REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SHMT1 Serine hydroxymethyltransferase, cytosolic [1] -2.45[2] -3.01[3] -2.15[4] -1.37[5] -2.30[6] 0.58[7]
2 SHMT2 Serine hydroxymethyltransferase, mitochondrial [8] 0.43[9] 1.02[10] 0.93[11] -0.19[12] 0.43[13] -0.73[14]
3 ALDH1L1 Cytosolic 10-formyltetrahydrofolate dehydrogenase [15] -3.58[16] -12.68[17] -13.26[18] -6.57[19] -7.04[20] 0.39[21]
4 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic [22] 0.20[23] -0.84[24] -0.56[25] 0.57[26] 0.58[27] 0.37[28]
5 MTHFS 5-formyltetrahydrofolate cyclo-ligase [29] -4.01[30] -3.78[31] -4.06[32] -4.20[33] -4.24[34] -3.11[35]
6 FPGS Folylpolyglutamate synthase, mitochondrial [36] -0.14[37] -1.14[38] -1.32[39] 0.75[40] -0.37[41] -0.82[42]
7 DHFR Dihydrofolate reductase [43] 2.09[44] 2.31[45] 3.04[46] 2.72[47] 2.93[48] -0.47[49]
8 SLC25A32 Mitochondrial folate transporter/carrier [50] 0.88[51] 0.54[52] 0.53[53] 2.54[54] 1.25[55] 0.14[56]
9 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial [57] 2.52[58] 1.66[59] 1.76[60] 2.15[61] 1.42[62] -2.47[63]
10 MTHFD2 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 3.45[64] 3.78[65] 2.84[66] 1.21[67] 3.28[68] -2.95[69]
11 SLC46A1 Proton-coupled folate transporter [70] 0.46[71] 0.35[72] 0.48[73] 0.14[74] -0.93[75] 0.62[76]
12 FOLR2 Folate receptor beta [77] -7.47[78] -4.52[79] [80] -8.80[81] [82] -0.77[83]
13 SLC19A1 Folate transporter 1 [84] 2.68[85] 1.61[86] 1.58[87] 2.03[88] 1.57[89] -0.10[90]
14 MTHFD2L Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 -0.90[91] 0.59[92] -0.80[93] 0.60[94] 0.50[95] 1.57[96]
15 MTHFR Methylenetetrahydrofolate reductase [97] 1.88[98] 2.75[99] 3.39[100] 4.17[101] 2.29[102] 3.21[103]
16 ALDH1L2 Mitochondrial 10-formyltetrahydrofolate dehydrogenase [104] 6.11[105] 1.21[106] 6.47[107] 2.03[108] 4.36[109] 2.47[110]
17 DHFR2 Dihydrofolate reductase 2, mitochondrial [111] [112] [113] [114] [115] [116] [117]
[1]
ref_hepatocyte SHMT1
Mean 76.7
Standard deviation 82
Values 15 16 18 1.7e+02 1.6e+02
[2]
HepG2 SHMT1
Mean 21.2
Standard deviation 4.7
Values 18 25
[3]
HepG2.C3A SHMT1
Mean 18
Standard deviation 5.4
Values 14 22
[4]
HuH.7 SHMT1
Mean 24
Standard deviation 7.5
Values 25 16 31
[5]
SNU475 SHMT1
Mean 19.7
Standard deviation 0.95
Values 20 19
[6]
THLE SHMT1
Mean 18.2
Standard deviation 3.2
Values 16 21
[7]
liver SHMT1
Mean 246
Standard deviation 1.2e+02
Values 3.3e+02 1.6e+02 3.7e+02 1.3e+02
[8]
ref_hepatocyte SHMT2
Mean 66.5
Standard deviation 44
Values 27 32 61 1.4e+02 78
[9]
HepG2 SHMT2
Mean 135
