REACTOME_METABOLISM_OF_NUCLEOTIDES |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
TXN |
Thioredoxin |
[1] |
-2.19[2] |
-2.23[3] |
-2.67[4] |
-1.77[5] |
-1.94[6] |
-2.43[7] |
2 |
NME2 |
Nucleoside diphosphate kinase B |
[8] |
-3.32[9] |
-3.48[10] |
-3.05[11] |
-4.08[12] |
-3.83[13] |
-5.91[14] |
3 |
TXNRD1 |
Thioredoxin reductase 1, cytoplasmic |
[15] |
0.13[16] |
-0.78[17] |
-0.89[18] |
2.17[19] |
1.16[20] |
-1.22[21] |
4 |
GUK1 |
Guanylate kinase |
[22] |
-1.49[23] |
-1.34[24] |
-1.83[25] |
-0.75[26] |
-1.30[27] |
-0.93[28] |
5 |
GLRX |
Glutaredoxin-1 |
[29] |
-0.78[30] |
0.18[31] |
-1.91[32] |
-2.19[33] |
-2.25[34] |
-0.56[35] |
6 |
DPYS |
Dihydropyrimidinase |
[36] |
[37] |
[38] |
-15.20[39] |
-12.30[40] |
[41] |
1.58[42] |
7 |
APRT |
Adenine phosphoribosyltransferase |
[43] |
-0.34[44] |
-0.21[45] |
-0.55[46] |
-1.88[47] |
-0.79[48] |
-0.85[49] |
8 |
TYMP |
Thymidine phosphorylase |
[50] |
-3.88[51] |
-3.37[52] |
-6.29[53] |
-8.25[54] |
-5.47[55] |
-1.34[56] |
9 |
CMPK1 |
UMP-CMP kinase |
[57] |
-0.52[58] |
-0.06[59] |
0.55[60] |
-0.43[61] |
0.04[62] |
1.03[63] |
10 |
NME1 |
Nucleoside diphosphate kinase A |
[64] |
-0.40[65] |
-0.93[66] |
-1.33[67] |
-1.84[68] |
-1.58[69] |
-1.78[70] |
11 |
NME4 |
Nucleoside diphosphate kinase, mitochondrial |
[71] |
0.11[72] |
-0.02[73] |
0.90[74] |
-1.06[75] |
-1.01[76] |
-0.74[77] |
12 |
AK2 |
Adenylate kinase 2, mitochondrial |
[78] |
0.73[79] |
0.66[80] |
0.35[81] |
0.40[82] |
0.56[83] |
0.75[84] |
13 |
IMPDH2 |
Inosine-5'-monophosphate dehydrogenase 2 |
[85] |
0.92[86] |
1.27[87] |
2.77[88] |
-0.46[89] |
0.25[90] |
-1.42[91] |
14 |
UPB1 |
Beta-ureidopropionase |
[92] |
-7.72[93] |
-5.44[94] |
-3.72[95] |
-7.74[96] |
-12.63[97] |
0.87[98] |
15 |
NUDT5 |
ADP-sugar pyrophosphatase |
[99] |
-0.06[100] |
-0.08[101] |
-0.83[102] |
0.14[103] |
0.14[104] |
0.05[105] |
16 |
GSR |
Glutathione reductase, mitochondrial |
[106] |
1.25[107] |
0.77[108] |
1.27[109] |
1.50[110] |
0.20[111] |
-0.02[112] |
17 |
PNP |
Purine nucleoside phosphorylase |
[113] |
0.08[114] |
-0.76[115] |
-0.09[116] |
-1.15[117] |
0.51[118] |
-1.11[119] |
18 |
DTYMK |
Thymidylate kinase |
[120] |
-0.26[121] |
0.45[122] |
-0.44[123] |
-0.90[124] |
-0.28[125] |
-2.08[126] |
19 |
PAICS |
Multifunctional protein ADE2 |
[127] |
2.23[128] |
2.57[129] |
2.39[130] |
1.07[131] |
2.07[132] |
0.90[133] |
20 |
ADK |
Adenosine kinase |
[134] |
-0.06[135] |
0.85[136] |
-0.61[137] |
-1.33[138] |
