REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | JUN | Transcription factor AP-1 | [1] | -0.67[2] | -2.25[3] | -1.99[4] | -1.95[5] | -1.20[6] | -2.18[7] |
2 | FOS | Proto-oncogene c-Fos | [8] | -6.19[9] | -4.97[10] | -5.64[11] | -6.42[12] | -5.17[13] | -1.68[14] |
3 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 0.62[15] | 0.41[16] | 0.32[17] | 0.96[18] | 0.47[19] | -0.23[20] | |
4 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 0.09[21] | 0.15[22] | -0.50[23] | 0.49[24] | 0.79[25] | -0.48[26] | |
5 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | -0.57[27] | -0.95[28] | -0.88[29] | -0.71[30] | -0.63[31] | -1.36[32] | |
6 | DUSP3 | Dual specificity protein phosphatase 3 | [33] | 0.59[34] | -0.04[35] | 0.48[36] | -0.93[37] | -0.73[38] | 1.03[39] |
7 | DUSP6 | Dual specificity protein phosphatase 6 | [40] | -0.67[41] | 1.38[42] | 0.64[43] | -4.16[44] | -0.19[45] | -0.12[46] |
8 | MAPKAPK | MAP kinase-activated protein kinase 2 | [47] | 0.28[48] | -0.72[49] | -0.32[50] | 1.14[51] | 0.54[52] | -1.32[53] |
9 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 0.27[54] | -0.29[55] | 0.11[56] | 0.02[57] | -0.01[58] | 2.56[59] | |
10 | MAPK1 | Mitogen-activated protein kinase 1 | [60] | 1.53[61] | 1.63[62] | 1.45[63] | 1.60[64] | 1.43[65] | 1.40[66] |
11 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [67] | [68] | [69] | [70] | [71] | [72] | [73] |
12 | VRK3 | Inactive serine/threonine-protein kinase VRK3 | [74] | -0.94[75] | -0.81[76] | -0.54[77] | -1.40[78] | -1.60[79] | -0.86[80] |
13 | MAPK14 | Mitogen-activated protein kinase 14 | [81] | 1.29[82] | 1.33[83] | 0.89[84] | 1.43[85] | 1.09[86] | 0.91[87] |
14 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 1.07[88] | 0.79[89] | 0.34[90] | 1.04[91] | 1.11[92] | -0.64[93] | |
15 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [94] | 0.46[95] | 1.47[96] | 1.69[97] | 0.53[98] | 0.49[99] | 0.64[100] |
16 | MAPK8 | Mitogen-activated protein kinase 8 | [101] | -1.63[102] | -0.25[103] | -1.39[104] | -1.15[105] | -1.11[106] | -0.89[107] |
17 | ELK1 | ETS domain-containing protein Elk-1 | [108] | -0.49[109] | -2.67[110] | -0.26[111] | 0.02[112] | 0.79[113] | -0.54[114] |
18 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [115] | [116] | [117] | [118] | [119] | [120] | [121] |
19 | ATF1 | Cyclic AMP-dependent transcription factor ATF-1 | [122] | -0.80[123] | 0.41[124] | 0.13[125] | -0.10[126] | -0.03[127] | -0.86[128] |
20 | MAPK9 | Mitogen-activated protein kinase 9 | [129] | 1.05[130] | 1.24[131] | 1.28[132] | 1.46[133] | 1.10[134] | 0.13[135] |
21 | MAPK3 | Mitogen-activated protein kinase 3 | [136] | 1.67[137] | 1.68[138] | 1.71[139] | 0.17[140] | 0.38[141] | -1.42[142] |
22 | MEF2A | Myocyte-specific enhancer factor 2A | [143] | -0.21[144] | 0.54[145] | 1.20[146] | 0.92[147] | 1.19[148] | 1.78[149] |
23 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [150] | 1.54[151] | 2.66[152] | 3.14[153] | 2.29[154] | 2.42[155] | 1.97[156] |
24 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [157] | [158] | [159] | [160] | [161] | [162] | [163] |
25 | DUSP7 | Dual specificity protein phosphatase 7 | [164] | 1.37[165] | 0.42[166] | 1.66[167] | -0.68[168] | 1.90[169] | -0.35[170] |
26 | MAPK7 | Mitogen-activated protein kinase 7 | [171] | 1.26[172] | 0.52[173] | 0.50[174] | 1.55[175] | 1.83[176] | -0.04[177] |
27 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | [178] | [179] | [180] | [181] | [182] | [183] | [184] |
28 | MAPK11 | Mitogen-activated protein kinase 11 | [185] | -0.35[186] | -0.49[187] | -1.39[188] | 0.10[189] | 2.28[190] | -0.21[191] |
29 | MEF2C | Myocyte-specific enhancer factor 2C | [192] | -3.29[193] | -2.20[194] | 2.75[195] | 5.36[196] | 1.53[197] | 4.91[198] |
30 | DUSP4 | Dual specificity protein phosphatase 4 | [199] | 5.33[200] | 2.28[201] | 8.17[202] | 7.48[203] | 5.61[204] | 3.46[205] |
31 | MAPK10 | Mitogen-activated protein kinase 10 | [206] | -1.66[207] | [208] | [209] | 8.66[210] | 4.58[211] | 6.87[212] |