REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.33[2] -0.58[3] -0.54[4] -0.63[5] -0.41[6] -0.12[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.11[16] 0.17[17] -0.18[18] 0.23[19] -0.03[20] 0.34[21]
4 SKP1 S-phase kinase-associated protein 1 [22] 0.88[23] 1.23[24] 0.25[25] 1.65[26] 1.63[27] 1.07[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.55[30] 2.41[31] 3.33[32] 1.62[33] 2.20[34] 1.10[35]
6 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [36] 0.94[37] 0.56[38] 1.03[39] 1.61[40] 1.88[41] 0.57[42]
7 IKBKG NF-kappa-B essential modulator [43] 0.98[44] 1.08[45] -1.29[46] 1.30[47] -0.15[48] 1.16[49]
8 TNIP2 TNFAIP3-interacting protein 2 [50] 1.18[51] 1.20[52] 0.80[53] 1.49[54] 0.61[55] 0.30[56]
9 CUL1 Cullin-1 [57] 1.48[58] 2.11[59] 1.55[60] 2.74[61] 2.15[62] 2.51[63]
10 NFKB1 Nuclear factor NF-kappa-B p105 subunit [64] 2.53[65] 2.17[66] 1.84[67] 1.91[68] 2.57[69] 2.21[70]
11 FBXW11 F-box/WD repeat-containing protein 11 [71] 3.24[72] 3.10[73] 3.75[74] 3.68[75] 3.35[76] 2.71[77]
12 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 [78] 2.57[79] 3.15[80] 2.24[81] 3.36[82] 2.52[83] 2.82[84]
13 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [85] 2.77[86] 3.94[87] 3.79[88] 2.80[89] 3.38[90] 3.28[91]
14 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [92] 2.39[93] 2.40[94] 2.39[95] 2.41[96] 2.26[97] 2.94[98]
15 BTRC F-box/WD repeat-containing protein 1A [99] 3.28[100] 4.02[101] 3.52[102] 2.91[103] 3.21[104] 3.11[105]
16 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 [106] 3.61[107] 3.57[108] 2.64[109] 2.26[110] 3.34[111] 2.25[112]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte SKP1
Mean 80.8
Standard deviation 44
Values 1.5e+02 92 24 71 71
[23]
HepG2 SKP1
Mean 90.4
Standard deviation 11
Values 83 98
[24]
HepG2.C3A SKP1
Mean 106
Standard deviation 20
Values 91 1.2e+02
[25]
HuH.7 SKP1
Mean 55.5
Standard deviation 13
Values 57 42 67
[26]
SNU475 SKP1
Mean 105
Standard deviation 22
Values 1.2e+02 89
[27]
THLE SKP1
Mean 137
Standard deviation 18
Values 1.2e+02 1.5e+02
[28]
liver SKP1
Mean 71
Standard deviation 55
Values 1.1e+02 27 1.3e+02 20
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[37]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[38]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[39]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[40]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[41]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[42]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[43]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[44]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[45]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[46]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[47]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[48]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[49]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[50]
ref_hepatocyte TNIP2
Mean 15.4
Standard deviation 9.7
Values 9.7 21 29 11 5.7
[51]
HepG2 TNIP2
Mean 21.1
Standard deviation 2.4
Values 23 19
[52]
HepG2.C3A TNIP2
Mean 19.7
Standard deviation 1.5
Values 21 19
[53]
HuH.7 TNIP2
Mean 15.5
Standard deviation 3
Values 16 12 18
[54]
SNU475 TNIP2
Mean 17.9
Standard deviation 0.3
Values 18 18
[55]
THLE TNIP2
Mean 12.9
Standard deviation 2
Values 11 14
[56]
liver TNIP2
Mean 7.97
Standard deviation 1.8
Values 10 7.1 7.8 6.5
[57]
ref_hepatocyte CUL1
Mean 14.3
Standard deviation 4.3
Values 13 22 12 14 11
[58]
HepG2 CUL1
Mean 24.2
Standard deviation 10
Values 17 31
[59]
HepG2.C3A CUL1
Mean 34.5
