REACTOME_MISCELLANEOUS_SUBSTRATES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP4A11 Cytochrome P450 4A11 [1] -11.01[2] -9.59[3] -9.08[4] -8.06[5] -8.14[6] -0.20[7]
2 CYP2D6 Cytochrome P450 2D6 [8] -4.24[9] -2.97[10] -3.13[11] -5.31[12] -4.89[13] 0.14[14]
3 CYP4F2 Phylloquinone omega-hydroxylase CYP4F2 [15] -2.96[16] -0.55[17] -9.88[18] -9.28[19] -6.45[20] -0.26[21]
4 CYP4F11 Phylloquinone omega-hydroxylase CYP4F11 [22] 1.13[23] -0.50[24] -5.43[25] 3.15[26] -5.95[27] -0.33[28]
5 CYP4F3 Docosahexaenoic acid omega-hydroxylase CYP4F3 [29] 0.20[30] -0.10[31] 3.54[32] -0.25[33] -5.45[34] 1.10[35]
6 CYP4A22 Cytochrome P450 4A22 [36] [37] [38] [39] [40] [41] 1.18[42]
7 CYP4F22 Cytochrome P450 4F22 [43] -2.22[44] [45] -6.07[46] -5.69[47] -2.94[48] -2.05[49]
8 CYP3A43 Cytochrome P450 3A43 [50] -1.19[51] 0.49[52] 2.67[53] [54] -4.93[55] 0.30[56]
9 CYP2U1 Cytochrome P450 2U1 [57] 3.84[58] -1.18[59] 1.39[60] 5.50[61] 7.23[62] 0.99[63]
10 CYP2W1 Cytochrome P450 2W1 [64] 7.36[65] 8.06[66] 4.34[67] 0.84[68] 1.37[69] -5.10[70]
11 CYP2S1 Cytochrome P450 2S1 [71] 6.57[72] 4.23[73] 5.78[74] 5.45[75] 6.47[76] -1.73[77]
12 CYP4B1 Cytochrome P450 4B1 [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte CYP4A11
Mean 109
Standard deviation 1.6e+02
Values 0 0 4 2e+02 3.4e+02
[2]
HepG2 CYP4A11
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[3]
HepG2.C3A CYP4A11
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[4]
HuH.7 CYP4A11
Mean 0.0135
Standard deviation 0.0098
Values 0.025 0.0064 0.0094
[5]
SNU475 CYP4A11
Mean 0.039
Standard deviation 0.0093
Values 0.032 0.046
[6]
THLE CYP4A11
Mean 0.0216
Standard deviation 0.022
Values 0.0059 0.037
[7]
liver CYP4A11
Mean 286
Standard deviation 2.2e+02
Values 5.7e+02 87 3.6e+02 1.3e+02
[8]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 0.24 0.47 3.7 1.1e+02 87
[9]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.36 0.4
[10]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 2.6 1.2
[11]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.23 0.4 0.31
[12]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.1 0.096
[13]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[14]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 3.1e+02 53 1.3e+02 57
[15]
ref_hepatocyte CYP4F2
Mean 30.2
Standard deviation 38
Values 1.2 0.054 11 51 87
[16]
HepG2 CYP4F2
Mean 0.677
Standard deviation 0.5
Values 1 0.32
[17]
HepG2.C3A CYP4F2
Mean 7.41
Standard deviation 4.8
Values 11 4
[18]
HuH.7 CYP4F2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[19]
SNU475 CYP4F2
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[20]
THLE CYP4F2
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[21]
liver CYP4F2
Mean 75.6
Standard deviation 42
Values 86 50 1.3e+02 36
[22]
ref_hepatocyte CYP4F11
Mean 14.8
Standard deviation 11
Values 1.7 6.9 14 28 23
[23]
HepG2 CYP4F11
Mean 5.67
Standard deviation 2.2
Values 7.3 4.1
[24]
HepG2.C3A CYP4F11
Mean 3.76
Standard deviation 0.42
Values 4.1 3.5
[25]
HuH.7 CYP4F11
Mean 0.023
Standard deviation 0.029
Values 0 0.013 0.056
[26]
SNU475 CYP4F11
Mean 12.6
Standard deviation 0.65
Values 12 13
[27]
THLE CYP4F11
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[28]
liver CYP4F11
Mean 35.3
Standard deviation 12
Values 20 46 34 42
[29]
ref_hepatocyte CYP4F3
Mean 13.8
Standard deviation 15
Values 3.1 2 2.4 29 33
[30]
HepG2 CYP4F3
Mean 2.77
Standard deviation 0.38
Values 3 2.5
[31]
HepG2.C3A CYP4F3
Mean 4.62
Standard deviation 0.54
Values 5 4.2
[32]
HuH.7 CYP4F3
Mean 10.7
Standard deviation 7.3
Values 7.3 19 5.8
[33]
SNU475 CYP4F3
Mean 1.11
Standard deviation 0.19
Values 1.2 0.97
