REACTOME_METHYLATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NNMT Nicotinamide N-methyltransferase [1] -11.14[2] -13.06[3] -5.53[4] -2.81[5] -0.67[6] -0.02[7]
2 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein [8] -0.89[9] -1.27[10] -1.44[11] -0.32[12] -1.07[13] -3.59[14]
3 MAT1A S-adenosylmethionine synthase isoform type-1 [15] -1.33[16] -0.04[17] -1.72[18] -7.47[19] -10.48[20] 1.24[21]
4 GSTO1 Glutathione S-transferase omega-1 [22] 0.24[23] 0.36[24] 0.08[25] -1.21[26] 0.48[27] -0.91[28]
5 CYP1A2 Cytochrome P450 1A2 [29] -8.73[30] -8.04[31] -8.45[32] -7.12[33] -8.03[34] -1.35[35]
6 AHCY Adenosylhomocysteinase [36] 3.17[37] 3.00[38] 3.48[39] 2.19[40] 1.27[41] -0.71[42]
7 COMT Catechol O-methyltransferase [43] 1.55[44] 1.55[45] -0.37[46] 1.23[47] 0.78[48] 0.67[49]
8 TPMT Thiopurine S-methyltransferase [50] 0.56[51] 0.74[52] -0.49[53] 1.57[54] 0.68[55] 0.16[56]
9 MAT2A S-adenosylmethionine synthase isoform type-2 [57] 2.70[58] 2.43[59] 2.48[60] 3.79[61] 3.53[62] 1.18[63]
10 AS3MT Arsenite methyltransferase [64] -3.97[65] -4.12[66] -2.70[67] -4.82[68] -4.35[69] -5.46[70]
11 MAT2B Methionine adenosyltransferase 2 subunit beta [71] 2.10[72] 1.58[73] 2.03[74] 3.43[75] 2.83[76] 0.33[77]
12 MTRR Methionine synthase reductase [78] 2.42[79] 2.49[80] 3.46[81] 3.52[82] 3.70[83] 1.52[84]
13 N6AMT1 HemK methyltransferase family member 2 [85] 0.66[86] 0.29[87] -1.57[88] 1.54[89] 0.97[90] -1.44[91]
14 MTR Methionine synthase [92] 4.45[93] 4.54[94] 4.93[95] 6.12[96] 4.96[97] 3.66[98]
[1]
ref_hepatocyte NNMT
Mean 598
Standard deviation 7.3e+02
Values 0 59 1.3e+02 1.5e+03 1.3e+03
[2]
HepG2 NNMT
Mean 0.129
Standard deviation 0.13
Values 0.22 0.034
[3]
HepG2.C3A NNMT
Mean 0.0458
Standard deviation 0.004
Values 0.049 0.043
[4]
HuH.7 NNMT
Mean 6.86
Standard deviation 2.3
Values 7.3 4.3 8.9
[5]
SNU475 NNMT
Mean 20.1
Standard deviation 7.5
Values 15 25
[6]
THLE NNMT
Mean 139
Standard deviation 16
Values 1.5e+02 1.3e+02
[7]
liver NNMT
Mean 680
Standard deviation 4.7e+02
Values 1.1e+03 2.7e+02 1.1e+03 2.7e+02
[8]
ref_hepatocyte TRMT112
Mean 230
Standard deviation 1.6e+02
Values 4.3e+02 3.8e+02 97 1.3e+02 1.2e+02
[9]
HepG2 TRMT112
Mean 60.4
Standard deviation 3.6
Values 58 63
[10]
HepG2.C3A TRMT112
Mean 62.8
Standard deviation 10
Values 55 70
[11]
HuH.7 TRMT112
Mean 45
Standard deviation 15
Values 40 33 62
[12]
SNU475 TRMT112
Mean 43.3
Standard deviation 3.3
Values 46 41
[13]
THLE TRMT112
Mean 40.8
Standard deviation 3.3
Values 38 43
[14]
liver TRMT112
Mean 22
Standard deviation 18
Values 33 8.3 42 4.6
[15]
ref_hepatocyte MAT1A
Mean 212
Standard deviation 2.8e+02
Values 46 12 7.2 3.6e+02 6.3e+02
[16]
HepG2 MAT1A
Mean 41.1
Standard deviation 3.9
Values 38 44
[17]
HepG2.C3A MAT1A
Mean 135
Standard deviation 10
Values 1.4e+02 1.3e+02
