REACTOME_MITOCHONDRIAL_IRON_SULFUR_CLUSTER_BIOGENESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GLRX5 Glutaredoxin-related protein 5, mitochondrial [1] -1.09[2] -0.55[3] -0.83[4] -0.87[5] -1.17[6] -1.70[7]
2 ISCU Iron-sulfur cluster assembly enzyme ISCU, mitochondrial [8] -0.84[9] -0.39[10] -0.56[11] -0.91[12] -0.75[13] -0.29[14]
3 ISCA1 Iron-sulfur cluster assembly 1 homolog, mitochondrial [15] -0.13[16] -0.13[17] 0.86[18] 0.52[19] 1.54[20] 0.90[21]
4 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial [22] -1.05[23] -0.35[24] -0.80[25] -0.03[26] -0.20[27] -0.52[28]
5 FDX1 Adrenodoxin, mitochondrial [29] -0.30[30] -0.90[31] -1.48[32] 1.32[33] 0.86[34] 1.70[35]
6 SLC25A28 Mitoferrin-2 [36] -1.89[37] -0.91[38] 0.32[39] -0.70[40] -0.34[41] -1.07[42]
7 LYRM4 LYR motif-containing protein 4 [43] 0.50[44] 0.79[45] 0.88[46] 0.56[47] -0.18[48] -0.97[49]
8 NFS1 Cysteine desulfurase, mitochondrial [50] 1.05[51] 0.75[52] 1.30[53] 1.53[54] 0.58[55] 0.84[56]
9 HSCB Iron-sulfur cluster co-chaperone protein HscB, mitochondrial [57] -1.67[58] -0.70[59] 0.49[60] -0.54[61] -1.46[62] -0.25[63]
10 FDXR NADPH:adrenodoxin oxidoreductase, mitochondrial [64] 3.00[65] 2.17[66] -0.03[67] -0.28[68] 0.43[69] -1.02[70]
11 FXN Frataxin, mitochondrial [71] 0.79[72] 0.87[73] 0.62[74] 0.39[75] 0.51[76] 1.92[77]
12 SLC25A37 Mitoferrin-1 [78] -0.59[79] -0.56[80] 0.78[81] 0.25[82] 1.61[83] 0.84[84]
13 FDX2 Ferredoxin-2, mitochondrial [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte GLRX5
Mean 55.2
Standard deviation 28
Values 99 25 35 58 59
[2]
HepG2 GLRX5
Mean 43.5
Standard deviation 4.5
Values 40 47
[3]
HepG2.C3A GLRX5
Mean 62.7
Standard deviation 9.2
Values 69 56
[4]
HuH.7 GLRX5
Mean 26
Standard deviation 3.9
Values 25 22 30
[5]
SNU475 GLRX5
Mean 18.1
Standard deviation 0.88
Values 19 17
[6]
THLE GLRX5
Mean 21.3
Standard deviation 3.5
Values 19 24
[7]
liver GLRX5
Mean 13
Standard deviation 7.6
Values 19 5.8 20 7.1
[8]
ref_hepatocyte ISCU
Mean 34.2
Standard deviation 13
Values 19 36 23 42 51
[9]
HepG2 ISCU
Mean 32.1
Standard deviation 5.8
Values 28 36
[10]
HepG2.C3A ISCU
Mean 43.4
Standard deviation 5.1
Values 40 47
[11]
HuH.7 ISCU
Mean 19.4
Standard deviation 5.1
Values 19 15 25
[12]
SNU475 ISCU
Mean 10.9
Standard deviation 0.73
Values 11 10
[13]
THLE ISCU
Mean 17.7
Standard deviation 0.66
Values 17 18
[14]
liver ISCU
Mean 21.4
Standard deviation 16
Values 37 9.8 33 5.8
[15]
ref_hepatocyte ISCA1
Mean 14.4
Standard deviation 5.2
