REACTOME_MITOTIC_SPINDLE_CHECKPOINT | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS27 | 40S ribosomal protein S27 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | DYNLL1 | Dynein light chain 1, cytoplasmic | [8] | -0.99[9] | -1.23[10] | -1.55[11] | -1.43[12] | -1.83[13] | -1.20[14] |
3 | NUDC | Nuclear migration protein nudC | [15] | -0.53[16] | -1.31[17] | -1.52[18] | -1.75[19] | -1.88[20] | -1.58[21] |
4 | SEC13 | Protein SEC13 homolog | [22] | -0.56[23] | -0.46[24] | -0.37[25] | -1.54[26] | -1.51[27] | -0.65[28] |
5 | ANAPC11 | Anaphase-promoting complex subunit 11 | [29] | -1.44[30] | -1.27[31] | -1.80[32] | -2.13[33] | -1.88[34] | -0.49[35] |
6 | DYNLL2 | Dynein light chain 2, cytoplasmic | [36] | -0.57[37] | -1.40[38] | -1.28[39] | -2.68[40] | -1.23[41] | -2.04[42] |
7 | CDC26 | Anaphase-promoting complex subunit CDC26 | [43] | -2.38[44] | -2.18[45] | -2.32[46] | -2.84[47] | -2.07[48] | -1.30[49] |
8 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 1.20[50] | 0.74[51] | 0.57[52] | 1.40[53] | 0.60[54] | 1.05[55] | |
9 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 0.67[56] | 0.48[57] | -0.25[58] | 0.93[59] | 0.92[60] | 0.80[61] | |
10 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 1.07[62] | 1.58[63] | 1.70[64] | 0.43[65] | 0.40[66] | -0.17[67] | |
11 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 0.00[68] | -0.62[69] | -0.64[70] | -0.27[71] | -0.50[72] | -0.08[73] | |
12 | RANGAP1 | Ran GTPase-activating protein 1 | [74] | 1.04[75] | 0.46[76] | 0.21[77] | -0.18[78] | 0.55[79] | -0.07[80] |
13 | UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 | [81] | -0.56[82] | -0.60[83] | 0.01[84] | -0.29[85] | -0.16[86] | -1.90[87] |
14 | MAPRE1 | Microtubule-associated protein RP/EB family member 1 | [88] | 2.07[89] | 1.39[90] | 0.63[91] | 1.88[92] | 0.98[93] | -0.64[94] |
15 | BUB3 | Mitotic checkpoint protein BUB3 | [95] | 0.71[96] | 1.31[97] | 0.60[98] | -0.12[99] | 1.21[100] | 0.31[101] |
16 | ANAPC16 | Anaphase-promoting complex subunit 16 | [102] | 0.58[103] | 1.02[104] | -0.25[105] | -0.24[106] | -0.13[107] | 1.45[108] |
17 | ANAPC5 | Anaphase-promoting complex subunit 5 | [109] | 1.27[110] | 1.66[111] | 1.72[112] | 0.53[113] | 0.86[114] | 1.62[115] |
18 | PMF1 | Polyamine-modulated factor 1 | [116] | -1.95[117] | -1.79[118] | -2.23[119] | -1.86[120] | -2.36[121] | -0.65[122] |
19 | DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 | [123] | 0.82[124] | 1.00[125] | 0.70[126] | 0.99[127] | 0.52[128] | 0.33[129] |
20 | DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 | [130] | 0.95[131] | 0.91[132] | 0.32[133] | 1.35[134] | 1.49[135] | 1.24[136] |
21 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | -0.73[137] | -0.11[138] | 0.51[139] | -0.06[140] | -1.31[141] | 1.54[142] | |
