REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [1] -1.26[2] -1.59[3] -1.56[4] -0.66[5] -0.39[6] -1.34[7]
2 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [8] -0.28[9] -0.60[10] -0.29[11] -0.96[12] -0.71[13] -1.85[14]
3 RAF1 RAF proto-oncogene serine/threonine-protein kinase [15] -0.39[16] 0.01[17] 0.72[18] -0.30[19] 0.33[20] 0.95[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 1.38[23] 1.52[24] 0.79[25] 1.74[26] 1.15[27] 1.63[28]
5 MAPK3 Mitogen-activated protein kinase 3 [29] 1.52[30] 1.57[31] 1.05[32] 0.31[33] 0.09[34] -1.19[35]
6 BRAF Serine/threonine-protein kinase B-raf [36] -0.08[37] -0.35[38] 1.12[39] 0.63[40] 0.08[41] 1.71[42]
[1]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[2]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[3]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[4]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[5]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[6]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[7]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[8]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[9]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[10]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[11]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[12]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[13]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[14]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[15]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 6 14 20 20 17
[16]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 29 36
[17]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 41 37
[18]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 85 93 89
[19]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 22 28
[20]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[21]
liver RAF1
Mean 47
Standard deviation 3.6
Values 51 42 49 46
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[29]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[30]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[31]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[32]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[33]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[34]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[35]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[36]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 0.56 1.2 2.3 0.67 0.67
[37]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 2.4 3.2
[38]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 1.6 2.5
[39]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 6.4 15 3.4
[40]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.2 3.4
[41]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[42]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 3.1 8 2.9 7.9