REACTOME_MTORC1_MEDIATED_SIGNALLING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RPS6 40S ribosomal protein S6 [1] [2] [3] [4] [5] [6] [7]
2 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A [8] 1.05[9] 0.47[10] -1.08[11] 1.21[12] 0.72[13] 0.10[14]
3 EIF4B Eukaryotic translation initiation factor 4B [15] 1.76[16] 2.80[17] 3.04[18] 1.35[19] 1.65[20] 1.53[21]
4 RHEB GTP-binding protein Rheb [22] -0.78[23] -0.39[24] -0.44[25] 0.37[26] 0.41[27] 0.39[28]
5 LAMTOR2 Ragulator complex protein LAMTOR2 [29] -2.25[30] -2.40[31] -2.60[32] -2.07[33] -1.94[34] -0.70[35]
6 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 [36] 2.04[37] 1.06[38] 1.49[39] 1.85[40] 2.17[41] 2.53[42]
7 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 [43] 0.17[44] -0.33[45] 0.30[46] -1.83[47] -0.35[48] -0.12[49]
8 YWHAB 14-3-3 protein beta/alpha [50] 2.20[51] 1.73[52] 1.03[53] 2.77[54] 2.13[55] 1.38[56]
9 LAMTOR1 Ragulator complex protein LAMTOR1 [57] 0.54[58] -0.38[59] -0.46[60] 0.39[61] 0.28[62] 0.17[63]
10 RRAGA Ras-related GTP-binding protein A [64] 1.48[65] 0.54[66] -0.72[67] 0.44[68] 0.97[69] 0.64[70]
11 AKT1S1 Proline-rich AKT1 substrate 1 [71] 0.70[72] 0.37[73] 0.74[74] 0.72[75] 1.27[76] 0.29[77]
12 EIF4E Eukaryotic translation initiation factor 4E [78] 1.30[79] 1.95[80] 1.33[81] 1.20[82] 2.15[83] 1.65[84]
13 MLST8 Target of rapamycin complex subunit LST8 [85] 0.99[86] 1.14[87] 1.53[88] 0.49[89] 0.77[90] 0.91[91]
14 RRAGC Ras-related GTP-binding protein C [92] 0.61[93] -0.41[94] 0.01[95] 1.84[96] 1.46[97] 0.52[98]
15 SLC38A9 Sodium-coupled neutral amino acid transporter 9 [99] 0.48[100] 0.54[101] -0.31[102] 0.55[103] 0.39[104] 1.25[105]
16 LAMTOR3 Ragulator complex protein LAMTOR3 [106] 2.15[107] 2.55[108] 1.68[109] 1.95[110] 2.39[111] 2.37[112]
17 MTOR Serine/threonine-protein kinase mTOR [113] 3.70[114] 4.53[115] 4.12[116] 4.15[117] 4.16[118] 4.93[119]
18 RPS6KB1 Ribosomal protein S6 kinase beta-1 [120] [121] [122] [123] [124] [125] [126]
19 EEF2K Eukaryotic elongation factor 2 kinase [127] 3.62[128] 2.89[129] 3.28[130] 3.04[131] 2.38[132] 3.62[133]
20 RPTOR Regulatory-associated protein of mTOR [134] 4.25[135] 3.30[136] 3.42[137] 3.32[138] 3.48[139] 3.81[140]
21 RRAGD Ras-related GTP-binding protein D [141] 0.15[142] -3.73[143] 4.18[144] 2.59[145] 0.79[146] 2.66[147]
22 RRAGB Ras-related GTP-binding protein B [148] 0.89[149] 1.27[150] -8.18[151] 1.92[152] 1.67[153] 2.07[154]
23 LAMTOR4 Ragulator complex protein LAMTOR4 [155] [156] [157] [158] [159] [160] [161]
24 LAMTOR5 Ragulator complex protein LAMTOR5 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte RPS6
Mean 819
Standard deviation 2.5e+02
Values 6.5e+02 6.1e+02 9e+02 1.2e+03 7.2e+02
[2]
HepG2 RPS6
Missing
[3]
HepG2.C3A RPS6
Missing
[4]
