REACTOME_LDL_CLEARANCE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 APOB Apolipoprotein B-100 [1] 1.26[2] 1.43[3] 0.96[4] -6.80[5] -6.98[6] 1.86[7]
2 CLTA Clathrin light chain A [8] -2.56[9] -3.33[10] -2.88[11] -1.82[12] -1.69[13] -6.27[14]
3 NPC2 Epididymal secretory protein E1 [15] -2.00[16] -1.79[17] -3.14[18] -1.23[19] -0.95[20] -5.28[21]
4 LSR Lipolysis-stimulated lipoprotein receptor [22] -1.72[23] -2.12[24] -2.70[25] -5.95[26] -3.48[27] -4.25[28]
5 LIPA Lysosomal acid lipase/cholesteryl ester hydrolase [29] -1.37[30] -1.96[31] -2.68[32] -1.27[33] -1.12[34] -3.28[35]
6 AP2M1 AP-2 complex subunit mu [36] -0.46[37] -1.26[38] -1.41[39] 1.62[40] 1.89[41] -3.17[42]
7 AP2S1 AP-2 complex subunit sigma [43] -2.30[44] -2.92[45] -1.88[46] -0.10[47] 0.10[48] -4.03[49]
8 CLTC Clathrin heavy chain 1 [50] 0.93[51] 0.44[52] 0.95[53] 2.32[54] 2.23[55] -0.55[56]
9 LDLR Low-density lipoprotein receptor [57] -0.49[58] -0.25[59] 1.10[60] -0.26[61] 0.70[62] -1.78[63]
10 AP2A1 AP-2 complex subunit alpha-1 [64] 0.52[65] -0.41[66] 0.77[67] 2.04[68] 1.88[69] -2.06[70]
11 PCSK9 Proprotein convertase subtilisin/kexin type 9 [71] -3.63[72] 0.86[73] 2.55[74] -5.34[75] -6.00[76] -1.75[77]
12 AP2B1 AP-2 complex subunit beta [78] 1.56[79] 0.69[80] 2.76[81] 3.19[82] 2.82[83] -2.07[84]
13 AP2A2 AP-2 complex subunit alpha-2 [85] 0.58[86] -0.17[87] 0.30[88] 1.49[89] 0.90[90] -2.34[91]
14 CES3 Carboxylesterase 3 [92] -1.93[93] -1.26[94] -3.71[95] -3.08[96] -3.97[97] -2.79[98]
15 LDLRAP1 Low density lipoprotein receptor adapter protein 1 [99] -0.88[100] -1.03[101] -1.63[102] 1.16[103] 0.94[104] -2.23[105]
16 NPC1 Niemann-Pick C1 protein [106] 1.28[107] 1.04[108] 1.35[109] 2.65[110] 1.91[111] -2.07[112]
17 SOAT1 Sterol O-acyltransferase 1 [113] 0.34[114] 0.29[115] 1.41[116] 3.55[117] 2.93[118] -1.35[119]
18 NCEH1 Neutral cholesterol ester hydrolase 1 [120] 0.03[121] -0.04[122] 0.47[123] 1.20[124] 2.43[125] -3.87[126]
19 SOAT2 Sterol O-acyltransferase 2 [127] 0.65[128] 2.53[129] 1.53[130] -5.65[131] -6.43[132] -4.35[133]
[1]
ref_hepatocyte APOB
Mean 165
Standard deviation 1.5e+02
Values 2.4e+02 15 8.3 2.2e+02 3.4e+02
[2]
HepG2 APOB
Mean 1.41e+03
Standard deviation 6.5e+02
Values 9.5e+02 1.9e+03
[3]
HepG2.C3A APOB
Mean 2.13e+03
Standard deviation 5.8e+02
Values 1.7e+03 2.5e+03
[4]
HuH.7 APOB
Mean 1.16e+03
Standard deviation 4.8e+02
Values 1.4e+03 1.5e+03 6.1e+02
[5]
SNU475 APOB
Mean 1.75
Standard deviation 0.12
Values 1.7 1.8
[6]
THLE APOB
Mean 2.04
Standard deviation 0.96
Values 2.7 1.4
[7]
liver APOB
Mean 6.85e+03
Standard deviation 4.5e+03
Values 2.9e+03 1.2e+04 3.6e+03 8.5e+03
[8]
ref_hepatocyte CLTA
Mean 139
Standard deviation 77
Values 2e+02 2.3e+02 1.4e+02 74 53
[9]
HepG2 CLTA
Mean 83.5
Standard deviation 9.9
Values 91 77
[10]
HepG2.C3A CLTA
Mean 65.7
Standard deviation 0.97
Values 66 65
[11]
