REACTOME_KETONE_BODY_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HMGCS2 Hydroxymethylglutaryl-CoA synthase, mitochondrial [1] -10.70[2] -8.90[3] -1.62[4] -7.18[5] -11.72[6] 0.18[7]
2 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial [8] 0.25[9] -0.41[10] -1.23[11] 0.51[12] -0.72[13] -0.07[14]
3 HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial [15] -0.18[16] 0.83[17] 0.47[18] 0.18[19] -0.44[20] -0.91[21]
4 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial [22] -0.69[23] 0.52[24] -3.97[25] -6.03[26] -0.08[27] 0.45[28]
5 ACSS3 Acyl-CoA synthetase short-chain family member 3, mitochondrial [29] 3.30[30] 3.20[31] 3.45[32] -0.69[33] -2.00[34] 0.56[35]
6 BDH2 3-hydroxybutyrate dehydrogenase type 2 [36] 1.62[37] 1.62[38] 2.46[39] 2.16[40] 3.05[41] -0.27[42]
7 AACS Acetoacetyl-CoA synthetase [43] 4.02[44] 4.02[45] 2.47[46] 3.75[47] 3.93[48] -1.13[49]
8 OXCT2 Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial [50] 1.81[51] 2.36[52] 2.72[53] 1.68[54] 1.87[55] -2.57[56]
9 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [57] 3.65[58] 2.18[59] 6.84[60] 7.43[61] 8.66[62] -0.05[63]
10 HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic [64] [65] [66] [67] [68] [69] [70]
[1]
ref_hepatocyte HMGCS2
Mean 222
Standard deviation 3.3e+02
Values 1.4 0.38 3.3 3.8e+02 7.2e+02
[2]
HepG2 HMGCS2
Mean 0.0443
Standard deviation 0.046
Values 0.011 0.077
[3]
HepG2.C3A HMGCS2
Mean 0.2
Standard deviation 0.1
Values 0.27 0.13
[4]
HuH.7 HMGCS2
Mean 23.3
Standard deviation 9.9
Values 18 35 17
[5]
SNU475 HMGCS2
Mean 0.265
Standard deviation 0.27
Values 0.46 0.071
[6]
THLE HMGCS2
Mean 0.0139
Standard deviation 0.0029
Values 0.012 0.016
[7]
liver HMGCS2
Mean 562
Standard deviation 3.1e+02
Values 9.5e+02 2.7e+02 6.9e+02 3.5e+02
[8]
ref_hepatocyte ACAT1
Mean 166
Standard deviation 1.7e+02
Values 49 47 23 3.2e+02 3.9e+02
[9]
HepG2 ACAT1
Mean 65.7
Standard deviation 6.9
Values 61 71
[10]
HepG2.C3A ACAT1
Mean 53.7
Standard deviation 16
Values 43 65
[11]
HuH.7 ACAT1
Mean 22.9
Standard deviation 6
Values 22 17 29
[12]
SNU475 ACAT1
Mean 40.9
Standard deviation 14
Values 51 31
[13]
THLE ACAT1
Mean 21.3
Standard deviation 4.8
Values 18 25
[14]
liver ACAT1
Mean 353
Standard deviation 1.8e+02
Values 4.7e+02 2.4e+02 5.4e+02 1.6e+02
[15]
ref_hepatocyte HMGCL
Mean 70.8
Standard deviation 75
Values 13 21 16 1.3e+02 1.7e+02
[16]
HepG2 HMGCL
Mean 20.8
Standard deviation 4.9
Values 24 17
[17]
HepG2.C3A HMGCL
Mean 54.2
Standard deviation 20
Values 68 40
[18]
HuH.7 HMGCL
Mean 31.8
Standard deviation 4.4
Values 29 30 37
[19]
SNU475 HMGCL
Mean 13.9
Standard deviation 6.4
Values 18 9.4
[20]
THLE HMGCL
Mean 11
Standard deviation 0.25
Values 11 11
[21]
liver HMGCL
Mean 84.2
Standard deviation 57
Values 1.3e+02 42 1.3e+02 29
[22]
ref_hepatocyte BDH1
Mean 25.6
Standard deviation 33
Values 3.3 1.2 2.5 50 72
[23]
HepG2 BDH1
Mean 5.26
Standard deviation 2
Values 3.9 6.7
[24]
HepG2.C3A BDH1
Mean 15.9
Standard deviation 1.5
Values 17 15
[25]
HuH.7 BDH1
Mean 0.531
Standard deviation 0.54
Values 0.21 1.2 0.22
[26]
SNU475 BDH1
Mean 0.0679
Standard deviation 0.0043