HuH.7 RPS6
Missing
[5]
SNU475 RPS6
Missing
[6]
THLE RPS6
Missing
[7]
liver RPS6
Missing
[8]
ref_hepatocyte FKBP1A
Mean 84.3
Standard deviation 51
Values 1.4e+02 1.4e+02 61 46 37
[9]
HepG2 FKBP1A
Mean 172
Standard deviation 7.9
Values 1.8e+02 1.7e+02
[10]
HepG2.C3A FKBP1A
Mean 116
Standard deviation 13
Values 1.1e+02 1.2e+02
[11]
HuH.7 FKBP1A
Mean 37.6
Standard deviation 14
Values 42 22 49
[12]
SNU475 FKBP1A
Mean 129
Standard deviation 5.7
Values 1.3e+02 1.3e+02
[13]
THLE FKBP1A
Mean 109
Standard deviation 15
Values 98 1.2e+02
[14]
liver FKBP1A
Mean 46.2
Standard deviation 42
Values 77 10 88 9.1
[15]
ref_hepatocyte EIF4B
Mean 76.3
Standard deviation 32
Values 1.2e+02 82 86 49 43
[16]
HepG2 EIF4B
Mean 255
Standard deviation 11
Values 2.6e+02 2.5e+02
[17]
HepG2.C3A EIF4B
Mean 530
Standard deviation 1.8e+02
Values 6.6e+02 4e+02
[18]
HuH.7 EIF4B
Mean 590
Standard deviation 80
Values 5.6e+02 6.8e+02 5.3e+02
[19]
SNU475 EIF4B
Mean 129
Standard deviation 20
Values 1.4e+02 1.1e+02
[20]
THLE EIF4B
Mean 186
Standard deviation 19
Values 1.7e+02 2e+02
[21]
liver EIF4B
Mean 113
Standard deviation 68
Values 62 1.9e+02 51 1.5e+02
[22]
ref_hepatocyte RHEB
Mean 67.3
Standard deviation 38
Values 64 96 1.1e+02 29 33
[23]
HepG2 RHEB
Mean 38.6
Standard deviation 1.7
Values 40 37
[24]
HepG2.C3A RHEB
Mean 51.2
Standard deviation 9.4
Values 45 58
[25]
HuH.7 RHEB
Mean 46.6
Standard deviation 5.3
Values 44 44 53
[26]
SNU475 RHEB
Mean 57.5
Standard deviation 1.9
Values 59 56
[27]
THLE RHEB
Mean 69.7
Standard deviation 5.7
Values 66 74
[28]
liver RHEB
Mean 44.9
Standard deviation 28
Values 77 25 59 18
[29]
ref_hepatocyte LAMTOR2
Mean 63.1
Standard deviation 21
Values 30 54 75 84 73
[30]
HepG2 LAMTOR2
Mean 13
Standard deviation 0.66
Values 13 14
[31]
HepG2.C3A LAMTOR2
Mean 11.9
Standard deviation 1.3
Values 11 13
[32]
HuH.7 LAMTOR2
Mean 9.81
Standard deviation 3.8
Values 9.9 6 14
[33]
SNU475 LAMTOR2
Mean 9.98
Standard deviation 2.3
Values 12 8.4
[34]
THLE LAMTOR2
Mean 12.8
Standard deviation 0.74
Values 12 13
[35]
liver LAMTOR2
Mean 19.8
Standard deviation 20
Values 39 3 35 2.1
[36]
ref_hepatocyte EIF4G1
Mean 58.8
Standard deviation 19
Values 41 88 63 57 44
[37]
HepG2 EIF4G1
Mean 239
Standard deviation 2.2
Values 2.4e+02 2.4e+02
[38]
HepG2.C3A EIF4G1
Mean 122
Standard deviation 11
Values 1.1e+02 1.3e+02
[39]
HuH.7 EIF4G1
Mean 156
Standard deviation 42
Values 2e+02 1.2e+02 1.5e+02
[40]
SNU475 EIF4G1
Mean 140
Standard deviation 19
Values 1.5e+02 1.3e+02
[41]
THLE EIF4G1
Mean 207
Standard deviation 56
Values 1.7e+02 2.5e+02
[42]
liver EIF4G1
Mean 173
Standard deviation 23
Values 1.6e+02 1.7e+02 1.6e+02 2.1e+02
[43]
ref_hepatocyte EIF4EBP1
Mean 48.7
Standard deviation 38
Values 11 35 90 87 20
[44]
HepG2 EIF4EBP1
Mean 54.1
