REACTOME_MAPK6_MAPK4_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.20[2] | -1.32[3] | -1.17[4] | -1.60[5] | -1.12[6] | -0.48[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.76[16] | -0.57[17] | -0.80[18] | -0.74[19] | -0.74[20] | -0.03[21] |
4 | HSPB1 | Heat shock protein beta-1 | [22] | -2.50[23] | -3.23[24] | -2.48[25] | -0.21[26] | -2.36[27] | -2.41[28] |
5 | PSME1 | Proteasome activator complex subunit 1 | [29] | -0.53[30] | -2.16[31] | -1.77[32] | -1.46[33] | -1.96[34] | -0.98[35] |
6 | PSME2 | Proteasome activator complex subunit 2 | [36] | -0.35[37] | -1.78[38] | -1.86[39] | -1.25[40] | -1.50[41] | -0.61[42] |
7 | CDC42 | Cell division control protein 42 homolog | [43] | 0.17[44] | 0.97[45] | -0.04[46] | 0.65[47] | -0.05[48] | -0.69[49] |
8 | PSMA7 | Proteasome subunit alpha type-7 | [50] | 0.61[51] | 0.69[52] | -0.62[53] | 0.38[54] | -0.03[55] | 0.41[56] |
9 | PSMB1 | Proteasome subunit beta type-1 | [57] | 0.15[58] | 0.24[59] | -0.81[60] | -0.87[61] | -0.06[62] | 0.25[63] |
10 | PSMB3 | Proteasome subunit beta type-3 | [64] | -0.33[65] | -1.15[66] | -0.09[67] | -0.89[68] | -0.97[69] | -0.05[70] |
11 | PSMB4 | Proteasome subunit beta type-4 | [71] | -0.08[72] | 0.05[73] | 0.21[74] | 0.54[75] | 0.57[76] | -0.37[77] |
12 | PSMB7 | Proteasome subunit beta type-7 | [78] | -1.03[79] | -1.05[80] | -0.89[81] | -1.23[82] | -0.75[83] | -0.81[84] |
13 | PSMB5 | Proteasome subunit beta type-5 | [85] | 1.37[86] | -0.09[87] | -0.13[88] | -0.51[89] | -0.19[90] | -0.34[91] |
14 | PSMA6 | Proteasome subunit alpha type-6 | [92] | 1.50[93] | 0.19[94] | 0.15[95] | 0.02[96] | 0.07[97] | -0.25[98] |
15 | PSMA4 | Proteasome subunit alpha type-4 | [99] | -0.43[100] | 0.21[101] | 0.03[102] | 0.32[103] | 0.19[104] | -0.33[105] |
16 | PSMC3 | 26S proteasome regulatory subunit 6A | [106] | -0.46[107] | -0.55[108] | 0.09[109] | -0.88[110] | -0.64[111] | 0.14[112] |
17 | PSMA3 | Proteasome subunit alpha type-3 | [113] | -1.05[114] | -0.07[115] | -0.72[116] | -0.13[117] | -0.54[118] | -0.09[119] |
18 | PSMB6 | Proteasome subunit beta type-6 | [120] | -0.50[121] | -0.38[122] | -0.20[123] | -0.68[124] | -0.90[125] | 0.07[126] |
19 | PSMA2 | Proteasome subunit alpha type-2 | [127] | -0.59[128] | 0.35[129] | 0.71[130] | -0.18[131] | 0.23[132] | 0.30[133] |
20 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [134] | -0.07[135] | -0.08[136] | 0.15[137] | 0.52[138] | 0.03[139] | -0.03[140] |
21 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [141] | -0.15[142] | 0.20[143] | 0.09[144] | -0.57[145] | -0.05[146] | -0.20[147] |
22 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [148] | 0.02[149] | 0.24[150] | 0.40[151] | -0.29[152] | 0.51[153] | -0.18[154] |
23 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [155] | 1.55[156] | 0.71[157] | 0.80[158] | 0.82[159] | 2.16[160] | 0.86[161] |