-0.64[139] |
1.15[140] |
21 |
CDA |
Cytidine deaminase |
[141] |
-1.40[142] |
-3.12[143] |
-5.93[144] |
-4.25[145] |
-5.35[146] |
-1.39[147] |
22 |
DHODH |
Dihydroorotate dehydrogenase (quinone), mitochondrial |
[148] |
-2.37[149] |
-2.38[150] |
-1.75[151] |
-2.92[152] |
-2.72[153] |
1.22[154] |
23 |
ADSL |
Adenylosuccinate lyase |
[155] |
0.88[156] |
0.99[157] |
1.42[158] |
-0.29[159] |
0.07[160] |
-0.42[161] |
24 |
ATIC |
Bifunctional purine biosynthesis protein PURH |
[162] |
1.87[163] |
1.62[164] |
1.61[165] |
0.33[166] |
0.93[167] |
-0.42[168] |
25 |
TYMS |
Thymidylate synthase |
[169] |
-0.55[170] |
-0.23[171] |
-0.36[172] |
-0.60[173] |
-0.27[174] |
-5.09[175] |
26 |
GMPR2 |
GMP reductase 2 |
[176] |
1.71[177] |
0.33[178] |
1.29[179] |
-0.84[180] |
0.01[181] |
-0.62[182] |
27 |
AGXT2 |
Alanine--glyoxylate aminotransferase 2, mitochondrial |
[183] |
-8.94[184] |
-9.95[185] |
-0.65[186] |
-9.93[187] |
-11.09[188] |
1.05[189] |
28 |
GART |
Trifunctional purine biosynthetic protein adenosine-3 |
[190] |
1.54[191] |
1.22[192] |
0.67[193] |
0.87[194] |
1.47[195] |
0.33[196] |
29 |
DGUOK |
Deoxyguanosine kinase, mitochondrial |
[197] |
0.00[198] |
-0.06[199] |
-0.29[200] |
-0.60[201] |
-0.41[202] |
-0.88[203] |
30 |
ITPA |
Inosine triphosphate pyrophosphatase |
[204] |
0.65[205] |
0.66[206] |
-1.02[207] |
-0.22[208] |
-0.80[209] |
-0.89[210] |
31 |
DCTD |
Deoxycytidylate deaminase |
[211] |
0.62[212] |
0.79[213] |
-1.35[214] |
-0.20[215] |
0.75[216] |
0.71[217] |
32 |
DUT |
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
[218] |
0.35[219] |
0.67[220] |
0.17[221] |
0.27[222] |
1.31[223] |
-0.22[224] |
33 |
AK4 |
Adenylate kinase 4, mitochondrial |
[225] |
2.22[226] |
2.68[227] |
2.39[228] |
-0.19[229] |
1.19[230] |
3.06[231] |
34 |
NT5C |
5'(3')-deoxyribonucleotidase, cytosolic type |
[232] |
-0.66[233] |
0.23[234] |
-0.81[235] |
-0.77[236] |
-0.48[237] |
-1.11[238] |
35 |
HPRT1 |
Hypoxanthine-guanine phosphoribosyltransferase |
[239] |
-0.10[240] |
0.00[241] |
1.02[242] |
0.69[243] |
0.95[244] |
-0.99[245] |
36 |
UPP1 |
Uridine phosphorylase 1 |
[246] |
-1.77[247] |
-1.93[248] |
-1.61[249] |
-1.07[250] |
0.10[251] |
-1.35[252] |
37 |
ENTPD6 |
Ectonucleoside triphosphate diphosphohydrolase 6 |
[253] |
2.60[254] |
2.67[255] |
-0.48[256] |
-0.04[257] |
0.26[258] |
0.53[259] |
38 |
NUDT9 |
ADP-ribose pyrophosphatase, mitochondrial |
[260] |
-0.81[261] |
-1.22[262] |
-1.80[263] |
