REACTOME_IRS_MEDIATED_SIGNALLING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TRIB3 Tribbles homolog 3 [1] -0.13[2] -0.09[3] -1.46[4] -2.58[5] -2.17[6] -1.48[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] -0.60[9] -0.41[10] -0.71[11] 0.32[12] 0.86[13] 0.20[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 0.15[16] -0.26[17] -0.39[18] -0.01[19] -0.19[20] -0.76[21]
4 FGFR4 Fibroblast growth factor receptor 4 [22] 0.91[23] 1.01[24] 1.33[25] -4.80[26] -5.02[27] -0.56[28]
5 NRAS GTPase NRas [29] -0.41[30] -0.23[31] -0.07[32] 0.43[33] -0.09[34] -1.31[35]
6 HRAS GTPase HRas [36] -2.05[37] -3.00[38] -4.05[39] -1.51[40] -1.82[41] -3.72[42]
7 AKT2 RAC-beta serine/threonine-protein kinase [43] -0.08[44] -0.06[45] -0.18[46] 0.29[47] -0.01[48] 0.07[49]
8 KLB Beta-klotho [50] -0.45[51] -0.86[52] 0.33[53] -6.53[54] -7.26[55] 0.49[56]
9 KRAS GTPase KRas [57] -1.56[58] -1.83[59] -0.48[60] 0.24[61] -0.20[62] -0.38[63]
10 FGFR3 Fibroblast growth factor receptor 3 [64] 1.69[65] 1.35[66] 1.42[67] -3.86[68] -2.61[69] -0.61[70]
11 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [71] -1.51[72] -1.64[73] -0.81[74] 1.50[75] 0.91[76] 1.94[77]
12 SOS1 Son of sevenless homolog 1 [78] -1.14[79] 0.14[80] -0.61[81] 0.28[82] -0.58[83] -0.52[84]
13 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [85] 0.83[86] 0.81[87] 1.16[88] 0.14[89] 0.61[90] -1.35[91]
14 PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 [92] -0.66[93] -0.28[94] -1.45[95] 0.24[96] 0.35[97] -0.43[98]
15 FGF2 Fibroblast growth factor 2 [99] -7.73[100] -7.72[101] -3.83[102] 0.37[103] 1.85[104] -2.72[105]
16 PDPK1 3-phosphoinositide-dependent protein kinase 1 [106] 1.29[107] 2.23[108] 0.69[109] 0.87[110] 1.17[111] 1.45[112]
17 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B [113] -0.59[114] 0.12[115] 0.11[116] -1.95[117] -2.48[118] 1.82[119]
18 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.17[120] 0.43[121] 0.33[122] 0.48[123] 0.55[124] 0.10[125]
19 IRS1 Insulin receptor substrate 1 [126] 1.05[127] 0.25[128] 1.42[129] 1.14[130] 0.63[131] 1.06[132]
20 IRS2 Insulin receptor substrate 2 [133] -6.69[134] [135] -4.34[136] -1.23[137] 2.50[138] 1.33[139]
21 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 [140] 0.12[141] -0.07[142] 0.64[143] 1.10[144] 1.48[145] 1.81[146]
22 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.42[147] -0.03[148] -0.10[149] 0.56[150] 0.67[151] 0.86[152]
23 THEM4 Acyl-coenzyme A thioesterase THEM4 [153] -0.40[154] -0.20[155] 0.09[156] 1.44[157] 0.76[158] 0.03[159]
24 FLT3LG Fms-related tyrosine kinase 3 ligand [160] -3.30[161] -3.45[162] -3.24[163] -2.90[164] -1.91[165] -3.22[166]
25 GAB2 GRB2-associated-binding protein 2 [167] 0.52[168] 0.06[169] 0.05[170] 0.36[171] 0.35[172] -0.51[173]
26 FGFR2 Fibroblast growth factor receptor 2 [174] -3.55[175] -2.59[176] 1.09[177] 0.89[178] -4.05[179] 2.37[180]
27 FRS2 Fibroblast growth factor receptor substrate 2 [181] 0.25[182] 1.09[183] 1.33[184] 2.34[185] 1.87[186] 2.28[187]
28 FGFR1 Fibroblast growth factor receptor 1 [188] 3.54[189] 1.60[190] 3.00[191] 4.49[192] 3.66[193] 0.60[194]
29 GAB1 GRB2-associated-binding protein 1 [195] 0.26[196] 1.10[197] 0.97[198] 1.37[199] 1.13[200] 1.82[201]
30 FGF7 Fibroblast growth factor 7 [202] -10.34[203] -6.89[204] [205] -5.94[206] -1.76[207] -2.51[208]
31 KL Klotho [209] -7.10[210] [211] [212] -1.96[213] -7.30[214] -0.81[215]
32 FGF5 Fibroblast growth factor 5 [216] -2.03[217] -0.96[218] -1.29[219] 0.92[220] 0.51[221] 2.08[222]
33 FGF1 Fibroblast growth factor 1 [223] -3.81[224] -3.26[225] -7.98[226] 0.02[227] 1.51[228] -1.02[229]
34 FGF19 Fibroblast growth factor 19 [230] -3.10[231] -2.20[232] 4.29[233] 0.26[234] -3.30[235] [236]
35 FLT3 Receptor-type tyrosine-protein kinase FLT3 [237] [238] [239] -5.04[240] -3.36[241] [242] 1.86[243]
36 FGF8 Fibroblast growth factor 8 [244] -4.37[245] -4.27[246] -0.03[247] -2.48[248] [249] 1.64[250]
37 FGF18 Fibroblast growth factor 18 [251] 0.74[252] -3.63[253] -1.71[254] 0.05[255] 0.55[256] -0.47[257]
38 FGF9 Fibroblast growth factor 9 [258] 1.22[259] -2.69[260] [261] 2.22[262] -2.99[263] -0.95[264]
39 FGF6 Fibroblast growth factor 6 [265] [266] [267] [268] [269] [270] [271]
40 FGF4 Fibroblast growth factor 4 [272] [273] [274] [275] [276] [277] [278]
41 TLR9 Toll-like receptor 9 [279] [280] [281] [282] [283] [284] [285]
42 FGF16 Fibroblast growth factor 16 [286] [287] [288] [289] [290] [291] [292]
43 FGF20 Fibroblast growth factor 20 [293] [294] [295] [296] [297] [298] [299]
44 FGF23 Fibroblast growth factor 23 [300] [301] [302] [303] [304] [305] [306]
45 FGF3 Fibroblast growth factor 3 [307] [308] [309] [310] [311] [312] [313]
46 FGF17 Fibroblast growth factor 17 [314] [315] [316] [317] [318] [319] [320]
47 FGF10 Fibroblast growth factor 10 [321] [322] [323] [324] [325] [326] [327]
48 FGF22 Fibroblast growth factor 22 [328] [329] [330] [331] [332] [333] [334]