Standard deviation 26
Values 72 36
[45]
HepG2.C3A EIF4EBP1
Mean 38.6
Standard deviation 15
Values 49 28
[46]
HuH.7 EIF4EBP1
Mean 56.5
Standard deviation 22
Values 64 32 73
[47]
SNU475 EIF4EBP1
Mean 9.08
Standard deviation 1.3
Values 8.2 10
[48]
THLE EIF4EBP1
Mean 29.8
Standard deviation 5
Values 33 26
[49]
liver EIF4EBP1
Mean 22.9
Standard deviation 28
Values 62 3.1 22 4.4
[50]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[51]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[52]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[53]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[54]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[55]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[56]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[57]
ref_hepatocyte LAMTOR1
Mean 35.3
Standard deviation 12
Values 22 29 52 44 30
[58]
HepG2 LAMTOR1
Mean 50.6
Standard deviation 1.5
Values 50 52
[59]
HepG2.C3A LAMTOR1
Mean 26.9
Standard deviation 3.3
Values 25 29
[60]
HuH.7 LAMTOR1
Mean 24.2
Standard deviation 7.1
Values 26 16 30
[61]
SNU475 LAMTOR1
Mean 30.7
Standard deviation 4.8
Values 34 27
[62]
THLE LAMTOR1
Mean 33.5
Standard deviation 7
Values 28 38
[63]
liver LAMTOR1
Mean 20.3
Standard deviation 16
Values 32 7.6 36 5.8
[64]
ref_hepatocyte RRAGA
Mean 26.7
Standard deviation 8.3
Values 31 31 12 31 28
[65]
HepG2 RRAGA
Mean 73.1
Standard deviation 1.7
Values 74 72
[66]
HepG2.C3A RRAGA
Mean 38.5
Standard deviation 1.9
Values 37 40
[67]
HuH.7 RRAGA
Mean 15.3
Standard deviation 2.5
Values 14 14 18
[68]
SNU475 RRAGA
Mean 23.9
Standard deviation 0.36
Values 24 24
[69]
THLE RRAGA
Mean 40.6
Standard deviation 2.9
Values 39 43
[70]
liver RRAGA
Mean 21.2
Standard deviation 16
Values 38 7.2 32 7.1
[71]
ref_hepatocyte AKT1S1
Mean 16.3
Standard deviation 7.1
Values 9.3 9.6 22 25 16
[72]
HepG2 AKT1S1
Mean 26.1
Standard deviation 2.4
Values 24 28
[73]
HepG2.C3A AKT1S1
Mean 20.9
Standard deviation 0.11
Values 21 21
[74]
HuH.7 AKT1S1
Mean 25.6
Standard deviation 5
Values 30 20 27
[75]
SNU475 AKT1S1
Mean 17.8
Standard deviation 0.54
Values 18 17
[76]
THLE AKT1S1
Mean 30.7
Standard deviation 8
Values 25 36
[77]
liver AKT1S1
Mean 10.2
Standard deviation 7
Values 14 4.3 18 4.2
[78]
ref_hepatocyte EIF4E
Mean 15
Standard deviation 8.3
Values 17 28 13 7.1 10
[79]
HepG2 EIF4E
Mean 36.5
Standard deviation 7.8
Values 31 42
[80]
HepG2.C3A EIF4E
Mean 57.7
Standard deviation 21
Values 43 72
[81]
HuH.7 EIF4E
Mean 35.6
Standard deviation 9.2
Values 41 25 41
[82]
SNU475 EIF4E
Mean 22.8
Standard deviation 0.41
Values 23 22
[83]
THLE EIF4E
Mean 52.1
Standard deviation 2.8
Values 50 54
[84]
liver EIF4E
Mean 24
Standard deviation 12
Values 33 16 36 12
[85]
ref_hepatocyte MLST8
Mean 10
Standard deviation 3.8
Values 7 5.5 14 14 10
