REACTOME_LAGGING_STRAND_SYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCNA Proliferating cell nuclear antigen [1] 0.73[2] 0.50[3] -1.15[4] -0.72[5] -0.40[6] -2.36[7]
2 POLD2 DNA polymerase delta subunit 2 [8] -0.76[9] -0.80[10] -0.53[11] -1.37[12] -0.96[13] 0.59[14]
3 POLD4 DNA polymerase delta subunit 4 [15] -2.29[16] -2.85[17] -1.01[18] 0.94[19] -2.61[20] 0.23[21]
4 RPA2 Replication protein A 32 kDa subunit [22] -1.62[23] -1.76[24] -1.44[25] -1.25[26] -1.13[27] -1.69[28]
5 RFC4 Replication factor C subunit 4 [29] -1.13[30] -0.72[31] -0.38[32] -1.47[33] -0.10[34] -2.04[35]
6 RFC1 Replication factor C subunit 1 [36] -0.02[37] 1.05[38] 1.20[39] -0.18[40] 0.70[41] 1.49[42]
7 RFC2 Replication factor C subunit 2 [43] -0.43[44] -0.78[45] -0.98[46] -0.33[47] 0.17[48] -0.06[49]
8 FEN1 Flap endonuclease 1 [50] 0.87[51] 0.44[52] 1.06[53] 0.17[54] 1.11[55] -0.38[56]
9 RPA1 Replication protein A 70 kDa DNA-binding subunit [57] 1.15[58] 0.67[59] 0.71[60] 1.35[61] 1.41[62] 0.71[63]
10 RPA3 Replication protein A 14 kDa subunit [64] -0.53[65] 0.06[66] 0.54[67] -1.41[68] -1.08[69] 0.02[70]
11 RFC5 Replication factor C subunit 5 [71] -0.03[72] 0.21[73] 0.17[74] -0.24[75] 0.33[76] -0.17[77]
12 RFC3 Replication factor C subunit 3 [78] 1.01[79] 1.66[80] 1.56[81] 0.75[82] 1.38[83] -0.16[84]
13 LIG1 DNA ligase 1 [85] 1.47[86] 1.27[87] 1.67[88] 0.00[89] 0.79[90] 0.34[91]
14 POLA2 DNA polymerase alpha subunit B [92] 0.48[93] -0.10[94] 0.22[95] 1.01[96] 1.36[97] -0.13[98]
15 PRIM1 DNA primase small subunit [99] 0.51[100] 1.62[101] 1.71[102] 0.65[103] 1.28[104] -0.20[105]
16 POLD1 DNA polymerase delta catalytic subunit [106] 1.70[107] 1.71[108] 2.29[109] 1.32[110] 2.12[111] 1.38[112]
17 PRIM2 DNA primase large subunit [113] 1.12[114] 0.71[115] 0.08[116] 0.68[117] 0.96[118] -0.87[119]
18 POLD3 DNA polymerase delta subunit 3 [120] 1.01[121] 0.67[122] 1.40[123] 1.61[124] 2.14[125] 1.69[126]
19 POLA1 DNA polymerase alpha catalytic subunit [127] 1.85[128] 1.74[129] 2.06[130] 2.48[131] 2.49[132] 2.38[133]
20 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2 [134] 1.60[135] 3.15[136] 2.12[137] 2.14[138] 1.84[139] 2.27[140]
[1]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[2]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[3]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[4]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[5]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[6]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[7]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[8]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[9]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[10]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[11]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[12]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[13]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[14]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[15]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[16]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[17]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[18]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[19]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[20]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[21]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[22]
ref_hepatocyte RPA2
Mean 23.6
Standard deviation 12
Values 23 41 28 15 11
[23]
HepG2 RPA2
Mean 19
Standard deviation 3.9
Values 16 22
[24]
HepG2.C3A RPA2
Mean 17.8
Standard deviation 8.2
Values 12 24
[25]
HuH.7 RPA2
Mean 25.2
Standard deviation 11
Values 27 14 35
[26]
SNU475 RPA2
Mean 25.9
Standard deviation 7.9
Values 20 31
[27]
THLE RPA2
Mean 30.6
Standard deviation 2.7
Values 29 33
[28]
liver RPA2
Mean 6.36
