REACTOME_METABOLISM_OF_COFACTORS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSP90AA1 Heat shock protein HSP 90-alpha [1] -0.02[2] 0.22[3] -0.42[4] 0.38[5] 0.35[6] -0.73[7]
2 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic [8] 0.11[9] 0.13[10] 1.33[11] -1.27[12] -1.97[13] 0.04[14]
3 GCHFR GTP cyclohydrolase 1 feedback regulatory protein [15] -2.46[16] -1.99[17] -2.93[18] -5.21[19] -4.54[20] -0.62[21]
4 AKT1 RAC-alpha serine/threonine-protein kinase [22] 0.70[23] -0.26[24] -1.20[25] 0.24[26] 0.54[27] 0.29[28]
5 SPR Sepiapterin reductase [29] -0.74[30] -0.76[31] -2.15[32] -1.77[33] -2.42[34] -0.29[35]
6 CALM1 Calmodulin-1 [36] 0.70[37] 0.01[38] 0.60[39] 1.87[40] 1.43[41] 2.15[42]
7 COQ9 Ubiquinone biosynthesis protein COQ9, mitochondrial [43] -0.29[44] -0.92[45] -1.91[46] -1.39[47] -0.73[48] 0.40[49]
8 PTS 6-pyruvoyl tetrahydrobiopterin synthase [50] -0.87[51] -1.48[52] -3.45[53] -1.38[54] -0.92[55] 0.20[56]
9 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [57] -0.51[58] -0.20[59] 0.12[60] -0.76[61] -0.92[62] -0.01[63]
10 GCH1 GTP cyclohydrolase 1 [64] -1.09[65] -0.87[66] -0.65[67] -2.35[68] -0.79[69] 1.31[70]
11 DHFR Dihydrofolate reductase [71] 2.16[72] 2.15[73] 2.62[74] 1.54[75] 2.69[76] 0.66[77]
12 COQ3 Ubiquinone biosynthesis O-methyltransferase, mitochondrial [78] -1.03[79] -1.62[80] -1.46[81] -1.46[82] -0.49[83] -0.83[84]
13 COQ6 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [85] -0.05[86] 0.27[87] -1.60[88] -0.65[89] -0.09[90] 0.89[91]
14 PDSS2 Decaprenyl-diphosphate synthase subunit 2 [92] 0.56[93] 0.07[94] 0.20[95] -1.27[96] 0.09[97] 1.62[98]
15 COQ2 4-hydroxybenzoate polyprenyltransferase, mitochondrial [99] -0.16[100] -0.84[101] -1.11[102] -1.52[103] 0.30[104] 0.24[105]
16 COQ7 5-demethoxyubiquinone hydroxylase, mitochondrial [106] 1.58[107] 1.04[108] -0.07[109] -0.24[110] 0.33[111] 0.40[112]
17 PDSS1 Decaprenyl-diphosphate synthase subunit 1 [113] 0.67[114] 0.81[115] 0.44[116] 0.56[117] 0.46[118] 0.42[119]
18 NOS3 Nitric oxide synthase, endothelial [120] 5.39[121] 1.77[122] 1.36[123] 0.35[124] 1.97[125] 3.30[126]
19 PRKG2 cGMP-dependent protein kinase 2 [127] 3.52[128] [129] [130] 7.08[131] 1.65[132] 2.57[133]
[1]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[2]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[3]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[4]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[5]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[6]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[7]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[8]
ref_hepatocyte IDH1
Mean 120
Standard deviation 80
Values 2.1e+02 57 23 1.2e+02 1.8e+02
[9]
HepG2 IDH1
Mean 186
Standard deviation 83
Values 1.3e+02 2.4e+02
[10]
HepG2.C3A IDH1
Mean 278
