REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAA1 | Serum amyloid A-1 protein | [1] | -14.92[2] | -15.06[3] | -10.31[4] | -13.32[5] | -4.66[6] | -0.39[7] |
2 | UBB | Polyubiquitin-B | [8] | 2.03[9] | 1.73[10] | 1.88[11] | 1.45[12] | 1.74[13] | 0.58[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | 2.47[23] | 2.48[24] | 2.24[25] | 2.31[26] | 2.12[27] | 1.03[28] |
5 | CD14 | Monocyte differentiation antigen CD14 | [29] | -4.11[30] | -4.28[31] | -1.47[32] | -0.57[33] | -1.93[34] | 1.95[35] |
6 | HMGB1 | High mobility group protein B1 | [36] | 3.93[37] | 4.57[38] | 4.31[39] | 4.69[40] | 4.01[41] | 1.90[42] |
7 | NFKBIA | NF-kappa-B inhibitor alpha | [43] | 3.17[44] | 1.28[45] | 0.90[46] | 0.71[47] | 2.43[48] | 1.32[49] |
8 | SKP1 | S-phase kinase-associated protein 1 | [50] | 3.25[51] | 3.55[52] | 2.67[53] | 3.73[54] | 3.78[55] | 1.76[56] |
9 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [57] | 3.40[58] | 3.63[59] | 3.86[60] | 3.49[61] | 3.80[62] | 2.31[63] |
10 | APP | Amyloid-beta A4 protein | [64] | 4.61[65] | 3.96[66] | 4.61[67] | 5.01[68] | 5.25[69] | 2.59[70] |
11 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [71] | 4.91[72] | 4.72[73] | 5.75[74] | 3.70[75] | 4.35[76] | 1.80[77] |
12 | JUN | Transcription factor AP-1 | [78] | 3.74[79] | 2.10[80] | 2.36[81] | 2.53[82] | 2.93[83] | 0.65[84] |
13 | FOS | Proto-oncogene c-Fos | [85] | -1.79[86] | -0.62[87] | -1.29[88] | -1.93[89] | -1.04[90] | 1.15[91] |
14 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [92] | 3.01[93] | 3.21[94] | 2.10[95] | 2.41[96] | 2.10[97] | 1.02[98] |
15 | UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | [99] | 0.35[100] | 0.07[101] | 0.20[102] | 0.35[103] | -0.47[104] | -2.55[105] |
16 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [106] | 3.30[107] | 2.87[108] | 3.45[109] | 3.69[110] | 4.03[111] | 1.26[112] |
17 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 5.03[113] | 4.76[114] | 4.68[115] | 5.44[116] | 4.60[117] | 2.60[118] | |
18 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 4.50[119] | 4.50[120] | 3.86[121] | 4.98[122] | 4.92[123] | 2.35[124] | |
19 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 3.83[125] | 3.40[126] | 3.47[127] | 3.78[128] | 3.50[129] | 1.47[130] | |
20 | DUSP3 | Dual specificity protein phosphatase 3 | [131] | 4.99[132] | 4.31[133] | 4.84[134] | 3.55[135] | 3.40[136] | 3.86[137] |
21 | IKBKG | NF-kappa-B essential modulator | [138] | 3.34[139] | 3.39[140] | 1.14[141] | 3.38[142] | 2.00[143] | 1.85[144] |
22 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [145] | 4.67[146] | 5.01[147] | 4.96[148] | 5.12[149] | 5.59[150] | 3.71[151] |
23 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [152] | 5.64[153] | 4.94[154] | 3.92[155] | 5.03[156] | 5.23[157] | 1.77[158] |
24 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [159] | 4.92[160] | 5.30[161] | 4.11[162] | 4.55[163] | 4.27[164] | 1.74[165] |
25 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [166] | 3.46[167] | 3.67[168] | 4.11[169] | 2.85[170] | 3.54[171] | -0.56[172] |
26 | RELA | Transcription factor p65 | [173] | 4.36[174] | 3.76[175] | 3.89[176] | 4.18[177] | 3.92[178] | 1.58[179] |
