REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.44[2] -0.70[3] -0.62[4] -0.68[5] -0.42[6] -0.02[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.00[16] 0.05[17] -0.25[18] 0.18[19] -0.04[20] 0.43[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.44[23] 2.29[24] 3.26[25] 1.57[26] 2.18[27] 1.20[28]
5 UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 [29] -2.12[30] -2.36[31] -2.29[32] -1.78[33] -2.64[34] -3.16[35]
6 IKBKG NF-kappa-B essential modulator [36] 0.87[37] 0.96[38] -1.36[39] 1.25[40] -0.16[41] 1.25[42]
7 IRAK1 Interleukin-1 receptor-associated kinase 1 [43] 3.18[44] 2.51[45] 1.42[46] 2.90[47] 3.06[48] 1.17[49]
8 UBE2N Ubiquitin-conjugating enzyme E2 N [50] 2.45[51] 2.87[52] 1.62[53] 2.42[54] 2.11[55] 1.13[56]
9 TAB2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [57] 2.12[58] 2.23[59] 2.43[60] 3.80[61] 3.06[62] 2.10[63]
10 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 [64] 1.66[65] 2.67[66] 2.47[67] 2.59[68] 2.57[69] 2.10[70]
11 IRAK2 Interleukin-1 receptor-associated kinase-like 2 [71] 1.68[72] 1.73[73] 1.44[74] -0.33[75] 1.02[76] 0.83[77]
12 MAPK8 Mitogen-activated protein kinase 8 [78] 0.31[79] 1.67[80] 0.47[81] 1.20[82] 0.85[83] 1.34[84]
13 TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [85] 1.82[86] 3.70[87] 3.73[88] 2.45[89] 3.45[90] 2.68[91]
14 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 [92] 2.46[93] 3.04[94] 2.17[95] 3.31[96] 2.50[97] 2.92[98]
15 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 [99] 1.19[100] 1.73[101] 1.67[102] 1.90[103] 1.67[104] 0.72[105]
16 MAPK9 Mitogen-activated protein kinase 9 [106] 2.99[107] 3.15[108] 3.14[109] 3.82[110] 3.07[111] 2.36[112]
17 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 [113] 2.72[114] 2.81[115] 3.31[116] 2.39[117] 2.74[118] 1.09[119]
18 TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [120] 2.41[121] 2.99[122] 3.00[123] 2.11[124] 2.25[125] 2.07[126]
19 TRAF6 TNF receptor-associated factor 6 [127] 2.85[128] 2.68[129] 3.18[130] 3.76[131] 3.02[132] 4.76[133]
20 NOD2 Nucleotide-binding oligomerization domain-containing protein 2 [134] -0.15[135] -2.17[136] [137] -1.51[138] 1.84[139] 1.32[140]
21 NOD1 Nucleotide-binding oligomerization domain-containing protein 1 [141] 2.78[142] 2.40[143] 3.13[144] 4.34[145] 3.76[146] 3.94[147]
22 MAPK10 Mitogen-activated protein kinase 10 [148] 0.28[149] [150] [151] 11.01[152] 6.54[153] 9.10[154]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte UBE2V1
Mean 30.9
Standard deviation 6.6
Values 41 25 33 29 27
[30]
HepG2 UBE2V1
Mean 4.65
Standard deviation 0.14
Values 4.6 4.7
[31]
HepG2.C3A UBE2V1
Mean 3.63
Standard deviation 0.17
Values 3.8 3.5
[32]
HuH.7 UBE2V1
Mean 3.85
Standard deviation 0.39
Values 4.3 3.8 3.5
[33]
SNU475 UBE2V1
Mean 3.83
Standard deviation 0.48
Values 4.2 3.5
[34]
THLE UBE2V1
Mean 2.74
Standard deviation 0.61
Values 2.3 3.2
[35]
liver UBE2V1
Mean 1.36
Standard deviation 0.64
Values 1.9 0.84 2 0.78
[36]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[37]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[38]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[39]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[40]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[41]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[42]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[43]
ref_hepatocyte IRAK1
Mean 21.3
Standard deviation 13
Values 18 30 38 16 5
[44]
HepG2 IRAK1
Mean 126
Standard deviation 40
Values 1.5e+02 97
[45]
HepG2.C3A IRAK1
Mean 73.4
Standard deviation 2.1
Values 72 75
[46]
HuH.7 IRAK1
Mean 34.7
Standard deviation 4.6
Values 40 31 34
[47]
SNU475 IRAK1
Mean 67.9
Standard deviation 14