Standard deviation 8.6
Values 28 41
[60]
HuH.7 CUL1
Mean 24.2
Standard deviation 1.9
Values 26 22 25
[61]
SNU475 CUL1
Mean 39.3
Standard deviation 2.3
Values 41 38
[62]
THLE CUL1
Mean 34.6
Standard deviation 5.4
Values 31 38
[63]
liver CUL1
Mean 34
Standard deviation 1.6
Values 32 35 34 36
[64]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 3 6.7 12 5.3 4.7
[65]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 18 26
[66]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 15 17
[67]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 14 12 13
[68]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 9.6 10
[69]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[70]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 9.7 15 7.2 17
[71]
ref_hepatocyte FBXW11
Mean 5.89
Standard deviation 2.7
Values 6 11 4.9 4 4
[72]
HepG2 FBXW11
Mean 33.7
Standard deviation 3.3
Values 31 36
[73]
HepG2.C3A FBXW11
Mean 28.2
Standard deviation 0.96
Values 28 29
[74]
HuH.7 FBXW11
Mean 45.8
Standard deviation 5.6
Values 50 48 39
[75]
SNU475 FBXW11
Mean 31.1
Standard deviation 3.5
Values 34 29
[76]
THLE FBXW11
Mean 32.8
Standard deviation 2.8
Values 31 35
[77]
liver FBXW11
Mean 16.1
Standard deviation 9.5
Values 9.3 26 6.9 22
[78]
ref_hepatocyte MAP2K4
Mean 5.23
Standard deviation 0.4
Values 5.1 5.9 5.1 4.9 5.2
[79]
HepG2 MAP2K4
Mean 18.8
Standard deviation 5.8
Values 15 23
[80]
HepG2.C3A MAP2K4
Mean 26
Standard deviation 3.4
Values 24 28
[81]
HuH.7 MAP2K4
Mean 14.3
Standard deviation 2.4
Values 14 17 12
[82]
SNU475 MAP2K4
Mean 22.2
Standard deviation 0.79
Values 23 22
[83]
THLE MAP2K4
Mean 16.4
Standard deviation 1.6
Values 15 17
[84]
liver MAP2K4
Mean 15.6
Standard deviation 2
Values 16 17 17 13
[85]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[86]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[87]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[88]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[89]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[90]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[91]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[92]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 2.9 4.3 4.2 3.5 2.5
[93]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[94]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 11 9.5
[95]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 11 8.4 12
[96]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 8.9 6.4
[97]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[98]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 11 11 11 12
[99]
ref_hepatocyte BTRC
Mean 2.1
Standard deviation 0.84
Values 3 2.5 2.6 1.4 1
[100]
HepG2 BTRC
Mean 12.3
Standard deviation 3.7
Values 9.7 15
[101]
HepG2.C3A BTRC
Mean 19
Standard deviation 2
Values 20 18
[102]
HuH.7 BTRC
Mean 13.9
Standard deviation 1.8
Values 14 16 12
[103]
SNU475 BTRC
Mean 6.5
Standard deviation 0.013
Values 6.5 6.5
[104]
THLE BTRC
Mean 10.6
Standard deviation 0.85
Values 10 11
[105]
liver BTRC
Mean 7.57
Standard deviation 0.65
Values 8.2 8 7.2 6.8
[106]
ref_hepatocyte MAP3K8
Mean 1.71
Standard deviation 2
Values 1.4 0.66 5.2 0.8 0.54
[107]
HepG2 MAP3K8
Mean 12.6
Standard deviation 0.62
Values 13 12
[108]
HepG2.C3A MAP3K8
Mean 11.3
Standard deviation 2.4
Values 9.6 13
[109]
HuH.7 MAP3K8
Mean 6.17
Standard deviation 0.35
Values 5.9 6.1 6.6
[110]
SNU475 MAP3K8
Mean 3.37
Standard deviation 0.26
Values 3.2 3.6
[111]
THLE MAP3K8
Mean 9.43
Standard deviation 0.46
Values 9.8 9.1
[112]
liver MAP3K8
Mean 3.4
Standard deviation 1
Values 3.1 3.3 2.4 4.8