[18]
HuH.7 MAT1A
Mean 34.1
Standard deviation 22
Values 20 60 22
[19]
SNU475 MAT1A
Mean 0.281
Standard deviation 0.061
Values 0.32 0.24
[20]
THLE MAT1A
Mean 0.055
Standard deviation 0.048
Values 0.089 0.021
[21]
liver MAT1A
Mean 578
Standard deviation 1.7e+02
Values 4.8e+02 6.1e+02 8.1e+02 4.1e+02
[22]
ref_hepatocyte GSTO1
Mean 150
Standard deviation 1e+02
Values 51 1.2e+02 79 2.1e+02 3e+02
[23]
HepG2 GSTO1
Mean 86.3
Standard deviation 4.3
Values 83 89
[24]
HepG2.C3A GSTO1
Mean 126
Standard deviation 39
Values 98 1.5e+02
[25]
HuH.7 GSTO1
Mean 84.1
Standard deviation 20
Values 84 65 1e+02
[26]
SNU475 GSTO1
Mean 15.2
Standard deviation 0.17
Values 15 15
[27]
THLE GSTO1
Mean 77.6
Standard deviation 17
Values 66 90
[28]
liver GSTO1
Mean 92.1
Standard deviation 75
Values 1.4e+02 39 1.7e+02 19
[29]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 0.97 71 3e+02
[30]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[31]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[32]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[33]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[34]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[35]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 55 12 58 19
[36]
ref_hepatocyte AHCY
Mean 72
Standard deviation 24
Values 1e+02 71 38 80 67
[37]
HepG2 AHCY
Mean 316
Standard deviation 75
Values 3.7e+02 2.6e+02
[38]
HepG2.C3A AHCY
Mean 377
Standard deviation 69
Values 4.3e+02 3.3e+02
[39]
HuH.7 AHCY
Mean 425
Standard deviation 39
Values 4.7e+02 4e+02 4e+02
[40]
SNU475 AHCY
Mean 77.3
Standard deviation 9.8
Values 84 70
[41]
THLE AHCY
Mean 64.2
Standard deviation 8.6
Values 58 70
[42]
liver AHCY
Mean 50.8
Standard deviation 11
Values 55 45 64 40
[43]
ref_hepatocyte COMT
Mean 41.6
Standard deviation 29
Values 24 25 14 61 83
[44]
HepG2 COMT
Mean 59.3
Standard deviation 6.8
Values 64 55
[45]
HepG2.C3A COMT
Mean 80
Standard deviation 0.37
Values 80 80
[46]
HuH.7 COMT
Mean 17.1
Standard deviation 2.6
Values 14 18 19
[47]
SNU475 COMT
Mean 22.9
Standard deviation 4.5
Values 26 20
[48]
THLE COMT
Mean 26.6
Standard deviation 0.81
Values 26 27
[49]
liver COMT
Mean 76.3
Standard deviation 82
Values 1.9e+02 20 71 20
[50]
ref_hepatocyte TPMT
Mean 23.4
Standard deviation 7.6
Values 18 24 32 14 29
[51]
HepG2 TPMT
Mean 16.8
Standard deviation 5.6
Values 13 21
[52]
HepG2.C3A TPMT
Mean 25.6
Standard deviation 12
Values 17 34
[53]
HuH.7 TPMT
Mean 8.85
Standard deviation 2.1
Values 9.3 6.6 11
[54]
SNU475 TPMT
Mean 16.4
Standard deviation 0.91
Values 17 16
[55]
THLE TPMT
Mean 13.9
Standard deviation 0.98
Values 13 15
[56]
liver TPMT
Mean 30.1
Standard deviation 12
Values 40 22 42 18
[57]
ref_hepatocyte MAT2A
Mean 23.3
Standard deviation 13
Values 15 27 14 44 16
[58]
HepG2 MAT2A
Mean 73.6
Standard deviation 11