-0.92[264] |
-0.11[265] |
0.73[266] |
39 |
DCTPP1 |
dCTP pyrophosphatase 1 |
[267] |
1.74[268] |
1.60[269] |
0.96[270] |
-0.87[271] |
0.16[272] |
-0.97[273] |
40 |
GMPS |
GMP synthase [glutamine-hydrolyzing] |
[274] |
0.97[275] |
1.03[276] |
1.28[277] |
1.57[278] |
2.00[279] |
0.20[280] |
41 |
AK1 |
Adenylate kinase isoenzyme 1 |
[281] |
0.10[282] |
-0.26[283] |
-1.16[284] |
0.53[285] |
0.97[286] |
0.79[287] |
42 |
RRM2 |
Ribonucleoside-diphosphate reductase subunit M2 |
[288] |
2.31[289] |
2.35[290] |
1.87[291] |
2.81[292] |
3.13[293] |
0.00[294] |
43 |
NT5C2 |
Cytosolic purine 5'-nucleotidase |
[295] |
1.30[296] |
1.72[297] |
2.38[298] |
1.45[299] |
1.54[300] |
1.15[301] |
44 |
ENTPD5 |
Ectonucleoside triphosphate diphosphohydrolase 5 |
[302] |
-0.90[303] |
1.03[304] |
-0.01[305] |
-2.31[306] |
-1.48[307] |
3.02[308] |
45 |
NME3 |
Nucleoside diphosphate kinase 3 |
[309] |
-1.15[310] |
-1.17[311] |
0.58[312] |
-1.14[313] |
-0.52[314] |
-0.31[315] |
46 |
NUDT16 |
U8 snoRNA-decapping enzyme |
[316] |
-0.03[317] |
-0.08[318] |
1.20[319] |
-0.75[320] |
0.13[321] |
1.75[322] |
47 |
UCK1 |
Uridine-cytidine kinase 1 |
[323] |
-0.07[324] |
0.67[325] |
0.12[326] |
-0.03[327] |
0.98[328] |
1.03[329] |
48 |
UCKL1 |
Uridine-cytidine kinase-like 1 |
[330] |
1.68[331] |
1.85[332] |
-0.23[333] |
0.34[334] |
-0.11[335] |
0.48[336] |
49 |
RRM1 |
Ribonucleoside-diphosphate reductase large subunit |
[337] |
2.20[338] |
1.64[339] |
2.37[340] |
2.75[341] |
3.15[342] |
0.93[343] |
50 |
DCK |
Deoxycytidine kinase |
[344] |
0.31[345] |
0.72[346] |
-0.05[347] |
0.74[348] |
1.52[349] |
-1.05[350] |
51 |
TK1 |
Thymidine kinase, cytosolic |
[351] |
2.64[352] |
1.81[353] |
1.45[354] |
1.95[355] |
2.39[356] |
-0.71[357] |
52 |
GDA |
Guanine deaminase |
[358] |
-1.31[359] |
-7.84[360] |
1.19[361] |
-7.73[362] |
-5.14[363] |
2.38[364] |
53 |
NUDT15 |
Nucleotide triphosphate diphosphatase NUDT15 |
[365] |
1.21[366] |
1.26[367] |
1.22[368] |
0.27[369] |
1.01[370] |
0.10[371] |
54 |
NT5E |
5'-nucleotidase |
[372] |
-0.58[373] |
2.80[374] |
2.85[375] |
0.03[376] |
2.30[377] |
2.22[378] |
55 |
AMPD2 |
AMP deaminase 2 |
[379] |
2.07[380] |
1.91[381] |
2.55[382] |
2.43[383] |
1.95[384] |
2.36[385] |
56 |
DPYD |
Dihydropyrimidine dehydrogenase [NADP(+)] |
[386] |
-4.24[387] |
-3.37[388] |
2.30[389] |
1.44[390] |
1.04[391] |
4.22[392] |
57 |
XDH |
Xanthine dehydrogenase/oxidase |
[393] |
-9.35[394] |
-8.28[395] |
-2.75[396] |