Values 0.065 0.071
[27]
THLE BDH1
Mean 5.14
Standard deviation 0.81
Values 4.6 5.7
[28]
liver BDH1
Mean 77.8
Standard deviation 38
Values 1.1e+02 59 1.1e+02 34
[29]
ref_hepatocyte ACSS3
Mean 12.3
Standard deviation 8.8
Values 26 7.2 2.4 13 13
[30]
HepG2 ACSS3
Mean 40.4
Standard deviation 5.8
Values 36 45
[31]
HepG2.C3A ACSS3
Mean 48.7
Standard deviation 8.3
Values 55 43
[32]
HuH.7 ACSS3
Mean 43.7
Standard deviation 12
Values 39 57 35
[33]
SNU475 ACSS3
Mean 1.32
Standard deviation 0.24
Values 1.1 1.5
[34]
THLE ACSS3
Mean 0.65
Standard deviation 0.14
Values 0.55 0.75
[35]
liver ACSS3
Mean 40.5
Standard deviation 19
Values 20 64 30 47
[36]
ref_hepatocyte BDH2
Mean 10.5
Standard deviation 9.1
Values 5.7 3.3 3.3 17 23
[37]
HepG2 BDH2
Mean 10.7
Standard deviation 2.5
Values 8.9 13
[38]
HepG2.C3A BDH2
Mean 14
Standard deviation 3.9
Values 11 17
[39]
HuH.7 BDH2
Mean 18.8
Standard deviation 1.6
Values 17 20 20
[40]
SNU475 BDH2
Mean 8.11
Standard deviation 2
Values 9.5 6.7
[41]
THLE BDH2
Mean 18.4
Standard deviation 0.014
Values 18 18
[42]
liver BDH2
Mean 19.5
Standard deviation 17
Values 43 6.8 19 8.7
[43]
ref_hepatocyte AACS
Mean 4.67
Standard deviation 4
Values 10 7.3 1.9 2.3 1.4
[44]
HepG2 AACS
Mean 25.3
Standard deviation 1.4
Values 26 24
[45]
HepG2.C3A AACS
Mean 32.7
Standard deviation 8.6
Values 39 27
[46]
HuH.7 AACS
Mean 8.41
Standard deviation 1.3
Values 8 9.9 7.4
[47]
SNU475 AACS
Mean 10.9
Standard deviation 2.4
Values 13 9.2
[48]
THLE AACS
Mean 15.1
Standard deviation 1.8
Values 14 16
[49]
liver AACS
Mean 4.75
Standard deviation 1
Values 4.7 4.2 6.2 3.9
[50]
ref_hepatocyte OXCT2
Mean 0.433
Standard deviation 0.41
Values 0 1.1 0.46 0.39 0.22
[51]
HepG2 OXCT2
Mean 0.505
Standard deviation 0.26
Values 0.69 0.32
[52]
HepG2.C3A OXCT2
Mean 0.955
Standard deviation 0.092
Values 1 0.89
[53]
HuH.7 OXCT2
Mean 0.925
Standard deviation 0.013
Values 0.93 0.91 0.94
[54]
SNU475 OXCT2
Mean 0.241
Standard deviation 0.032
Values 0.22 0.26
[55]
THLE OXCT2
Mean 0.334
Standard deviation 0.054
Values 0.3 0.37
[56]
liver OXCT2
Mean 0.163
Standard deviation 0.082
Values 0.094 0.27 0.18 0.11
[57]
ref_hepatocyte OXCT1
Mean 0.426
Standard deviation 0.43
Values 0.13 1.1 0.46 0.078 0.31
[58]
HepG2 OXCT1
Mean 1.77
Standard deviation 0.78
Values 1.2 2.3
[59]
HepG2.C3A OXCT1
Mean 0.831
Standard deviation 0.43
Values 0.52 1.1
[60]
HuH.7 OXCT1
Mean 15.8
Standard deviation 7.7
Values 21 6.9 20
[61]
SNU475 OXCT1
Mean 12.7
Standard deviation 0.31
Values 13 13
[62]
THLE OXCT1
Mean 36.5
Standard deviation 3
Values 34 39
[63]
liver OXCT1
Mean 0.915
Standard deviation 0.1
Values 1.1 0.84 0.92 0.83
[64]
ref_hepatocyte HMGCLL1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 HMGCLL1
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A HMGCLL1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[67]
HuH.7 HMGCLL1
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 HMGCLL1
Mean 0.395
Standard deviation 0.31
Values 0.61 0.18
[69]
THLE HMGCLL1
Mean 0.0145
Standard deviation 0.013
Values 0.024 0.0053
[70]
liver HMGCLL1
Mean 0.313
Standard deviation 0.094
Values 0.33 0.4 0.18 0.34