Standard deviation 3.6
Values 6.9 4.2 11 3.2
[29]
ref_hepatocyte RFC4
Mean 11
Standard deviation 7.9
Values 17 21 9.8 4.7 2.4
[30]
HepG2 RFC4
Mean 12.4
Standard deviation 2.7
Values 10 14
[31]
HepG2.C3A RFC4
Mean 17
Standard deviation 7.7
Values 12 22
[32]
HuH.7 RFC4
Mean 24.4
Standard deviation 12
Values 26 12 35
[33]
SNU475 RFC4
Mean 10.3
Standard deviation 3.5
Values 7.8 13
[34]
THLE RFC4
Mean 29.1
Standard deviation 0.079
Values 29 29
[35]
liver RFC4
Mean 2.31
Standard deviation 1.2
Values 2.3 1.9 4 1
[36]
ref_hepatocyte RFC1
Mean 9.26
Standard deviation 5.4
Values 15 15 7.1 4.1 5
[37]
HepG2 RFC1
Mean 22.5
Standard deviation 11
Values 15 30
[38]
HepG2.C3A RFC1
Mean 49.1
Standard deviation 4.6
Values 46 52
[39]
HuH.7 RFC1
Mean 61.4
Standard deviation 8.8
Values 66 67 51
[40]
SNU475 RFC1
Mean 21.2
Standard deviation 2
Values 20 23
[41]
THLE RFC1
Mean 42.7
Standard deviation 3.9
Values 45 40
[42]
liver RFC1
Mean 22.6
Standard deviation 3.4
Values 24 26 18 23
[43]
ref_hepatocyte RFC2
Mean 8.95
Standard deviation 3.2
Values 7.3 13 6.2 11 6.5
[44]
HepG2 RFC2
Mean 16.5
Standard deviation 2.8
Values 14 18
[45]
HepG2.C3A RFC2
Mean 13.3
Standard deviation 5.7
Values 9.3 17
[46]
HuH.7 RFC2
Mean 13.1
Standard deviation 6.2
Values 15 6.1 18
[47]
SNU475 RFC2
Mean 18.6
Standard deviation 4.4
Values 16 22
[48]
THLE RFC2
Mean 28.7
Standard deviation 3.4
Values 26 31
[49]
liver RFC2
Mean 7.44
Standard deviation 4.1
Values 10 4.9 11 3.1
[50]
ref_hepatocyte FEN1
Mean 8.88
Standard deviation 4.9
Values 17 9.6 7.8 7 3.4
[51]
HepG2 FEN1
Mean 40
Standard deviation 13
Values 31 49
[52]
HepG2.C3A FEN1
Mean 30.8
Standard deviation 20
Values 17 45
[53]
HuH.7 FEN1
Mean 53.6
Standard deviation 31
Values 63 19 79
[54]
SNU475 FEN1
Mean 26.1
Standard deviation 5.2
Values 22 30
[55]
THLE FEN1
Mean 54.6
Standard deviation 11
Values 47 62
[56]
liver FEN1
Mean 5.91
Standard deviation 2.9
Values 3.7 5.8 10 4.1
[57]
ref_hepatocyte RPA1
Mean 8.25
Standard deviation 3.9
Values 9.2 15 5.5 5.3 6.7
[58]
HepG2 RPA1
Mean 45.3
Standard deviation 8.3
Values 39 51
[59]
HepG2.C3A RPA1
Mean 33.6
Standard deviation 11
Values 26 41
[60]
HuH.7 RPA1
Mean 39
Standard deviation 14
Values 47 23 48
[61]
SNU475 RPA1
Mean 54.6
Standard deviation 1
Values 55 54
[62]
THLE RPA1
Mean 62.1
Standard deviation 11
Values 54 70
[63]
liver RPA1
Mean 11.7
Standard deviation 1.8
Values 12 12 14 9.5
[64]
ref_hepatocyte RPA3
Mean 8.22
Standard deviation 4.8
Values 6.2 7.6 1.9 11 15
[65]
HepG2 RPA3
Mean 14.1
Standard deviation 4
Values 11 17
[66]
HepG2.C3A RPA3
Mean 21.8
Standard deviation 13
Values 13 31
[67]
HuH.7 RPA3
Mean 34.5
Standard deviation 16
Values 35 18 50
[68]
SNU475 RPA3
Mean 8.05
Standard deviation 1.5
Values 9.1 7
[69]
THLE RPA3
Mean 11
Standard deviation 2.9
Values 8.9 13
[70]
liver RPA3
Mean 7.22
Standard deviation 6.1
Values 13 2.4 12 1.4
[71]
ref_hepatocyte RFC5
Mean 5.54
Standard deviation 4.9
Values 13 7.4 0.42 3.6 3.2
[72]
HepG2 RFC5
Mean 13.4
Standard deviation 5.4
Values 9.6 17
[73]
HepG2.C3A RFC5
Mean 16.4
Standard deviation 10
Values 9 24
[74]
HuH.7 RFC5
Mean 18.1
Standard deviation 6.8
Values 23 10 21
[75]
SNU475 RFC5
Mean 12.2
Standard deviation 2.4
Values 11 14
[76]
THLE RFC5
Mean 19.8
Standard deviation 2.4
Values 18 22
[77]
liver RFC5
Mean 4.29
Standard deviation 1.7
Values 4.9 3.5 6.3 2.5
[78]
ref_hepatocyte RFC3
Mean 3.17
Standard deviation 3.1
Values 6.3 6.7 1.4 0.35 1.1
[79]
HepG2 RFC3
Mean 15.8
Standard deviation 7.8
Values 10 21
[80]
HepG2.C3A RFC3
Mean 25.6
Standard deviation 17
Values 14 37
[81]
HuH.7 RFC3
Mean 27.1
Standard deviation 12
Values 35 14 33
[82]
SNU475 RFC3
Mean 13.8
Standard deviation 3.5
Values 11 16
[83]
THLE RFC3
Mean 23.5
Standard deviation 5.4
Values 20 27
[84]
liver RFC3
Mean 2.46
Standard deviation 0.85