22 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isofor | 0.09[143] | 0.69[144] | 0.29[145] | 1.13[146] | 0.81[147] | 0.71[148] | |
23 | CDC27 | Cell division cycle protein 27 homolog | [149] | 0.61[150] | 1.17[151] | 0.42[152] | 1.37[153] | 0.79[154] | 1.05[155] |
24 | XPO1 | Exportin-1 | [156] | 1.75[157] | 2.19[158] | 2.12[159] | 2.32[160] | 2.28[161] | 1.77[162] |
25 | CDC16 | Cell division cycle protein 16 homolog | [163] | -0.10[164] | -0.15[165] | -0.90[166] | -0.23[167] | 0.09[168] | 0.78[169] |
26 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 0.85[170] | 0.05[171] | 0.36[172] | 0.46[173] | 0.12[174] | 3.84[175] | |
27 | DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 | [176] | -0.18[177] | -0.21[178] | 0.69[179] | -0.56[180] | -0.06[181] | -0.11[182] |
28 | NDEL1 | Nuclear distribution protein nudE-like 1 | [183] | 0.05[184] | 0.47[185] | -0.67[186] | -0.38[187] | -0.45[188] | 0.50[189] |
29 | UBE2C | Ubiquitin-conjugating enzyme E2 C | [190] | 0.16[191] | 0.26[192] | 0.93[193] | 0.32[194] | 1.08[195] | -2.89[196] |
30 | SPC25 | Kinetochore protein Spc25 | [197] | -1.31[198] | -0.77[199] | -1.29[200] | -0.93[201] | -0.76[202] | -1.29[203] |
31 | SEH1L | Nucleoporin SEH1 | [204] | 0.62[205] | 0.83[206] | 1.19[207] | 0.76[208] | -0.14[209] | 1.09[210] |
32 | CLIP1 | CAP-Gly domain-containing linker protein 1 | [211] | -0.20[212] | 0.97[213] | 1.27[214] | 1.19[215] | 1.01[216] | 2.52[217] |
33 | UBE2S | Ubiquitin-conjugating enzyme E2 S | [218] | 0.84[219] | 0.14[220] | 2.22[221] | 1.15[222] | 2.39[223] | -1.68[224] |
34 | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha | [225] | 1.18[226] | 1.02[227] | 0.86[228] | 2.33[229] | 2.06[230] | 1.75[231] |
35 | DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 | [232] | 3.96[233] | 2.28[234] | 2.99[235] | 3.84[236] | 3.73[237] | 4.10[238] |
36 | MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A | [239] | 0.99[240] | 1.84[241] | 1.07[242] | 0.24[243] | 1.23[244] | -1.97[245] |
37 | ZWINT | ZW10 interactor | [246] | 1.32[247] | 1.77[248] | 0.67[249] | 1.58[250] | 1.68[251] | -1.34[252] |
38 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 1.65[253] | 1.13[254] | 0.59[255] | 1.48[256] | 1.24[257] | 0.64[258] | |
39 | CENPT | Centromere protein T | [259] | 0.28[260] | 0.33[261] | -0.11[262] | -0.47[263] | -0.13[264] | 0.78[265] |
40 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [266] | 1.97[267] | 2.14[268] | 2.00[269] | 0.87[270] | 1.57[271] | -1.41[272] |
41 | CDC23 | Cell division cycle protein 23 homolog | [273] | 0.77[274] | 0.69[275] | 0.85[276] | 1.22[277] | 0.80[278] | 1.10[279] |
42 | NUP85 | Nuclear pore complex protein Nup85 | [280] | 1.14[281] | 1.22[282] | 1.36[283] | 0.76[284] | 0.84[285] | 1.13[286] |