[34]
THLE CYP4F3
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[35]
liver CYP4F3
Mean 88.9
Standard deviation 26
Values 68 1.2e+02 95 70
[36]
ref_hepatocyte CYP4A22
Mean 3.13
Standard deviation 4
Values 0 0.14 0.49 7.2 7.8
[37]
HepG2 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[38]
HepG2.C3A CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[39]
HuH.7 CYP4A22
Mean 0
Standard deviation 0
Values 0 0 0
[40]
SNU475 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[41]
THLE CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[42]
liver CYP4A22
Mean 21.4
Standard deviation 17
Values 46 6.3 15 18
[43]
ref_hepatocyte CYP4F22
Mean 2.74
Standard deviation 3.4
Values 0 0.23 8.2 3.5 1.8
[44]
HepG2 CYP4F22
Mean 0.103
Standard deviation 0.15
Values 0.21 0
[45]
HepG2.C3A CYP4F22
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 CYP4F22
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[47]
SNU475 CYP4F22
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[48]
THLE CYP4F22
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[49]
liver CYP4F22
Mean 1.99
Standard deviation 1.8
Values 4.7 0.59 1.6 1.1
[50]
ref_hepatocyte CYP3A43
Mean 1.46
Standard deviation 2.7
Values 0.059 0 0 1.1 6.1
[51]
HepG2 CYP3A43
Mean 0.112
Standard deviation 0.061
Values 0.069 0.15
[52]
HepG2.C3A CYP3A43
Mean 0.735
Standard deviation 0.42
Values 1 0.44
[53]
HuH.7 CYP3A43
Mean 0.622
Standard deviation 0.91
Values 0.057 1.7 0.14
[54]
SNU475 CYP3A43
Mean 0
Standard deviation 0
Values 0 0
[55]
THLE CYP3A43
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[56]
liver CYP3A43
Mean 5.41
Standard deviation 4.2
Values 12 2.9 3.4 3.6
[57]
ref_hepatocyte CYP2U1
Mean 1.09
Standard deviation 0.48
Values 0.81 1.1 0.46 1.4 1.7
[58]
HepG2 CYP2U1
Mean 2.73
Standard deviation 0.62
Values 2.3 3.2
[59]
HepG2.C3A CYP2U1
Mean 0.173
Standard deviation 0.15
Values 0.068 0.28
[60]
HuH.7 CYP2U1
Mean 0.192
Standard deviation 0.045
Values 0.16 0.17 0.24
[61]
SNU475 CYP2U1
Mean 4.71
Standard deviation 1
Values 5.4 4
[62]
THLE CYP2U1
Mean 9.13
Standard deviation 0.16
Values 9 9.2
[63]
liver CYP2U1
Mean 6.54
Standard deviation 1.6
Values 5.5 8.3 7.4 5
[64]
ref_hepatocyte CYP2W1
Mean 0.591
Standard deviation 1.2
Values 2.8 0 0 0.16 0
[65]
HepG2 CYP2W1
Mean 16.9
Standard deviation 4.5
Values 14 20
[66]
HepG2.C3A CYP2W1
Mean 56.5
Standard deviation 39
Values 84 29
[67]
HuH.7 CYP2W1
Mean 0.798
Standard deviation 0.23
Values 0.68 1.1 0.65
[68]
SNU475 CYP2W1
Mean 0.101
Standard deviation 0.028
Values 0.12 0.081
[69]
THLE CYP2W1
Mean 0.0849
Standard deviation 0.022
Values 0.1 0.069
[70]
liver CYP2W1
Mean 0.0517
Standard deviation 0.06
Values 0 0.11 0 0.093
[71]
ref_hepatocyte CYP2S1
Mean 0.536
Standard deviation 0.51
Values 0.27 0.31 1.4 0.1 0.61
[72]
HepG2 CYP2S1
Mean 8.91
Standard deviation 2.7
Values 11 7
[73]
HepG2.C3A CYP2S1
Mean 3.61
Standard deviation 0.85
Values 4.2 3
[74]
HuH.7 CYP2S1
Mean 1.97
Standard deviation 1.2
Values 3 0.73 2.2
[75]
SNU475 CYP2S1
Mean 2.23
Standard deviation 1.5
Values 1.2 3.3
[76]
THLE CYP2S1
Mean 2.64
Standard deviation 0.9
Values 2 3.3
[77]
liver CYP2S1
Mean 0.486
Standard deviation 0.16
Values 0.38 0.4 0.72 0.45
[78]
ref_hepatocyte CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 CYP4B1
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[80]
HepG2.C3A CYP4B1
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 CYP4B1
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[83]
THLE CYP4B1
Mean 0.129
Standard deviation 0.077
Values 0.18 0.074
[84]
liver CYP4B1
Mean 0.0575
Standard deviation 0.045
Values 0.047 0 0.077 0.11