-6.69[397] |
-4.39[398] |
3.61[399] |
58 |
UMPS |
Uridine 5'-monophosphate synthase |
[400] |
2.26[401] |
2.43[402] |
1.95[403] |
1.23[404] |
2.13[405] |
2.47[406] |
59 |
RRM2B |
Ribonucleoside-diphosphate reductase subunit M2 B |
[407] |
1.96[408] |
2.04[409] |
0.89[410] |
1.71[411] |
1.79[412] |
1.29[413] |
60 |
UCK2 |
Uridine-cytidine kinase 2 |
[414] |
2.17[415] |
1.95[416] |
2.03[417] |
2.55[418] |
2.79[419] |
1.05[420] |
61 |
IMPDH1 |
Inosine-5'-monophosphate dehydrogenase 1 |
[421] |
2.63[422] |
1.83[423] |
1.61[424] |
2.76[425] |
2.50[426] |
-0.40[427] |
62 |
TK2 |
Thymidine kinase 2, mitochondrial |
[428] |
0.79[429] |
1.13[430] |
-0.03[431] |
1.02[432] |
2.18[433] |
2.95[434] |
63 |
PPAT |
Amidophosphoribosyltransferase |
[435] |
1.96[436] |
2.41[437] |
2.56[438] |
1.43[439] |
2.27[440] |
1.12[441] |
64 |
SAMHD1 |
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
[442] |
2.21[443] |
1.43[444] |
0.24[445] |
2.30[446] |
2.13[447] |
2.72[448] |
65 |
CTPS2 |
CTP synthase 2 |
[449] |
2.13[450] |
1.95[451] |
2.52[452] |
1.68[453] |
1.80[454] |
1.29[455] |
66 |
ENTPD4 |
Ectonucleoside triphosphate diphosphohydrolase 4 |
[456] |
2.07[457] |
2.45[458] |
2.02[459] |
2.17[460] |
2.80[461] |
3.14[462] |
67 |
GMPR |
GMP reductase 1 |
[463] |
-5.98[464] |
[465] |
-8.99[466] |
-0.30[467] |
-0.09[468] |
-0.78[469] |
68 |
NUDT1 |
7,8-dihydro-8-oxoguanine triphosphatase |
[470] |
0.29[471] |
-0.13[472] |
1.31[473] |
0.09[474] |
1.22[475] |
-2.24[476] |
69 |
ENTPD7 |
Ectonucleoside triphosphate diphosphohydrolase 7 |
[477] |
1.66[478] |
2.72[479] |
2.62[480] |
1.86[481] |
2.11[482] |
3.36[483] |
70 |
ENTPD8 |
Ectonucleoside triphosphate diphosphohydrolase 8 |
[484] |
-1.44[485] |
-0.28[486] |
-2.53[487] |
-4.66[488] |
-5.77[489] |
0.85[490] |
71 |
PFAS |
Phosphoribosylformylglycinamidine synthase |
[491] |
3.47[492] |
2.95[493] |
3.73[494] |
2.87[495] |
3.44[496] |
2.39[497] |
72 |
CAD |
CAD protein |
[498] |
4.05[499] |
3.85[500] |
4.34[501] |
3.85[502] |
4.24[503] |
3.07[504] |
73 |
ADA |
Adenosine deaminase |
[505] |
1.89[506] |
0.94[507] |
-1.05[508] |
2.62[509] |
0.34[510] |
-0.18[511] |
74 |
NUDT18 |
8-oxo-dGDP phosphatase NUDT18 |
[512] |
0.85[513] |
0.12[514] |
0.43[515] |
-0.11[516] |
-0.23[517] |
-0.36[518] |
75 |
ADAL |
Adenosine deaminase-like protein |
[519] |
0.92[520] |
1.44[521] |
1.02[522] |
1.74[523] |
1.55[524] |
1.14[525] |
76 |
AMPD3 |
AMP deaminase 3 |
[526] |
0.64[527] |