43 | SKA2 | Spindle and kinetochore-associated protein 2 | [287] | 0.18[288] | 0.94[289] | 1.51[290] | 0.42[291] | 1.31[292] | 0.37[293] |
44 | RANBP2 | E3 SUMO-protein ligase RanBP2 | [294] | 0.87[295] | 2.28[296] | 1.92[297] | 1.72[298] | 1.75[299] | 3.86[300] |
45 | NUP98 | Nuclear pore complex protein Nup98-Nup96 | [301] | 2.57[302] | 1.98[303] | 2.14[304] | 2.42[305] | 1.85[306] | 2.76[307] |
46 | RCC2 | Protein RCC2 | [308] | 2.46[309] | 1.95[310] | 1.83[311] | 2.57[312] | 2.20[313] | 0.33[314] |
47 | NUP107 | Nuclear pore complex protein Nup107 | [315] | 0.90[316] | 1.73[317] | 1.62[318] | 1.48[319] | 1.28[320] | 0.90[321] |
48 | ANAPC7 | Anaphase-promoting complex subunit 7 | [322] | 1.40[323] | 1.52[324] | 0.89[325] | 1.09[326] | 1.22[327] | 1.09[328] |
49 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isofor | 0.51[329] | 0.41[330] | -0.16[331] | 1.05[332] | 0.71[333] | 1.10[334] | |
50 | CKAP5 | Cytoskeleton-associated protein 5 | [335] | 2.86[336] | 2.74[337] | 3.35[338] | 2.67[339] | 2.87[340] | 2.40[341] |
51 | ANAPC2 | Anaphase-promoting complex subunit 2 | [342] | 1.00[343] | 0.16[344] | 0.68[345] | 0.23[346] | 0.06[347] | 0.95[348] |
52 | NUP37 | Nucleoporin Nup37 | [349] | 1.05[350] | 1.06[351] | 1.05[352] | 0.64[353] | 0.50[354] | -0.52[355] |
53 | AURKB | Aurora kinase B | [356] | 0.98[357] | 1.07[358] | 1.99[359] | 0.53[360] | 0.94[361] | -2.45[362] |
54 | MIS12 | Protein MIS12 homolog | [363] | 0.14[364] | 0.50[365] | 0.27[366] | 0.63[367] | 0.79[368] | 0.78[369] |
55 | MAD1L1 | Mitotic spindle assembly checkpoint protein MAD1 | [370] | 1.03[371] | 0.24[372] | 0.25[373] | -0.46[374] | -0.05[375] | 0.62[376] |
56 | PLK1 | Serine/threonine-protein kinase PLK1 | [377] | 2.89[378] | 2.35[379] | 2.11[380] | 1.43[381] | 2.34[382] | -1.72[383] |
57 | DSN1 | Kinetochore-associated protein DSN1 homolog | [384] | 1.18[385] | 1.18[386] | 1.31[387] | 1.46[388] | 1.35[389] | -0.04[390] |
58 | CENPN | Centromere protein N | [391] | 1.42[392] | 1.83[393] | 2.27[394] | 1.53[395] | 2.09[396] | 0.62[397] |
59 | NUP160 | Nuclear pore complex protein Nup160 | [398] | 2.25[399] | 2.12[400] | 2.62[401] | 1.36[402] | 1.54[403] | 2.38[404] |
60 | ZW10 | Centromere/kinetochore protein zw10 homolog | [405] | 1.02[406] | 0.61[407] | 0.22[408] | 1.45[409] | 1.09[410] | 1.48[411] |
61 | NUP133 | Nuclear pore complex protein Nup133 | [412] | 1.58[413] | 1.65[414] | 2.51[415] | 2.40[416] | 1.62[417] | 1.95[418] |
62 | CDC20 | Cell division cycle protein 20 homolog | [419] | 2.75[420] | 2.49[421] | 2.76[422] | 2.69[423] | 3.22[424] | -1.40[425] |
63 | ANAPC1 | Anaphase-promoting complex subunit 1 | [426] | 2.80[427] | 2.71[428] | 2.49[429] | 2.11[430] | 2.01[431] | 2.36[432] |
64 | AHCTF1 | Protein ELYS | [433] | 0.85[434] | 1.95[435] | 2.16[436] | 2.41[437] | 1.58[438] | 2.65[439] |