24 | PSMC1 | 26S proteasome regulatory subunit 4 | [162] | -0.13[163] | -0.09[164] | -0.71[165] | 1.00[166] | 0.57[167] | 0.02[168] |
25 | PSMA1 | Proteasome subunit alpha type-1 | [169] | 0.05[170] | 0.42[171] | 0.51[172] | 0.58[173] | 0.13[174] | 0.51[175] |
26 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [176] | 1.67[177] | 1.66[178] | 2.71[179] | 0.65[180] | 1.49[181] | 0.74[182] |
27 | PSMC5 | 26S proteasome regulatory subunit 8 | [183] | 0.37[184] | 0.24[185] | 0.35[186] | -0.01[187] | 0.44[188] | 0.27[189] |
28 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [190] | 0.60[191] | 0.35[192] | 1.07[193] | 1.20[194] | 1.20[195] | 0.43[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.77[198] | 0.24[199] | 0.86[200] | 0.52[201] | 0.79[202] | -0.01[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.63[205] | -2.24[206] | -9.43[207] | 0.49[208] | -0.77[209] | -0.70[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.06[212] | 0.53[213] | 0.81[214] | 0.38[215] | 0.46[216] | -0.16[217] |
32 | DNAJB1 | DnaJ homolog subfamily B member 1 | [218] | 1.24[219] | 0.79[220] | 0.75[221] | -0.20[222] | 0.14[223] | -0.13[224] |
33 | PSMC4 | 26S proteasome regulatory subunit 6B | [225] | 0.37[226] | 0.38[227] | 0.34[228] | 0.01[229] | 0.17[230] | 0.32[231] |
34 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [232] | -0.78[233] | -0.32[234] | -1.38[235] | -0.62[236] | 0.24[237] | -0.27[238] |
35 | JUN | Transcription factor AP-1 | [239] | 0.51[240] | -0.96[241] | -0.68[242] | -0.52[243] | 0.07[244] | -0.42[245] |
36 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [246] | 0.41[247] | 0.51[248] | 1.03[249] | 0.44[250] | 0.00[251] | -0.08[252] |
37 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [253] | -0.41[254] | -0.35[255] | -0.63[256] | 0.06[257] | 0.18[258] | -0.16[259] |
38 | PSMC6 | 26S proteasome regulatory subunit 10B | [260] | -0.11[261] | 1.45[262] | 0.29[263] | 0.42[264] | 0.40[265] | 0.50[266] |
39 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [267] | 0.77[268] | 0.37[269] | 0.98[270] | 0.83[271] | 1.03[272] | 1.32[273] |
40 | PSMC2 | 26S proteasome regulatory subunit 7 | [274] | 0.53[275] | 0.91[276] | 0.71[277] | 1.22[278] | 1.10[279] | 1.37[280] |
41 | MYC | Myc proto-oncogene protein | [281] | 1.42[282] | 1.17[283] | -0.86[284] | -1.61[285] | 0.78[286] | -0.61[287] |
42 | PSME3 | Proteasome activator complex subunit 3 | [288] | 1.76[289] | 1.45[290] | 1.16[291] | 1.25[292] | 1.56[293] | 0.94[294] |
43 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [295] | 1.52[296] | 1.81[297] | 1.72[298] | 2.05[299] | 2.11[300] | 2.13[301] |
44 | MAPK6 | Mitogen-activated protein kinase 6 | [302] | 1.03[303] | 2.57[304] | 2.72[305] | 1.82[306] | 1.04[307] | 1.33[308] |
45 | PSMB10 | Proteasome subunit beta type-10 | [309] | -1.21[310] | -0.63[311] | -2.50[312] | -0.16[313] | -1.28[314] | -0.02[315] |
