REACTOME_MICRORNA_MIRNA_BIOGENESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RAN GTP-binding nuclear protein Ran [1] -0.23[2] -0.15[3] -0.57[4] -0.62[5] -0.54[6] -1.40[7]
2 POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5 [8] -2.34[9] -2.39[10] -2.39[11] -1.66[12] -1.88[13] -0.80[14]
3 POLR2J DNA-directed RNA polymerase II subunit RPB11-a [15] -3.03[16] -2.79[17] -2.27[18] -2.89[19] -2.71[20] -2.55[21]
4 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 [22] 0.74[23] 0.65[24] 0.98[25] -0.03[26] 0.68[27] 1.02[28]
5 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 [29] -1.44[30] -0.86[31] -0.65[32] -2.14[33] -1.60[34] -1.42[35]
6 POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 [36] -1.13[37] -0.94[38] -1.52[39] -2.07[40] -1.48[41] -0.53[42]
7 POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 [43] -1.45[44] -0.65[45] -0.51[46] -0.42[47] -0.66[48] -0.74[49]
8 POLR2G DNA-directed RNA polymerase II subunit RPB7 [50] -1.03[51] -0.79[52] -1.06[53] -0.62[54] -0.90[55] -1.29[56]
9 POLR2C DNA-directed RNA polymerase II subunit RPB3 [57] 0.96[58] 1.02[59] 0.75[60] 0.30[61] 0.38[62] 0.08[63]
10 POLR2I DNA-directed RNA polymerase II subunit RPB9 [64] -1.45[65] -1.37[66] -1.21[67] -1.74[68] -1.81[69] -0.49[70]
11 POLR2B DNA-directed RNA polymerase II subunit RPB2 [71] 1.36[72] 1.69[73] 1.86[74] 1.64[75] 2.19[76] 1.49[77]
12 POLR2D DNA-directed RNA polymerase II subunit RPB4 [78] 0.39[79] 0.47[80] 0.01[81] 0.13[82] 0.20[83] 0.10[84]
13 POLR2A DNA-directed RNA polymerase II subunit RPB1 [85] 2.87[86] 1.36[87] 2.59[88] 2.69[89] 2.93[90] 2.33[91]
14 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0.48[92] 1.25[93] 0.53[94] 0.56[95] 0.28[96] -0.32[97]
15 TARBP2 RISC-loading complex subunit TARBP2 [98] 0.19[99] 0.87[100] 0.81[101] 0.20[102] 0.18[103] 0.03[104]
16 XPO5 Exportin-5 [105] 3.07[106] 2.67[107] 2.36[108] 3.17[109] 2.44[110] 1.61[111]
17 DROSHA Ribonuclease 3 [112] 1.62[113] 1.54[114] 1.81[115] 2.50[116] 2.70[117] 1.44[118]
18 DGCR8 Microprocessor complex subunit DGCR8 [119] 1.46[120] 1.22[121] 1.65[122] 1.79[123] 1.83[124] 2.02[125]
19 DICER1 Endoribonuclease Dicer [126] 1.83[127] 2.92[128] 1.92[129] 3.68[130] 2.36[131] 4.46[132]
20 BCDIN3D Pre-miRNA 5'-monophosphate methyltransferase [133] -1.05[134] -1.05[135] -0.51[136] -0.32[137] -0.77[138] 0.59[139]
21 AGO2 Protein argonaute-2 [140] [141] [142] [143] [144] [145] [146]
22 AGO1 Protein argonaute-1 [147] [148] [149] [150] [151] [152] [153]
23 AGO3 Protein argonaute-3 [154] [155] [156] [157] [158] [159] [160]
24 MIR23B [161] [162] [163] [164] [165] [166] [167]
25 AGO4 Protein argonaute-4 [168] [169] [170] [171] [172] [173] [174]
[1]
ref_hepatocyte RAN
Mean 147
Standard deviation 67
Values 1.3e+02 2e+02 2.3e+02 1.2e+02 63
[2]
HepG2 RAN
Mean 253
Standard deviation 28
Values 2.3e+02 2.7e+02
[3]
HepG2.C3A RAN
Mean 246
