REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DIO1 Type I iodothyronine deiodinase [1] -0.14[2] -0.47[3] -2.13[4] -5.03[5] -4.43[6] -0.10[7]
2 DDC Aromatic-L-amino-acid decarboxylase [8] 0.04[9] 0.50[10] 1.30[11] -2.14[12] -3.26[13] -0.34[14]
3 IYD Iodotyrosine deiodinase 1 [15] -1.20[16] -1.70[17] -1.49[18] -0.28[19] -0.16[20] 1.16[21]
4 ASMT Acetylserotonin O-methyltransferase [22] [23] [24] [25] [26] [27] [28]
5 DIO3 Thyroxine 5-deiodinase [29] [30] [31] -2.87[32] -0.15[33] -2.13[34] -3.21[35]
6 SLC5A5 Sodium/iodide cotransporter [36] 0.00[37] 0.10[38] 0.04[39] 3.43[40] 2.71[41] -2.26[42]
7 DUOX2 Dual oxidase 2 [43] 2.76[44] -2.94[45] -1.77[46] 1.31[47] 0.81[48] -2.28[49]
8 DBH Dopamine beta-hydroxylase [50] 2.45[51] 3.77[52] 1.95[53] -1.43[54] 2.72[55] 4.49[56]
9 DUOX1 Dual oxidase 1 [57] 1.10[58] 0.91[59] -0.35[60] 3.22[61] 3.83[62] 0.88[63]
10 TH Tyrosine 3-monooxygenase [64] 3.49[65] [66] [67] [68] 1.03[69] 1.05[70]
11 CGA Glycoprotein hormones alpha chain [71] [72] [73] -1.58[74] 1.55[75] 0.16[76] -4.61[77]
12 DIO2 Type II iodothyronine deiodinase [78] 1.04[79] [80] -0.55[81] 10.58[82] 10.58[83] 1.65[84]
13 AANAT Serotonin N-acetyltransferase [85] 1.47[86] 3.27[87] 2.71[88] 6.44[89] 5.85[90] 0.63[91]
14 TPH2 Tryptophan 5-hydroxylase 2 [92] [93] [94] [95] [96] [97] [98]
15 PNMT Phenylethanolamine N-methyltransferase [99] [100] [101] [102] [103] [104] [105]
16 TPH1 Tryptophan 5-hydroxylase 1 [106] [107] [108] [109] [110] [111] [112]
17 TPO Thyroid peroxidase [113] [114] [115] [116] [117] [118] [119]
18 TSHB Thyrotropin subunit beta [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte DIO1
Mean 29
Standard deviation 27
Values 24 2.5 3.8 53 61
[2]
HepG2 DIO1
Mean 13.4
Standard deviation 8.3
Values 7.5 19
[3]
HepG2.C3A DIO1
Mean 15.8
Standard deviation 0.073
Values 16 16
[4]
HuH.7 DIO1
Mean 7.28
Standard deviation 4.8
Values 3.8 13 5.3
[5]
SNU475 DIO1
Mean 0.0487
Standard deviation 0.0099
Values 0.042 0.056
[6]
THLE DIO1
Mean 0.0872
Standard deviation 0.011
Values 0.095 0.08
[7]
liver DIO1
Mean 54.4
Standard deviation 59
Values 1.4e+02 13 23 41
[8]
ref_hepatocyte DDC
Mean 16.2
Standard deviation 7.9
Values 20 15 3.1 19 24
[9]
HepG2 DDC
Mean 8.45
Standard deviation 3.2
Values 6.2 11
[10]
HepG2.C3A DDC
Mean 17.3
Standard deviation 4.6
Values 14 21
[11]
HuH.7 DDC
Mean 43.9
Standard deviation 9.4
Values 45 34 53
[12]
SNU475 DDC
Mean 0.201
Standard deviation 0.063
Values 0.25 0.16
[13]
THLE DDC
Mean 0.11
Standard deviation 0.087
Values 0.17 0.048
[14]
liver DDC
Mean 25.7
Standard deviation 11
Values 41 15 19 28
[15]
ref_hepatocyte IYD
Mean 1.19
Standard deviation 1.6
Values 0.14 0.6 0.038 1.2 4
[16]
HepG2 IYD
Mean 0.263
Standard deviation 0.11
Values 0.34 0.19
[17]
HepG2.C3A IYD
Mean 0.278
Standard deviation 0.077
Values 0.22 0.33
[18]
HuH.7 IYD
Mean 0.469
Standard deviation 0.18
Values 0.41 0.67 0.33
[19]
SNU475 IYD
Mean 0.0538
Standard deviation 0.017
Values 0.042 0.066
[20]
THLE IYD
Mean 0.0692
Standard deviation 0.023
Values 0.053 0.085
[21]
liver IYD
Mean 5.38
Standard deviation 0.69
Values 6 5.9 5 4.6
[22]
ref_hepatocyte ASMT
Mean 0.657
Standard deviation 0.74
Values 0.29 0.27 0 1.8 0.88
[23]
HepG2 ASMT
Missing
[24]
HepG2.C3A ASMT
Missing
[25]
HuH.7 ASMT
Missing
[26]
SNU475 ASMT
Missing
[27]
THLE ASMT
Missing
[28]
liver ASMT
Missing
[29]
ref_hepatocyte DIO3
Mean 0.359
Standard deviation 0.52
Values 0 0 0.65 1.1 0
[30]
HepG2 DIO3
Mean 0
