REACTOME_MET_ACTIVATES_RAP1_AND_RAC1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RAP1B Ras-related protein Rap-1b [1] -2.09[2] -1.50[3] -1.98[4] -0.66[5] -0.70[6] -1.67[7]
2 RAC1 Ras-related C3 botulinum toxin substrate 1 [8] -0.18[9] -0.54[10] -0.08[11] -0.13[12] 0.07[13] -0.74[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 1.41[16] 1.22[17] 1.09[18] 0.41[19] 0.54[20] 0.52[21]
4 CRK Adapter molecule crk [22] 0.02[23] -0.08[24] -0.27[25] -0.38[26] 0.23[27] 1.07[28]
5 RAP1A Ras-related protein Rap-1A [29] -0.83[30] -0.92[31] -0.34[32] -0.36[33] -0.39[34] -1.07[35]
6 MET Hepatocyte growth factor receptor [36] 0.30[37] 0.30[38] 0.68[39] 1.39[40] 0.32[41] 1.19[42]
7 CRKL Crk-like protein [43] 1.92[44] 1.98[45] 2.34[46] 0.99[47] 1.39[48] 1.68[49]
8 RAPGEF1 Rap guanine nucleotide exchange factor 1 [50] 2.31[51] 2.10[52] 1.57[53] 1.12[54] 1.00[55] 1.40[56]
9 DOCK7 Dedicator of cytokinesis protein 7 [57] 1.75[58] 2.33[59] 1.58[60] 1.24[61] 1.07[62] 1.70[63]
10 GAB1 GRB2-associated-binding protein 1 [64] 1.52[65] 2.57[66] 2.45[67] 1.79[68] 1.86[69] 3.10[70]
11 HGF Hepatocyte growth factor [71] [72] [73] -1.72[74] 4.45[75] 1.69[76] 9.12[77]
[1]
ref_hepatocyte RAP1B
Mean 100
Standard deviation 77
Values 1.1e+02 2.1e+02 1.3e+02 25 29
[2]
HepG2 RAP1B
Mean 44.7
Standard deviation 8.8
Values 39 51
[3]
HepG2.C3A RAP1B
Mean 61.1
Standard deviation 18
Values 48 74
[4]
HuH.7 RAP1B
Mean 50.2
Standard deviation 5.6
Values 52 44 54
[5]
SNU475 RAP1B
Mean 128
Standard deviation 17
Values 1.4e+02 1.2e+02
[6]
THLE RAP1B
Mean 121
Standard deviation 4
Values 1.2e+02 1.2e+02
[7]
liver RAP1B
Mean 38.3
Standard deviation 18
Values 53 27 54 20
[8]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[9]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[10]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[11]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[12]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[13]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[14]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte CRK
Mean 18.5
Standard deviation 12
Values 16 38 19 11 8.5
[23]
HepG2 CRK
Mean 35.5
Standard deviation 2.8
Values 34 38
[24]
HepG2.C3A CRK
Mean 30.2
Standard deviation 5.3
Values 27 34
[25]
HuH.7 CRK
Mean 30.3
Standard deviation 2.4
Values 32 32 28
[26]
SNU475 CRK
Mean 28.8
Standard deviation 1.2
Values 30 28
[27]
THLE CRK
Mean 42.5
Standard deviation 6.6
Values 38 47
[28]
liver CRK
Mean 47.1
Standard deviation 5.8
Values 41 55 45 47
[29]
ref_hepatocyte RAP1A
Mean 17.1
Standard deviation 7.2
Values 17 20 8.5 13 28
[30]
HepG2 RAP1A
Mean 18.3
Standard deviation 5.4
Values 14 22
[31]
HepG2.C3A RAP1A
Mean 15.6
Standard deviation 1.3
Values 15 17
[32]
HuH.7 RAP1A
Mean 26.7
Standard deviation 1.9
Values 25 29 26
[33]
SNU475 RAP1A
Mean 27.1
Standard deviation 7
Values 32 22
[34]
THLE RAP1A
Mean 25.7
