REACTOME_MTOR_SIGNALLING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [8] | 0.86[9] | 0.24[10] | -1.36[11] | 0.91[12] | 0.45[13] | -0.29[14] |
3 | EIF4B | Eukaryotic translation initiation factor 4B | [15] | 1.57[16] | 2.58[17] | 2.76[18] | 1.05[19] | 1.37[20] | 1.14[21] |
4 | RHEB | GTP-binding protein Rheb | [22] | -0.97[23] | -0.62[24] | -0.72[25] | 0.07[26] | 0.14[27] | 0.00[28] |
5 | LAMTOR2 | Ragulator complex protein LAMTOR2 | [29] | -2.44[30] | -2.63[31] | -2.88[32] | -2.37[33] | -2.21[34] | -1.09[35] |
6 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 | [36] | 1.86[37] | 0.83[38] | 1.21[39] | 1.55[40] | 1.90[41] | 2.14[42] |
7 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [43] | -0.01[44] | -0.56[45] | 0.02[46] | -2.13[47] | -0.62[48] | -0.51[49] |
8 | YWHAB | 14-3-3 protein beta/alpha | [50] | 2.02[51] | 1.50[52] | 0.75[53] | 2.47[54] | 1.86[55] | 0.99[56] |
9 | AKT1 | RAC-alpha serine/threonine-protein kinase | [57] | 1.06[58] | 0.60[59] | -0.51[60] | 1.12[61] | 1.10[62] | 0.84[63] |
10 | LAMTOR1 | Ragulator complex protein LAMTOR1 | [64] | 0.36[65] | -0.61[66] | -0.74[67] | 0.09[68] | 0.01[69] | -0.21[70] |
11 | RRAGA | Ras-related GTP-binding protein A | [71] | 1.29[72] | 0.31[73] | -1.00[74] | 0.14[75] | 0.69[76] | 0.25[77] |
12 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [78] | -0.44[79] | -0.13[80] | -0.04[81] | 0.83[82] | 0.49[83] | -0.56[84] |
13 | STRADB | STE20-related kinase adapter protein beta | [85] | 0.24[86] | 0.49[87] | 0.33[88] | 0.17[89] | -0.36[90] | 1.58[91] |
14 | AKT1S1 | Proline-rich AKT1 substrate 1 | [92] | 0.52[93] | 0.14[94] | 0.46[95] | 0.42[96] | 1.00[97] | -0.10[98] |
15 | EIF4E | Eukaryotic translation initiation factor 4E | [99] | 1.12[100] | 1.72[101] | 1.05[102] | 0.90[103] | 1.88[104] | 1.26[105] |
16 | CAB39 | Calcium-binding protein 39 | [106] | 0.49[107] | 0.64[108] | 1.00[109] | 1.38[110] | 1.56[111] | 1.15[112] |
17 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [113] | -3.08[114] | -8.40[115] | -2.00[116] | -0.57[117] | -0.47[118] | 0.61[119] |
18 | STK11 | Serine/threonine-protein kinase STK11 | [120] | 0.89[121] | 0.61[122] | 0.83[123] | 0.46[124] | 0.77[125] | 0.23[126] |
19 | AKT2 | RAC-beta serine/threonine-protein kinase | [127] | 1.94[128] | 1.99[129] | 2.09[130] | 2.03[131] | 1.78[132] | 2.22[133] |
20 | MLST8 | Target of rapamycin complex subunit LST8 | [134] | 0.81[135] | 0.91[136] | 1.25[137] | 0.20[138] | 0.50[139] | 0.52[140] |
21 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [141] | 0.90[142] | 1.95[143] | 3.44[144] | 2.63[145] | 2.86[146] | 3.15[147] |
22 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [148] | 1.87[149] | 2.83[150] | 2.91[151] | 2.20[152] | 1.12[153] | 2.50[154] |
23 | RRAGC | Ras-related GTP-binding protein C | [155] | 0.43[156] | -0.64[157] | -0.27[158] | 1.54[159] | 1.19[160] | 0.13[161] |
24 | SLC38A9 | Sodium-coupled neutral amino acid transporter 9 | [162] | 0.30[163] | 0.32[164] | -0.59[165] | 0.25[166] | 0.12[167] | 0.86[168] |
25 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [169] | 1.69[170] | 2.00[171] | 1.12[172] | 1.11[173] | 1.17[174] | 1.09[175] |
26 | PPM1A | Protein phosphatase 1A | [176] | 1.30[177] | 2.03[178] | 1.97[179] | 2.40[180] | 2.41[181] | 3.29[182] |
27 | LAMTOR3 | Ragulator complex protein LAMTOR3 | [183] | 1.96[184] | 2.32[185] | 1.41[186] | 1.65[187] | 2.12[188] | 1.98[189] |
28 | MTOR | Serine/threonine-protein kinase mTOR | [190] | 3.51[191] | 4.30[192] | 3.84[193] | 3.85[194] | 3.89[195] | 4.54[196] |
29 | TSC2 | Tuberin | [197] | 2.79[198] | 2.10[199] | 2.75[200] | 2.37[201] | 2.85[202] | 3.17[203] |
30 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [204] | [205] | [206] | [207] | [208] | [209] | [210] |
31 | STRADA | STE20-related kinase adapter protein alpha | [211] | 1.93[212] | 1.81[213] | 1.57[214] | 2.25[215] | 2.00[216] | 1.35[217] |
32 | EEF2K | Eukaryotic elongation factor 2 kinase | [218] | 3.43[219] | 2.66[220] | 3.00[221] | 2.74[222] | 2.11[223] | 3.23[224] |
33 | RPTOR | Regulatory-associated protein of mTOR | [225] | 4.06[226] | 3.08[227] | 3.14[228] | 3.02[229] | 3.21[230] | 3.42[231] |
34 | RRAGD | Ras-related GTP-binding protein D | [232] | -0.03[233] | -3.96[234] | 3.90[235] | 2.29[236] | 0.52[237] | 2.27[238] |
35 | TSC1 | Hamartin | [239] | 2.87[240] | 3.31[241] | 3.42[242] | 3.23[243] | 3.40[244] | 3.84[245] |
36 | RRAGB | Ras-related GTP-binding protein B | [246] | 0.70[247] | 1.04[248] | -8.46[249] | 1.62[250] | 1.39[251] | 1.68[252] |
37 | CAB39L | Calcium-binding protein 39-like | [253] | 0.48[254] | 0.76[255] | 1.40[256] | 0.33[257] | 1.42[258] | 1.63[259] |
38 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [260] | 4.01[261] | 4.24[262] | 4.23[263] | 4.21[264] | 2.21[265] | 2.94[266] |
39 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [267] | -0.76[268] | [269] | -1.34[270] | 0.16[271] | [272] | 4.21[273] |
40 | LAMTOR5 | Ragulator complex protein LAMTOR5 | [274] | [275] | [276] | [277] | [278] | [279] | [280] |
41 | LAMTOR4 | Ragulator complex protein LAMTOR4 | [281] | [282] | [283] | [284] | [285] | [286] | [287] |