[86]
HepG2 MLST8
Mean 19.6
Standard deviation 1.4
Values 21 19
[87]
HepG2.C3A MLST8
Mean 22
Standard deviation 3.6
Values 24 19
[88]
HuH.7 MLST8
Mean 27.2
Standard deviation 3.6
Values 28 23 30
[89]
SNU475 MLST8
Mean 9.36
Standard deviation 0.84
Values 9.9 8.8
[90]
THLE MLST8
Mean 13.3
Standard deviation 1.9
Values 12 15
[91]
liver MLST8
Mean 9.64
Standard deviation 7.6
Values 17 2.5 15 3.8
[92]
ref_hepatocyte RRAGC
Mean 7.75
Standard deviation 6.6
Values 7.7 18 8.6 2.6 1.6
[93]
HepG2 RRAGC
Mean 11.7
Standard deviation 0.47
Values 11 12
[94]
HepG2.C3A RRAGC
Mean 5.81
Standard deviation 0.53
Values 6.2 5.4
[95]
HuH.7 RRAGC
Mean 7.34
Standard deviation 1.9
Values 6.2 9.6 6.3
[96]
SNU475 RRAGC
Mean 18.4
Standard deviation 2.1
Values 20 17
[97]
THLE RRAGC
Mean 16.6
Standard deviation 4.8
Values 13 20
[98]
liver RRAGC
Mean 5.66
Standard deviation 2.9
Values 9.7 4.4 5.4 3
[99]
ref_hepatocyte SLC38A9
Mean 7.25
Standard deviation 6.3
Values 17 11 2.1 3.4 3.1
[100]
HepG2 SLC38A9
Mean 9.99
Standard deviation 3.4
Values 7.6 12
[101]
HepG2.C3A SLC38A9
Mean 10.5
Standard deviation 2.3
Values 8.9 12
[102]
HuH.7 SLC38A9
Mean 5.5
Standard deviation 0.54
Values 6.1 5 5.4
[103]
SNU475 SLC38A9
Mean 7.04
Standard deviation 0.79
Values 7.6 6.5
[104]
THLE SLC38A9
Mean 7.44
Standard deviation 0.15
Values 7.5 7.3
[105]
liver SLC38A9
Mean 8.79
Standard deviation 1.7
Values 8.2 11 8.9 7.1
[106]
ref_hepatocyte LAMTOR3
Mean 4.25
Standard deviation 0.84
Values 3.6 3.8 4.1 4 5.7
[107]
HepG2 LAMTOR3
Mean 18.6
Standard deviation 5.4
Values 15 22
[108]
HepG2.C3A LAMTOR3
Mean 24.8
Standard deviation 7.5
Values 19 30
[109]
HuH.7 LAMTOR3
Mean 12.9
Standard deviation 2.5
Values 12 11 16
[110]
SNU475 LAMTOR3
Mean 10.9
Standard deviation 1.1
Values 12 10
[111]
THLE LAMTOR3
Mean 17.4
Standard deviation 1.9
Values 16 19
[112]
liver LAMTOR3
Mean 11.2
Standard deviation 4.2
Values 16 8.8 14 6.6
[113]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 2.6 3.1 4.3 3.5 3.2
[114]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 38 47
[115]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 89 65
[116]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 73 50 41
[117]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 39 40
[118]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[119]
liver MTOR
Mean 51.8
Standard deviation 18
Values 34 72 39 62
[120]
ref_hepatocyte RPS6KB1
Mean 3.19
Standard deviation 1.6
Values 5.1 4.9 1.9 2 2.1
[121]
HepG2 RPS6KB1
Missing
[122]
HepG2.C3A RPS6KB1
Missing
[123]
HuH.7 RPS6KB1
Missing
[124]
SNU475 RPS6KB1
Missing
[125]
THLE RPS6KB1
Missing
[126]
liver RPS6KB1
Missing
[127]
ref_hepatocyte EEF2K
Mean 2.13
Standard deviation 0.55
Values 3.1 2.2 1.9 1.8 1.7
[128]
HepG2 EEF2K
Mean 25.8