Standard deviation 72
Values 2.3e+02 3.3e+02
[11]
HuH.7 IDH1
Mean 559
Standard deviation 1.1e+02
Values 5.8e+02 4.4e+02 6.5e+02
[12]
SNU475 IDH1
Mean 74.8
Standard deviation 19
Values 88 61
[13]
THLE IDH1
Mean 42.2
Standard deviation 1.1
Values 43 41
[14]
liver IDH1
Mean 121
Standard deviation 35
Values 1.4e+02 1.2e+02 1.5e+02 74
[15]
ref_hepatocyte GCHFR
Mean 58.5
Standard deviation 74
Values 8.9 0.84 8.4 1.1e+02 1.6e+02
[16]
HepG2 GCHFR
Mean 15.3
Standard deviation 6.8
Values 10 20
[17]
HepG2.C3A GCHFR
Mean 31.2
Standard deviation 10
Values 24 38
[18]
HuH.7 GCHFR
Mean 14.2
Standard deviation 5.9
Values 13 9.3 21
[19]
SNU475 GCHFR
Mean 2.37
Standard deviation 0.69
Values 2.9 1.9
[20]
THLE GCHFR
Mean 3.48
Standard deviation 0.0078
Values 3.5 3.5
[21]
liver GCHFR
Mean 37.5
Standard deviation 37
Values 74 5.6 65 5.1
[22]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[23]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[24]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[25]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[26]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[27]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[28]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[29]
ref_hepatocyte SPR
Mean 32.1
Standard deviation 17
Values 11 25 26 54 44
[30]
HepG2 SPR
Mean 27.6
Standard deviation 12
Values 19 36
[31]
HepG2.C3A SPR
Mean 40.1
Standard deviation 7.9
Values 35 46
[32]
HuH.7 SPR
Mean 13.4
Standard deviation 3.9
Values 13 9.4 17
[33]
SNU475 SPR
Mean 14.2
Standard deviation 2.4
Values 16 12
[34]
THLE SPR
Mean 8.29
Standard deviation 1.3
Values 7.4 9.2
[35]
liver SPR
Mean 25.9
Standard deviation 13
Values 40 15 34 15
[36]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[37]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[38]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[39]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[40]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[41]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[42]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[43]
ref_hepatocyte COQ9
Mean 23.8
Standard deviation 6.2
Values 19 17 24 33 26
[44]
HepG2 COQ9
Mean 28.1
Standard deviation 3.8
Values 25 31
[45]
HepG2.C3A COQ9
Mean 26.6
Standard deviation 4.2
Values 24 30
[46]
HuH.7 COQ9
Mean 11.8
Standard deviation 4.2
Values 11 7.9 16
[47]
SNU475 COQ9
Mean 13.7
Standard deviation 1.5
Values 15 13
[48]
THLE COQ9
Mean 19.9
Standard deviation 1.5
Values 21 19
[49]
liver COQ9
Mean 30.9
Standard deviation 11
Values 33 26 46 19
[50]
ref_hepatocyte PTS
Mean 17.2
Standard deviation 9.6
Values 8.7 15 7.7 28 26
[51]
HepG2 PTS
Mean 13.5
Standard deviation 2.8
Values 12 15
[52]
HepG2.C3A PTS
Mean 13
Standard deviation 2.8
Values 11 15
[53]
HuH.7 PTS
Mean 2.92