Standard deviation 40
Values 1.6e+02 1.1e+02
[10]
HepG2.C3A SHMT2
Mean 256
Standard deviation 1e+02
Values 3.3e+02 1.8e+02
[11]
HuH.7 SHMT2
Mean 175
Standard deviation 6.4
Values 1.7e+02 1.8e+02 1.8e+02
[12]
SNU475 SHMT2
Mean 38.7
Standard deviation 3
Values 37 41
[13]
THLE SHMT2
Mean 105
Standard deviation 2.1
Values 1.1e+02 1e+02
[14]
liver SHMT2
Mean 86.4
Standard deviation 29
Values 1e+02 67 1.2e+02 59
[15]
ref_hepatocyte ALDH1L1
Mean 53.8
Standard deviation 57
Values 22 12 4.3 1.1e+02 1.3e+02
[16]
HepG2 ALDH1L1
Mean 6.81
Standard deviation 2.3
Values 8.4 5.2
[17]
HepG2.C3A ALDH1L1
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[18]
HuH.7 ALDH1L1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[19]
SNU475 ALDH1L1
Mean 0.375
Standard deviation 0.16
Values 0.26 0.49
[20]
THLE ALDH1L1
Mean 0.478
Standard deviation 0.039
Values 0.45 0.51
[21]
liver ALDH1L1
Mean 151
Standard deviation 64
Values 1.2e+02 1.5e+02 2.4e+02 90
[22]
ref_hepatocyte MTHFD1
Mean 38.3
Standard deviation 33
Values 17 24 7.6 54 88
[23]
HepG2 MTHFD1
Mean 66.6
Standard deviation 5.5
Values 63 70
[24]
HepG2.C3A MTHFD1
Mean 40.6
Standard deviation 9.4
Values 34 47
[25]
HuH.7 MTHFD1
Mean 36.1
Standard deviation 17
Values 50 17 42
[26]
SNU475 MTHFD1
Mean 37.7
Standard deviation 1.4
Values 39 37
[27]
THLE MTHFD1
Mean 67.1
Standard deviation 15
Values 56 78
[28]
liver MTHFD1
Mean 106
Standard deviation 16
Values 90 99 1.3e+02 1.1e+02
[29]
ref_hepatocyte MTHFS
Mean 33.8
Standard deviation 36
Values 4.8 6.2 12 75 71
[30]
HepG2 MTHFS
Mean 3.16
Standard deviation 0.23
Values 3 3.3
[31]
HepG2.C3A MTHFS
Mean 4.68
Standard deviation 1.1
Values 3.9 5.5
[32]
HuH.7 MTHFS
Mean 2.82
Standard deviation 0.4
Values 2.4 3.2 2.8
[33]
SNU475 MTHFS
Mean 1.22
Standard deviation 0.081
Values 1.3 1.2
[34]
THLE MTHFS
Mean 2.1
Standard deviation 0.12
Values 2 2.2
[35]
liver MTHFS
Mean 8.42
Standard deviation 9.4
Values 19 0.66 13 0.46
[36]
ref_hepatocyte FPGS
Mean 21
Standard deviation 12
Values 5.1 15 38 25 21
[37]
HepG2 FPGS
Mean 28.7
Standard deviation 1.3
Values 30 28
[38]
HepG2.C3A FPGS
Mean 18.1
Standard deviation 0.57
Values 18 18
[39]
HuH.7 FPGS
Mean 11.7
Standard deviation 4.7
Values 14 6.3 15
[40]
SNU475 FPGS
Mean 23.3
Standard deviation 4.6
Values 27 20
[41]
THLE FPGS
Mean 19
Standard deviation 5.3
Values 15 23
[42]
liver FPGS
Mean 25.6
Standard deviation 13
Values 33 15 41 13
[43]
ref_hepatocyte DHFR
Mean 6.89
Standard deviation 3.8
Values 10 7.9 0.65 6.3 9.3
[44]
HepG2 DHFR
Mean 44.3
Standard deviation 17