[1]
ref_hepatocyte TRIB3
Mean 31.8
Standard deviation 22
Values 21 25 60 47 5.9
[2]
HepG2 TRIB3
Mean 132
Standard deviation 85
Values 1.9e+02 72
[3]
HepG2.C3A TRIB3
Mean 144
Standard deviation 1.1e+02
Values 2.2e+02 66
[4]
HuH.7 TRIB3
Mean 63.7
Standard deviation 8.9
Values 57 74 61
[5]
SNU475 TRIB3
Mean 14.5
Standard deviation 3.3
Values 12 17
[6]
THLE TRIB3
Mean 23
Standard deviation 5.7
Values 27 19
[7]
liver TRIB3
Mean 33.8
Standard deviation 26
Values 72 16 30 17
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[23]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[24]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[25]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[26]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[27]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[28]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[44]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[45]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[46]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[47]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[48]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[49]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[50]
ref_hepatocyte KLB
Mean 9.92
Standard deviation 12
Values 30 1.9 0.71 6.7 9.9
[51]
HepG2 KLB
Mean 33.1
Standard deviation 23
Values 17 49
[52]
HepG2.C3A KLB
Mean 26.3
Standard deviation 0.12
Values 26 26
[53]
HuH.7 KLB
Mean 68.9
Standard deviation 30
Values 57 1e+02 46
[54]
SNU475 KLB
Mean 0.292
Standard deviation 0.04
Values 0.32 0.26
[55]
THLE KLB
Mean 0.21
Standard deviation 0.004
Values 0.21 0.21
[56]
liver KLB
Mean 41.2
Standard deviation 7.6
Values 52 37 40 36
[57]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[58]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[59]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[60]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[61]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[62]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[63]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[64]
ref_hepatocyte FGFR3
Mean 7.46
Standard deviation 9.2
Values 23 2.7 0.18 4.6 6.4
[65]
HepG2 FGFR3
Mean 109
Standard deviation 1.1
Values 1.1e+02 1.1e+02
[66]
HepG2.C3A FGFR3
Mean 91.5
Standard deviation 12
Values 1e+02 83
[67]
HuH.7 FGFR3
Mean 110
Standard deviation 12
Values 1.2e+02 97 1.2e+02
[68]
SNU475 FGFR3
Mean 1.4
Standard deviation 0.25
Values 1.6 1.2
[69]
THLE FGFR3
Mean 3.99
Standard deviation 0.31
Values 3.8 4.2
[70]
liver FGFR3
Mean 14.5
Standard deviation 8.7
Values 9.3 18 5.8 25
[71]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[72]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[73]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[74]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[75]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[76]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[77]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[78]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[79]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[80]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[81]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[82]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[83]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[84]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[85]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[86]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[87]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[88]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[89]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[90]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[91]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[92]
ref_hepatocyte PIK3C3
Mean 4.59
Standard deviation 2.3
Values 8 5.9 2.3 3.8 3
[93]
HepG2 PIK3C3
Mean 13.2
Standard deviation 3.3
Values 11 16
[94]
HepG2.C3A PIK3C3
Mean 18.2
Standard deviation 1.3
Values 17 19
[95]
HuH.7 PIK3C3
Mean 9.26
Standard deviation 1.9
Values 9.1 11 7.5
[96]
SNU475 PIK3C3
Mean 14.7
Standard deviation 3.2
Values 17 12
[97]
THLE PIK3C3
Mean 19.1
Standard deviation 0.92
Values 18 20
[98]
liver PIK3C3
Mean 10.1
Standard deviation 4.2
Values 6.9 15 6.8 11
[99]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[100]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[101]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[102]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[103]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[104]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[105]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[106]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 6.9 3.4 3.6 1.8 2
[107]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 35 43
