REACTOME_KSRP_KHSRP_BINDS_AND_DESTABILIZES_MRNA Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAZ 14-3-3 protein zeta/delta [1] -0.40[2] -0.51[3] -0.42[4] 0.48[5] -0.29[6] -0.77[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] 0.25[9] 0.07[10] -1.24[11] -0.47[12] 0.19[13] 0.63[14]
3 EXOSC4 Exosome complex component RRP41 [15] -1.35[16] -0.93[17] -1.80[18] -2.26[19] -2.29[20] -0.80[21]
4 EXOSC7 Exosome complex component RRP42 [22] -1.18[23] -1.15[24] -0.81[25] -3.13[26] -1.53[27] -0.97[28]
5 KHSRP Far upstream element-binding protein 2 [29] 1.59[30] 0.86[31] 2.04[32] 0.28[33] 1.11[34] -0.55[35]
6 EXOSC3 Exosome complex component RRP40 [36] -0.93[37] -0.99[38] -0.50[39] -2.35[40] -1.04[41] -0.94[42]
7 EXOSC9 Exosome complex component RRP45 [43] -1.16[44] -0.67[45] -1.43[46] -1.86[47] 0.47[48] -1.26[49]
8 EXOSC5 Exosome complex component RRP46 [50] -0.77[51] -0.69[52] 0.15[53] -2.34[54] -1.26[55] -0.19[56]
9 MAPK14 Mitogen-activated protein kinase 14 [57] 1.65[58] 1.76[59] 1.11[60] 1.26[61] 1.38[62] 2.16[63]
10 PARN Poly(A)-specific ribonuclease PARN [64] 1.10[65] 0.50[66] -0.08[67] -0.46[68] 0.14[69] 0.81[70]
11 EXOSC2 Exosome complex component RRP4 [71] 0.40[72] 0.28[73] 0.37[74] -0.75[75] 0.84[76] 0.18[77]
12 EXOSC1 Exosome complex component CSL4 [78] 0.08[79] 0.81[80] 0.88[81] -1.33[82] 0.24[83] -0.08[84]
13 EXOSC6 Exosome complex component MTR3 [85] -0.04[86] 0.03[87] -1.43[88] -1.47[89] -0.24[90] 0.24[91]
14 EXOSC8 Exosome complex component RRP43 [92] 0.32[93] 1.20[94] 1.16[95] -1.16[96] 0.54[97] 0.21[98]
15 DIS3 Exosome complex exonuclease RRP44 [99] 1.08[100] 2.15[101] 2.59[102] 1.37[103] 2.06[104] 2.83[105]
16 DCP2 m7GpppN-mRNA hydrolase [106] 1.96[107] 3.73[108] 2.66[109] 2.01[110] 2.55[111] 4.08[112]
17 MAPK11 Mitogen-activated protein kinase 11 [113] 0.00[114] -0.06[115] -1.17[116] -0.06[117] 2.57[118] 1.04[119]
[1]
ref_hepatocyte YWHAZ
Mean 161
Standard deviation 1.6e+02
Values 1.3e+02 4.3e+02 1.6e+02 40 41
[2]
HepG2 YWHAZ
Mean 239
Standard deviation 21
Values 2.2e+02 2.5e+02
[3]
HepG2.C3A YWHAZ
Mean 191
Standard deviation 28
Values 1.7e+02 2.1e+02
[4]
HuH.7 YWHAZ
Mean 229
Standard deviation 23
Values 2.5e+02 2.1e+02 2.3e+02
[5]
SNU475 YWHAZ
Mean 552
Standard deviation 94
Values 6.2e+02 4.9e+02
[6]
THLE YWHAZ
Mean 232
Standard deviation 39
Values 2e+02 2.6e+02
[7]
liver YWHAZ
Mean 73.1
Standard deviation 31
Values 81 60 1.1e+02 39
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[15]
ref_hepatocyte EXOSC4
Mean 20
Standard deviation 9.6
Values 7.2 18 34 23 18
[16]
HepG2 EXOSC4
Mean 15.4
Standard deviation 1
Values 16 15
[17]
HepG2.C3A EXOSC4
Mean 17.7
Standard deviation 0.81
Values 18 17
[18]
HuH.7 EXOSC4
Mean 10.9
Standard deviation 5
Values 12 5.5 15
[19]
SNU475 EXOSC4
Mean 10.2
Standard deviation 1.9
Values 8.9 12
[20]
THLE EXOSC4
Mean 7.19
Standard deviation 1.1
Values 6.4 8
[21]
liver EXOSC4
Mean 8.91
Standard deviation 7.7
Values 18 2.2 13 2.8
[22]
ref_hepatocyte EXOSC7
Mean 19.5
Standard deviation 5.3
Values 20 25 24 15 13
[23]
HepG2 EXOSC7
Mean 16.8
Standard deviation 1.4
Values 18 16
[24]
HepG2.C3A EXOSC7
Mean 14.8
Standard deviation 0.76
Values 15 14
[25]
HuH.7 EXOSC7
Mean 21.1
Standard deviation 7.8
Values 22 13 28
[26]