Values 19 20 8.2 15 9.8
[16]
HepG2 ISCA1
Mean 22
Standard deviation 5.7
Values 18 26
[17]
HepG2.C3A ISCA1
Mean 21.9
Standard deviation 5.9
Values 18 26
[18]
HuH.7 ISCA1
Mean 21.8
Standard deviation 1.5
Values 22 20 23
[19]
SNU475 ISCA1
Mean 12.4
Standard deviation 0.77
Values 13 12
[20]
THLE ISCA1
Mean 36.5
Standard deviation 1.2
Values 36 37
[21]
liver ISCA1
Mean 20.6
Standard deviation 12
Values 26 13 35 9.2
[22]
ref_hepatocyte ISCA2
Mean 13.2
Standard deviation 4.3
Values 19 17 8.2 11 12
[23]
HepG2 ISCA2
Mean 10.7
Standard deviation 0.73
Values 10 11
[24]
HepG2.C3A ISCA2
Mean 17.3
Standard deviation 4.7
Values 14 21
[25]
HuH.7 ISCA2
Mean 6.33
Standard deviation 1.5
Values 5.7 5.2 8.1
[26]
SNU475 ISCA2
Mean 7.75
Standard deviation 0.87
Values 8.4 7.1
[27]
THLE ISCA2
Mean 9.98
Standard deviation 0.95
Values 9.3 11
[28]
liver ISCA2
Mean 7.06
Standard deviation 5.8
Values 13 2 11 2.1
[29]
ref_hepatocyte FDX1
Mean 11.4
Standard deviation 6.1
Values 10 11 2.2 14 19
[30]
HepG2 FDX1
Mean 15.5
Standard deviation 0.65
Values 15 16
[31]
HepG2.C3A FDX1
Mean 10.2
Standard deviation 2.3
Values 8.6 12
[32]
HuH.7 FDX1
Mean 3.41
Standard deviation 0.095
Values 3.3 3.4 3.5
[33]
SNU475 FDX1
Mean 17.1
Standard deviation 1.7
Values 18 16
[34]
THLE FDX1
Mean 18.1
Standard deviation 3.7
Values 15 21
[35]
liver FDX1
Mean 28.4
Standard deviation 18
Values 44 15 44 12
[36]
ref_hepatocyte SLC25A28
Mean 11.4
Standard deviation 8.2
Values 3.1 3.3 21 18 11
[37]
HepG2 SLC25A28
Mean 5.14
Standard deviation 0.14
Values 5.2 5
[38]
HepG2.C3A SLC25A28
Mean 10.1
Standard deviation 2
Values 11 8.7
[39]
HuH.7 SLC25A28
Mean 11.9
Standard deviation 5.4
Values 11 6.8 18
[40]
SNU475 SLC25A28
Mean 4.19
Standard deviation 0.58
Values 3.8 4.6
[41]
THLE SLC25A28
Mean 7.8
Standard deviation 0.85
Values 8.4 7.2
[42]
liver SLC25A28
Mean 4.14
Standard deviation 1.4
Values 5.4 2.7 5.3 3.3
[43]
ref_hepatocyte LYRM4
Mean 11.4
Standard deviation 4.6
Values 16 8.9 17 9.5 6
[44]
HepG2 LYRM4
Mean 27
Standard deviation 1.5
Values 28 26
[45]
HepG2.C3A LYRM4
Mean 32.7
Standard deviation 3.8
Values 35 30
[46]
HuH.7 LYRM4
Mean 17.5
Standard deviation 4.6
Values 17 13 22
[47]
SNU475 LYRM4
Mean 10
Standard deviation 0.72
Values 11 9.5
[48]
THLE LYRM4
Mean 8.75
Standard deviation 0.46
Values 8.4 9.1
[49]
liver LYRM4
Mean 4.43
Standard deviation 3.4
Values 7.7 1.7 7 1.4
[50]
ref_hepatocyte NFS1
Mean 9.84
Standard deviation 3.3
Values 9.1 7.6 6.2 12 14
[51]
HepG2 NFS1
Mean 34.3
Standard deviation 6.3
