REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GPS2 G protein pathway suppressor 2 [1] -2.25[2] -2.72[3] -3.69[4] -3.30[5] -3.20[6] -3.50[7]
2 CALM1 Calmodulin-1 [8] -0.14[9] -0.07[10] -0.19[11] 0.77[12] 0.31[13] 0.93[14]
3 HDAC1 Histone deacetylase 1 [15] 0.29[16] 0.34[17] 0.45[18] -0.17[19] -0.12[20] -1.15[21]
4 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [22] -0.38[23] -0.52[24] -1.10[25] -1.28[26] -0.43[27] -1.47[28]
5 HDAC3 Histone deacetylase 3 [29] 0.26[30] 0.36[31] -0.42[32] -0.87[33] -0.44[34] -1.09[35]
6 NCOR1 Nuclear receptor corepressor 1 [36] 0.86[37] 1.40[38] 1.47[39] 0.75[40] 1.07[41] 2.11[42]
7 MECP2 Methyl-CpG-binding protein 2 [43] 0.51[44] 0.84[45] 0.46[46] 0.77[47] 1.15[48] 0.14[49]
8 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 [50] 0.86[51] 1.44[52] 1.50[53] 1.59[54] 1.43[55] 2.18[56]
9 TBL1X F-box-like/WD repeat-containing protein TBL1X [57] 1.12[58] 1.57[59] 2.54[60] -5.22[61] 0.54[62] 1.06[63]
10 SIN3A Paired amphipathic helix protein Sin3a [64] 1.16[65] 1.29[66] 1.90[67] 1.17[68] 1.19[69] 0.59[70]
11 NCOR2 Nuclear receptor corepressor 2 [71] 3.13[72] 1.56[73] 1.08[74] 3.33[75] 3.10[76] 1.20[77]
12 BDNF Brain-derived neurotrophic factor [78] -1.88[79] -4.61[80] -3.27[81] 5.93[82] 4.96[83] 1.41[84]
13 CAMK4 Calcium/calmodulin-dependent protein kinase type IV [85] [86] -1.94[87] -3.19[88] 0.63[89] 2.97[90] 3.56[91]
[1]
ref_hepatocyte GPS2
Mean 53.3
Standard deviation 32
Values 77 93 49 33 14
[2]
HepG2 GPS2
Mean 28.8
Standard deviation 2.4
Values 27 30
[3]
HepG2.C3A GPS2
Mean 18
Standard deviation 4.4
Values 15 21
[4]
HuH.7 GPS2
Mean 13.2
Standard deviation 2.2
Values 14 11 15
[5]
SNU475 GPS2
Mean 17.5
Standard deviation 6.1
Values 13 22
[6]
THLE GPS2
Mean 17.4
Standard deviation 0.2
Values 18 17
[7]
liver GPS2
Mean 10.8
Standard deviation 9.1
Values 21 3.2 16 2.9
[8]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[9]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[10]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[11]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[12]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[13]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[14]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[15]
ref_hepatocyte HDAC1
Mean 20.8
Standard deviation 4.1
Values 22 28 19 18 18
[16]
HepG2 HDAC1
Mean 65.4
Standard deviation 11
Values 73 58
[17]
HepG2.C3A HDAC1
Mean 58.9
Standard deviation 2.3
Values 57 60
[18]
HuH.7 HDAC1
Mean 90.9
Standard deviation 22
Values 94 68 1.1e+02
[19]
SNU475 HDAC1
Mean 59.8
Standard deviation 8
Values 65 54
[20]
THLE HDAC1
Mean 57.8
Standard deviation 6.8
Values 53 63
[21]
liver HDAC1
Mean 21.5
Standard deviation 6.8
Values 25 18 29 14
[22]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 7.6 11 11 27 23
[23]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 29 33
[24]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 27 22
[25]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[26]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 23 19
[27]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[28]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 18 8.8 16 8.9
[29]
ref_hepatocyte HDAC3
Mean 12.4
Standard deviation 2.7
Values 17 10 11 14 10
[30]
HepG2 HDAC3
Mean 38.3
Standard deviation 1.2
Values 37 39
[31]
HepG2.C3A HDAC3
Mean 35.4
Standard deviation 3.2
Values 33 38
[32]
HuH.7 HDAC3
Mean 29.6
Standard deviation 5.9
Values 28 24 36
[33]
SNU475 HDAC3
Mean 22
Standard deviation 2.2
Values 24 20
[34]
THLE HDAC3
Mean 27.5
Standard deviation 0.73
Values 27 28
[35]
liver HDAC3
Mean 13.3
Standard deviation 5.1
Values 19 8.2 16 10
[36]
ref_hepatocyte NCOR1
Mean 7.02
Standard deviation 2.9
Values 10 10 5.5 4.3 5.1
[37]
HepG2 NCOR1
Mean 32.8