Standard deviation 0.83
Values 2.3 2.5 3.9
[54]
SNU475 PTS
Mean 9.89
Standard deviation 0.52
Values 10 9.5
[55]
THLE PTS
Mean 12.6
Standard deviation 0.8
Values 12 13
[56]
liver PTS
Mean 19.4
Standard deviation 15
Values 33 6.8 32 6.1
[57]
ref_hepatocyte COQ5
Mean 16.3
Standard deviation 8
Values 19 10 5.6 22 24
[58]
HepG2 COQ5
Mean 16.3
Standard deviation 0.47
Values 16 17
[59]
HepG2.C3A COQ5
Mean 29.9
Standard deviation 2.6
Values 28 32
[60]
HuH.7 COQ5
Mean 32.8
Standard deviation 3.1
Values 31 31 36
[61]
SNU475 COQ5
Mean 14.4
Standard deviation 2
Values 16 13
[62]
THLE COQ5
Mean 11.9
Standard deviation 0.8
Values 11 12
[63]
liver COQ5
Mean 15.9
Standard deviation 9
Values 23 9.3 25 7
[64]
ref_hepatocyte GCH1
Mean 15.7
Standard deviation 4.4
Values 16 11 12 21 19
[65]
HepG2 GCH1
Mean 10.6
Standard deviation 1.9
Values 9.3 12
[66]
HepG2.C3A GCH1
Mean 18.2
Standard deviation 3.9
Values 15 21
[67]
HuH.7 GCH1
Mean 18.5
Standard deviation 5
Values 20 13 23
[68]
SNU475 GCH1
Mean 4.64
Standard deviation 1.2
Values 3.8 5.5
[69]
THLE GCH1
Mean 12.6
Standard deviation 0.17
Values 13 12
[70]
liver GCH1
Mean 38.4
Standard deviation 10
Values 28 47 47 30
[71]
ref_hepatocyte DHFR
Mean 6.89
Standard deviation 3.8
Values 10 7.9 0.65 6.3 9.3
[72]
HepG2 DHFR
Mean 44.3
Standard deviation 17
Values 32 56
[73]
HepG2.C3A DHFR
Mean 64.7
Standard deviation 42
Values 35 95
[74]
HuH.7 DHFR
Mean 78.4
Standard deviation 42
Values 1.1e+02 31 96
[75]
SNU475 DHFR
Mean 30.2
Standard deviation 0.92
Values 31 30
[76]
THLE DHFR
Mean 61.5
Standard deviation 17
Values 50 73
[77]
liver DHFR
Mean 10.7
Standard deviation 3.8
Values 15 9.2 6.4 12
[78]
ref_hepatocyte COQ3
Mean 6.58
Standard deviation 4.2
Values 3.7 12 1.5 6.7 9.1
[79]
HepG2 COQ3
Mean 4.63
Standard deviation 0.3
Values 4.8 4.4
[80]
HepG2.C3A COQ3
Mean 4.52
Standard deviation 2.3
Values 2.9 6.1
[81]
HuH.7 COQ3
Mean 4.42
Standard deviation 2.4
Values 4.9 1.9 6.5
[82]
SNU475 COQ3
Mean 3.6
Standard deviation 0.0035
Values 3.6 3.6
[83]
THLE COQ3
Mean 6.48
Standard deviation 0.91
Values 5.8 7.1
[84]
liver COQ3
Mean 3.64
Standard deviation 2.6
Values 5.4 1.5 6.2 1.4
[85]
ref_hepatocyte COQ6
Mean 5.95
Standard deviation 5.4
Values 2.2 3.1 1.6 14 8.5
[86]
HepG2 COQ6
Mean 8.25
Standard deviation 1.3
Values 7.3 9.2
[87]
HepG2.C3A COQ6
Mean 15.1
Standard deviation 0.61
Values 15 16
[88]
HuH.7 COQ6
Mean 3.63
Standard deviation 0.73
Values 3.6 2.9 4.4
[89]
SNU475 COQ6
Mean 5.7
Standard deviation 0.18
Values 5.8 5.6
[90]
THLE COQ6
Mean 7.71
Standard deviation 0.21
Values 7.6 7.9
[91]
liver COQ6
Mean 10.9
Standard deviation 7
Values 12 7.1 20 4
[92]
ref_hepatocyte PDSS2
Mean 5.1
Standard deviation 2
Values 3.9 4.6 2.7 6.8 7.5
[93]
HepG2 PDSS2
Mean 10.8
Standard deviation 2.8
Values 8.8 13
[94]
HepG2.C3A PDSS2