Standard deviation 68
Values 2e+02 2.9e+02
[4]
HuH.7 RAN
Mean 150
Standard deviation 58
Values 1.6e+02 88 2e+02
[5]
SNU475 RAN
Mean 122
Standard deviation 1.4
Values 1.2e+02 1.2e+02
[6]
THLE RAN
Mean 160
Standard deviation 29
Values 1.4e+02 1.8e+02
[7]
liver RAN
Mean 54.6
Standard deviation 19
Values 59 53 76 29
[8]
ref_hepatocyte POLR2L
Mean 67.8
Standard deviation 41
Values 12 45 1.2e+02 88 75
[9]
HepG2 POLR2L
Mean 26.9
Standard deviation 9.4
Values 20 34
[10]
HepG2.C3A POLR2L
Mean 23.8
Standard deviation 11
Values 16 31
[11]
HuH.7 POLR2L
Mean 19.4
Standard deviation 11
Values 20 8.1 30
[12]
SNU475 POLR2L
Mean 27.1
Standard deviation 4.2
Values 30 24
[13]
THLE POLR2L
Mean 29.2
Standard deviation 3.5
Values 27 32
[14]
liver POLR2L
Mean 38.1
Standard deviation 40
Values 74 3.8 71 3.9
[15]
ref_hepatocyte POLR2J
Mean 37.5
Standard deviation 21
Values 11 18 56 56 47
[16]
HepG2 POLR2J
Mean 9.2
Standard deviation 0.083
Values 9.3 9.1
[17]
HepG2.C3A POLR2J
Mean 10
Standard deviation 2.4
Values 8.3 12
[18]
HuH.7 POLR2J
Mean 11.7
Standard deviation 3.3
Values 12 8.1 15
[19]
SNU475 POLR2J
Mean 6.41
Standard deviation 0.42
Values 6.7 6.1
[20]
THLE POLR2J
Mean 9.03
Standard deviation 0.31
Values 9.2 8.8
[21]
liver POLR2J
Mean 6.28
Standard deviation 6.7
Values 14 0.84 9.4 0.7
[22]
ref_hepatocyte POLR2E
Mean 27.9
Standard deviation 6.6
Values 19 23 30 33 35
[23]
HepG2 POLR2E
Mean 93.8
Standard deviation 2.1
Values 95 92
[24]
HepG2.C3A POLR2E
Mean 81.1
Standard deviation 3.3
Values 83 79
[25]
HuH.7 POLR2E
Mean 82.6
Standard deviation 22
Values 97 58 93
[26]
SNU475 POLR2E
Mean 34.6
Standard deviation 3.7
Values 37 32
[27]
THLE POLR2E
Mean 70.5
Standard deviation 6.2
Values 66 75
[28]
liver POLR2E
Mean 55.3
Standard deviation 38
Values 84 18 92 27
[29]
ref_hepatocyte POLR2H
Mean 27.5
Standard deviation 6.8
Values 24 25 29 38 21
[30]
HepG2 POLR2H
Mean 20.4
Standard deviation 2.4
Values 19 22
[31]
HepG2.C3A POLR2H
Mean 28
Standard deviation 0.23
Values 28 28
[32]
HuH.7 POLR2H
Mean 26.4
Standard deviation 6.6
Values 24 21 34
[33]
SNU475 POLR2H
Mean 7.91
Standard deviation 0.017
Values 7.9 7.9
[34]
THLE POLR2H
Mean 14.3
Standard deviation 0.26
Values 14 14
[35]
liver POLR2H
Mean 10.1
Standard deviation 4.7
Values 14 6.5 14 5.4
[36]
ref_hepatocyte POLR2F
Mean 24.8
Standard deviation 6.1
Values 23 34 19 28 21
[37]
HepG2 POLR2F
Mean 22.8
Standard deviation 0.98
Values 22 23
[38]
HepG2.C3A POLR2F
Mean 23.9
Standard deviation 6.4
Values 19 28
[39]
HuH.7 POLR2F
Mean 13
Standard deviation 3.5
Values 13 9.7 17
[40]
SNU475 POLR2F
Mean 7.49
Standard deviation 0.4
Values 7.2 7.8
[41]
THLE POLR2F
Mean 14
Standard deviation 3
Values 12 16
[42]
liver POLR2F
Mean 16.8
Standard deviation 16
Values 36 4.2 24 2.4
[43]
ref_hepatocyte POLR2K
Mean 24.4
Standard deviation 5.5
Values 20 27 17 29 29
[44]
HepG2 POLR2K
Mean 17.9
Standard deviation 2.7
Values 16 20