Standard deviation 0
Values 0 0
[31]
HepG2.C3A DIO3
Mean 0
Standard deviation 0
Values 0 0
[32]
HuH.7 DIO3
Mean 0.0541
Standard deviation 0.065
Values 0.025 0.13 0.0094
[33]
SNU475 DIO3
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[34]
THLE DIO3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[35]
liver DIO3
Mean 0.0785
Standard deviation 0.08
Values 0.024 0.17 0 0.12
[36]
ref_hepatocyte SLC5A5
Mean 0.297
Standard deviation 0.18
Values 0.61 0.27 0.15 0.23 0.21
[37]
HepG2 SLC5A5
Mean 0.151
Standard deviation 0.011
Values 0.14 0.16
[38]
HepG2.C3A SLC5A5
Mean 0.241
Standard deviation 0.038
Values 0.21 0.27
[39]
HuH.7 SLC5A5
Mean 0.336
Standard deviation 0.081
Values 0.25 0.42 0.34
[40]
SNU475 SLC5A5
Mean 0.175
Standard deviation 0.054
Values 0.21 0.14
[41]
THLE SLC5A5
Mean 0.127
Standard deviation 0.089
Values 0.19 0.064
[42]
liver SLC5A5
Mean 0.125
Standard deviation 0.1
Values 0.047 0.27 0.051 0.13
[43]
ref_hepatocyte DUOX2
Mean 0.247
Standard deviation 0.52
Values 0 0 1.2 0.052 0
[44]
HepG2 DUOX2
Mean 0.851
Standard deviation 0.48
Values 1.2 0.51
[45]
HepG2.C3A DUOX2
Mean 0.0243
Standard deviation 0.034
Values 0.049 0
[46]
HuH.7 DUOX2
Mean 0.0795
Standard deviation 0.0089
Values 0.074 0.09 0.075
[47]
SNU475 DUOX2
Mean 0.0335
Standard deviation 0.012
Values 0.042 0.025
[48]
THLE DUOX2
Mean 0.0281
Standard deviation 0.0021
Values 0.03 0.027
[49]
liver DUOX2
Mean 0.102
Standard deviation 0.078
Values 0.024 0.11 0.21 0.066
[50]
ref_hepatocyte DBH
Mean 0.238
Standard deviation 0.38
Values 0 0 0 0.31 0.88
[51]
HepG2 DBH
Mean 0.659
Standard deviation 0.37
Values 0.4 0.92
[52]
HepG2.C3A DBH
Mean 2.44
Standard deviation 0.22
Values 2.6 2.3
[53]
HuH.7 DBH
Mean 1.01
Standard deviation 0.5
Values 0.98 1.5 0.53
[54]
SNU475 DBH
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[55]
THLE DBH
Mean 0.102
Standard deviation 0.031
Values 0.12 0.08
[56]
liver DBH
Mean 10.8
Standard deviation 6.3
Values 4.7 7.6 19 12
[57]
ref_hepatocyte DUOX1
Mean 0.147
Standard deviation 0.22
Values 0.042 0 0.52 0.17 0
[58]
HepG2 DUOX1
Mean 0.161
Standard deviation 0.033
Values 0.14 0.18
[59]
HepG2.C3A DUOX1
Mean 0.209
Standard deviation 0.0073
Values 0.2 0.21
[60]
HuH.7 DUOX1
Mean 0.128
Standard deviation 0.14
Values 0.082 0.28 0.019
[61]
SNU475 DUOX1
Mean 0.0755
Standard deviation 0.015
Values 0.065 0.086
[62]
THLE DUOX1
Mean 0.136
Standard deviation 0.034
Values 0.16 0.11
[63]
liver DUOX1
Mean 0.548
Standard deviation 0.41
Values 0.33 0.56 0.18 1.1
[64]
ref_hepatocyte TH
Mean 0.0869
Standard deviation 0.15
Values 0 0 0.35 0 0.089
[65]
HepG2 TH
Mean 0.495
Standard deviation 0.24
Values 0.66 0.33
[66]
HepG2.C3A TH
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 TH
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 TH
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE TH
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[70]
liver TH
Mean 0.362
Standard deviation 0.4
Values 0.16 0.23 0.1 0.95
[71]
ref_hepatocyte CGA
Mean 0.0776
Standard deviation 0.17
Values 0 0 0 0.39 0
[72]
HepG2 CGA
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A CGA
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 CGA
Mean 0.0287
Standard deviation 0.011
Values 0.016 0.032 0.037
[75]
SNU475 CGA
Mean 0.0125
Standard deviation 0.011
Values 0.0046 0.02
[76]
THLE CGA
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[77]
liver CGA
Mean 0.00642
Standard deviation 0.013
Values 0 0 0.026 0
