REACTOME_MAP2K_AND_MAPK_ACTIVATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FGG | Fibrinogen gamma chain | [1] | -3.98[2] | -2.56[3] | -2.46[4] | -10.26[5] | -12.17[6] | -0.60[7] |
2 | FGA | Fibrinogen alpha chain | [8] | -3.64[9] | -2.81[10] | -2.36[11] | -9.48[12] | -12.19[13] | 0.07[14] |
3 | FGB | Fibrinogen beta chain | [15] | -4.85[16] | -3.58[17] | -1.37[18] | -7.60[19] | -10.82[20] | 0.85[21] |
4 | ACTB | Actin, cytoplasmic 1 | [22] | 1.23[23] | 0.99[24] | 1.45[25] | 2.02[26] | 1.63[27] | -1.22[28] |
5 | ACTG1 | Actin, cytoplasmic 2 | [29] | 2.51[30] | 1.63[31] | 1.57[32] | 1.83[33] | 2.21[34] | -1.97[35] |
6 | PEBP1 | Phosphatidylethanolamine-binding protein 1 | [36] | 0.77[37] | 1.57[38] | 0.40[39] | -1.77[40] | -1.21[41] | -0.76[42] |
7 | FN1 | Fibronectin | [43] | 6.11[44] | 6.03[45] | 5.76[46] | 5.94[47] | 6.13[48] | 2.25[49] |
8 | RAP1B | Ras-related protein Rap-1b | [50] | 0.31[51] | 1.38[52] | 0.99[53] | 2.49[54] | 2.23[55] | -1.93[56] |
9 | LAMTOR2 | Ragulator complex protein LAMTOR2 | [57] | -0.80[58] | -0.32[59] | -0.70[60] | -0.52[61] | -0.33[62] | -2.22[63] |
10 | YWHAB | 14-3-3 protein beta/alpha | [64] | 3.65[65] | 3.81[66] | 2.93[67] | 4.32[68] | 3.74[69] | -0.14[70] |
11 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [71] | 1.69[72] | 1.81[73] | 2.22[74] | 2.48[75] | 2.97[76] | -1.23[77] |
12 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [78] | 2.67[79] | 2.79[80] | 3.50[81] | 2.18[82] | 2.65[83] | -1.74[84] |
13 | RAP1A | Ras-related protein Rap-1A | [85] | 1.57[86] | 1.96[87] | 2.63[88] | 2.80[89] | 2.55[90] | -1.33[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | 2.55[93] | 3.41[94] | 4.51[95] | 2.83[96] | 3.68[97] | 1.06[98] |
15 | NRAS | GTPase NRas | [99] | 3.25[100] | 4.12[101] | 4.37[102] | 4.02[103] | 3.57[104] | -0.29[105] |
16 | ARAF | Serine/threonine-protein kinase A-Raf | [106] | 2.16[107] | 2.30[108] | 2.41[109] | 2.92[110] | 2.94[111] | 0.84[112] |
17 | TLN1 | Talin-1 | [113] | 5.61[114] | 4.68[115] | 5.30[116] | 6.13[117] | 6.13[118] | 3.32[119] |
18 | VCL | Vinculin | [120] | 3.39[121] | 3.55[122] | 3.52[123] | 5.85[124] | 4.93[125] | 0.76[126] |
19 | HRAS | GTPase HRas | [127] | 1.61[128] | 1.35[129] | 0.39[130] | 2.07[131] | 1.84[132] | -2.70[133] |
20 | APBB1IP | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | -5.92[134] | [135] | -3.71[136] | -0.28[137] | -3.06[138] | -0.58[139] | |
21 | MAPK1 | Mitogen-activated protein kinase 1 | [140] | 4.33[141] | 4.91[142] | 4.58[143] | 4.87[144] | 4.50[145] | 1.74[146] |
22 | CSK | Tyrosine-protein kinase CSK | [147] | 2.99[148] | 2.94[149] | 3.14[150] | 3.01[151] | 2.59[152] | -0.91[153] |
23 | KRAS | GTPase KRas | [154] | 2.10[155] | 2.53[156] | 3.96[157] | 3.82[158] | 3.46[159] | 0.64[160] |
24 | MARK3 | MAP/microtubule affinity-regulating kinase 3 | [161] | 2.54[162] | 3.25[163] | 3.08[164] | 4.15[165] | 3.82[166] | 0.23[167] |
25 | ARRB2 | Beta-arrestin-2 | [168] | 2.78[169] | 3.62[170] | 3.41[171] | 1.70[172] | 2.49[173] | -0.91[174] |
26 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | [175] | 4.47[176] | 4.47[177] | 4.71[178] | 6.99[179] | 6.82[180] | 1.99[181] |
27 | WDR83 | WD repeat domain-containing protein 83 | [182] | 1.09[183] | 1.58[184] | 2.28[185] | 1.06[186] | 1.69[187] | -1.97[188] |
28 | LAMTOR3 | Ragulator complex protein LAMTOR3 | [189] | 3.60[190] | 4.63[191] | 3.58[192] | 3.50[193] | 3.99[194] | 0.85[195] |
29 | MAPK3 | Mitogen-activated protein kinase 3 | [196] | 4.47[197] | 4.96[198] | 4.84[199] | 3.44[200] | 3.45[201] | -1.08[202] |
30 | SRC | Proto-oncogene tyrosine-protein kinase Src | [203] | 5.64[204] | 6.07[205] | 4.91[206] | 5.42[207] | 4.58[208] | -0.89[209] |
31 | ITGB3 | Integrin beta-3 | [210] | 0.98[211] | -1.28[212] | 2.08[213] | 5.87[214] | 5.52[215] | 1.29[216] |
32 | BRAF | Serine/threonine-protein kinase B-raf | [217] | 2.86[218] | 3.04[219] | 4.91[220] | 3.76[221] | 3.44[222] | 1.81[223] |
33 | ARRB1 | Beta-arrestin-1 | [224] | 6.20[225] | 6.45[226] | 5.58[227] | 5.17[228] | 4.96[229] | 3.23[230] |
34 | CNKSR1 | Connector enhancer of kinase suppressor of ras 1 | [231] | 4.88[232] | 6.80[233] | 2.53[234] | 1.81[235] | 1.25[236] | 0.35[237] |
35 | KSR1 | Kinase suppressor of Ras 1 | [238] | 5.88[239] | 6.03[240] | 2.78[241] | 5.06[242] | 5.55[243] | 0.69[244] |
36 | IL17RD | Interleukin-17 receptor D | [245] | 4.29[246] | 3.81[247] | 4.04[248] | 4.60[249] | 4.07[250] | 1.65[251] |
37 | CNKSR2 | Connector enhancer of kinase suppressor of ras 2 | [252] | -1.18[253] | -0.76[254] | 8.71[255] | 6.72[256] | 4.86[257] | 3.09[258] |
38 | VWF | von Willebrand factor | [259] | 3.59[260] | 1.88[261] | -0.67[262] | 3.17[263] | 0.58[264] | 5.67[265] |
39 | ITGA2B | Integrin alpha-IIb | [266] | 6.22[267] | 6.95[268] | 6.79[269] | 6.04[270] | 4.39[271] | 2.58[272] |
40 | KSR2 | Kinase suppressor of Ras 2 | [273] | 2.85[274] | 2.29[275] | [276] | 1.75[277] | [278] | 1.27[279] |