[45]
HepG2.C3A POLR2K
Mean 28.8
Standard deviation 10
Values 22 36
[46]
HuH.7 POLR2K
Mean 25.7
Standard deviation 7.6
Values 25 19 34
[47]
SNU475 POLR2K
Mean 23.1
Standard deviation 3.2
Values 25 21
[48]
THLE POLR2K
Mean 24.3
Standard deviation 2.2
Values 23 26
[49]
liver POLR2K
Mean 14.3
Standard deviation 12
Values 26 5.3 23 3.1
[50]
ref_hepatocyte POLR2G
Mean 24.2
Standard deviation 8.6
Values 18 28 13 34 28
[51]
HepG2 POLR2G
Mean 23.8
Standard deviation 0.4
Values 24 24
[52]
HepG2.C3A POLR2G
Mean 25.8
Standard deviation 7.7
Values 20 31
[53]
HuH.7 POLR2G
Mean 17.4
Standard deviation 8.7
Values 15 10 27
[54]
SNU475 POLR2G
Mean 19.9
Standard deviation 4.4
Values 23 17
[55]
THLE POLR2G
Mean 20.5
Standard deviation 2.2
Values 19 22
[56]
liver POLR2G
Mean 9.68
Standard deviation 8.6
Values 14 2.8 20 2.3
[57]
ref_hepatocyte POLR2C
Mean 17.6
Standard deviation 4.3
Values 15 13 24 20 17
[58]
HepG2 POLR2C
Mean 68.6
Standard deviation 8
Values 63 74
[59]
HepG2.C3A POLR2C
Mean 66
Standard deviation 11
Values 58 74
[60]
HuH.7 POLR2C
Mean 44.6
Standard deviation 6.4
Values 45 38 51
[61]
SNU475 POLR2C
Mean 27.4
Standard deviation 1.2
Values 28 27
[62]
THLE POLR2C
Mean 36.1
Standard deviation 1
Values 37 35
[63]
liver POLR2C
Mean 18.3
Standard deviation 4.9
Values 20 16 24 13
[64]
ref_hepatocyte POLR2I
Mean 14.8
Standard deviation 8.2
Values 6.7 5.5 20 18 24
[65]
HepG2 POLR2I
Mean 10.9
Standard deviation 0.95
Values 12 10
[66]
HepG2.C3A POLR2I
Mean 10.6
Standard deviation 0.63
Values 10 11
[67]
HuH.7 POLR2I
Mean 9.58
Standard deviation 4.2
Values 9.6 5.4 14
[68]
SNU475 POLR2I
Mean 5.6
Standard deviation 1.6
Values 4.4 6.8
[69]
THLE POLR2I
Mean 6.67
Standard deviation 0.3
Values 6.9 6.5
[70]
liver POLR2I
Mean 10.3
Standard deviation 10
Values 20 2.1 19 0.83
[71]
ref_hepatocyte POLR2B
Mean 11.1
Standard deviation 5.1
Values 14 19 8.6 7.8 6.5
[72]
HepG2 POLR2B
Mean 56.9
Standard deviation 17
Values 45 69
[73]
HepG2.C3A POLR2B
Mean 66.2
Standard deviation 18
Values 54 79
[74]
HuH.7 POLR2B
Mean 60.6
Standard deviation 7.6
Values 65 52 65
[75]
SNU475 POLR2B
Mean 43.8
Standard deviation 2.4
Values 42 46
[76]
THLE POLR2B
Mean 79.8
Standard deviation 7.8
Values 74 85
[77]
liver POLR2B
Mean 30.4
Standard deviation 5.1
Values 27 37 26 33
[78]
ref_hepatocyte POLR2D
Mean 10.5
Standard deviation 5.2
Values 17 13 12 6.5 4.1
[79]
HepG2 POLR2D
Mean 27.7
Standard deviation 1.1
Values 27 29
[80]
HepG2.C3A POLR2D
Mean 27
Standard deviation 7.8
Values 22 33
[81]
HuH.7 POLR2D
Mean 15.9
Standard deviation 5.1
Values 19 10 19
[82]
SNU475 POLR2D
Mean 14.6
Standard deviation 0.75
Values 14 15
[83]
THLE POLR2D
Mean 19.2
Standard deviation 4.2
Values 16 22
[84]
liver POLR2D
Mean 11
Standard deviation 2.8
Values 13 8.6 14 8.7
[85]
ref_hepatocyte POLR2A
Mean 7.79
Standard deviation 4.5
Values 9.5 5.3 15 4.9 4.5
[86]
HepG2 POLR2A
Mean 114