[108]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 89 71
[109]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 35 33 26
[110]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 17 18
[111]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[112]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 34 27 22 31
[113]
ref_hepatocyte PDE3B
Mean 3.29
Standard deviation 1.7
Values 4.3 2 1.3 3.2 5.6
[114]
HepG2 PDE3B
Mean 9.91
Standard deviation 5.3
Values 6.1 14
[115]
HepG2.C3A PDE3B
Mean 17.2
Standard deviation 3.4
Values 15 20
[116]
HuH.7 PDE3B
Mean 19.6
Standard deviation 4.7
Values 20 24 15
[117]
SNU475 PDE3B
Mean 2.32
Standard deviation 0.34
Values 2.6 2.1
[118]
THLE PDE3B
Mean 1.92
Standard deviation 0.37
Values 2.2 1.7
[119]
liver PDE3B
Mean 34.3
Standard deviation 15
Values 28 53 17 40
[120]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[121]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[122]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[123]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[124]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[125]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[126]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[127]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[128]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[129]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[130]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[131]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[132]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[133]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[134]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[135]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[136]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[138]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[139]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[140]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[141]
ref_hepatocyte PIK3R4
Mean 1.95
Standard deviation 0.81
Values 1.4 1.7 1.2 2.4 3.2
[142]
HepG2 PIK3R4
Mean 9.67
Standard deviation 3.2
Values 7.4 12
[143]
HepG2.C3A PIK3R4
Mean 8.97
Standard deviation 1.7
Values 7.8 10
[144]
HuH.7 PIK3R4
Mean 16.8
Standard deviation 2.8
Values 20 14 16
[145]
SNU475 PIK3R4
Mean 11.4
Standard deviation 0.1
Values 11 11
[146]
THLE PIK3R4
Mean 17.7
Standard deviation 1.3
Values 17 19
[147]
liver PIK3R4
Mean 20.3
Standard deviation 7.7
Values 15 27 12 27
[148]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[149]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[150]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[151]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[152]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[153]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[154]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[155]
ref_hepatocyte THEM4
Mean 1.85
Standard deviation 0.19
Values 1.8 1.7 2.1 2 1.7
[156]
HepG2 THEM4
Mean 6.4
Standard deviation 0.64
Values 5.9 6.9
[157]
HepG2.C3A THEM4
Mean 7.77
Standard deviation 1.9
Values 6.5 9.1
[158]
HuH.7 THEM4
Mean 10.9
Standard deviation 3.9
Values 12 6.4 14
[159]
SNU475 THEM4
Mean 13.7
Standard deviation 1.8
Values 12 15
[160]
THLE THEM4
Mean 10.2
Standard deviation 1.5
Values 9.2 11
[161]
liver THEM4
Mean 5.58
Standard deviation 2.4
Values 8.6 3.8 6.5 3.5
[162]
ref_hepatocyte FLT3LG
Mean 1.73
Standard deviation 1.8
Values 0 0 4.1 1.9 2.7
[163]
HepG2 FLT3LG
Mean 0.799
Standard deviation 0.045
Values 0.83 0.77
[164]
HepG2.C3A FLT3LG
Mean 0.761
Standard deviation 0.27
Values 0.95 0.57
[165]
HuH.7 FLT3LG
Mean 1.01
Standard deviation 0.09
Values 1 1.1 0.92
[166]
SNU475 FLT3LG
Mean 0.629
Standard deviation 0.022
Values 0.64 0.61
[167]
THLE FLT3LG
Mean 1.5
Standard deviation 0.22
Values 1.7 1.3
[168]
liver FLT3LG
Mean 0.55
Standard deviation 0.58
Values 1.3 0.1 0.62 0.15
[169]
ref_hepatocyte GAB2
Mean 1.62
Standard deviation 1.7
Values 1.2 1.9 4.5 0.25 0.31
[170]
HepG2 GAB2
Mean 10.6
Standard deviation 4.9
Values 14 7.1
[171]
HepG2.C3A GAB2
Mean 8.12
Standard deviation 3.2
Values 10 5.9
[172]
HuH.7 GAB2
Mean 9.24
Standard deviation 2.5
Values 9.6 12 6.6
[173]
SNU475 GAB2
Mean 5.63
Standard deviation 0.73
Values 6.1 5.1
[174]
THLE GAB2
Mean 6.7
Standard deviation 0.57
Values 7.1 6.3
[175]
liver GAB2
Mean 3.35
Standard deviation 1.3
Values 2.8 4.2 1.8 4.6
[176]
ref_hepatocyte FGFR2
Mean 1.34
Standard deviation 1.4
Values 0.47 0.46 0.084 2.4 3.2
[177]
HepG2 FGFR2
Mean 0.519
Standard deviation 0.3
Values 0.3 0.73
[178]
HepG2.C3A FGFR2
Mean 1.07
Standard deviation 0.3
Values 0.86 1.3
[179]
HuH.7 FGFR2
Mean 15.7
Standard deviation 0.71
Values 16 15 16
[180]
SNU475 FGFR2
Mean 6.74
Standard deviation 6.4
Values 11 2.2
[181]
THLE FGFR2
Mean 0.263
Standard deviation 0.0039
Values 0.27 0.26
[182]
liver FGFR2
Mean 20.4
Standard deviation 8