HuH.7 CLTA
Mean 68.1
Standard deviation 8
Values 60 68 76
[12]
SNU475 CLTA
Mean 46.3
Standard deviation 2.6
Values 48 45
[13]
THLE CLTA
Mean 67.1
Standard deviation 17
Values 55 79
[14]
liver CLTA
Mean 20.5
Standard deviation 13
Values 32 10 31 8.4
[15]
ref_hepatocyte NPC2
Mean 63.3
Standard deviation 56
Values 1.6e+02 21 23 55 60
[16]
HepG2 NPC2
Mean 56.2
Standard deviation 20
Values 42 70
[17]
HepG2.C3A NPC2
Mean 87.5
Standard deviation 5.2
Values 91 84
[18]
HuH.7 NPC2
Mean 25.9
Standard deviation 7.4
Values 19 34 25
[19]
SNU475 NPC2
Mean 31.8
Standard deviation 1.4
Values 33 31
[20]
THLE NPC2
Mean 51.1
Standard deviation 15
Values 40 62
[21]
liver NPC2
Mean 18.6
Standard deviation 15
Values 34 7.5 28 4.6
[22]
ref_hepatocyte LSR
Mean 52.9
Standard deviation 28
Values 18 29 68 66 84
[23]
HepG2 LSR
Mean 57
Standard deviation 14
Values 67 47
[24]
HepG2.C3A LSR
Mean 58
Standard deviation 27
Values 77 39
[25]
HuH.7 LSR
Mean 29.3
Standard deviation 4.4
Values 31 24 33
[26]
SNU475 LSR
Mean 1.01
Standard deviation 0.26
Values 1.2 0.83
[27]
THLE LSR
Mean 7.37
Standard deviation 1.1
Values 8.2 6.6
[28]
liver LSR
Mean 31.7
Standard deviation 19
Values 37 15 57 18
[29]
ref_hepatocyte LIPA
Mean 49.8
Standard deviation 49
Values 1.3e+02 52 9.5 23 31
[30]
HepG2 LIPA
Mean 68.3
Standard deviation 18
Values 56 81
[31]
HepG2.C3A LIPA
Mean 61.2
Standard deviation 4.6
Values 64 58
[32]
HuH.7 LIPA
Mean 28.1
Standard deviation 2.4
Values 27 31 27
[33]
SNU475 LIPA
Mean 24.3
Standard deviation 3
Values 26 22
[34]
THLE LIPA
Mean 35.6
Standard deviation 1.9
Values 34 37
[35]
liver LIPA
Mean 58.5
Standard deviation 24
Values 43 79 79 33
[36]
ref_hepatocyte AP2M1
Mean 41.6
Standard deviation 13
Values 28 39 35 63 44
[37]
HepG2 AP2M1
Mean 107
Standard deviation 14
Values 97 1.2e+02
[38]
HepG2.C3A AP2M1
Mean 83
Standard deviation 17
Values 71 95
[39]
HuH.7 AP2M1
Mean 56.4
Standard deviation 14
Values 67 40 62
[40]
SNU475 AP2M1
Mean 150
Standard deviation 32
Values 1.7e+02 1.3e+02
[41]
THLE AP2M1
Mean 241
Standard deviation 26
Values 2.2e+02 2.6e+02
[42]
liver AP2M1
Mean 52.8
Standard deviation 26
Values 55 35 89 32
[43]
ref_hepatocyte AP2S1
Mean 38.3
Standard deviation 23
Values 13 36 20 57 66
[44]
HepG2 AP2S1
Mean 27.5
Standard deviation 0.19
Values 28 27
[45]
HepG2.C3A AP2S1
Mean 24.1
Standard deviation 3.4
Values 22 27
[46]
HuH.7 AP2S1
Mean 37.6
Standard deviation 15
Values 43 21 49
[47]
SNU475 AP2S1
Mean 42
Standard deviation 3.1
Values 44 40
[48]
THLE AP2S1
Mean 63.5
Standard deviation 6.7
Values 59 68
[49]
liver AP2S1
Mean 26.7
Standard deviation 27
Values 53 3.8 46 3.4
[50]
ref_hepatocyte CLTC
Mean 30
Standard deviation 17
Values 53 42 13 19 24
[51]
HepG2 CLTC
Mean 203
Standard deviation 93
Values 1.4e+02 2.7e+02
[52]
HepG2.C3A CLTC
Mean 193
Standard deviation 28
Values 1.7e+02 2.1e+02
[53]
HuH.7 CLTC