Standard deviation 23
Values 98 1.3e+02
[87]
HepG2.C3A POLR2A
Mean 37
Standard deviation 6.8
Values 32 42
[88]
HuH.7 POLR2A
Mean 70.7
Standard deviation 33
Values 1.1e+02 40 66
[89]
SNU475 POLR2A
Mean 63.7
Standard deviation 8.3
Values 70 58
[90]
THLE POLR2A
Mean 93.7
Standard deviation 26
Values 75 1.1e+02
[91]
liver POLR2A
Mean 38.4
Standard deviation 3.6
Values 41 33 40 40
[92]
ref_hepatocyte PRKRA
Mean 7.79
Standard deviation 4.9
Values 16 4.6 3.5 6.9 8.2
[93]
HepG2 PRKRA
Mean 21.8
Standard deviation 0.36
Values 22 22
[94]
HepG2.C3A PRKRA
Mean 34.2
Standard deviation 1.4
Values 33 35
[95]
HuH.7 PRKRA
Mean 17
Standard deviation 1.6
Values 18 15 18
[96]
SNU475 PRKRA
Mean 14.5
Standard deviation 1.6
Values 16 13
[97]
THLE PRKRA
Mean 15
Standard deviation 1.4
Values 16 14
[98]
liver PRKRA
Mean 6.09
Standard deviation 3
Values 9.1 3.6 8.1 3.5
[99]
ref_hepatocyte TARBP2
Mean 6.68
Standard deviation 3.9
Values 2.5 4 5.2 11 11
[100]
HepG2 TARBP2
Mean 15.3
Standard deviation 0.75
Values 15 16
[101]
HepG2.C3A TARBP2
Mean 22.6
Standard deviation 3.4
Values 20 25
[102]
HuH.7 TARBP2
Mean 17.6
Standard deviation 4.1
Values 17 14 22
[103]
SNU475 TARBP2
Mean 9.7
Standard deviation 1.1
Values 10 8.9
[104]
THLE TARBP2
Mean 12
Standard deviation 2.2
Values 10 14
[105]
liver TARBP2
Mean 6.7
Standard deviation 3.6
Values 9 3.6 10 3.7
[106]
ref_hepatocyte XPO5
Mean 3.96
Standard deviation 1.7
Values 5.4 5.1 5 2.6 1.7
[107]
HepG2 XPO5
Mean 66.9
Standard deviation 6.7
Values 72 62
[108]
HepG2.C3A XPO5
Mean 46.5
Standard deviation 1.7
Values 48 45
[109]
HuH.7 XPO5
Mean 30.6
Standard deviation 9.8
Values 41 21 30
[110]
SNU475 XPO5
Mean 45.1
Standard deviation 4.6
Values 42 48
[111]
THLE XPO5
Mean 34
Standard deviation 4.5
Values 31 37
[112]
liver XPO5
Mean 11.9
Standard deviation 3.4
Values 7.7 16 11 13
[113]
ref_hepatocyte DROSHA
Mean 3.35
Standard deviation 1.4
Values 5.1 4.1 3.4 2 2
[114]
HepG2 DROSHA
Mean 20.7
Standard deviation 6.9
Values 16 26
[115]
HepG2.C3A DROSHA
Mean 18.1
Standard deviation 4.4
Values 15 21
[116]
HuH.7 DROSHA
Mean 17.7
Standard deviation 6.6
Values 24 11 18
[117]
SNU475 DROSHA
Mean 23.9
Standard deviation 1.3
Values 25 23
[118]
THLE DROSHA
Mean 34.3
Standard deviation 0.86
Values 34 35
[119]
liver DROSHA
Mean 8.89
Standard deviation 1.2
Values 7.8 11 8.3 8.7
[120]
ref_hepatocyte DGCR8
Mean 3.11
Standard deviation 0.68
Values 4.3 2.8 3 2.9 2.6
[121]
HepG2 DGCR8
Mean 17.2
Standard deviation 0.021
Values 17 17
[122]
HepG2.C3A DGCR8
Mean 13.4
Standard deviation 2.2
Values 12 15
[123]
HuH.7 DGCR8
Mean 14.7
Standard deviation 4.5
Values 16 9.7 19
[124]
SNU475 DGCR8
Mean 13.7
Standard deviation 1
Values 13 14
[125]
THLE DGCR8
Mean 17.5
Standard deviation 0.73
Values 17 18
[126]
liver DGCR8
Mean 12.3
Standard deviation 3.6
Values 12 16 7.5 14
[127]
ref_hepatocyte DICER1
Mean 2.81
Standard deviation 0.99
Values 4.4 3.1 2.4 2 2.2