46 | PSMA5 | Proteasome subunit alpha type-5 | [316] | 1.84[317] | 2.25[318] | 1.84[319] | 2.11[320] | 1.71[321] | 1.97[322] |
47 | PSMF1 | Proteasome inhibitor PI31 subunit | [323] | 2.22[324] | 2.25[325] | 1.08[326] | 1.11[327] | 0.92[328] | 1.91[329] |
48 | PSMB2 | Proteasome subunit beta type-2 | [330] | 2.00[331] | 1.72[332] | 2.13[333] | 2.41[334] | 2.44[335] | 2.45[336] |
49 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [337] | 0.83[338] | 0.74[339] | 0.74[340] | 0.71[341] | 1.32[342] | 0.61[343] |
50 | PSMB9 | Proteasome subunit beta type-9 | [344] | -2.00[345] | -4.64[346] | -6.93[347] | 1.66[348] | -0.56[349] | -0.44[350] |
51 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [351] | 0.38[352] | 0.85[353] | -0.11[354] | 0.29[355] | 0.77[356] | 0.78[357] |
52 | XPO1 | Exportin-1 | [358] | 2.35[359] | 3.15[360] | 3.18[361] | 3.31[362] | 3.42[363] | 2.25[364] |
53 | PAK2 | Serine/threonine-protein kinase PAK 2 | [365] | 2.44[366] | 2.27[367] | 2.57[368] | 1.94[369] | 2.50[370] | 2.76[371] |
54 | MAPKAPK | MAP kinase-activated protein kinase 5 | [372] | 0.17[373] | 1.09[374] | 1.04[375] | -0.02[376] | 0.24[377] | 0.44[378] |
55 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [379] | 0.94[380] | 1.24[381] | 1.29[382] | 1.96[383] | 1.32[384] | 0.77[385] |
56 | PSME4 | Proteasome activator complex subunit 4 | [386] | 2.46[387] | 3.35[388] | 3.38[389] | 2.52[390] | 2.52[391] | 3.03[392] |
57 | MOV10 | Putative helicase MOV-10 | [393] | 1.98[394] | 2.28[395] | 2.27[396] | 2.26[397] | 2.12[398] | 2.47[399] |
58 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [400] | 1.35[401] | 0.89[402] | 2.47[403] | 2.34[404] | 2.47[405] | 2.21[406] |
59 | CDK1 | Cyclin-dependent kinase 1 | [407] | 2.25[408] | 4.39[409] | 3.13[410] | 3.45[411] | 4.29[412] | -1.08[413] |
60 | CDC14B | Dual specificity protein phosphatase CDC14B | [414] | 1.81[415] | 2.02[416] | 2.01[417] | 1.36[418] | 2.04[419] | 2.80[420] |
61 | MMP10 | Stromelysin-2 | [421] | -5.32[422] | -9.66[423] | [424] | -7.00[425] | [426] | [427] |
62 | CCND3 | G1/S-specific cyclin-D3 | [428] | 1.95[429] | 0.96[430] | -0.66[431] | 4.85[432] | 4.04[433] | 2.05[434] |
63 | FOXO3 | Forkhead box protein O3 | [435] | 1.45[436] | 1.62[437] | 2.26[438] | 1.58[439] | 2.84[440] | 3.73[441] |
64 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [442] | 0.16[443] | 1.02[444] | 2.31[445] | 3.42[446] | 2.29[447] | 3.10[448] |
65 | TNRC6A | Trinucleotide repeat-containing gene 6A protein | [449] | 3.24[450] | 3.97[451] | 3.16[452] | 3.47[453] | 3.53[454] | 4.39[455] |
66 | NCOA3 | Nuclear receptor coactivator 3 | [456] | 3.71[457] | 3.20[458] | 3.51[459] | 4.29[460] | 3.26[461] | 4.04[462] |
67 | IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 | [463] | 5.91[464] | 5.45[465] | 6.22[466] | 4.96[467] | -2.27[468] | -4.39[469] |