Values 66 81
[59]
HepG2.C3A MAT2A
Mean 82.6
Standard deviation 22
Values 67 98
[60]
HuH.7 MAT2A
Mean 68.8
Standard deviation 31
Values 79 34 93
[61]
SNU475 MAT2A
Mean 75.8
Standard deviation 6
Values 72 80
[62]
THLE MAT2A
Mean 99.7
Standard deviation 1.6
Values 1e+02 99
[63]
liver MAT2A
Mean 61
Standard deviation 25
Values 78 46 86 34
[64]
ref_hepatocyte AS3MT
Mean 12.3
Standard deviation 6.5
Values 10 12 2.5 19 18
[65]
HepG2 AS3MT
Mean 0.381
Standard deviation 0.013
Values 0.37 0.39
[66]
HepG2.C3A AS3MT
Mean 0.462
Standard deviation 0.062
Values 0.51 0.42
[67]
HuH.7 AS3MT
Mean 1
Standard deviation 0.094
Values 1.1 0.97 0.93
[68]
SNU475 AS3MT
Mean 0.102
Standard deviation 0.059
Values 0.14 0.061
[69]
THLE AS3MT
Mean 0.222
Standard deviation 0.047
Values 0.19 0.26
[70]
liver AS3MT
Mean 0.321
Standard deviation 0.3
Values 0.68 0.1 0.46 0.04
[71]
ref_hepatocyte MAT2B
Mean 12.1
Standard deviation 5.7
Values 13 9.7 6.8 9.4 21
[72]
HepG2 MAT2B
Mean 25.3
Standard deviation 2.8
Values 23 27
[73]
HepG2.C3A MAT2B
Mean 23.8
Standard deviation 7.6
Values 18 29
[74]
HuH.7 MAT2B
Mean 26.2
Standard deviation 6.2
Values 27 20 32
[75]
SNU475 MAT2B
Mean 30.8
Standard deviation 4.2
Values 34 28
[76]
THLE MAT2B
Mean 32
Standard deviation 4.5
Values 29 35
[77]
liver MAT2B
Mean 17.5
Standard deviation 7.4
Values 22 12 26 10
[78]
ref_hepatocyte MTRR
Mean 6.08
Standard deviation 1.7
Values 3.7 7.4 5.1 8 6.2
[79]
HepG2 MTRR
Mean 15.8
Standard deviation 4.2
Values 13 19
[80]
HepG2.C3A MTRR
Mean 22.3
Standard deviation 4.3
Values 19 25
[81]
HuH.7 MTRR
Mean 35.5
Standard deviation 8.3
Values 42 26 38
[82]
SNU475 MTRR
Mean 16.4
Standard deviation 3.1
Values 14 19
[83]
THLE MTRR
Mean 29.4
Standard deviation 7.2
Values 34 24
[84]
liver MTRR
Mean 20.1
Standard deviation 4.3
Values 21 20 25 14
[85]
ref_hepatocyte N6AMT1
Mean 3.2
Standard deviation 2.9
Values 2.4 8.3 2.2 1.7 1.4
[86]
HepG2 N6AMT1
Mean 2.45
Standard deviation 0.37
Values 2.2 2.7
[87]
HepG2.C3A N6AMT1
Mean 2.56
Standard deviation 0.6
Values 2.1 3
[88]
HuH.7 N6AMT1
Mean 0.57
Standard deviation 0.17
Values 0.56 0.41 0.74
[89]
SNU475 N6AMT1
Mean 2.18
Standard deviation 0.67
Values 2.7 1.7
[90]
THLE N6AMT1
Mean 2.31
Standard deviation 0.044
Values 2.3 2.3
[91]
liver N6AMT1
Mean 1.36
Standard deviation 0.85
Values 2.3 0.61 1.8 0.68
[92]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 2.9 2.1 1.2 0.53 0.48
[93]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 12 18
[94]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 22 21
[95]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 29 21 20
[96]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 29 18
[97]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[98]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 12 34 14 24