REACTOME_METABOLISM_OF_PORPHYRINS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ALB | Serum albumin | [1] | 0.02[2] | 0.21[3] | 0.00[4] | -5.74[5] | -5.07[6] | 0.16[7] |
2 | FABP1 | Fatty acid-binding protein, liver | [8] | -6.34[9] | -2.61[10] | -0.71[11] | -7.08[12] | -6.52[13] | -1.95[14] |
3 | GSTA1 | Glutathione S-transferase A1 | [15] | -2.33[16] | -8.54[17] | -0.62[18] | -1.71[19] | -6.03[20] | -3.32[21] |
4 | BLVRB | Flavin reductase (NADPH) | [22] | -0.21[23] | -2.30[24] | 0.25[25] | 2.89[26] | 3.07[27] | -1.28[28] |
5 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | [29] | -3.06[30] | -11.75[31] | -4.87[32] | 3.97[33] | -5.53[34] | 0.24[35] |
6 | UGT1A4 | UDP-glucuronosyltransferase 1-4 | [36] | -10.44[37] | [38] | -10.77[39] | -5.31[40] | [41] | 0.43[42] |
7 | ALAS1 | 5-aminolevulinate synthase, nonspecific, mitochondrial | [43] | 1.60[44] | -1.20[45] | 1.23[46] | 4.42[47] | 5.20[48] | 1.37[49] |
8 | HMOX1 | Heme oxygenase 1 | [50] | 2.82[51] | -0.53[52] | 0.07[53] | 4.72[54] | 4.98[55] | -1.79[56] |
9 | UROD | Uroporphyrinogen decarboxylase | [57] | 2.35[58] | 0.20[59] | 1.30[60] | 4.67[61] | 5.91[62] | -0.57[63] |
10 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | [64] | -11.87[65] | -10.52[66] | -3.57[67] | -6.03[68] | [69] | 1.86[70] |
11 | UROS | Uroporphyrinogen-III synthase | [71] | 1.11[72] | -1.46[73] | 0.43[74] | 3.10[75] | 4.59[76] | -1.65[77] |
12 | HMOX2 | Heme oxygenase 2 | [78] | 2.09[79] | -0.27[80] | -0.44[81] | 3.69[82] | 4.92[83] | -0.19[84] |
13 | ABCC2 | Canalicular multispecific organic anion transporter 1 | [85] | 4.14[86] | 3.27[87] | 3.41[88] | 6.07[89] | -0.22[90] | 2.24[91] |
14 | SLCO2B1 | Solute carrier organic anion transporter family member 2B1 | [92] | 1.73[93] | 0.73[94] | 3.47[95] | 5.67[96] | -1.56[97] | 2.03[98] |
15 | ALAD | Delta-aminolevulinic acid dehydratase | [99] | 1.96[100] | 0.56[101] | 1.90[102] | 4.72[103] | 6.34[104] | 0.85[105] |
16 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | [106] | -4.41[107] | -5.42[108] | 1.15[109] | -4.28[110] | -3.92[111] | 2.23[112] |
17 | HMBS | Porphobilinogen deaminase | [113] | 3.68[114] | 1.45[115] | 2.60[116] | 6.37[117] | 6.46[118] | 0.00[119] |
18 | CPOX | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial | [120] | 3.81[121] | 1.47[122] | 3.71[123] | 5.86[124] | 7.16[125] | -0.01[126] |
19 | BLVRA | Biliverdin reductase A | [127] | 4.28[128] | 1.62[129] | 0.36[130] | 6.94[131] | 6.82[132] | -2.20[133] |
20 | FECH | Ferrochelatase, mitochondrial | [134] | 4.51[135] | 1.38[136] | 2.75[137] | 8.06[138] | 7.82[139] | 2.68[140] |
21 | COX15 | Cytochrome c oxidase assembly protein COX15 homolog | [141] | 5.11[142] | 3.13[143] | 5.45[144] | 7.63[145] | 8.39[146] | 2.33[147] |
22 | COX10 | Protoheme IX farnesyltransferase, mitochondrial | [148] | 3.32[149] | 1.11[150] | 3.37[151] | 6.20[152] | 6.60[153] | 0.68[154] |
23 | ABCG2 | ATP-binding cassette sub-family G member 2 | [155] | 3.36[156] | 0.82[157] | 3.67[158] | 5.97[159] | 5.35[160] | 0.56[161] |
24 | PPOX | Protoporphyrinogen oxidase | [162] | 3.15[163] | 1.04[164] | 3.14[165] | 6.81[166] | 6.73[167] | 0.03[168] |
25 | FLVCR1 | Feline leukemia virus subgroup C receptor-related protein 1 | [169] | 4.25[170] | 3.17[171] | 4.67[172] | 7.50[173] | 6.99[174] | 0.60[175] |
26 | ABCC1 | Multidrug resistance-associated protein 1 | [176] | 8.55[177] | 3.31[178] | 4.11[179] | 10.73[180] | 9.67[181] | 1.07[182] |
27 | ALAS2 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial | [183] | 1.64[184] | -3.77[185] | -0.13[186] | [187] | 0.24[188] | 0.04[189] |