REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CES1 Liver carboxylesterase 1 [1] -1.39[2] -8.19[3] -8.26[4] -1.19[5] -8.32[6] -1.99[7]
2 AGT Angiotensinogen [8] 0.33[9] 1.21[10] 0.45[11] -4.03[12] -8.38[13] 1.36[14]
3 CPB2 Carboxypeptidase B2 [15] -3.33[16] -0.70[17] -0.73[18] -9.79[19] -9.18[20] -0.03[21]
4 CTSD Cathepsin D [22] 2.16[23] 1.42[24] 2.27[25] 2.69[26] 1.50[27] 0.08[28]
5 CTSZ Cathepsin Z [29] -8.16[30] -7.86[31] -0.01[32] 0.30[33] 0.96[34] -2.88[35]
6 ANPEP Aminopeptidase N [36] 1.16[37] 1.65[38] -0.43[39] -2.71[40] 0.65[41] 0.20[42]
7 ATP6AP2 Renin receptor [43] 1.52[44] 1.21[45] 2.47[46] 2.88[47] 4.49[48] -0.48[49]
8 ENPEP Glutamyl aminopeptidase [50] -7.15[51] [52] 0.14[53] 0.99[54] -0.82[55] 1.96[56]
9 MME Neprilysin [57] -5.76[58] -5.77[59] -4.14[60] 2.02[61] 7.11[62] 1.17[63]
10 CTSG Cathepsin G [64] [65] [66] [67] [68] [69] -2.66[70]
11 CPA3 Mast cell carboxypeptidase A [71] [72] [73] [74] -0.91[75] -2.24[76] -0.94[77]
12 ACE Angiotensin-converting enzyme [78] -2.60[79] -5.17[80] -1.83[81] 0.57[82] 0.44[83] 1.69[84]
13 ACE2 Angiotensin-converting enzyme 2 [85] 1.85[86] 3.11[87] 2.97[88] -4.44[89] -3.12[90] -0.57[91]
14 CMA1 Chymase [92] -2.68[93] -4.54[94] [95] -5.15[96] [97] -2.86[98]
15 REN Renin [99] -0.78[100] [101] [102] 0.72[103] [104] -2.34[105]
16 GZMH Granzyme H [106] [107] [108] [109] [110] [111] -0.88[112]
17 CPB1 Carboxypeptidase B [113] [114] [115] [116] [117] [118] [119]
18 AOPEP Aminopeptidase O [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte CES1
Mean 819
Standard deviation 9e+02
Values 1.5e+02 1.8e+02 1.5e+02 1.9e+03 1.7e+03
[2]
HepG2 CES1
Mean 154
Standard deviation 89
Values 2.2e+02 91
[3]
HepG2.C3A CES1
Mean 1.3
Standard deviation 0.53
Values 1.7 0.92
[4]
HuH.7 CES1
Mean 0.67
Standard deviation 0.32
Values 0.52 1 0.46
[5]
SNU475 CES1
Mean 111
Standard deviation 23
Values 1.3e+02 94
[6]
THLE CES1
Mean 0.535
Standard deviation 0.14
Values 0.63 0.44
[7]
liver CES1
Mean 411
Standard deviation 2.6e+02
Values 4.6e+02 3.2e+02 7.4e+02 1.3e+02
[8]
ref_hepatocyte AGT
Mean 439
Standard deviation 4.5e+02
Values 3.3e+02 6.7 77 1.1e+03 7e+02
[9]
HepG2 AGT
Mean 273
Standard deviation 17
Values 2.6e+02 2.9e+02
[10]
HepG2.C3A AGT
Mean 471
Standard deviation 99
Values 5.4e+02 4e+02
[11]
HuH.7 AGT
Mean 150
Standard deviation 28
Values 1.3e+02 1.8e+02 1.4e+02
[12]
SNU475 AGT
Mean 8.25
Standard deviation 2.2
Values 6.7 9.8
[13]
THLE AGT
Mean 0.276
Standard deviation 0.11
Values 0.35 0.2
[14]
liver AGT
Mean 2.25e+03
Standard deviation 2.3e+03
Values 5.5e+03 6.9e+02 2.2e+03 6.1e+02
[15]
ref_hepatocyte CPB2
Mean 186
Standard deviation 2.3e+02
Values 22 9.5 24 3.7e+02 5e+02
[16]
HepG2 CPB2
Mean 9.09
Standard deviation 7
Values 4.2 14
[17]
HepG2.C3A CPB2
Mean 53.2
Standard deviation 15
Values 43 64
[18]
HuH.7 CPB2
Mean 28
Standard deviation 5.1
Values 31 22 31
[19]
SNU475 CPB2
Mean 0.0646
Standard deviation 0.052
Values 0.028 0.1
[20]
THLE CPB2
Mean 0.0671
Standard deviation 0.0029
Values 0.065 0.069
[21]
liver CPB2
Mean 363
Standard deviation 56
Values 4.1e+02 3.3e+02 4.1e+02 3e+02
[22]
ref_hepatocyte CTSD
Mean 163
Standard deviation 1.5e+02
Values 55 47 52 3.5e+02 3.1e+02
[23]
HepG2 CTSD
Mean 358
Standard deviation 87
Values 4.2e+02 3e+02
[24]
HepG2.C3A CTSD
Mean 202
Standard deviation 99
Values 2.7e+02 1.3e+02
[25]
HuH.7 CTSD
Mean 197
Standard deviation 23