[128]
HepG2 DICER1
Mean 20
Standard deviation 7.9
Values 14 26
[129]
HepG2.C3A DICER1
Mean 39.2
Standard deviation 6.9
Values 34 44
[130]
HuH.7 DICER1
Mean 16
Standard deviation 3.7
Values 19 16 12
[131]
SNU475 DICER1
Mean 45.5
Standard deviation 10
Values 53 38
[132]
THLE DICER1
Mean 22.8
Standard deviation 3.2
Values 25 21
[133]
liver DICER1
Mean 60.6
Standard deviation 26
Values 42 90 35 75
[134]
ref_hepatocyte BCDIN3D
Mean 1.3
Standard deviation 0.81
Values 0.77 0.8 0.69 2.6 1.7
[135]
HepG2 BCDIN3D
Mean 1.26
Standard deviation 0.31
Values 1.5 1
[136]
HepG2.C3A BCDIN3D
Mean 1.16
Standard deviation 0.02
Values 1.2 1.1
[137]
HuH.7 BCDIN3D
Mean 1.37
Standard deviation 0.13
Values 1.3 1.3 1.5
[138]
SNU475 BCDIN3D
Mean 1.32
Standard deviation 0.14
Values 1.2 1.4
[139]
THLE BCDIN3D
Mean 1.21
Standard deviation 0.039
Values 1.2 1.2
[140]
liver BCDIN3D
Mean 1.92
Standard deviation 0.46
Values 1.9 1.7 2.6 1.5
[141]
ref_hepatocyte AGO2
Missing
[142]
HepG2 AGO2
Mean 8.7
Standard deviation 0.3
Values 8.5 8.9
[143]
HepG2.C3A AGO2
Mean 3.98
Standard deviation 0.75
Values 3.5 4.5
[144]
HuH.7 AGO2
Mean 7.66
Standard deviation 4.2
Values 11 9.3 2.9
[145]
SNU475 AGO2
Mean 7.03
Standard deviation 0.082
Values 7 7.1
[146]
THLE AGO2
Mean 8.62
Standard deviation 3.3
Values 6.3 11
[147]
liver AGO2
Mean 6.59
Standard deviation 5
Values 2.8 10 1.8 12
[148]
ref_hepatocyte AGO1
Missing
[149]
HepG2 AGO1
Mean 20.3
Standard deviation 2.8
Values 18 22
[150]
HepG2.C3A AGO1
Mean 11.1
Standard deviation 1.1
Values 10 12
[151]
HuH.7 AGO1
Mean 27.7
Standard deviation 9.7
Values 39 23 21
[152]
SNU475 AGO1
Mean 21.2
Standard deviation 5.4
Values 25 17
[153]
THLE AGO1
Mean 13.5
Standard deviation 1.7
Values 12 15
[154]
liver AGO1
Mean 12.3
Standard deviation 5.7
Values 8.4 15 6.8 19
[155]
ref_hepatocyte AGO3
Missing
[156]
HepG2 AGO3
Mean 3.11
Standard deviation 1.2
Values 2.3 3.9
[157]
HepG2.C3A AGO3
Mean 2.68
Standard deviation 0.41
Values 2.4 3
[158]
HuH.7 AGO3
Mean 2.94
Standard deviation 0.85
Values 3 3.8 2.1
[159]
SNU475 AGO3
Mean 4.2
Standard deviation 0.38
Values 4.5 3.9
[160]
THLE AGO3
Mean 3.9
Standard deviation 0.43
Values 3.6 4.2
[161]
liver AGO3
Mean 9.72
Standard deviation 3.7
Values 7.4 13 5.8 12
[162]
ref_hepatocyte MIR23B
Missing
[163]
HepG2 MIR23B
Missing
[164]
HepG2.C3A MIR23B
Missing
[165]
HuH.7 MIR23B
Missing
[166]
SNU475 MIR23B
Missing
[167]
THLE MIR23B
Missing
[168]
liver MIR23B
Missing
[169]
ref_hepatocyte AGO4
Missing
[170]
HepG2 AGO4
Mean 7.33
Standard deviation 0.39
Values 7.6 7
[171]
HepG2.C3A AGO4
Mean 6.02
Standard deviation 1.9
Values 7.4 4.7
[172]
HuH.7 AGO4
Mean 9.39
Standard deviation 3
Values 8.7 13 6.8
[173]
SNU475 AGO4
Mean 7.87
Standard deviation 2.6
Values 9.7 6
[174]
THLE AGO4
Mean 6.07
Standard deviation 0.55
Values 6.5 5.7
[175]
liver AGO4
Mean 12.1
Standard deviation 8.6
Values 4.5 22 5.4 16