Values 30 39
[52]
HepG2.C3A NFS1
Mean 27.5
Standard deviation 3.1
Values 25 30
[53]
HuH.7 NFS1
Mean 20.2
Standard deviation 8.6
Values 22 11 28
[54]
SNU475 NFS1
Mean 17.1
Standard deviation 2.1
Values 19 16
[55]
THLE NFS1
Mean 12.8
Standard deviation 1
Values 12 13
[56]
liver NFS1
Mean 13.5
Standard deviation 6.1
Values 17 8.7 20 8.1
[57]
ref_hepatocyte HSCB
Mean 8.85
Standard deviation 6
Values 6.3 4.2 3.2 14 16
[58]
HepG2 HSCB
Mean 4.66
Standard deviation 0.15
Values 4.6 4.8
[59]
HepG2.C3A HSCB
Mean 9.1
Standard deviation 1
Values 8.4 9.8
[60]
HuH.7 HSCB
Mean 10.4
Standard deviation 2.1
Values 8.2 11 12
[61]
SNU475 HSCB
Mean 3.66
Standard deviation 1.1
Values 2.9 4.5
[62]
THLE HSCB
Mean 2.81
Standard deviation 0.69
Values 2.3 3.3
[63]
liver HSCB
Mean 5.7
Standard deviation 4
Values 9.7 2.6 8.5 2
[64]
ref_hepatocyte FDXR
Mean 7.28
Standard deviation 6.2
Values 18 3.2 2.7 8.3 4.5
[65]
HepG2 FDXR
Mean 97.8
Standard deviation 8.7
Values 92 1e+02
[66]
HepG2.C3A FDXR
Mean 54.6
Standard deviation 14
Values 45 64
[67]
HuH.7 FDXR
Mean 5.93
Standard deviation 2.4
Values 6.5 3.4 8
[68]
SNU475 FDXR
Mean 3.59
Standard deviation 0.45
Values 3.9 3.3
[69]
THLE FDXR
Mean 8.51
Standard deviation 1.3
Values 9.4 7.6
[70]
liver FDXR
Mean 2.74
Standard deviation 1.3
Values 3.3 2 4.4 1.3
[71]
ref_hepatocyte FXN
Mean 5.6
Standard deviation 1.1
Values 6.6 6.3 4.1 6.2 4.8
[72]
HepG2 FXN
Mean 16.3
Standard deviation 0.78
Values 16 17
[73]
HepG2.C3A FXN
Mean 17.1
Standard deviation 3.2
Values 15 19
[74]
HuH.7 FXN
Mean 7.2
Standard deviation 1.3
Values 7.8 5.7 8.1
[75]
SNU475 FXN
Mean 4.41
Standard deviation 0.4
Values 4.7 4.1
[76]
THLE FXN
Mean 6.96
Standard deviation 0.9
Values 6.3 7.6
[77]
liver FXN
Mean 16.2
Standard deviation 6.6
Values 22 8.4 21 13
[78]
ref_hepatocyte SLC25A37
Mean 4.38
Standard deviation 0.87
Values 4.2 4.2 5.7 3.3 4.5
[79]
HepG2 SLC25A37
Mean 4.89
Standard deviation 0.81
Values 5.5 4.3
[80]
HepG2.C3A SLC25A37
Mean 4.93
Standard deviation 0.38
Values 5.2 4.7
[81]
HuH.7 SLC25A37
Mean 6.28
Standard deviation 0.54
Values 6.7 5.7 6.5
[82]
SNU475 SLC25A37
Mean 3.13
Standard deviation 0.29
Values 2.9 3.3
[83]
THLE SLC25A37
Mean 11.6
Standard deviation 4.1
Values 14 8.7
[84]
liver SLC25A37
Mean 5.98
Standard deviation 1.3
Values 6.3 5.3 7.7 4.6
[85]
ref_hepatocyte FDX2
Missing
[86]
HepG2 FDX2
Missing
[87]
HepG2.C3A FDX2
Missing
[88]
HuH.7 FDX2
Missing
[89]
SNU475 FDX2
Missing
[90]
THLE FDX2
Missing
[91]
liver FDX2
Missing