27 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [180] | 1.11[181] | 2.04[182] | -0.36[183] | 1.11[184] | 4.71[185] | 0.38[186] |
28 | TNIP2 | TNFAIP3-interacting protein 2 | [187] | 3.54[188] | 3.51[189] | 3.22[190] | 3.57[191] | 2.77[192] | 1.00[193] |
29 | DUSP6 | Dual specificity protein phosphatase 6 | [194] | 3.74[195] | 5.73[196] | 5.00[197] | 0.32[198] | 3.94[199] | 2.71[200] |
30 | CUL1 | Cullin-1 | [201] | 3.84[202] | 4.43[203] | 3.97[204] | 4.82[205] | 4.30[206] | 3.20[207] |
31 | NFKBIB | NF-kappa-B inhibitor beta | [208] | 3.06[209] | 2.79[210] | 3.12[211] | 2.42[212] | 2.59[213] | 0.73[214] |
32 | MAPKAPK | MAP kinase-activated protein kinase 2 | [215] | 4.69[216] | 3.63[217] | 4.03[218] | 5.63[219] | 4.67[220] | 1.51[221] |
33 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 4.68[222] | 4.06[223] | 4.47[224] | 4.51[225] | 4.12[226] | 5.39[227] | |
34 | IRF7 | Interferon regulatory factor 7 | [228] | -5.01[229] | -4.10[230] | -3.01[231] | 1.09[232] | 0.66[233] | 2.39[234] |
35 | UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 | [235] | 5.23[236] | 5.18[237] | 4.45[238] | 5.03[239] | 5.06[240] | 2.42[241] |
36 | MAPK1 | Mitogen-activated protein kinase 1 | [242] | 5.94[243] | 5.98[244] | 5.80[245] | 6.08[246] | 5.56[247] | 4.23[248] |
37 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [249] | 4.47[250] | 5.33[251] | 4.27[252] | 4.65[253] | 5.27[254] | 3.18[255] |
38 | IRF3 | Interferon regulatory factor 3 | [256] | 4.53[257] | 4.60[258] | 5.32[259] | 4.59[260] | 4.01[261] | 1.27[262] |
39 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [263] | [264] | [265] | [266] | [267] | [268] | [269] |
40 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [270] | 4.59[271] | 4.66[272] | 4.92[273] | 5.93[274] | 5.22[275] | 2.70[276] |
41 | VRK3 | Inactive serine/threonine-protein kinase VRK3 | [277] | 3.47[278] | 3.54[279] | 3.81[280] | 3.09[281] | 2.53[282] | 1.97[283] |
42 | FADD | FAS-associated death domain protein | [284] | 4.27[285] | 3.46[286] | 4.18[287] | 6.17[288] | 3.81[289] | 0.68[290] |
43 | CASP8 | Caspase-8 | [291] | 4.25[292] | 4.72[293] | 3.89[294] | 4.15[295] | 3.24[296] | 1.04[297] |
44 | MAPK14 | Mitogen-activated protein kinase 14 | [298] | 5.70[299] | 5.67[300] | 5.24[301] | 5.92[302] | 5.22[303] | 3.74[304] |
45 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [305] | 4.13[306] | 5.10[307] | 4.97[308] | 4.72[309] | 4.74[310] | 2.70[311] |
46 | TANK | TRAF family member-associated NF-kappa-B activator | [312] | 3.09[313] | 4.98[314] | 4.60[315] | 4.36[316] | 3.43[317] | 2.99[318] |
47 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [319] | 4.15[320] | 4.16[321] | 3.93[322] | 1.80[323] | 3.18[324] | 1.43[325] |
48 | MAPKAPK | MAP kinase-activated protein kinase 3 | [326] | 5.24[327] | 5.09[328] | 4.17[329] | 2.75[330] | 4.30[331] | 2.22[332] |
49 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 5.48[333] | 5.14[334] | 4.69[335] | 5.52[336] | 5.24[337] | 2.19[338] | |
50 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [339] | 4.87[340] | 5.82[341] | 6.04[342] | 5.02[343] | 4.62[344] | 3.48[345] |