Values 32 56
[45]
HepG2.C3A DHFR
Mean 64.7
Standard deviation 42
Values 35 95
[46]
HuH.7 DHFR
Mean 78.4
Standard deviation 42
Values 1.1e+02 31 96
[47]
SNU475 DHFR
Mean 30.2
Standard deviation 0.92
Values 31 30
[48]
THLE DHFR
Mean 61.5
Standard deviation 17
Values 50 73
[49]
liver DHFR
Mean 10.7
Standard deviation 3.8
Values 15 9.2 6.4 12
[50]
ref_hepatocyte SLC25A32
Mean 5.13
Standard deviation 3.2
Values 4.5 11 4.5 2.7 3.3
[51]
HepG2 SLC25A32
Mean 14.3
Standard deviation 1.8
Values 13 16
[52]
HepG2.C3A SLC25A32
Mean 14.1
Standard deviation 2.9
Values 12 16
[53]
HuH.7 SLC25A32
Mean 10.3
Standard deviation 2.6
Values 13 7.4 11
[54]
SNU475 SLC25A32
Mean 19.7
Standard deviation 0.15
Values 20 20
[55]
THLE SLC25A32
Mean 14.3
Standard deviation 2.7
Values 12 16
[56]
liver SLC25A32
Mean 12.2
Standard deviation 1.3
Values 14 11 13 11
[57]
ref_hepatocyte MTHFD1L
Mean 5.11
Standard deviation 3.9
Values 4.8 6.5 11 3.2 0.36
[58]
HepG2 MTHFD1L
Mean 44.3
Standard deviation 12
Values 53 36
[59]
HepG2.C3A MTHFD1L
Mean 30.6
Standard deviation 12
Values 39 22
[60]
HuH.7 MTHFD1L
Mean 23.9
Standard deviation 6.6
Values 30 17 26
[61]
SNU475 MTHFD1L
Mean 15
Standard deviation 1.1
Values 14 16
[62]
THLE MTHFD1L
Mean 16
Standard deviation 2
Values 15 17
[63]
liver MTHFD1L
Mean 1.99
Standard deviation 0.21
Values 2.2 2 1.7 2.1
[64]
ref_hepatocyte MTHFD2
Mean 4.93
Standard deviation 5.2
Values 14 1.1 5.2 3.3 1.3
[65]
HepG2 MTHFD2
Mean 81.4
Standard deviation 25
Values 99 64
[66]
HepG2.C3A MTHFD2
Mean 129
Standard deviation 63
Values 1.7e+02 84
[67]
HuH.7 MTHFD2
Mean 49.2
Standard deviation 11
Values 55 37 55
[68]
SNU475 MTHFD2
Mean 7.54
Standard deviation 0.064
Values 7.6 7.5
[69]
THLE MTHFD2
Mean 56.2
Standard deviation 0.51
Values 56 57
[70]
liver MTHFD2
Mean 1.38
Standard deviation 0.47
Values 2.1 1.2 1 1.2
[71]
ref_hepatocyte SLC46A1
Mean 4.01
Standard deviation 2.2
Values 5.3 1.5 1.7 6.2 5.3
[72]
HepG2 SLC46A1
Mean 8.35
Standard deviation 1.4
Values 7.4 9.4
[73]
HepG2.C3A SLC46A1
Mean 9.72
Standard deviation 1.6
Values 11 8.6
[74]
HuH.7 SLC46A1
Mean 7.78
Standard deviation 1.9
Values 7.2 9.9 6.3
[75]
SNU475 SLC46A1
Mean 2.94
Standard deviation 0.048
Values 2.9 3
[76]
THLE SLC46A1
Mean 2.47
Standard deviation 0.27
Values 2.3 2.7
[77]
liver SLC46A1
Mean 13.2
Standard deviation 3.5
Values 16 9.6 11 16
[78]
ref_hepatocyte FOLR2
Mean 3.11
Standard deviation 4.2
Values 0 0.11 0 7 8.5
[79]
HepG2 FOLR2
Mean 0.0265
Standard deviation 0.019
Values 0.04 0.013
[80]
HepG2.C3A FOLR2
Mean 0.258
Standard deviation 0.21
