REACTOME_MAPK1_ERK2_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [1] -0.45[2] -1.06[3] -0.18[4] -1.63[5] -1.79[6] -3.66[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] -0.06[9] 0.08[10] 0.05[11] 0.10[12] 0.09[13] -0.70[14]
3 IL6ST Interleukin-6 receptor subunit beta [15] -0.25[16] 0.71[17] 0.25[18] 0.94[19] 1.46[20] 1.82[21]
4 JAK1 Tyrosine-protein kinase JAK1 [22] 0.01[23] -0.80[24] -0.60[25] -0.16[26] -0.16[27] -0.43[28]
5 MAPK1 Mitogen-activated protein kinase 1 [29] 1.20[30] 1.05[31] 0.89[32] 1.06[33] 0.06[34] -0.18[35]
6 IL6R Interleukin-6 receptor subunit alpha [36] -0.72[37] -0.69[38] -1.50[39] -1.66[40] -6.41[41] -0.30[42]
7 TYK2 Non-receptor tyrosine-protein kinase TYK2 [43] 0.63[44] 0.70[45] 0.84[46] -0.04[47] 0.24[48] 0.03[49]
8 IL6 Interleukin-6 [50] -8.95[51] [52] -5.62[53] -1.64[54] 0.22[55] [56]
9 JAK2 Tyrosine-protein kinase JAK2 [57] -0.28[58] -0.57[59] -1.00[60] -0.02[61] -0.08[62] 0.75[63]
[1]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[2]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[3]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[4]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[5]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[6]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[7]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte IL6ST
Mean 16.5
Standard deviation 5.8
Values 24 18 9.5 12 19
[16]
HepG2 IL6ST
Mean 43.6
Standard deviation 25
Values 26 61
[17]
HepG2.C3A IL6ST
Mean 92.3
Standard deviation 8.3
Values 86 98
[18]
HuH.7 IL6ST
Mean 63.5
Standard deviation 38
Values 50 1.1e+02 35
[19]
SNU475 IL6ST
Mean 100
Standard deviation 15
Values 90 1.1e+02
[20]
THLE IL6ST
Mean 252
Standard deviation 68
Values 3e+02 2e+02
[21]
liver IL6ST
Mean 321
Standard deviation 1.1e+02
Values 2.5e+02 4.2e+02 2.1e+02 4.1e+02
[22]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[23]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[24]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[25]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[26]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[27]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[28]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[29]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[30]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[31]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[32]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[33]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[34]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[35]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[36]
ref_hepatocyte IL6R
Mean 10.5
Standard deviation 4.3
Values 6.9 11 17 6.6 11
[37]
HepG2 IL6R
Mean 20
Standard deviation 0.31
Values 20 20
[38]
HepG2.C3A IL6R
Mean 22.3
Standard deviation 0.4
Values 22 23
[39]
HuH.7 IL6R
Mean 12.1
Standard deviation 3.9
Values 10 17 9.4
[40]
SNU475 IL6R
Mean 10.6
Standard deviation 4
Values 13 7.7
[41]
THLE IL6R
Mean 0.69
Standard deviation 0.095
Values 0.76 0.62
[42]
liver IL6R
Mean 47.1
Standard deviation 10
Values 49 49 33 57
[43]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[44]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[45]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[46]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[47]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[48]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[49]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[50]
ref_hepatocyte IL6
Mean 1.35
Standard deviation 2.5
Values 0 0 5.9 0.6 0.28
[51]
HepG2 IL6
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[52]
HepG2.C3A IL6
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 IL6
Mean 0.0895
Standard deviation 0.012
Values 0.082 0.083 0.1
[54]
SNU475 IL6
Mean 1.37
Standard deviation 1.7
Values 0.15 2.6
[55]
THLE IL6
Mean 8.81
Standard deviation 1.5
Values 7.7 9.9
[56]
liver IL6
Mean 0
Standard deviation 0
Values 0 0 0 0
[57]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[58]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[59]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[60]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[61]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[62]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[63]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8