Standard deviation 2.2
Values 24 27
[35]
liver RAP1A
Mean 9.95
Standard deviation 5.1
Values 17 7.4 10 5.3
[36]
ref_hepatocyte MET
Mean 12.9
Standard deviation 12
Values 6.9 32 16 3.7 5.7
[37]
HepG2 MET
Mean 30.2
Standard deviation 2.7
Values 32 28
[38]
HepG2.C3A MET
Mean 27.5
Standard deviation 6.5
Values 23 32
[39]
HuH.7 MET
Mean 40.8
Standard deviation 7.3
Values 43 47 33
[40]
SNU475 MET
Mean 68.7
Standard deviation 7.1
Values 64 74
[41]
THLE MET
Mean 31.7
Standard deviation 2
Values 33 30
[42]
liver MET
Mean 35.9
Standard deviation 13
Values 27 46 22 48
[43]
ref_hepatocyte CRKL
Mean 7.86
Standard deviation 3.2
Values 13 7.5 7.1 6.1 5.2
[44]
HepG2 CRKL
Mean 56.6
Standard deviation 7.1
Values 52 62
[45]
HepG2.C3A CRKL
Mean 53.9
Standard deviation 8
Values 60 48
[46]
HuH.7 CRKL
Mean 78.7
Standard deviation 6.8
Values 86 76 74
[47]
SNU475 CRKL
Mean 31.5
Standard deviation 0.52
Values 32 31
[48]
THLE CRKL
Mean 40.6
Standard deviation 0.46
Values 41 40
[49]
liver CRKL
Mean 30.6
Standard deviation 3.9
Values 25 32 32 33
[50]
ref_hepatocyte RAPGEF1
Mean 4.9
Standard deviation 2.3
Values 6.6 5.4 7.5 2.5 2.6
[51]
HepG2 RAPGEF1
Mean 46
Standard deviation 2.9
Values 48 44
[52]
HepG2.C3A RAPGEF1
Mean 36.5
Standard deviation 6.8
Values 41 32
[53]
HuH.7 RAPGEF1
Mean 28.7
Standard deviation 4.9
Values 30 33 23
[54]
SNU475 RAPGEF1
Mean 21.5
Standard deviation 2.8
Values 23 20
[55]
THLE RAPGEF1
Mean 19.2
Standard deviation 5.1
Values 16 23
[56]
liver RAPGEF1
Mean 15.7
Standard deviation 4.8
Values 16 19 8.9 19
[57]
ref_hepatocyte DOCK7
Mean 4.08
Standard deviation 3.8
Values 9.9 5.9 2.5 1.2 0.92
[58]
HepG2 DOCK7
Mean 26
Standard deviation 8.1
Values 20 32
[59]
HepG2.C3A DOCK7
Mean 35.5
Standard deviation 1.4
Values 35 37
[60]
HuH.7 DOCK7
Mean 24.1
Standard deviation 3.7
Values 27 26 20
[61]
SNU475 DOCK7
Mean 19.5
Standard deviation 3.4
Values 22 17
[62]
THLE DOCK7
Mean 16.8
Standard deviation 1.4
Values 16 18
[63]
liver DOCK7
Mean 16.2
Standard deviation 5.1
Values 14 22 10 18
[64]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[65]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[66]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[67]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[68]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[69]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[70]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[71]
ref_hepatocyte HGF
Mean 0.0217
Standard deviation 0.03
Values 0 0 0 0.052 0.057
[72]
HepG2 HGF
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A HGF
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 HGF
Mean 0.0131
Standard deviation 0.017
Values 0.033 0.0064 0
[75]
SNU475 HGF
Mean 0.963
Standard deviation 0.42
Values 1.3 0.67
[76]
THLE HGF
Mean 0.138
Standard deviation 0.061
Values 0.095 0.18
[77]
liver HGF
Mean 14.7
Standard deviation 7.2
Values 9.2 24 9.5 16