Values 0.41 0.11
[81]
HuH.7 FOLR2
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 FOLR2
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[83]
THLE FOLR2
Mean 0
Standard deviation 0
Values 0 0
[84]
liver FOLR2
Mean 3.93
Standard deviation 2
Values 4.2 3.2 6.6 1.7
[85]
ref_hepatocyte SLC19A1
Mean 2.51
Standard deviation 1.1
Values 3.6 3.4 1.9 2.7 0.89
[86]
HepG2 SLC19A1
Mean 24.3
Standard deviation 7.4
Values 30 19
[87]
HepG2.C3A SLC19A1
Mean 14.5
Standard deviation 4.8
Values 18 11
[88]
HuH.7 SLC19A1
Mean 10.4
Standard deviation 4.1
Values 13 5.7 13
[89]
SNU475 SLC19A1
Mean 6.79
Standard deviation 1.7
Values 5.6 8
[90]
THLE SLC19A1
Mean 8.7
Standard deviation 1.3
Values 7.8 9.6
[91]
liver SLC19A1
Mean 5.03
Standard deviation 3.4
Values 9.2 1.8 2.8 6.3
[92]
ref_hepatocyte MTHFD2L
Mean 0.936
Standard deviation 0.65
Values 0.6 0.5 0.99 0.55 2
[93]
HepG2 MTHFD2L
Mean 0.759
Standard deviation 0.11
Values 0.68 0.84
[94]
HepG2.C3A MTHFD2L
Mean 2.66
Standard deviation 0.36
Values 2.4 2.9
[95]
HuH.7 MTHFD2L
Mean 0.745
Standard deviation 0.26
Values 0.55 1 0.65
[96]
SNU475 MTHFD2L
Mean 0.939
Standard deviation 0.43
Values 0.64 1.2
[97]
THLE MTHFD2L
Mean 1.55
Standard deviation 0.053
Values 1.6 1.5
[98]
liver MTHFD2L
Mean 5.97
Standard deviation 3.1
Values 6.3 10 2.6 5
[99]
ref_hepatocyte MTHFR
Mean 0.857
Standard deviation 0.14
Values 0.9 0.92 0.91 0.95 0.6
[100]
HepG2 MTHFR
Mean 4.76
Standard deviation 0.36
Values 4.5 5
[101]
HepG2.C3A MTHFR
Mean 10.9
Standard deviation 2
Values 12 9.5
[102]
HuH.7 MTHFR
Mean 12.4
Standard deviation 3.7
Values 11 17 9.7
[103]
SNU475 MTHFR
Mean 10.2
Standard deviation 3.7
Values 13 7.6
[104]
THLE MTHFR
Mean 4.9
Standard deviation 0.19
Values 5 4.8
[105]
liver MTHFR
Mean 17.1
Standard deviation 4.4
Values 17 21 11 19
[106]
ref_hepatocyte ALDH1L2
Mean 0.0484
Standard deviation 0.017
Values 0.042 0.078 0.038 0.043 0.041
[107]
HepG2 ALDH1L2
Mean 5.04
Standard deviation 3.2
Values 7.3 2.8
[108]
HepG2.C3A ALDH1L2
Mean 0.212
Standard deviation 0.057
Values 0.25 0.17
[109]
HuH.7 ALDH1L2
Mean 5.94
Standard deviation 1.2
Values 6.6 6.7 4.5
[110]
SNU475 ALDH1L2
Mean 0.131
Standard deviation 0.064
Values 0.18 0.086
[111]
THLE ALDH1L2
Mean 1.16
Standard deviation 0.26
Values 1.3 0.97
[112]
liver ALDH1L2
Mean 0.578
Standard deviation 0.5
Values 0.16 1 0.13 1
[113]
ref_hepatocyte DHFR2
Missing
[114]
HepG2 DHFR2
Missing
[115]
HepG2.C3A DHFR2
Missing
[116]
HuH.7 DHFR2
Missing
[117]
SNU475 DHFR2
Missing
[118]
THLE DHFR2
Missing
[119]
liver DHFR2
Missing