65 | NUP43 | Nucleoporin Nup43 | [440] | 2.31[441] | 2.21[442] | 1.86[443] | 2.27[444] | 1.88[445] | 1.22[446] |
66 | ITGB3BP | Centromere protein R | [447] | -0.52[448] | 0.90[449] | 1.09[450] | -0.18[451] | 0.36[452] | -0.54[453] |
67 | NDC80 | Kinetochore protein NDC80 homolog | [454] | 0.01[455] | 1.85[456] | 1.94[457] | 2.31[458] | 2.32[459] | -1.59[460] |
68 | SPC24 | Kinetochore protein Spc24 | [461] | -0.96[462] | -1.12[463] | -0.61[464] | -1.10[465] | -0.36[466] | -3.80[467] |
69 | ANAPC4 | Anaphase-promoting complex subunit 4 | [468] | 0.59[469] | 1.24[470] | 1.46[471] | 1.38[472] | 0.72[473] | 1.89[474] |
70 | KIF2A | Kinesin-like protein KIF2A | [475] | 1.24[476] | 1.34[477] | 2.06[478] | 2.53[479] | 2.10[480] | 1.45[481] |
71 | ZWILCH | Protein zwilch homolog | [482] | 1.05[483] | 2.05[484] | 2.97[485] | 1.80[486] | 2.37[487] | 0.38[488] |
72 | CLASP1 | CLIP-associating protein 1 | [489] | 2.93[490] | 2.65[491] | 2.24[492] | 2.71[493] | 2.63[494] | 3.82[495] |
73 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [496] | 1.19[497] | 1.78[498] | 2.02[499] | 1.71[500] | 1.34[501] | 1.41[502] |
74 | CENPA | Histone H3-like centromeric protein A | [503] | 0.90[504] | 1.43[505] | 0.57[506] | 0.52[507] | 1.22[508] | -3.69[509] |
75 | CDCA8 | Borealin | [510] | 2.11[511] | 2.17[512] | 2.76[513] | 2.02[514] | 2.68[515] | -1.35[516] |
76 | ANAPC10 | Anaphase-promoting complex subunit 10 | [517] | 0.16[518] | 0.77[519] | 0.06[520] | -0.04[521] | 0.62[522] | 1.03[523] |
77 | INCENP | Inner centromere protein | [524] | 1.85[525] | 1.34[526] | 2.39[527] | 2.34[528] | 2.62[529] | 0.14[530] |
78 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | 1.17[531] | 0.66[532] | -0.09[533] | 0.48[534] | 1.52[535] | 1.00[536] | |
79 | NUF2 | Kinetochore protein Nuf2 | [537] | 0.29[538] | 2.39[539] | 1.74[540] | 2.29[541] | 2.22[542] | -1.96[543] |
80 | CENPH | Centromere protein H | [544] | 0.57[545] | 1.51[546] | 2.66[547] | 1.40[548] | 1.35[549] | -2.39[550] |
81 | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | [551] | 2.53[552] | 2.97[553] | 2.78[554] | 3.26[555] | 3.41[556] | -0.69[557] |
82 | BUB1 | Mitotic checkpoint serine/threonine-protein kinase BUB1 | [558] | 2.58[559] | 3.46[560] | 2.98[561] | 3.28[562] | 3.51[563] | -0.41[564] |
83 | TAOK1 | Serine/threonine-protein kinase TAO1 | [565] | 2.79[566] | 3.32[567] | 4.15[568] | 4.28[569] | 3.61[570] | 4.74[571] |
84 | CLASP2 | CLIP-associating protein 2 | [572] | 2.25[573] | 2.24[574] | 3.36[575] | 2.49[576] | 2.71[577] | 3.42[578] |
85 | CENPK | Centromere protein K | [579] | 0.38[580] | 1.94[581] | 2.67[582] | 1.68[583] | 2.16[584] | -1.63[585] |
86 | CENPQ | Centromere protein Q | [586] | 0.20[587] | 1.61[588] | 1.06[589] | 1.63[590] | 1.44[591] | -0.65[592] |
87 | KIF2C | Kinesin-like protein KIF2C | [593] | 3.56[594] | 3.61[595] | 3.89[596] | 3.32[597] | 4.32[598] | -0.61[599] |