-1.19[528] |
-0.08[529] |
2.11[530] |
1.32[531] |
-0.40[532] |
77 |
NUDT13 |
Nucleoside diphosphate-linked moiety X motif 13 |
[533] |
-0.14[534] |
1.61[535] |
-2.20[536] |
-1.98[537] |
-1.92[538] |
1.03[539] |
78 |
UPP2 |
Uridine phosphorylase 2 |
[540] |
-6.74[541] |
[542] |
-4.36[543] |
[544] |
-7.49[545] |
2.22[546] |
79 |
ENTPD1 |
Ectonucleoside triphosphate diphosphohydrolase 1 |
[547] |
3.47[548] |
4.12[549] |
3.77[550] |
2.27[551] |
3.85[552] |
4.09[553] |
80 |
NT5M |
5'(3')-deoxyribonucleotidase, mitochondrial |
[554] |
0.21[555] |
1.66[556] |
1.23[557] |
2.03[558] |
1.16[559] |
-0.42[560] |
81 |
ENTPD2 |
Ectonucleoside triphosphate diphosphohydrolase 2 |
[561] |
5.89[562] |
5.43[563] |
2.25[564] |
-3.29[565] |
-3.07[566] |
-0.97[567] |
82 |
AK7 |
Adenylate kinase 7 |
[568] |
-1.70[569] |
-0.37[570] |
3.72[571] |
-0.45[572] |
0.13[573] |
2.57[574] |
83 |
AK8 |
Adenylate kinase 8 |
[575] |
1.11[576] |
0.54[577] |
1.85[578] |
3.11[579] |
3.99[580] |
2.47[581] |
84 |
AMPD1 |
AMP deaminase 1 |
[582] |
[583] |
[584] |
-0.57[585] |
-1.15[586] |
-1.93[587] |
[588] |
85 |
ADPRM |
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase |
[589] |
[590] |
[591] |
[592] |
[593] |
[594] |
[595] |
86 |
PUDP |
Pseudouridine-5'-phosphatase |
[596] |
[597] |
[598] |
[599] |
[600] |
[601] |
[602] |
87 |
NT5C1B |
Cytosolic 5'-nucleotidase 1B |
[603] |
[604] |
[605] |
[606] |
[607] |
[608] |
[609] |
88 |
CTPS1 |
CTP synthase 1 |
[610] |
[611] |
[612] |
[613] |
[614] |
[615] |
[616] |
89 |
AK5 |
Adenylate kinase isoenzyme 5 |
[617] |
[618] |
[619] |
[620] |
[621] |
[622] |
[623] |
90 |
DNPH1 |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
[624] |
[625] |
[626] |
[627] |
[628] |
[629] |
[630] |
91 |
ADSS2 |
|
[631] |
[632] |
[633] |
[634] |
[635] |
[636] |
[637] |
92 |
NT5C3A |
Cytosolic 5'-nucleotidase 3A |
[638] |
[639] |
[640] |
[641] |
[642] |
[643] |
[644] |
93 |
ADSS1 |
|
[645] |
[646] |
[647] |
[648] |
[649] |
[650] |
[651] |
94 |
AK9 |
Adenylate kinase 9 |
[652] |
[653] |
[654] |
[655] |
[656] |
[657] |
[658] |
95 |
NT5C1A |
Cytosolic 5'-nucleotidase 1A |
[659] |
[660] |
[661] |
[662] |
[663] |
[664] |
[665] |
96 |
AK6 |
Adenylate kinase isoenzyme 6 |
[666] |
[667] |
[668] |
[669] |
[670] |
[671] |
[672] |
97 |
ENTPD3 |
Ectonucleoside triphosphate diphosphohydrolase 3 |
[673] |
[674] |
[675] |
[676] |
[677] |
[678] |
[679] |
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