Mean 209
Standard deviation 37
Values 2.5e+02 2.1e+02 1.7e+02
[54]
SNU475 CLTC
Mean 176
Standard deviation 18
Values 1.9e+02 1.6e+02
[55]
THLE CLTC
Mean 218
Standard deviation 18
Values 2.1e+02 2.3e+02
[56]
liver CLTC
Mean 234
Standard deviation 1.1e+02
Values 1.2e+02 3.7e+02 1.8e+02 2.7e+02
[57]
ref_hepatocyte LDLR
Mean 13.7
Standard deviation 8.6
Values 7.7 14 27 16 4.3
[58]
HepG2 LDLR
Mean 34.6
Standard deviation 16
Values 46 23
[59]
HepG2.C3A LDLR
Mean 55.1
Standard deviation 38
Values 82 29
[60]
HuH.7 LDLR
Mean 106
Standard deviation 31
Values 1e+02 1.4e+02 78
[61]
SNU475 LDLR
Mean 13.5
Standard deviation 6.6
Values 18 8.9
[62]
THLE LDLR
Mean 34.7
Standard deviation 13
Values 25 44
[63]
liver LDLR
Mean 45.8
Standard deviation 27
Values 45 24 30 84
[64]
ref_hepatocyte AP2A1
Mean 10.6
Standard deviation 3.7
Values 6.9 8.6 9.7 17 11
[65]
HepG2 AP2A1
Mean 54
Standard deviation 4.5
Values 57 51
[66]
HepG2.C3A AP2A1
Mean 38.1
Standard deviation 9.3
Values 45 32
[67]
HuH.7 AP2A1
Mean 65.1
Standard deviation 18
Values 85 50 60
[68]
SNU475 AP2A1
Mean 51.3
Standard deviation 9.3
Values 58 45
[69]
THLE AP2A1
Mean 60.6
Standard deviation 7.6
Values 55 66
[70]
liver AP2A1
Mean 29.1
Standard deviation 3.1
Values 28 27 27 34
[71]
ref_hepatocyte PCSK9
Mean 9.97
Standard deviation 5.7
Values 5.6 3.3 9.8 16 15
[72]
HepG2 PCSK9
Mean 2.85
Standard deviation 1.6
Values 1.7 4
[73]
HepG2.C3A PCSK9
Mean 86.2
Standard deviation 65
Values 1.3e+02 40
[74]
HuH.7 PCSK9
Mean 210
Standard deviation 31
Values 1.8e+02 2.4e+02 2e+02
[75]
SNU475 PCSK9
Mean 0.289
Standard deviation 0.022
Values 0.27 0.3
[76]
THLE PCSK9
Mean 0.242
Standard deviation 0.1
Values 0.31 0.17
[77]
liver PCSK9
Mean 34
Standard deviation 15
Values 18 39 27 52
[78]
ref_hepatocyte AP2B1
Mean 9
Standard deviation 4.1
Values 11 15 5.6 5.9 7.2
[79]
HepG2 AP2B1
Mean 93.9
Standard deviation 10
Values 87 1e+02
[80]
HepG2.C3A AP2B1
Mean 69.3
Standard deviation 14
Values 79 59
[81]
HuH.7 AP2B1
Mean 220
Standard deviation 43
Values 2.7e+02 2e+02 1.9e+02
[82]
SNU475 AP2B1
Mean 96.9
Standard deviation 32
Values 1.2e+02 74
[83]
THLE AP2B1
Mean 98.4
Standard deviation 18
Values 86 1.1e+02
[84]
liver AP2B1
Mean 24.4
Standard deviation 6.6
Values 18 34 23 23
[85]
ref_hepatocyte AP2A2
Mean 8.24
Standard deviation 1.1
Values 7.8 6.8 8.3 9.9 8.3
[86]
HepG2 AP2A2
Mean 43.6
Standard deviation 9.6
Values 50 37
[87]
HepG2.C3A AP2A2
Mean 34.8
Standard deviation 12
Values 43 26
[88]
HuH.7 AP2A2
Mean 36.5
Standard deviation 2.7
Values 39 36 34
[89]
SNU475 AP2A2
Mean 27.1
Standard deviation 8.1
Values 33 21
[90]
THLE AP2A2
Mean 23.9
Standard deviation 4.3
Values 21 27
[91]
liver AP2A2
Mean 18.6
Standard deviation 3.8
Values 21 19 13 22
[92]
ref_hepatocyte CES3
Mean 6.53
Standard deviation 8
Values 1.7 0.79 1.3 9.7 19
[93]
HepG2 CES3
Mean 6.06
Standard deviation 0.99