51 | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 | [346] | 4.98[347] | 3.63[348] | 4.69[349] | 4.81[350] | 4.45[351] | 2.66[352] |
52 | MAPK8 | Mitogen-activated protein kinase 8 | [353] | 2.78[354] | 4.10[355] | 2.96[356] | 3.33[357] | 3.02[358] | 1.94[359] |
53 | TBK1 | Serine/threonine-protein kinase TBK1 | [360] | 3.59[361] | 5.17[362] | 4.31[363] | 4.73[364] | 4.64[365] | 2.93[366] |
54 | ELK1 | ETS domain-containing protein Elk-1 | [367] | 3.91[368] | 1.68[369] | 4.09[370] | 4.51[371] | 4.92[372] | 2.29[373] |
55 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [374] | 4.28[375] | 6.13[376] | 6.22[377] | 4.58[378] | 5.61[379] | 3.29[380] |
56 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [381] | 4.90[382] | 4.48[383] | 4.26[384] | 3.99[385] | 4.73[386] | 2.91[387] |
57 | FBXW11 | F-box/WD repeat-containing protein 11 | [388] | 5.60[389] | 5.42[390] | 6.17[391] | 5.76[392] | 5.50[393] | 3.40[394] |
58 | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 | [395] | 2.86[396] | 2.56[397] | 3.77[398] | 3.69[399] | 3.80[400] | 2.23[401] |
59 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [402] | 4.93[403] | 5.47[404] | 4.66[405] | 5.44[406] | 4.67[407] | 3.52[408] |
60 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [409] | [410] | [411] | [412] | [413] | [414] | [415] |
61 | ATF1 | Cyclic AMP-dependent transcription factor ATF-1 | [416] | 3.60[417] | 4.76[418] | 4.48[419] | 4.39[420] | 4.10[421] | 1.98[422] |
62 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [423] | 3.65[424] | 4.16[425] | 4.16[426] | 4.03[427] | 3.83[428] | 1.33[429] |
63 | TICAM1 | TIR domain-containing adapter molecule 1 | [430] | 3.52[431] | 2.32[432] | 3.24[433] | 3.01[434] | 3.89[435] | 1.96[436] |
64 | MAPK9 | Mitogen-activated protein kinase 9 | [437] | 5.45[438] | 5.58[439] | 5.64[440] | 5.95[441] | 5.24[442] | 2.97[443] |
65 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [444] | 4.52[445] | 4.58[446] | 4.26[447] | 5.31[448] | 4.67[449] | 3.94[450] |
66 | MAPK3 | Mitogen-activated protein kinase 3 | [451] | 6.08[452] | 6.03[453] | 6.06[454] | 4.66[455] | 4.51[456] | 1.42[457] |
67 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [458] | 5.13[459] | 6.25[460] | 6.21[461] | 4.88[462] | 5.53[463] | 3.97[464] |
68 | MEF2A | Myocyte-specific enhancer factor 2A | [465] | 4.20[466] | 4.89[467] | 5.56[468] | 5.41[469] | 5.32[470] | 4.61[471] |
69 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [472] | 5.19[473] | 5.24[474] | 5.81[475] | 4.52[476] | 4.90[477] | 1.70[478] |
70 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [479] | 4.87[480] | 5.42[481] | 5.50[482] | 4.24[483] | 4.41[484] | 2.68[485] |
71 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [486] | 4.75[487] | 4.71[488] | 4.81[489] | 4.49[490] | 4.42[491] | 3.64[492] |
72 | LY96 | Lymphocyte antigen 96 | [493] | 1.58[494] | 1.09[495] | -5.33[496] | 2.87[497] | -0.92[498] | 1.09[499] |
73 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [500] | 5.02[501] | 5.79[502] | 6.13[503] | 5.75[504] | 5.35[505] | 2.96[506] |