Values 58 78
[48]
THLE IRAK1
Mean 98.2
Standard deviation 12
Values 90 1.1e+02
[49]
liver IRAK1
Mean 18.8
Standard deviation 3.7
Values 17 19 15 24
[50]
ref_hepatocyte UBE2N
Mean 19.2
Standard deviation 7.8
Values 19 28 25 11 12
[51]
HepG2 UBE2N
Mean 68.4
Standard deviation 19
Values 55 82
[52]
HepG2.C3A UBE2N
Mean 84.8
Standard deviation 36
Values 60 1.1e+02
[53]
HuH.7 UBE2N
Mean 36
Standard deviation 8.3
Values 38 27 43
[54]
SNU475 UBE2N
Mean 44
Standard deviation 3.7
Values 47 41
[55]
THLE UBE2N
Mean 45.7
Standard deviation 8
Values 40 51
[56]
liver UBE2N
Mean 16.6
Standard deviation 11
Values 25 8.3 27 5.9
[57]
ref_hepatocyte TAB2
Mean 9.62
Standard deviation 3.5
Values 7.9 8.1 16 8.4 7.8
[58]
HepG2 TAB2
Mean 27.4
Standard deviation 8.1
Values 22 33
[59]
HepG2.C3A TAB2
Mean 27.3
Standard deviation 2.5
Values 29 26
[60]
HuH.7 TAB2
Mean 31.5
Standard deviation 8.5
Values 28 41 25
[61]
SNU475 TAB2
Mean 57.4
Standard deviation 2.2
Values 59 56
[62]
THLE TAB2
Mean 44.2
Standard deviation 0.52
Values 44 45
[63]
liver TAB2
Mean 16.2
Standard deviation 4.7
Values 21 15 10 19
[64]
ref_hepatocyte MAP3K7
Mean 8.64
Standard deviation 6.6
Values 18 13 4.6 4 3.6
[65]
HepG2 MAP3K7
Mean 17.8
Standard deviation 6.7
Values 13 23
[66]
HepG2.C3A MAP3K7
Mean 33.3
Standard deviation 3
Values 31 35
[67]
HuH.7 MAP3K7
Mean 29.2
Standard deviation 2.3
Values 31 27 30
[68]
SNU475 MAP3K7
Mean 22.3
Standard deviation 2.2
Values 24 21
[69]
THLE MAP3K7
Mean 28.3
Standard deviation 1.5
Values 29 27
[70]
liver MAP3K7
Mean 14.6
Standard deviation 1.8
Values 14 16 16 12
[71]
ref_hepatocyte IRAK2
Mean 8.12
Standard deviation 8.7
Values 2.6 12 22 2.3 1.9
[72]
HepG2 IRAK2
Mean 17
Standard deviation 8.7
Values 23 11
[73]
HepG2.C3A IRAK2
Mean 16.3
Standard deviation 5.4
Values 20 12
[74]
HuH.7 IRAK2
Mean 13.4
Standard deviation 4.3
Values 10 18 11
[75]
SNU475 IRAK2
Mean 2.77
Standard deviation 1.6
Values 1.6 3.9
[76]
THLE IRAK2
Mean 9.08
Standard deviation 2
Values 7.7 10
[77]
liver IRAK2
Mean 5.68
Standard deviation 1
Values 4.5 5.2 6.5 6.5
[78]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 6.5 5.6 15 3.8 4.7
[79]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 5.1 6.5
[80]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 11 17
[81]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 6.5 6.2 5.2
[82]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 7.3 6.6
[83]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[84]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.3 7.8 5.6 7.6
[85]
ref_hepatocyte TAB3
Mean 6.67
Standard deviation 6.1
Values 17 5.7 5.5 1.9 3.1
[86]
HepG2 TAB3
Mean 15.3
Standard deviation 7.1
Values 10 20
[87]
HepG2.C3A TAB3
Mean 52.5
Standard deviation 9.3
Values 59 46
[88]
HuH.7 TAB3
Mean 53.9
Standard deviation 32
Values 42 90 30
[89]
SNU475 TAB3
Mean 15.6
Standard deviation 5
Values 19 12
[90]
THLE TAB3
Mean 40.2
Standard deviation 2.3
Values 42 39
[91]
liver TAB3
Mean 16.8
Standard deviation 3.6
Values 21 18 15 13
[92]
ref_hepatocyte MAP2K4
Mean 5.23
Standard deviation 0.4
Values 5.1 5.9 5.1 4.9 5.2
[93]
HepG2 MAP2K4
Mean 18.8
Standard deviation 5.8
Values 15 23
[94]
HepG2.C3A MAP2K4
Mean 26
Standard deviation 3.4
Values 24 28
[95]
HuH.7 MAP2K4
Mean 14.3
Standard deviation 2.4
Values 14 17 12
[96]
SNU475 MAP2K4
Mean 22.2
Standard deviation 0.79
Values 23 22
[97]
THLE MAP2K4
Mean 16.4
Standard deviation 1.6
Values 15 17
[98]
liver MAP2K4
Mean 15.6
Standard deviation 2
Values 16 17 17 13
[99]
ref_hepatocyte RIPK2
Mean 4.75
Standard deviation 3.4
Values 4.6 4.7 10 2.7 1.5
[100]
HepG2 RIPK2
Mean 7.05
Standard deviation 1.9
Values 5.7 8.4
[101]
HepG2.C3A RIPK2
Mean 9.51
Standard deviation 0.29