88 | NDE1 | Nuclear distribution protein nudE homolog 1 | [600] | 3.06[601] | 2.05[602] | 0.95[603] | 0.94[604] | 1.79[605] | 0.85[606] |
89 | CENPL | Centromere protein L | [607] | 0.79[608] | 0.68[609] | 1.03[610] | 2.34[611] | 2.15[612] | -0.56[613] |
90 | CENPO | Centromere protein O | [614] | 2.86[615] | 2.72[616] | 2.40[617] | 2.55[618] | 2.72[619] | 0.87[620] |
91 | NSL1 | Kinetochore-associated protein NSL1 homolog | [621] | 3.22[622] | 3.87[623] | 3.71[624] | 3.28[625] | 2.77[626] | 4.01[627] |
92 | CENPI | Centromere protein I | [628] | 0.20[629] | 0.69[630] | 1.92[631] | 2.10[632] | 1.59[633] | -1.52[634] |
93 | SKA1 | Spindle and kinetochore-associated protein 1 | [635] | 2.08[636] | 2.30[637] | 1.69[638] | 2.38[639] | 3.06[640] | 0.72[641] |
94 | B9D2 | B9 domain-containing protein 2 | [642] | -0.62[643] | -0.30[644] | -0.74[645] | -0.69[646] | -0.35[647] | 0.20[648] |
95 | CENPF | Centromere protein F | [649] | 2.97[650] | 5.34[651] | 5.08[652] | 5.24[653] | 5.34[654] | 2.35[655] |
96 | CENPP | Centromere protein P | [656] | 0.17[657] | 0.05[658] | 0.42[659] | -0.06[660] | 0.76[661] | -0.30[662] |
97 | CENPE | Centromere-associated protein E | [663] | 1.19[664] | 4.00[665] | 3.50[666] | 2.88[667] | 4.35[668] | 1.27[669] |
98 | CENPM | Centromere protein M | [670] | 3.05[671] | 2.85[672] | 2.38[673] | 1.58[674] | 2.60[675] | -0.07[676] |
99 | DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 | [677] | -4.27[678] | -7.05[679] | 1.15[680] | 0.84[681] | -2.57[682] | -0.44[683] |
100 | KNTC1 | Kinetochore-associated protein 1 | [684] | 3.17[685] | 4.66[686] | 4.97[687] | 4.22[688] | 4.55[689] | 3.04[690] |
101 | KIF18A | Kinesin-like protein KIF18A | [691] | 1.74[692] | 3.58[693] | 4.39[694] | 4.44[695] | 3.46[696] | 0.45[697] |
102 | ERCC6L | DNA excision repair protein ERCC-6-like | [698] | 2.51[699] | 2.63[700] | 3.32[701] | 3.98[702] | 3.91[703] | 2.24[704] |
103 | SGO2 | Shugoshin 2 | [705] | [706] | [707] | [708] | [709] | [710] | [711] |
104 | KNL1 | Kinetochore scaffold 1 | [712] | [713] | [714] | [715] | [716] | [717] | [718] |
105 | SGO1 | Shugoshin 1 | [719] | [720] | [721] | [722] | [723] | [724] | [725] |
106 | SPDL1 | Protein Spindly | [726] | [727] | [728] | [729] | [730] | [731] | [732] |
107 | ANAPC15 | Anaphase-promoting complex subunit 15 | [733] | [734] | [735] | [736] | [737] | [738] | [739] |
108 | KIF2B | Kinesin-like protein KIF2B | [740] | [741] | [742] | [743] | [744] | [745] | [746] |
109 | CENPU | Centromere protein U | [747] | [748] | [749] | [750] | [751] | [752] | [753] |
110 | CENPC | Centromere protein C | [754] | [755] | [756] | [757] | [758] | [759] | [760] |
111 | CENPS | Centromere protein S | [761] | [762] | [763] | [764] | [765] | [766] | [767] |