Values 18 19 13 32
[183]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[184]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[185]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[186]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[187]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[188]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[189]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[190]
ref_hepatocyte FGFR1
Mean 0.81
Standard deviation 0.63
Values 1.2 0.49 1.6 0.06 0.62
[191]
HepG2 FGFR1
Mean 42.7
Standard deviation 4
Values 40 46
[192]
HepG2.C3A FGFR1
Mean 11.8
Standard deviation 3.5
Values 9.3 14
[193]
HuH.7 FGFR1
Mean 35.6
Standard deviation 13
Values 43 20 43
[194]
SNU475 FGFR1
Mean 49.5
Standard deviation 1.4
Values 50 49
[195]
THLE FGFR1
Mean 33.4
Standard deviation 3.3
Values 36 31
[196]
liver FGFR1
Mean 3.64
Standard deviation 0.67
Values 3 4.2 3.2 4.3
[197]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[198]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[199]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[200]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[201]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[202]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[203]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[204]
ref_hepatocyte FGF7
Mean 0.61
Standard deviation 0.64
Values 0 0.3 0.46 0.6 1.7
[205]
HepG2 FGF7
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[206]
HepG2.C3A FGF7
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[207]
HuH.7 FGF7
Mean 0
Standard deviation 0
Values 0 0 0
[208]
SNU475 FGF7
Mean 0.027
Standard deviation 0.012
Values 0.019 0.035
[209]
THLE FGF7
Mean 0.584
Standard deviation 0.1
Values 0.66 0.51
[210]
liver FGF7
Mean 0.317
Standard deviation 0.15
Values 0.28 0.31 0.51 0.16
[211]
ref_hepatocyte KL
Mean 0.258
Standard deviation 0.29
Values 0 0 0.4 0.2 0.69
[212]
HepG2 KL
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[213]
HepG2.C3A KL
Mean 0
Standard deviation 0
Values 0 0
[214]
HuH.7 KL
Mean 0
Standard deviation 0
Values 0 0 0
[215]
SNU475 KL
Mean 0.181
Standard deviation 0.026
Values 0.2 0.16
[216]
THLE KL
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[217]
liver KL
Mean 0.436
Standard deviation 0.32
Values 0.38 0.31 0.15 0.9
[218]
ref_hepatocyte FGF5
Mean 0.241
Standard deviation 0.27
Values 0.042 0.036 0.09 0.64 0.4
[219]
HepG2 FGF5
Mean 0.268
Standard deviation 0.022
Values 0.25 0.28
[220]
HepG2.C3A FGF5
Mean 0.596
Standard deviation 0.024
Values 0.61 0.58
[221]
HuH.7 FGF5
Mean 0.543
Standard deviation 0.15
Values 0.62 0.65 0.37
[222]
SNU475 FGF5
Mean 1.24
Standard deviation 0.35
Values 0.99 1.5
[223]
THLE FGF5
Mean 1.11
Standard deviation 0.17
Values 0.99 1.2
[224]
liver FGF5
Mean 3.01
Standard deviation 1.5
Values 2.3 4.5 1.2 4.1
[225]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[226]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[227]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[228]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[229]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[230]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[231]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[232]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0 0 0.61 0 0
[233]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.069 0.06
[234]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[235]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 11 17 12
[236]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.51 0.29
[237]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[238]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[239]
ref_hepatocyte FLT3
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[240]
HepG2 FLT3
Mean 0
Standard deviation 0
Values 0 0
[241]
HepG2.C3A FLT3
Mean 0
Standard deviation 0
Values 0 0
[242]
HuH.7 FLT3
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[243]
SNU475 FLT3
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[244]
THLE FLT3
Mean 0
Standard deviation 0
Values 0 0
[245]
liver FLT3
Mean 0.402
Standard deviation 0.15
Values 0.21 0.44 0.39 0.57