Mean 11.3
Standard deviation 1.6
Values 10 12
[95]
HuH.7 PDSS2
Mean 10.9
Standard deviation 0.57
Values 11 10 11
[96]
SNU475 PDSS2
Mean 3.17
Standard deviation 0.19
Values 3.3 3
[97]
THLE PDSS2
Mean 7.52
Standard deviation 0.72
Values 7 8
[98]
liver PDSS2
Mean 15.4
Standard deviation 2
Values 16 14 18 13
[99]
ref_hepatocyte COQ2
Mean 5.05
Standard deviation 1.9
Values 6.1 4.7 1.9 6.6 5.9
[100]
HepG2 COQ2
Mean 6.49
Standard deviation 2.5
Values 4.7 8.3
[101]
HepG2.C3A COQ2
Mean 5.97
Standard deviation 2.6
Values 4.2 7.8
[102]
HuH.7 COQ2
Mean 4.32
Standard deviation 1.9
Values 4.4 2.4 6.2
[103]
SNU475 COQ2
Mean 2.65
Standard deviation 0.55
Values 3 2.3
[104]
THLE COQ2
Mean 8.62
Standard deviation 1.3
Values 7.7 9.6
[105]
liver COQ2
Mean 5.88
Standard deviation 3
Values 7.1 4.9 9.2 2.3
[106]
ref_hepatocyte COQ7
Mean 3
Standard deviation 1.6
Values 5.2 3.1 0.67 3 3
[107]
HepG2 COQ7
Mean 12.9
Standard deviation 0.69
Values 12 13
[108]
HepG2.C3A COQ7
Mean 13.1
Standard deviation 2.3
Values 11 15
[109]
HuH.7 COQ7
Mean 5.31
Standard deviation 1.2
Values 5.9 4 6.1
[110]
SNU475 COQ7
Mean 3.81
Standard deviation 0.56
Values 4.2 3.4
[111]
THLE COQ7
Mean 5.23
Standard deviation 2.2
Values 3.7 6.8
[112]
liver COQ7
Mean 3.89
Standard deviation 1.3
Values 4 2.8 5.7 3
[113]
ref_hepatocyte PDSS1
Mean 2.39
Standard deviation 0.94
Values 1.8 3.6 3.2 1.9 1.5
[114]
HepG2 PDSS1
Mean 5.47
Standard deviation 0.88
Values 4.8 6.1
[115]
HepG2.C3A PDSS1
Mean 8.85
Standard deviation 4.4
Values 5.8 12
[116]
HuH.7 PDSS1
Mean 6.03
Standard deviation 3.1
Values 6.3 2.8 8.9
[117]
SNU475 PDSS1
Mean 5.28
Standard deviation 1.6
Values 4.2 6.4
[118]
THLE PDSS1
Mean 4.54
Standard deviation 1.2
Values 3.7 5.4
[119]
liver PDSS1
Mean 3.14
Standard deviation 1
Values 3.6 2.8 4.2 1.9
[120]
ref_hepatocyte NOS3
Mean 0.251
Standard deviation 0.22
Values 0.58 0.37 0.014 0.12 0.18
[121]
HepG2 NOS3
Mean 15.1
Standard deviation 1.3
Values 14 16
[122]
HepG2.C3A NOS3
Mean 1.81
Standard deviation 0.061
Values 1.8 1.9
[123]
HuH.7 NOS3
Mean 1.2
Standard deviation 0.2
Values 1.4 1 1.2
[124]
SNU475 NOS3
Mean 0.48
Standard deviation 0.28
Values 0.68 0.28
[125]
THLE NOS3
Mean 1.36
Standard deviation 0.21
Values 1.5 1.2
[126]
liver NOS3
Mean 2.44
Standard deviation 1.3
Values 1.5 2.3 1.6 4.3
[127]
ref_hepatocyte PRKG2
Mean 0.00924
Standard deviation 0.021
Values 0 0 0.046 0 0
[128]
HepG2 PRKG2
Mean 0.153
Standard deviation 0.12
Values 0.24 0.064
[129]
HepG2.C3A PRKG2
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 PRKG2
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 PRKG2
Mean 1.87
Standard deviation 0.4
Values 2.2 1.6
[132]
THLE PRKG2
Mean 0.0402
Standard deviation 0.048
Values 0.0059 0.074
[133]
liver PRKG2
Mean 0.054
Standard deviation 0.05
Values 0.024 0.1 0 0.093