REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.68[2] | -0.84[3] | -0.85[4] | -1.04[5] | -0.72[6] | -0.31[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.23[16] | -0.09[17] | -0.49[18] | -0.19[19] | -0.34[20] | 0.14[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.20[23] | 2.15[24] | 3.02[25] | 1.21[26] | 1.89[27] | 0.91[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 2.32[29] | 2.18[30] | 1.95[31] | 2.95[32] | 2.14[33] | 1.71[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.79[35] | 1.93[36] | 1.13[37] | 2.48[38] | 2.46[39] | 1.46[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 1.13[41] | 0.82[42] | 0.74[43] | 1.28[44] | 1.04[45] | 0.58[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | 1.97[48] | 2.44[49] | 2.23[50] | 2.63[51] | 3.12[52] | 2.82[53] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [54] | 2.72[55] | 2.59[56] | 2.55[57] | 2.29[58] | 2.07[59] | 1.86[60] |
10 | MAPK1 | Mitogen-activated protein kinase 1 | [61] | 3.23[62] | 3.41[63] | 3.07[64] | 3.59[65] | 3.10[66] | 3.34[67] |
11 | MAPK3 | Mitogen-activated protein kinase 3 | [68] | 3.37[69] | 3.46[70] | 3.33[71] | 2.16[72] | 2.05[73] | 0.52[74] |
12 | FGF2 | Fibroblast growth factor 2 | [75] | -5.16[76] | -4.87[77] | -0.89[78] | 2.67[79] | 4.12[80] | -0.10[81] |
13 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [82] | 1.89[83] | 1.55[84] | 1.90[85] | 2.08[86] | 1.55[87] | 2.26[88] |
14 | SRC | Proto-oncogene tyrosine-protein kinase Src | [89] | 4.55[90] | 4.57[91] | 3.40[92] | 4.14[93] | 3.18[94] | 0.71[95] |
15 | SPRY2 | Protein sprouty homolog 2 | [96] | 0.93[97] | 1.11[98] | 3.37[99] | -0.53[100] | 1.35[101] | 1.74[102] |
16 | FGFR2 | Fibroblast growth factor receptor 2 | [103] | -0.99[104] | 0.26[105] | 4.03[106] | 3.19[107] | -1.78[108] | 4.99[109] |
17 | FRS2 | Fibroblast growth factor receptor substrate 2 | [110] | 2.81[111] | 3.94[112] | 4.27[113] | 4.64[114] | 4.13[115] | 4.91[116] |
18 | BRAF | Serine/threonine-protein kinase B-raf | [117] | 1.77[118] | 1.54[119] | 3.40[120] | 2.48[121] | 2.04[122] | 3.42[123] |
19 | FGF7 | Fibroblast growth factor 7 | [124] | -7.77[125] | -4.04[126] | [127] | -3.64[128] | 0.50[129] | 0.11[130] |
20 | CBL | E3 ubiquitin-protein ligase CBL | [131] | 5.97[132] | 4.95[133] | 5.01[134] | 6.87[135] | 6.22[136] | 5.32[137] |
21 | FGF5 | Fibroblast growth factor 5 | [138] | 0.53[139] | 1.89[140] | 1.65[141] | 3.22[142] | 2.77[143] | 4.70[144] |
22 | FGF1 | Fibroblast growth factor 1 | [145] | -1.24[146] | -0.42[147] | -5.04[148] | 2.32[149] | 3.77[150] | 1.60[151] |
23 | FGF8 | Fibroblast growth factor 8 | [152] | -1.81[153] | -1.42[154] | 2.91[155] | -0.18[156] | [157] | 4.26[158] |
24 | FGF18 | Fibroblast growth factor 18 | [159] | 3.30[160] | -0.78[161] | 1.23[162] | 2.35[163] | 2.81[164] | 2.15[165] |
25 | FGF9 | Fibroblast growth factor 9 | [166] | 3.78[167] | 0.16[168] | [169] | 4.52[170] | -0.73[171] | 1.67[172] |
26 | FGF16 | Fibroblast growth factor 16 | [173] | [174] | [175] | [176] | [177] | [178] | [179] |
27 | FGF4 | Fibroblast growth factor 4 | [180] | [181] | [182] | [183] | [184] | [185] | [186] |
28 | FGF22 | Fibroblast growth factor 22 | [187] | [188] | [189] | [190] | [191] | [192] | [193] |
29 | FGF10 | Fibroblast growth factor 10 | [194] | [195] | [196] | [197] | [198] | [199] | [200] |
30 | FGF17 | Fibroblast growth factor 17 | [201] | [202] | [203] | [204] | [205] | [206] | [207] |
31 | FGF3 | Fibroblast growth factor 3 | [208] | [209] | [210] | [211] | [212] | [213] | [214] |
32 | FGF23 | Fibroblast growth factor 23 | [215] | [216] | [217] | [218] | [219] | [220] | [221] |
33 | FGF20 | Fibroblast growth factor 20 | [222] | [223] | [224] | [225] | [226] | [227] | [228] |
34 | FGF6 | Fibroblast growth factor 6 | [229] | [230] | [231] | [232] | [233] | [234] | [235] |