[246]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[247]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[248]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[249]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[250]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[251]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[252]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[253]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[254]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[255]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[256]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[257]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[258]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[259]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[260]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[261]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[262]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[263]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[264]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[265]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[266]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[267]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[268]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[269]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[270]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[271]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[272]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[273]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[274]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[275]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[276]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[277]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[278]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[279]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[280]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[281]
ref_hepatocyte TLR9
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[282]
HepG2 TLR9
Mean 0.0229
Standard deviation 0.032
Values 0.046 0
[283]
HepG2.C3A TLR9
Mean 0.197
Standard deviation 0.2
Values 0.34 0.054
[284]
HuH.7 TLR9
Mean 1.11
Standard deviation 1.2
Values 0.44 2.5 0.37
[285]
SNU475 TLR9
Mean 0.0454
Standard deviation 0.021
Values 0.06 0.03
[286]
THLE TLR9
Mean 0.22
Standard deviation 0.12
Values 0.3 0.14
[287]
liver TLR9
Mean 0.227
Standard deviation 0.11
Values 0.12 0.23 0.18 0.38
[288]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[289]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[290]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[291]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[292]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[293]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[294]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[295]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[296]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[297]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[298]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[299]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[300]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[301]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[302]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[303]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[304]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[305]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[306]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[307]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[308]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[309]
ref_hepatocyte FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[310]
HepG2 FGF3
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[311]
HepG2.C3A FGF3
Mean 0
Standard deviation 0
Values 0 0
[312]
HuH.7 FGF3
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[313]
SNU475 FGF3
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[314]
THLE FGF3
Mean 0
Standard deviation 0
Values 0 0
[315]
liver FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0
[316]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[317]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[318]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[319]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[320]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[321]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[322]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[323]
ref_hepatocyte FGF10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[324]
HepG2 FGF10
Mean 0
Standard deviation 0
Values 0 0
[325]
HepG2.C3A FGF10
Mean 0
Standard deviation 0
Values 0 0
[326]
HuH.7 FGF10
Mean 0
Standard deviation 0
Values 0 0 0
[327]
SNU475 FGF10
Mean 0
Standard deviation 0
Values 0 0
[328]
THLE FGF10
Mean 0
Standard deviation 0
Values 0 0
[329]
liver FGF10
Mean 0.0234
Standard deviation 0.038
Values 0 0.014 0 0.079
[330]
ref_hepatocyte FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[331]
HepG2 FGF22
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[332]
HepG2.C3A FGF22
Mean 0
Standard deviation 0
Values 0 0
[333]
HuH.7 FGF22
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[334]
SNU475 FGF22
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[335]
THLE FGF22
Mean 0
Standard deviation 0
Values 0 0
[336]
liver FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0