68 | PAK1 | Serine/threonine-protein kinase PAK 1 | [470] | 0.98[471] | 0.30[472] | 2.72[473] | -0.67[474] | 3.13[475] | 1.66[476] |
69 | CDC42EP2 | Cdc42 effector protein 2 | [477] | 1.45[478] | 0.79[479] | 1.37[480] | 2.06[481] | 2.69[482] | 0.38[483] |
70 | FOXO1 | Forkhead box protein O1 | [484] | 2.69[485] | 2.43[486] | 2.58[487] | 2.36[488] | 4.39[489] | 4.48[490] |
71 | KALRN | Kalirin | [491] | 2.34[492] | 3.97[493] | 3.47[494] | 3.09[495] | -1.56[496] | 4.95[497] |
72 | TNRC6B | Trinucleotide repeat-containing gene 6B protein | [498] | 3.22[499] | 3.51[500] | 5.19[501] | 3.90[502] | 3.89[503] | 6.73[504] |
73 | CDC42EP3 | Cdc42 effector protein 3 | [505] | -0.70[506] | -4.93[507] | -3.10[508] | 6.56[509] | 6.17[510] | 3.70[511] |
74 | ETV4 | ETS translocation variant 4 | [512] | 6.87[513] | 7.77[514] | 7.29[515] | 3.06[516] | 4.68[517] | -0.17[518] |
75 | TNRC6C | Trinucleotide repeat-containing gene 6C protein | [519] | 3.08[520] | 3.11[521] | 3.40[522] | 1.95[523] | 1.95[524] | 4.69[525] |
76 | CDC14A | Dual specificity protein phosphatase CDC14A | [526] | 1.84[527] | 2.71[528] | 3.32[529] | 2.83[530] | 2.50[531] | 2.56[532] |
77 | CDC42EP5 | Cdc42 effector protein 5 | [533] | 0.76[534] | 1.99[535] | -0.79[536] | 0.58[537] | 2.28[538] | -0.58[539] |
78 | MAPK4 | Mitogen-activated protein kinase 4 | [540] | -5.92[541] | -3.81[542] | 3.38[543] | -5.23[544] | -2.36[545] | 4.40[546] |
79 | MMP2 | 72 kDa type IV collagenase | [547] | 4.43[548] | -2.48[549] | -1.19[550] | 8.62[551] | 8.19[552] | 5.32[553] |
80 | RAG1 | V(D)J recombination-activating protein 1 | [554] | 0.92[555] | 1.23[556] | 3.46[557] | 4.13[558] | 1.90[559] | 4.01[560] |
81 | PAK3 | Serine/threonine-protein kinase PAK 3 | [561] | -5.41[562] | [563] | [564] | -0.42[565] | 1.32[566] | 2.18[567] |
82 | RAG2 | V(D)J recombination-activating protein 2 | [568] | -0.04[569] | -1.45[570] | -0.78[571] | 0.52[572] | 0.89[573] | 1.33[574] |
83 | MIR34B | [575] | [576] | [577] | [578] | [579] | [580] | [581] | |
84 | SEPTIN7 | [582] | [583] | [584] | [585] | [586] | [587] | [588] | |
85 | AGO4 | Protein argonaute-4 | [589] | [590] | [591] | [592] | [593] | [594] | [595] |
86 | SEM1 | Putative protein SEM1, isoform 2 | [596] | [597] | [598] | [599] | [600] | [601] | [602] |
87 | PSMA8 | Proteasome subunit alpha type-7-like | [603] | [604] | [605] | [606] | [607] | [608] | [609] |
88 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [610] | [611] | [612] | [613] | [614] | [615] | [616] |
89 | AGO3 | Protein argonaute-3 | [617] | [618] | [619] | [620] | [621] | [622] | [623] |
90 | AGO2 | Protein argonaute-2 | [624] | [625] | [626] | [627] | [628] | [629] | [630] |
91 | PSMB11 | Proteasome subunit beta type-11 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |
92 | MIR34C | [638] | [639] | [640] | [641] | [642] | [643] | [644] | |
93 | AGO1 | Protein argonaute-1 | [645] | [646] | [647] | [648] | [649] | [650] | [651] |