[78]
ref_hepatocyte DIO2
Mean 0.0226
Standard deviation 0.031
Values 0.061 0 0 0.052 0
[79]
HepG2 DIO2
Mean 0.0236
Standard deviation 0.0091
Values 0.017 0.03
[80]
HepG2.C3A DIO2
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 DIO2
Mean 0.017
Standard deviation 0.011
Values 0.016 0.0064 0.028
[82]
SNU475 DIO2
Mean 1.89
Standard deviation 1.3
Values 0.99 2.8
[83]
THLE DIO2
Mean 2.25
Standard deviation 0.12
Values 2.2 2.3
[84]
liver DIO2
Mean 0.143
Standard deviation 0.12
Values 0 0.26 0.077 0.24
[85]
ref_hepatocyte AANAT
Mean 0.00813
Standard deviation 0.018
Values 0 0 0 0 0.041
[86]
HepG2 AANAT
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[87]
HepG2.C3A AANAT
Mean 0.0593
Standard deviation 0.054
Values 0.097 0.021
[88]
HuH.7 AANAT
Mean 0.0585
Standard deviation 0.03
Values 0.066 0.026 0.084
[89]
SNU475 AANAT
Mean 0.0386
Standard deviation 0.0044
Values 0.042 0.035
[90]
THLE AANAT
Mean 0.0305
Standard deviation 0.0096
Values 0.024 0.037
[91]
liver AANAT
Mean 0.0253
Standard deviation 0.021
Values 0.024 0 0.051 0.026
[92]
ref_hepatocyte TPH2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 TPH2
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A TPH2
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 TPH2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[96]
SNU475 TPH2
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE TPH2
Mean 0
Standard deviation 0
Values 0 0
[98]
liver TPH2
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[99]
ref_hepatocyte PNMT
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 PNMT
Mean 0.115
Standard deviation 0.096
Values 0.18 0.047
[101]
HepG2.C3A PNMT
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[102]
HuH.7 PNMT
Mean 0.00975
Standard deviation 0.0086
Values 0.016 0.013 0
[103]
SNU475 PNMT
Mean 0.0652
Standard deviation 0.0062
Values 0.07 0.061
[104]
THLE PNMT
Mean 0.089
Standard deviation 0.058
Values 0.13 0.048
[105]
liver PNMT
Mean 0.0565
Standard deviation 0.034
Values 0.094 0.029 0.077 0.026
[106]
ref_hepatocyte TPH1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 TPH1
Mean 0.0701
Standard deviation 0.01
Values 0.063 0.077
[108]
HepG2.C3A TPH1
Mean 0.269
Standard deviation 0.11
Values 0.19 0.34
[109]
HuH.7 TPH1
Mean 0.0367
Standard deviation 0.025
Values 0.066 0.026 0.019
[110]
SNU475 TPH1
Mean 0.0361
Standard deviation 0.008
Values 0.042 0.03
[111]
THLE TPH1
Mean 0.0911
Standard deviation 0.039
Values 0.12 0.064
[112]
liver TPH1
Mean 0.0508
Standard deviation 0.037
Values 0 0.086 0.051 0.066
[113]
ref_hepatocyte TPO
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 TPO
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[115]
HepG2.C3A TPO
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[116]
HuH.7 TPO
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 TPO
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE TPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[119]
liver TPO
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte TSHB
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 TSHB
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A TSHB
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 TSHB
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 TSHB
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[125]
THLE TSHB
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[126]
liver TSHB
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0