REACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.72[2] | -0.85[3] | -0.87[4] | -1.10[5] | -0.76[6] | -0.29[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.27[16] | -0.10[17] | -0.51[18] | -0.25[19] | -0.38[20] | 0.16[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.16[23] | 2.13[24] | 3.00[25] | 1.15[26] | 1.85[27] | 0.93[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 2.28[29] | 2.17[30] | 1.92[31] | 2.89[32] | 2.10[33] | 1.73[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.75[35] | 1.91[36] | 1.11[37] | 2.42[38] | 2.42[39] | 1.49[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 1.09[41] | 0.81[42] | 0.72[43] | 1.22[44] | 1.01[45] | 0.60[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | 1.93[48] | 2.42[49] | 2.21[50] | 2.57[51] | 3.09[52] | 2.85[53] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [54] | 2.68[55] | 2.58[56] | 2.53[57] | 2.23[58] | 2.03[59] | 1.89[60] |
10 | MAPK1 | Mitogen-activated protein kinase 1 | [61] | 3.19[62] | 3.39[63] | 3.05[64] | 3.53[65] | 3.06[66] | 3.36[67] |
11 | MAPK3 | Mitogen-activated protein kinase 3 | [68] | 3.33[69] | 3.44[70] | 3.31[71] | 2.10[72] | 2.01[73] | 0.55[74] |
12 | FGF2 | Fibroblast growth factor 2 | [75] | -5.20[76] | -4.89[77] | -0.91[78] | 2.62[79] | 4.08[80] | -0.08[81] |
13 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [82] | 1.85[83] | 1.54[84] | 1.88[85] | 2.02[86] | 1.51[87] | 2.29[88] |
14 | SRC | Proto-oncogene tyrosine-protein kinase Src | [89] | 4.51[90] | 4.56[91] | 3.38[92] | 4.08[93] | 3.14[94] | 0.74[95] |
15 | SPRY2 | Protein sprouty homolog 2 | [96] | 0.88[97] | 1.10[98] | 3.35[99] | -0.59[100] | 1.32[101] | 1.76[102] |
16 | FRS2 | Fibroblast growth factor receptor substrate 2 | [103] | 2.77[104] | 3.93[105] | 4.25[106] | 4.58[107] | 4.09[108] | 4.93[109] |
17 | BRAF | Serine/threonine-protein kinase B-raf | [110] | 1.73[111] | 1.52[112] | 3.38[113] | 2.42[114] | 2.00[115] | 3.44[116] |
18 | FGFR1 | Fibroblast growth factor receptor 1 | [117] | 6.06[118] | 4.44[119] | 5.92[120] | 6.74[121] | 5.89[122] | 3.25[123] |
19 | CBL | E3 ubiquitin-protein ligase CBL | [124] | 5.93[125] | 4.94[126] | 4.99[127] | 6.82[128] | 6.18[129] | 5.35[130] |
20 | KL | Klotho | [131] | -4.57[132] | [133] | [134] | 0.29[135] | -5.08[136] | 1.84[137] |
21 | FGF5 | Fibroblast growth factor 5 | [138] | 0.49[139] | 1.88[140] | 1.63[141] | 3.16[142] | 2.73[143] | 4.72[144] |
22 | FGF1 | Fibroblast growth factor 1 | [145] | -1.28[146] | -0.43[147] | -5.06[148] | 2.27[149] | 3.73[150] | 1.63[151] |
23 | FGF8 | Fibroblast growth factor 8 | [152] | -1.85[153] | -1.43[154] | 2.89[155] | -0.24[156] | [157] | 4.28[158] |
24 | FGF9 | Fibroblast growth factor 9 | [159] | 3.74[160] | 0.15[161] | [162] | 4.46[163] | -0.77[164] | 1.69[165] |
25 | FGF6 | Fibroblast growth factor 6 | [166] | [167] | [168] | [169] | [170] | [171] | [172] |
26 | ANOS1 | Anosmin-1 | [173] | [174] | [175] | [176] | [177] | [178] | [179] |
27 | FGF10 | Fibroblast growth factor 10 | [180] | [181] | [182] | [183] | [184] | [185] | [186] |
28 | FGF22 | Fibroblast growth factor 22 | [187] | [188] | [189] | [190] | [191] | [192] | [193] |
29 | FGF17 | Fibroblast growth factor 17 | [194] | [195] | [196] | [197] | [198] | [199] | [200] |
30 | FGF3 | Fibroblast growth factor 3 | [201] | [202] | [203] | [204] | [205] | [206] | [207] |
31 | FGF20 | Fibroblast growth factor 20 | [208] | [209] | [210] | [211] | [212] | [213] | [214] |
32 | FGF23 | Fibroblast growth factor 23 | [215] | [216] | [217] | [218] | [219] | [220] | [221] |
33 | FGF4 | Fibroblast growth factor 4 | [222] | [223] | [224] | [225] | [226] | [227] | [228] |