REACTOME_MAPK3_ERK1_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [1] -1.24[2] -2.22[3] -1.31[4] -1.32[5] -1.62[6] -3.05[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] 0.13[9] -0.09[10] 0.20[11] 0.11[12] -0.06[13] -0.60[14]
3 IL6ST Interleukin-6 receptor subunit beta [15] -0.05[16] 0.54[17] 0.40[18] 0.95[19] 1.31[20] 1.92[21]
4 JAK1 Tyrosine-protein kinase JAK1 [22] 0.20[23] -0.97[24] -0.45[25] -0.15[26] -0.31[27] -0.33[28]
5 IL6R Interleukin-6 receptor subunit alpha [29] -0.53[30] -0.86[31] -1.35[32] -1.65[33] -6.55[34] -0.20[35]
6 CDK1 Cyclin-dependent kinase 1 [36] 0.94[37] 2.35[38] 1.41[39] 1.49[40] 1.51[41] -4.32[42]
7 TYK2 Non-receptor tyrosine-protein kinase TYK2 [43] 0.83[44] 0.53[45] 0.99[46] -0.03[47] 0.09[48] 0.13[49]
8 MAPK3 Mitogen-activated protein kinase 3 [50] 1.54[51] 0.93[52] 1.30[53] -0.36[54] -1.14[55] -2.90[56]
9 IL6 Interleukin-6 [57] -8.75[58] [59] -5.47[60] -1.63[61] 0.08[62] [63]
10 JAK2 Tyrosine-protein kinase JAK2 [64] -0.08[65] -0.74[66] -0.86[67] -0.02[68] -0.22[69] 0.85[70]
[1]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[2]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[3]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[4]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[5]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[6]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[7]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte IL6ST
Mean 16.5
Standard deviation 5.8
Values 24 18 9.5 12 19
[16]
HepG2 IL6ST
Mean 43.6
Standard deviation 25
Values 26 61
[17]
HepG2.C3A IL6ST
Mean 92.3
Standard deviation 8.3
Values 86 98
[18]
HuH.7 IL6ST
Mean 63.5
Standard deviation 38
Values 50 1.1e+02 35
[19]
SNU475 IL6ST
Mean 100
Standard deviation 15
Values 90 1.1e+02
[20]
THLE IL6ST
Mean 252
Standard deviation 68
Values 3e+02 2e+02
[21]
liver IL6ST
Mean 321
Standard deviation 1.1e+02
Values 2.5e+02 4.2e+02 2.1e+02 4.1e+02
[22]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[23]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[24]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[25]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[26]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[27]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[28]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[29]
ref_hepatocyte IL6R
Mean 10.5
Standard deviation 4.3
Values 6.9 11 17 6.6 11
[30]
HepG2 IL6R
Mean 20
Standard deviation 0.31
Values 20 20
[31]
HepG2.C3A IL6R
Mean 22.3
Standard deviation 0.4
Values 22 23
[32]
HuH.7 IL6R
Mean 12.1
Standard deviation 3.9
Values 10 17 9.4
[33]
SNU475 IL6R
Mean 10.6
Standard deviation 4
Values 13 7.7
[34]
THLE IL6R
Mean 0.69
Standard deviation 0.095
Values 0.76 0.62
[35]
liver IL6R
Mean 47.1
Standard deviation 10
Values 49 49 33 57
[36]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[37]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[38]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[39]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[40]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[41]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[42]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[43]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[44]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[45]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[46]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[47]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[48]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[49]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[50]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[51]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[52]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[53]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[54]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[55]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[56]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[57]
ref_hepatocyte IL6
Mean 1.35
Standard deviation 2.5
Values 0 0 5.9 0.6 0.28
[58]
HepG2 IL6
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[59]
HepG2.C3A IL6
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 IL6
Mean 0.0895
Standard deviation 0.012
Values 0.082 0.083 0.1
[61]
SNU475 IL6
Mean 1.37
Standard deviation 1.7
Values 0.15 2.6
[62]
THLE IL6
Mean 8.81
Standard deviation 1.5
Values 7.7 9.9
[63]
liver IL6
Mean 0
Standard deviation 0
Values 0 0 0 0
[64]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[65]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[66]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[67]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[68]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[69]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[70]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8