Values 2e+02 2.2e+02 1.7e+02
[26]
SNU475 CTSD
Mean 323
Standard deviation 45
Values 3.5e+02 2.9e+02
[27]
THLE CTSD
Mean 96
Standard deviation 31
Values 74 1.2e+02
[28]
liver CTSD
Mean 342
Standard deviation 2.6e+02
Values 5.9e+02 1.2e+02 5.4e+02 1.2e+02
[29]
ref_hepatocyte CTSZ
Mean 117
Standard deviation 72
Values 0.16 1.8e+02 96 1.7e+02 1.5e+02
[30]
HepG2 CTSZ
Mean 0.203
Standard deviation 0.011
Values 0.19 0.21
[31]
HepG2.C3A CTSZ
Mean 0.234
Standard deviation 0.15
Values 0.34 0.13
[32]
HuH.7 CTSZ
Mean 29.3
Standard deviation 2.2
Values 27 29 32
[33]
SNU475 CTSZ
Mean 44.5
Standard deviation 7.5
Values 50 39
[34]
THLE CTSZ
Mean 47.8
Standard deviation 2.1
Values 46 49
[35]
liver CTSZ
Mean 31.8
Standard deviation 31
Values 7.1 52 3.2 65
[36]
ref_hepatocyte ANPEP
Mean 59.7
Standard deviation 59
Values 13 14 24 1.2e+02 1.2e+02
[37]
HepG2 ANPEP
Mean 65.7
Standard deviation 12
Values 57 74
[38]
HepG2.C3A ANPEP
Mean 86.7
Standard deviation 36
Values 1.1e+02 61
[39]
HuH.7 ANPEP
Mean 11.1
Standard deviation 2.1
Values 11 13 9.3
[40]
SNU475 ANPEP
Mean 2.8
Standard deviation 2
Values 1.4 4.2
[41]
THLE ANPEP
Mean 19.6
Standard deviation 4.8
Values 16 23
[42]
liver ANPEP
Mean 137
Standard deviation 57
Values 1.9e+02 72 1.8e+02 1.1e+02
[43]
ref_hepatocyte ATP6AP2
Mean 27.6
Standard deviation 12
Values 30 41 8.8 27 31
[44]
HepG2 ATP6AP2
Mean 39.1
Standard deviation 6
Values 35 43
[45]
HepG2.C3A ATP6AP2
Mean 29.7
Standard deviation 1.8
Values 28 31
[46]
HuH.7 ATP6AP2
Mean 38.4
Standard deviation 4.6
Values 36 36 44
[47]
SNU475 ATP6AP2
Mean 62.4
Standard deviation 9.8
Values 69 55
[48]
THLE ATP6AP2
Mean 130
Standard deviation 21
Values 1.2e+02 1.4e+02
[49]
liver ATP6AP2
Mean 39.5
Standard deviation 21
Values 52 25 62 19
[50]
ref_hepatocyte ENPEP
Mean 5.78
Standard deviation 6.1
Values 0.12 4 0.61 10 14
[51]
HepG2 ENPEP
Mean 0.02
Standard deviation 0.02
Values 0.0057 0.034
[52]
HepG2.C3A ENPEP
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 ENPEP
Mean 1.59
Standard deviation 0.32
Values 1.4 2 1.4
[54]
SNU475 ENPEP
Mean 3.53
Standard deviation 0.67
Values 4 3.1
[55]
THLE ENPEP
Mean 0.686
Standard deviation 0.59
Values 1.1 0.27
[56]
liver ENPEP
Mean 44.8
Standard deviation 6.8
Values 45 53 36 45
[57]
ref_hepatocyte MME
Mean 2.99
Standard deviation 3.7
Values 0.021 1.4 0.39 4.1 9
[58]
HepG2 MME
Mean 0.0272
Standard deviation 0.026
Values 0.046 0.0086
[59]
HepG2.C3A MME
Mean 0.0253
Standard deviation 0.0055
Values 0.029 0.021
[60]
HuH.7 MME
Mean 0.0425
Standard deviation 0.021
Values 0.057 0.051 0.019
[61]
SNU475 MME
Mean 3.72
Standard deviation 2
Values 2.3 5.1
[62]
THLE MME
Mean 86.1
Standard deviation 25
Values 1e+02 68
[63]
liver MME
Mean 13.4
Standard deviation 7.6
Values 6.5 24 11 12
[64]
ref_hepatocyte CTSG
Mean 0.731
Standard deviation 1.1
Values 0 0 0 1.2 2.4
[65]
HepG2 CTSG
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A CTSG
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 CTSG
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 CTSG
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE CTSG
Mean 0
Standard deviation 0
Values 0 0
[70]
liver CTSG
Mean 0.232
Standard deviation 0.29
Values 0.071 0.21 0.64 0
[71]
ref_hepatocyte CPA3
Mean 0.435
Standard deviation 0.62
Values 0 0 0 1.4 0.82
[72]
HepG2 CPA3
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A CPA3
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 CPA3