Standard deviation 3.7
Values 28 23
[129]
HepG2.C3A EEF2K
Mean 15.7
Standard deviation 0.89
Values 15 16
[130]
HuH.7 EEF2K
Mean 19.5
Standard deviation 3.3
Values 23 16 19
[131]
SNU475 EEF2K
Mean 11.6
Standard deviation 4.3
Values 15 8.5
[132]
THLE EEF2K
Mean 8.67
Standard deviation 2.4
Values 6.9 10
[133]
liver EEF2K
Mean 13.4
Standard deviation 5.2
Values 11 14 8 20
[134]
ref_hepatocyte RPTOR
Mean 1.96
Standard deviation 0.72
Values 2.5 2.4 2.6 1.1 1.2
[135]
HepG2 RPTOR
Mean 36.8
Standard deviation 1
Values 36 38
[136]
HepG2.C3A RPTOR
Mean 19.3
Standard deviation 0.98
Values 20 19
[137]
HuH.7 RPTOR
Mean 19.8
Standard deviation 7.4
Values 28 14 17
[138]
SNU475 RPTOR
Mean 13
Standard deviation 0.49
Values 13 13
[139]
THLE RPTOR
Mean 17.1
Standard deviation 3.1
Values 15 19
[140]
liver RPTOR
Mean 14.1
Standard deviation 7.6
Values 7.5 20 7.6 21
[141]
ref_hepatocyte RRAGD
Mean 1.86
Standard deviation 1.2
Values 0.26 2.6 1.4 3.3 1.6
[142]
HepG2 RRAGD
Mean 2.03
Standard deviation 0.87
Values 2.6 1.4
[143]
HepG2.C3A RRAGD
Mean 0.139
Standard deviation 0.031
Values 0.12 0.16
[144]
HuH.7 RRAGD
Mean 31.7
Standard deviation 11
Values 28 44 23
[145]
SNU475 RRAGD
Mean 7.38
Standard deviation 0.39
Values 7.7 7.1
[146]
THLE RRAGD
Mean 2.51
Standard deviation 0.37
Values 2.8 2.3
[147]
liver RRAGD
Mean 5.98
Standard deviation 1.6
Values 6.8 7.7 5.5 4
[148]
ref_hepatocyte RRAGB
Mean 1.68
Standard deviation 0.6
Values 2 2.3 1.2 0.93 2.1
[149]
HepG2 RRAGB
Mean 3.06
Standard deviation 0.91
Values 2.4 3.7
[150]
HepG2.C3A RRAGB
Mean 4.04
Standard deviation 0.25
Values 4.2 3.9
[151]
HuH.7 RRAGB
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[152]
SNU475 RRAGB
Mean 4.2
Standard deviation 0.86
Values 4.8 3.6
[153]
THLE RRAGB
Mean 4.16
Standard deviation 0.15
Values 4.1 4.3
[154]
liver RRAGB
Mean 3.59
Standard deviation 1
Values 4.6 2.9 4.4 2.5
[155]
ref_hepatocyte LAMTOR4
Missing
[156]
HepG2 LAMTOR4
Mean 20.8
Standard deviation 1.5
Values 20 22
[157]
HepG2.C3A LAMTOR4
Mean 19.9
Standard deviation 3
Values 18 22
[158]
HuH.7 LAMTOR4
Mean 28
Standard deviation 11
Values 24 20 40
[159]
SNU475 LAMTOR4
Mean 12.5
Standard deviation 3.8
Values 15 9.8
[160]
THLE LAMTOR4
Mean 13.8
Standard deviation 0.82
Values 13 14
[161]
liver LAMTOR4
Mean 13.8
Standard deviation 13
Values 26 2.6 24 2.1
[162]
ref_hepatocyte LAMTOR5
Missing
[163]
HepG2 LAMTOR5
Mean 34.9
Standard deviation 5.2
Values 31 39
[164]
HepG2.C3A LAMTOR5
Mean 36.7
Standard deviation 11
Values 29 45
[165]
HuH.7 LAMTOR5
Mean 29.8
Standard deviation 10
Values 25 23 41
[166]
SNU475 LAMTOR5
Mean 28.3
Standard deviation 7.1
Values 33 23
[167]
THLE LAMTOR5
Mean 26.2
Standard deviation 0.031
Values 26 26
[168]
liver LAMTOR5
Mean 23.1
Standard deviation 24
Values 48 2.6 40 2.1