SNU475 EXOSC7
Mean 5.45
Standard deviation 0.71
Values 6 4.9
[27]
THLE EXOSC7
Mean 11.8
Standard deviation 0.76
Values 11 12
[28]
liver EXOSC7
Mean 7.69
Standard deviation 4.4
Values 12 4.5 11 3.4
[29]
ref_hepatocyte KHSRP
Mean 16.2
Standard deviation 6
Values 20 18 24 10 9.7
[30]
HepG2 KHSRP
Mean 95.2
Standard deviation 11
Values 1e+02 88
[31]
HepG2.C3A KHSRP
Mean 49.8
Standard deviation 4.2
Values 47 53
[32]
HuH.7 KHSRP
Mean 126
Standard deviation 44
Values 1.7e+02 84 1.2e+02
[33]
SNU475 KHSRP
Mean 48.4
Standard deviation 5.5
Values 44 52
[34]
THLE KHSRP
Mean 61.7
Standard deviation 16
Values 50 73
[35]
liver KHSRP
Mean 8.59
Standard deviation 5.9
Values 4.6 11 3 15
[36]
ref_hepatocyte EXOSC3
Mean 15.3
Standard deviation 11
Values 24 29 9.4 7.1 6.5
[37]
HepG2 EXOSC3
Mean 15.6
Standard deviation 2
Values 14 17
[38]
HepG2.C3A EXOSC3
Mean 13
Standard deviation 5
Values 9.5 17
[39]
HuH.7 EXOSC3
Mean 20.5
Standard deviation 9.1
Values 23 10 28
[40]
SNU475 EXOSC3
Mean 7.33
Standard deviation 0.48
Values 7 7.7
[41]
THLE EXOSC3
Mean 13
Standard deviation 1.4
Values 12 14
[42]
liver EXOSC3
Mean 6.17
Standard deviation 1.8
Values 7.1 4.7 8.3 4.6
[43]
ref_hepatocyte EXOSC9
Mean 11.8
Standard deviation 9.9
Values 17 27 6.1 4.9 4
[44]
HepG2 EXOSC9
Mean 10.3
Standard deviation 2.7
Values 8.4 12
[45]
HepG2.C3A EXOSC9
Mean 12.5
Standard deviation 4.3
Values 9.4 16
[46]
HuH.7 EXOSC9
Mean 8.29
Standard deviation 1.6
Values 8.5 6.6 9.8
[47]
SNU475 EXOSC9
Mean 7.97
Standard deviation 2
Values 6.6 9.4
[48]
THLE EXOSC9
Mean 28.7
Standard deviation 1
Values 29 28
[49]
liver EXOSC9
Mean 3.81
Standard deviation 1.1
Values 5.2 3.3 4.1 2.7
[50]
ref_hepatocyte EXOSC5
Mean 10.7
Standard deviation 6.4
Values 3.4 5.9 17 18 9.8
[51]
HepG2 EXOSC5
Mean 12.3
Standard deviation 4.6
Values 16 9.1
[52]
HepG2.C3A EXOSC5
Mean 11.2
Standard deviation 0.51
Values 11 12
[53]
HuH.7 EXOSC5
Mean 22.5
Standard deviation 11
Values 26 9.8 31
[54]
SNU475 EXOSC5
Mean 5.21
Standard deviation 1.6
Values 4 6.4
[55]
THLE EXOSC5
Mean 7.89
Standard deviation 0.98
Values 7.2 8.6
[56]
liver EXOSC5
Mean 7.26
Standard deviation 6.1
Values 13 2.2 12 1.8
[57]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 12 8.5 7.2 7.5 8.3
[58]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 47 60
[59]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[60]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 37 36 34
[61]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 52 51
[62]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[63]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 24 38 22 37
[64]
ref_hepatocyte PARN
Mean 8.43
Standard deviation 4.9
Values 17 7.1 8.4 5.2 4.7
[65]
HepG2 PARN
Mean 35.5
Standard deviation 6.6
Values 31 40
[66]
HepG2.C3A PARN
Mean 20.2
Standard deviation 1.7
Values 19 21
[67]
HuH.7 PARN
Mean 15.2
Standard deviation 2.1
Values 17 13 16
[68]
SNU475 PARN
Mean 15
Standard deviation 0.41
Values 15 15
[69]
THLE PARN
Mean 16.4
Standard deviation 5.2
Values 13 20
[70]
liver PARN
Mean 11.5
Standard deviation 1.2
Values 10 12 13 10
[71]
ref_hepatocyte EXOSC2
Mean 7.07
Standard deviation 2.8
Values 6.3 12 7.1 6.6 3.7
[72]
HepG2 EXOSC2
Mean 18.3
Standard deviation 0.66
Values 18 19
[73]
HepG2.C3A EXOSC2