Standard deviation 11
Values 25 41
[38]
HepG2.C3A NCOR1
Mean 41.3
Standard deviation 1.3
Values 40 42
[39]
HuH.7 NCOR1
Mean 62.2
Standard deviation 16
Values 78 63 46
[40]
SNU475 NCOR1
Mean 38.2
Standard deviation 4.6
Values 42 35
[41]
THLE NCOR1
Mean 44.2
Standard deviation 1.4
Values 43 45
[42]
liver NCOR1
Mean 69.4
Standard deviation 14
Values 87 68 52 70
[43]
ref_hepatocyte MECP2
Mean 4.65
Standard deviation 3.2
Values 0.97 2.9 9 6.8 3.6
[44]
HepG2 MECP2
Mean 17
Standard deviation 0.35
Values 17 17
[45]
HepG2.C3A MECP2
Mean 18.5
Standard deviation 2.1
Values 20 17
[46]
HuH.7 MECP2
Mean 20.4
Standard deviation 2.7
Values 24 19 19
[47]
SNU475 MECP2
Mean 25.6
Standard deviation 3.5
Values 28 23
[48]
THLE MECP2
Mean 30.9
Standard deviation 2.7
Values 29 33
[49]
liver MECP2
Mean 11.7
Standard deviation 2.4
Values 14 9.6 9.8 14
[50]
ref_hepatocyte TBL1XR1
Mean 4.61
Standard deviation 1.6
Values 4.2 6.5 3.3 3.1 6
[51]
HepG2 TBL1XR1
Mean 21.5
Standard deviation 5.1
Values 18 25
[52]
HepG2.C3A TBL1XR1
Mean 27.8
Standard deviation 0.088
Values 28 28
[53]
HuH.7 TBL1XR1
Mean 41.7
Standard deviation 12
Values 37 55 33
[54]
SNU475 TBL1XR1
Mean 45
Standard deviation 0.79
Values 46 44
[55]
THLE TBL1XR1
Mean 37.2
Standard deviation 0.85
Values 38 37
[56]
liver TBL1XR1
Mean 47.9
Standard deviation 6.3
Values 46 56 41 48
[57]
ref_hepatocyte TBL1X
Mean 4.34
Standard deviation 1.4
Values 6.3 5.1 2.8 3.5 4
[58]
HepG2 TBL1X
Mean 24.3
Standard deviation 2.7
Values 22 26
[59]
HepG2.C3A TBL1X
Mean 28.6
Standard deviation 4.5
Values 32 25
[60]
HuH.7 TBL1X
Mean 80.9
Standard deviation 15
Values 88 92 63
[61]
SNU475 TBL1X
Mean 0.377
Standard deviation 0.13
Values 0.28 0.47
[62]
THLE TBL1X
Mean 19
Standard deviation 0.42
Values 19 19
[63]
liver TBL1X
Mean 20.7
Standard deviation 8.5
Values 33 18 19 13
[64]
ref_hepatocyte SIN3A
Mean 3.84
Standard deviation 1.6
Values 4.4 6 4.1 2.3 2.4
[65]
HepG2 SIN3A
Mean 22
Standard deviation 0.2
Values 22 22
[66]
HepG2.C3A SIN3A
Mean 20.9
Standard deviation 1.9
Values 22 20
[67]
HuH.7 SIN3A
Mean 46
Standard deviation 6.9
Values 54 44 41
[68]
SNU475 SIN3A
Mean 28
Standard deviation 1.4
Values 27 29
[69]
THLE SIN3A
Mean 26.4
Standard deviation 5.5
Values 23 30
[70]
liver SIN3A
Mean 13.3
Standard deviation 1.8
Values 13 15 11 14
[71]
ref_hepatocyte NCOR2
Mean 2.59
Standard deviation 0.92
Values 2.5 2.2 4.1 2.4 1.7
[72]
HepG2 NCOR2
Mean 58.1
Standard deviation 18
Values 71 46
[73]
HepG2.C3A NCOR2
Mean 17
Standard deviation 4.1
Values 20 14
[74]
HuH.7 NCOR2
Mean 17.5
Standard deviation 6.7
Values 25 14 13
[75]
SNU475 NCOR2
Mean 84.3
Standard deviation 15
Values 95 73
[76]
THLE NCOR2
Mean 66.6
Standard deviation 7.4
Values 61 72
[77]
liver NCOR2
Mean 13.6
Standard deviation 4.9
Values 11 14 8.8 20
[78]
ref_hepatocyte BDNF
Mean 0.0532
Standard deviation 0.065
Values 0 0 0.095 0.15 0.024
[79]
HepG2 BDNF
Mean 0.0372
Standard deviation 0.0041
Values 0.04 0.034
[80]
HepG2.C3A BDNF
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 BDNF
Mean 0.0177
Standard deviation 0.024
Values 0.0082 0.045 0
[82]
SNU475 BDNF
Mean 10.5
Standard deviation 1.7
Values 9.3 12
[83]
THLE BDNF
Mean 4.97
Standard deviation 1.1
Values 5.7 4.2
[84]
liver BDNF
Mean 0.324
Standard deviation 0.17
Values 0.19 0.57 0.23 0.3
[85]
ref_hepatocyte CAMK4
Mean 0.0277
Standard deviation 0.046
Values 0 0.11 0 0 0.033
[86]
HepG2 CAMK4
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A CAMK4
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[88]
HuH.7 CAMK4
Mean 0.00975
Standard deviation 0.0086
Values 0.016 0.013 0
[89]
SNU475 CAMK4
Mean 0.139
Standard deviation 0.098
Values 0.07 0.21
[90]
THLE CAMK4
Mean 0.651
Standard deviation 0.27
Values 0.46 0.84
[91]
liver CAMK4
Mean 0.748
Standard deviation 0.17
Values 0.75 0.8 0.92 0.52