Values 9.3 9.7
[102]
HuH.7 RIPK2
Mean 9.2
Standard deviation 1.4
Values 9.4 10 7.7
[103]
SNU475 RIPK2
Mean 7.59
Standard deviation 1.2
Values 6.7 8.5
[104]
THLE RIPK2
Mean 8.33
Standard deviation 0.54
Values 7.9 8.7
[105]
liver RIPK2
Mean 3.08
Standard deviation 0.94
Values 3.6 2.6 4.1 2
[106]
ref_hepatocyte MAPK9
Mean 4.45
Standard deviation 2.7
Values 8.6 5.3 1.4 3.7 3.3
[107]
HepG2 MAPK9
Mean 23
Standard deviation 4.4
Values 20 26
[108]
HepG2.C3A MAPK9
Mean 24
Standard deviation 3.3
Values 22 26
[109]
HuH.7 MAPK9
Mean 24
Standard deviation 2.9
Values 26 21 25
[110]
SNU475 MAPK9
Mean 26.8
Standard deviation 2.4
Values 29 25
[111]
THLE MAPK9
Mean 20.6
Standard deviation 0.2
Values 21 21
[112]
liver MAPK9
Mean 9.01
Standard deviation 3.1
Values 7.1 12 5.7 11
[113]
ref_hepatocyte MAP2K7
Mean 3.82
Standard deviation 2
Values 2.7 1.5 6.2 5.7 3
[114]
HepG2 MAP2K7
Mean 16.4
Standard deviation 3.3
Values 19 14
[115]
HepG2.C3A MAP2K7
Mean 16.2
Standard deviation 4
Values 19 13
[116]
HuH.7 MAP2K7
Mean 23.1
Standard deviation 1.5
Values 24 22 23
[117]
SNU475 MAP2K7
Mean 8.53
Standard deviation 0.26
Values 8.3 8.7
[118]
THLE MAP2K7
Mean 14
Standard deviation 0.17
Values 14 14
[119]
liver MAP2K7
Mean 3.21
Standard deviation 0.87
Values 3.1 3 2.3 4.4
[120]
ref_hepatocyte TAB1
Mean 3.61
Standard deviation 1.3
Values 2.3 2.1 5.1 4.4 4.1
[121]
HepG2 TAB1
Mean 12.5
Standard deviation 0.3
Values 13 12
[122]
HepG2.C3A TAB1
Mean 17.4
Standard deviation 1.8
Values 19 16
[123]
HuH.7 TAB1
Mean 17.6
Standard deviation 2.2
Values 19 15 19
[124]
SNU475 TAB1
Mean 6.68
Standard deviation 1.2
Values 7.5 5.8
[125]
THLE TAB1
Mean 9.45
Standard deviation 1.6
Values 8.3 11
[126]
liver TAB1
Mean 5.99
Standard deviation 1.7
Values 7.6 4.1 7.1 5.1
[127]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[128]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[129]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[130]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[131]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[132]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[133]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[134]
ref_hepatocyte NOD2
Mean 0.638
Standard deviation 1.3
Values 0 0.1 2.9 0.095 0.065
[135]
HepG2 NOD2
Mean 0.376
Standard deviation 0.25
Values 0.55 0.2
[136]
HepG2.C3A NOD2
Mean 0.0856
Standard deviation 0.03
Values 0.11 0.064
[137]
HuH.7 NOD2
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 NOD2
Mean 0.0958
Standard deviation 0.044
Values 0.065 0.13
[139]
THLE NOD2
Mean 1.26
Standard deviation 0.96
Values 1.9 0.58
[140]
liver NOD2
Mean 0.628
Standard deviation 0.28
Values 0.82 0.74 0.21 0.74
[141]
ref_hepatocyte NOD1
Mean 0.485
Standard deviation 0.18
Values 0.6 0.52 0.63 0.18 0.5
[142]
HepG2 NOD1
Mean 2.17
Standard deviation 0.27
Values 2.4 2
[143]
HepG2.C3A NOD1
Mean 1.55
Standard deviation 0.59
Values 1.1 2
[144]
HuH.7 NOD1
Mean 2.59
Standard deviation 0.8
Values 3.3 1.7 2.8
[145]
SNU475 NOD1
Mean 4.21
Standard deviation 0.18
Values 4.3 4.1
[146]
THLE NOD1
Mean 3.63
Standard deviation 0.052
Values 3.6 3.7
[147]
liver NOD1
Mean 2.92
Standard deviation 0.79
Values 2.1 3.5 2.4 3.7
[148]
ref_hepatocyte MAPK10
Mean 0.00272
Standard deviation 0.0061
Values 0 0 0.014 0 0
[149]
HepG2 MAPK10
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[150]
HepG2.C3A MAPK10
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 MAPK10
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 MAPK10
Mean 2.4
Standard deviation 0.56
Values 2.8 2
[153]
THLE MAPK10
Mean 0.14
Standard deviation 0.07
Values 0.19 0.09
[154]
liver MAPK10
Mean 0.586
Standard deviation 0.14
Values 0.52 0.8 0.54 0.49