Mean 14.5
Standard deviation 5.8
Values 10 19
[74]
HuH.7 EXOSC2
Mean 17.3
Standard deviation 8.4
Values 20 7.8 24
[75]
SNU475 EXOSC2
Mean 10.3
Standard deviation 1.6
Values 9.2 11
[76]
THLE EXOSC2
Mean 22.3
Standard deviation 6.3
Values 18 27
[77]
liver EXOSC2
Mean 6.22
Standard deviation 0.73
Values 5.8 6.9 6.7 5.4
[78]
ref_hepatocyte EXOSC1
Mean 6.86
Standard deviation 3.7
Values 3.9 5 4 12 9
[79]
HepG2 EXOSC1
Mean 14.2
Standard deviation 0.4
Values 15 14
[80]
HepG2.C3A EXOSC1
Mean 20.3
Standard deviation 1.4
Values 19 21
[81]
HuH.7 EXOSC1
Mean 24
Standard deviation 5.1
Values 23 19 29
[82]
SNU475 EXOSC1
Mean 6.72
Standard deviation 0.24
Values 6.9 6.5
[83]
THLE EXOSC1
Mean 14.3
Standard deviation 0.39
Values 15 14
[84]
liver EXOSC1
Mean 5.02
Standard deviation 3.7
Values 8.6 2 7.9 1.6
[85]
ref_hepatocyte EXOSC6
Mean 6.69
Standard deviation 5
Values 15 5.3 4 3.2 5.5
[86]
HepG2 EXOSC6
Mean 12.7
Standard deviation 0.74
Values 13 12
[87]
HepG2.C3A EXOSC6
Mean 11.5
Standard deviation 1.3
Values 11 12
[88]
HuH.7 EXOSC6
Mean 4.71
Standard deviation 1.3
Values 4.4 3.6 6.2
[89]
SNU475 EXOSC6
Mean 5.93
Standard deviation 0.11
Values 5.9 6
[90]
THLE EXOSC6
Mean 9.98
Standard deviation 1.4
Values 9 11
[91]
liver EXOSC6
Mean 6.12
Standard deviation 2.8
Values 3.1 7.5 4.5 9.4
[92]
ref_hepatocyte EXOSC8
Mean 5.67
Standard deviation 0.99
Values 4.8 5.8 4.7 7.1 5.9
[93]
HepG2 EXOSC8
Mean 13.9
Standard deviation 2.4
Values 12 16
[94]
HepG2.C3A EXOSC8
Mean 21.9
Standard deviation 7.8
Values 16 27
[95]
HuH.7 EXOSC8
Mean 24
Standard deviation 11
Values 24 13 35
[96]
SNU475 EXOSC8
Mean 6.25
Standard deviation 0.33
Values 6 6.5
[97]
THLE EXOSC8
Mean 14.5
Standard deviation 0.013
Values 15 15
[98]
liver EXOSC8
Mean 5.08
Standard deviation 4
Values 8.7 1.9 8.3 1.4
[99]
ref_hepatocyte DIS3
Mean 3.36
Standard deviation 0.85
Values 3.9 3.2 4.6 2.8 2.4
[100]
HepG2 DIS3
Mean 13.9
Standard deviation 5.1
Values 10 17
[101]
HepG2.C3A DIS3
Mean 25.1
Standard deviation 4.1
Values 22 28
[102]
HuH.7 DIS3
Mean 38.4
Standard deviation 2.7
Values 42 37 36
[103]
SNU475 DIS3
Mean 21.4
Standard deviation 0.63
Values 21 22
[104]
THLE DIS3
Mean 24.8
Standard deviation 1.5
Values 26 24
[105]
liver DIS3
Mean 18.5
Standard deviation 4.7
Values 16 25 15 19
[106]
ref_hepatocyte DCP2
Mean 1.54
Standard deviation 1.2
Values 3.4 2.2 0.65 0.48 1
[107]
HepG2 DCP2
Mean 11.8
Standard deviation 4.5
Values 8.6 15
[108]
HepG2.C3A DCP2
Mean 34.5
Standard deviation 0.73
Values 34 35
[109]
HuH.7 DCP2
Mean 18.4
Standard deviation 1.8
Values 21 17 18
[110]
SNU475 DCP2
Mean 15.3
Standard deviation 1.8
Values 17 14
[111]
THLE DCP2
Mean 15.9
Standard deviation 2.3
Values 17 14
[112]
liver DCP2
Mean 20.1
Standard deviation 9
Values 10 31 15 24
[113]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0 0.34 0.22 0.71 0.64
[114]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.62 0.88
[115]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.53 0.71
[116]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.28 0.2 0.49
[117]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 1.1 0.66
[118]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[119]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.96 0.49 0.23 0.75