[29] | 2.09[30] | 1.86[31] | 2.96[32] | 2.14[33] | 1.72[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.70[35] | 1.83[36] | 1.04[37] | 2.49[38] | 2.46[39] | 1.47[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 1.03[41] | 0.73[42] | 0.65[43] | 1.29[44] | 1.04[45] | 0.59[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | 1.87[48] | 2.34[49] | 2.14[50] | 2.64[51] | 3.12[52] | 2.84[53] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [54] | 2.62[55] | 2.50[56] | 2.46[57] | 2.30[58] | 2.07[59] | 1.88[60] |
10 | MAPK1 | Mitogen-activated protein kinase 1 | [61] | 3.13[62] | 3.31[63] | 2.98[64] | 3.60[65] | 3.10[66] | 3.35[67] |
11 | FGFR3 | Fibroblast growth factor receptor 3 | [68] | 4.15[69] | 4.11[70] | 4.28[71] | -1.54[72] | -0.34[73] | 2.03[74] |
12 | MAPK3 | Mitogen-activated protein kinase 3 | [75] | 3.28[76] | 3.36[77] | 3.24[78] | 2.17[79] | 2.05[80] | 0.54[81] |
13 | FGF2 | Fibroblast growth factor 2 | [82] | -5.26[83] | -4.97[84] | -0.98[85] | 2.68[86] | 4.12[87] | -0.09[88] |
14 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [89] | 1.79[90] | 1.46[91] | 1.81[92] | 2.09[93] | 1.55[94] | 2.28[95] |
15 | SRC | Proto-oncogene tyrosine-protein kinase Src | [96] | 4.45[97] | 4.48[98] | 3.31[99] | 4.15[100] | 3.18[101] | 0.73[102] |
16 | SPRY2 | Protein sprouty homolog 2 | [103] | 0.83[104] | 1.02[105] | 3.28[106] | -0.52[107] | 1.36[108] | 1.75[109] |
17 | FRS2 | Fibroblast growth factor receptor substrate 2 | [110] | 2.71[111] | 3.85[112] | 4.19[113] | 4.65[114] | 4.13[115] | 4.92[116] |
18 | BRAF | Serine/threonine-protein kinase B-raf | [117] | 1.67[118] | 1.44[119] | 3.31[120] | 2.49[121] | 2.04[122] | 3.43[123] |
19 | CBL | E3 ubiquitin-protein ligase CBL | [124] | 5.87[125] | 4.86[126] | 4.92[127] | 6.88[128] | 6.22[129] | 5.33[130] |
20 | FGF5 | Fibroblast growth factor 5 | [131] | 0.43[132] | 1.80[133] | 1.56[134] | 3.23[135] | 2.77[136] | 4.71[137] |
21 | FGF1 | Fibroblast growth factor 1 | [138] | -1.34[139] | -0.51[140] | -5.13[141] | 2.34[142] | 3.77[143] | 1.62[144] |
22 | FGF8 | Fibroblast growth factor 8 | [145] | -1.90[146] | -1.51[147] | 2.82[148] | -0.17[149] | [150] | 4.27[151] |
23 | FGF18 | Fibroblast growth factor 18 | [152] | 3.20[153] | -0.87[154] | 1.14[155] | 2.37[156] | 2.81[157] | 2.16[158] |
24 | FGF9 | Fibroblast growth factor 9 | [159] | 3.68[160] | 0.07[161] | [162] | 4.53[163] | -0.73[164] | 1.68[165] |
25 | FGF17 | Fibroblast growth factor 17 | [166] | [167] | [168] | [169] | [170] | [171] | [172] |
26 | FGF23 | Fibroblast growth factor 23 | [173] | [174] | [175] | [176] | [177] | [178] | [179] |
27 | FGF20 | Fibroblast growth factor 20 | [180] | [181] | [182] | [183] | [184] | [185] | [186] |
28 | FGF16 | Fibroblast growth factor 16 | [187] | [188] | [189] | [190] | [191] | [192] | [193] |
29 | FGF4 | Fibroblast growth factor 4 | [194] | [195] | [196] | [197] | [198] | [199] | [200] |