74 | BTRC | F-box/WD repeat-containing protein 1A | [507] | 5.64[508] | 6.34[509] | 5.94[510] | 4.99[511] | 5.36[512] | 3.80[513] |
75 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [514] | 5.95[515] | 7.01[516] | 7.49[517] | 6.78[518] | 6.55[519] | 4.80[520] |
76 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [521] | 5.97[522] | 5.88[523] | 5.06[524] | 4.34[525] | 5.49[526] | 2.94[527] |
77 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [528] | 4.52[529] | 1.21[530] | 6.06[531] | 5.24[532] | 1.04[533] | 0.84[534] |
78 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [535] | [536] | [537] | [538] | [539] | [540] | [541] |
79 | TRAF3 | TNF receptor-associated factor 3 | [542] | 7.12[543] | 6.44[544] | 6.04[545] | 7.06[546] | 7.31[547] | 4.38[548] |
80 | DUSP7 | Dual specificity protein phosphatase 7 | [549] | 5.78[550] | 4.77[551] | 6.01[552] | 3.81[553] | 6.03[554] | 2.49[555] |
81 | MAPK7 | Mitogen-activated protein kinase 7 | [556] | 5.66[557] | 4.87[558] | 4.86[559] | 6.04[560] | 5.96[561] | 2.79[562] |
82 | TRAF6 | TNF receptor-associated factor 6 | [563] | 5.32[564] | 5.11[565] | 5.67[566] | 5.90[567] | 5.18[568] | 5.36[569] |
83 | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | [570] | 5.95[571] | 5.72[572] | 4.61[573] | 6.80[574] | 6.18[575] | 2.22[576] |
84 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | [577] | 2.32[578] | 0.26[579] | [580] | 0.62[581] | 4.01[582] | 1.93[583] |
85 | TLR4 | Toll-like receptor 4 | [584] | 4.50[585] | -0.75[586] | -1.65[587] | -0.86[588] | 9.39[589] | 6.92[590] |
86 | S100A12 | Protein S100-A12 | [591] | [592] | [593] | [594] | [595] | [596] | 2.74[597] |
87 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | [598] | 5.25[599] | 4.83[600] | 5.63[601] | 6.47[602] | 5.93[603] | 4.54[604] |
88 | TICAM2 | TIR domain-containing adapter molecule 2 | [605] | -3.65[606] | [607] | -3.17[608] | 2.74[609] | 2.91[610] | 0.48[611] |
89 | AGER | Advanced glycosylation end product-specific receptor | [612] | 3.18[613] | 6.26[614] | 5.18[615] | 4.87[616] | 4.47[617] | 2.35[618] |
90 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | [619] | [620] | [621] | [622] | [623] | [624] | [625] |
91 | MAPK11 | Mitogen-activated protein kinase 11 | [626] | 4.05[627] | 3.86[628] | 2.96[629] | 4.59[630] | 6.41[631] | 2.62[632] |
92 | RIPK3 | Receptor-interacting serine/threonine-protein kinase 3 | [633] | -2.42[634] | [635] | -1.20[636] | [637] | -1.31[638] | 3.01[639] |
93 | SARM1 | Sterile alpha and TIR motif-containing protein 1 | [640] | 2.65[641] | 2.83[642] | 4.52[643] | 2.91[644] | 8.04[645] | 5.46[646] |
94 | MEF2C | Myocyte-specific enhancer factor 2C | [647] | 1.12[648] | 2.15[649] | 7.11[650] | 9.85[651] | 5.66[652] | 7.74[653] |
95 | S100B | Protein S100-B | [654] | 0.37[655] | -0.70[656] | [657] | 2.48[658] | -1.71[659] | 3.60[660] |
96 | DUSP4 | Dual specificity protein phosphatase 4 | [661] | 9.73[662] | 6.63[663] | 12.52[664] | 11.96[665] | 9.74[666] | 6.29[667] |
97 | MAPK10 | Mitogen-activated protein kinase 10 | [668] | 2.74[669] | [670] | [671] | 13.14[672] | 8.71[673] | 9.70[674] |