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 CPA3
Mean 0.0711
Standard deviation 0.05
Values 0.11 0.035
[76]
THLE CPA3
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[77]
liver CPA3
Mean 0.453
Standard deviation 0.52
Values 0.024 1.2 0.49 0.13
[78]
ref_hepatocyte ACE
Mean 0.377
Standard deviation 0.39
Values 0 0.023 0.66 0.9 0.31
[79]
HepG2 ACE
Mean 0.0308
Standard deviation 0.037
Values 0.057 0.0043
[80]
HepG2.C3A ACE
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 ACE
Mean 0.0267
Standard deviation 0.016
Values 0.016 0.045 0.019
[82]
SNU475 ACE
Mean 0.172
Standard deviation 0.014
Values 0.16 0.18
[83]
THLE ACE
Mean 0.107
Standard deviation 0.024
Values 0.12 0.09
[84]
liver ACE
Mean 2.42
Standard deviation 0.61
Values 1.7 3.1 2.2 2.7
[85]
ref_hepatocyte ACE2
Mean 0.357
Standard deviation 0.39
Values 0.17 1 0 0.21 0.41
[86]
HepG2 ACE2
Mean 0.635
Standard deviation 0.46
Values 0.31 0.96
[87]
HepG2.C3A ACE2
Mean 1.43
Standard deviation 0.89
Values 0.81 2.1
[88]
HuH.7 ACE2
Mean 0.702
Standard deviation 0.38
Values 0.5 1.1 0.47
[89]
SNU475 ACE2
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[90]
THLE ACE2
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[91]
liver ACE2
Mean 0.481
Standard deviation 0.28
Values 0.4 0.9 0.28 0.34
[92]
ref_hepatocyte CMA1
Mean 0.269
Standard deviation 0.51
Values 0 0 0 0.18 1.2
[93]
HepG2 CMA1
Mean 0.0207
Standard deviation 0.013
Values 0.011 0.03
[94]
HepG2.C3A CMA1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[95]
HuH.7 CMA1
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 CMA1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[97]
THLE CMA1
Mean 0
Standard deviation 0
Values 0 0
[98]
liver CMA1
Mean 0.0741
Standard deviation 0.051
Values 0 0.11 0.1 0.079
[99]
ref_hepatocyte REN
Mean 0.266
Standard deviation 0.46
Values 0 0 1.1 0.095 0.16
[100]
HepG2 REN
Mean 0.0766
Standard deviation 0.029
Values 0.097 0.056
[101]
HepG2.C3A REN
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 REN
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 REN
Mean 0.135
Standard deviation 0.12
Values 0.046 0.22
[104]
THLE REN
Mean 0
Standard deviation 0
Values 0 0
[105]
liver REN
Mean 0.105
Standard deviation 0.13
Values 0 0.14 0 0.28
[106]
ref_hepatocyte GZMH
Mean 0.219
Standard deviation 0.31
Values 0 0 0 0.64 0.46
[107]
HepG2 GZMH
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A GZMH
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 GZMH
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 GZMH
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE GZMH
Mean 0
Standard deviation 0
Values 0 0
[112]
liver GZMH
Mean 0.237
Standard deviation 0.2
Values 0.12 0.17 0.54 0.12
[113]
ref_hepatocyte CPB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 CPB1
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A CPB1
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 CPB1
Mean 0.0403
Standard deviation 0.042
Values 0 0.083 0.037
[117]
SNU475 CPB1
Mean 0.222
Standard deviation 0.18
Values 0.35 0.096
[118]
THLE CPB1
Mean 0
Standard deviation 0
Values 0 0
[119]
liver CPB1
Mean 0.0567
Standard deviation 0.088
Values 0.19 0 0.026 0.013
[120]
ref_hepatocyte AOPEP
Missing
[121]
HepG2 AOPEP
Missing
[122]
HepG2.C3A AOPEP
Missing
[123]
HuH.7 AOPEP
Missing
[124]
SNU475 AOPEP
Missing
[125]
THLE AOPEP
Missing
[126]
liver AOPEP
Missing