Values 5.4 6.8
[94]
HepG2.C3A CES3
Mean 13
Standard deviation 5.7
Values 17 8.9
[95]
HuH.7 CES3
Mean 1.8
Standard deviation 0.042
Values 1.8 1.8 1.8
[96]
SNU475 CES3
Mean 0.906
Standard deviation 0.074
Values 0.85 0.96
[97]
THLE CES3
Mean 0.649
Standard deviation 0.28
Values 0.85 0.45
[98]
liver CES3
Mean 10.8
Standard deviation 2.4
Values 13 10 7.9 12
[99]
ref_hepatocyte LDLRAP1
Mean 4.65
Standard deviation 2.5
Values 1.3 4.3 3.9 8.1 5.7
[100]
HepG2 LDLRAP1
Mean 8.97
Standard deviation 0.22
Values 8.8 9.1
[101]
HepG2.C3A LDLRAP1
Mean 10.9
Standard deviation 0.36
Values 11 11
[102]
HuH.7 LDLRAP1
Mean 5.41
Standard deviation 0.72
Values 6.1 4.6 5.5
[103]
SNU475 LDLRAP1
Mean 12.3
Standard deviation 0.53
Values 12 13
[104]
THLE LDLRAP1
Mean 13.9
Standard deviation 0.87
Values 13 15
[105]
liver LDLRAP1
Mean 11.4
Standard deviation 4.1
Values 15 6.2 14 10
[106]
ref_hepatocyte NPC1
Mean 4.23
Standard deviation 2.9
Values 4.8 3.1 9.1 2.5 1.7
[107]
HepG2 NPC1
Mean 36.4
Standard deviation 3.3
Values 39 34
[108]
HepG2.C3A NPC1
Mean 41.5
Standard deviation 19
Values 55 28
[109]
HuH.7 NPC1
Mean 39
Standard deviation 8.4
Values 39 47 31
[110]
SNU475 NPC1
Mean 31.4
Standard deviation 4.3
Values 28 34
[111]
THLE NPC1
Mean 24.7
Standard deviation 1.5
Values 24 26
[112]
liver NPC1
Mean 11.6
Standard deviation 4.1
Values 8.6 12 8.5 17
[113]
ref_hepatocyte SOAT1
Mean 4.02
Standard deviation 3.9
Values 11 3.3 0.73 2.5 2.8
[114]
HepG2 SOAT1
Mean 18
Standard deviation 7.3
Values 13 23
[115]
HepG2.C3A SOAT1
Mean 23.4
Standard deviation 4.3
Values 20 26
[116]
HuH.7 SOAT1
Mean 38.5
Standard deviation 5
Values 44 36 36
[117]
SNU475 SOAT1
Mean 55.4
Standard deviation 0.022
Values 55 55
[118]
THLE SOAT1
Mean 47.6
Standard deviation 11
Values 40 56
[119]
liver SOAT1
Mean 18.1
Standard deviation 2.1
Values 17 21 16 18
[120]
ref_hepatocyte NCEH1
Mean 3.51
Standard deviation 3.3
Values 7.4 6.6 2.7 0.38 0.48
[121]
HepG2 NCEH1
Mean 12.7
Standard deviation 2
Values 11 14
[122]
HepG2.C3A NCEH1
Mean 16.3
Standard deviation 3.3
Values 19 14
[123]
HuH.7 NCEH1
Mean 17.6
Standard deviation 5.1
Values 16 23 14
[124]
SNU475 NCEH1
Mean 9.51
Standard deviation 2.5
Values 7.7 11
[125]
THLE NCEH1
Mean 29.4
Standard deviation 2.7
Values 27 31
[126]
liver NCEH1
Mean 2.75
Standard deviation 0.55
Values 2.5 3.3 3.1 2.1
[127]
ref_hepatocyte SOAT2
Mean 1.25
Standard deviation 1.8
Values 4.4 0 0.4 0.34 1.1
[128]
HepG2 SOAT2
Mean 6.93
Standard deviation 0.014
Values 6.9 6.9
[129]
HepG2.C3A SOAT2
Mean 34.3
Standard deviation 14
Values 44 25
[130]
HuH.7 SOAT2
Mean 13
Standard deviation 2.2
Values 11 15 13
[131]
SNU475 SOAT2
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[132]
THLE SOAT2
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[133]
liver SOAT2
Mean 0.7
Standard deviation 0.61
Values 1.6 0.29 0.36 0.56