Values 2 2.9 3.4 1.5
[85]
ref_hepatocyte LIG1
Mean 3.08
Standard deviation 2.7
Values 7.4 3.8 0.82 2.1 1.3
[86]
HepG2 LIG1
Mean 21.1
Standard deviation 4.6
Values 18 24
[87]
HepG2.C3A LIG1
Mean 19
Standard deviation 5
Values 15 23
[88]
HuH.7 LIG1
Mean 28.4
Standard deviation 13
Values 35 13 37
[89]
SNU475 LIG1
Mean 8.05
Standard deviation 0.33
Values 8.3 7.8
[90]
THLE LIG1
Mean 15.1
Standard deviation 4
Values 12 18
[91]
liver LIG1
Mean 3.39
Standard deviation 0.66
Values 3.3 3.3 4.3 2.7
[92]
ref_hepatocyte POLA2
Mean 2.46
Standard deviation 0.96
Values 1.8 2.8 3.9 2.3 1.5
[93]
HepG2 POLA2
Mean 8.49
Standard deviation 2.2
Values 6.9 10
[94]
HepG2.C3A POLA2
Mean 5.87
Standard deviation 3.6
Values 3.3 8.4
[95]
HuH.7 POLA2
Mean 8.32
Standard deviation 5.1
Values 11 2.5 11
[96]
SNU475 POLA2
Mean 12.9
Standard deviation 3.1
Values 11 15
[97]
THLE POLA2
Mean 17.9
Standard deviation 4
Values 15 21
[98]
liver POLA2
Mean 1.96
Standard deviation 0.6
Values 1.2 1.9 2.6 2.2
[99]
ref_hepatocyte PRIM1
Mean 2.43
Standard deviation 1.4
Values 4.4 2.6 0.57 2.6 1.9
[100]
HepG2 PRIM1
Mean 8.54
Standard deviation 0.87
Values 7.9 9.2
[101]
HepG2.C3A PRIM1
Mean 19.1
Standard deviation 8.1
Values 13 25
[102]
HuH.7 PRIM1
Mean 23.1
Standard deviation 6.2
Values 27 16 26
[103]
SNU475 PRIM1
Mean 9.98
Standard deviation 3.1
Values 7.8 12
[104]
THLE PRIM1
Mean 16.8
Standard deviation 2.1
Values 15 18
[105]
liver PRIM1
Mean 1.84
Standard deviation 0.34
Values 2.1 1.6 2.1 1.5
[106]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[107]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[108]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[109]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[110]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[111]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[112]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[113]
ref_hepatocyte PRIM2
Mean 2.32
Standard deviation 2.3
Values 6.1 2.9 0.46 1.4 0.78
[114]
HepG2 PRIM2
Mean 12.4
Standard deviation 3.6
Values 9.9 15
[115]
HepG2.C3A PRIM2
Mean 9.66
Standard deviation 4.4
Values 6.5 13
[116]
HuH.7 PRIM2
Mean 7.1
Standard deviation 1.5
Values 7.8 5.4 8.1
[117]
SNU475 PRIM2
Mean 9.65
Standard deviation 1.6
Values 8.5 11
[118]
THLE PRIM2
Mean 12.8
Standard deviation 1.5
Values 12 14
[119]
liver PRIM2
Mean 1.1
Standard deviation 0.41
Values 0.68 1.5 0.82 1.4
[120]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[121]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[122]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[123]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[124]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[125]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[126]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[127]
ref_hepatocyte POLA1
Mean 0.985
Standard deviation 0.81
Values 1.8 2 0.27 0.52 0.41
[128]
HepG2 POLA1
Mean 8.75
Standard deviation 4.7
Values 5.4 12
[129]
HepG2.C3A POLA1
Mean 8.42
Standard deviation 3.5
Values 5.9 11
[130]
HuH.7 POLA1
Mean 11.9
Standard deviation 5.3
Values 17 6.3 13
[131]
SNU475 POLA1
Mean 14.3
Standard deviation 5.6
Values 10 18
[132]
THLE POLA1
Mean 15.7
Standard deviation 1.1
Values 15 17
[133]
liver POLA1
Mean 4.45
Standard deviation 2.4
Values 1.9 7.6 3.5 4.8
[134]
ref_hepatocyte DNA2
Mean 0.686
Standard deviation 0.42
Values 1.2 1.1 0.52 0.36 0.28
[135]
HepG2 DNA2
Mean 5.13
Standard deviation 3.4
Values 2.7 7.6
[136]
HepG2.C3A DNA2
Mean 15.6
Standard deviation 12
Values 7.4 24
[137]
HuH.7 DNA2
Mean 8.62
Standard deviation 3.7
Values 11 4.3 11
[138]
SNU475 DNA2
Mean 7.89
Standard deviation 1.4
Values 6.9 8.9
[139]
THLE DNA2
Mean 7
Standard deviation 0.46
Values 6.7 7.3
[140]
liver DNA2
Mean 2.88
Standard deviation 1.1
Values 2.8 3.6 1.3 3.8