REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 XRCC6 X-ray repair cross-complementing protein 6 [1] -0.58[2] -0.80[3] -1.16[4] -1.43[5] -1.29[6] -1.36[7]
2 XRCC5 X-ray repair cross-complementing protein 5 [8] 0.48[9] 0.73[10] 0.05[11] 0.25[12] 0.37[13] 0.26[14]
3 DDX41 Probable ATP-dependent RNA helicase DDX41 [15] -0.56[16] -0.58[17] -0.41[18] -0.93[19] -1.17[20] -0.85[21]
4 IRF3 Interferon regulatory factor 3 [22] -0.28[23] 0.02[24] 0.21[25] -0.21[26] -0.73[27] -1.07[28]
5 TBK1 Serine/threonine-protein kinase TBK1 [29] -1.22[30] 0.60[31] -0.80[32] -0.08[33] -0.10[34] 0.58[35]
6 PRKDC DNA-dependent protein kinase catalytic subunit [36] 3.63[37] 3.24[38] 4.58[39] 4.32[40] 4.30[41] 4.35[42]
7 DTX4 E3 ubiquitin-protein ligase DTX4 [43] 0.31[44] 0.46[45] 1.13[46] 0.21[47] -3.37[48] 2.50[49]
8 TREX1 Three-prime repair exonuclease 1 [50] -4.13[51] -2.71[52] -2.31[53] -2.30[54] 0.03[55] -0.71[56]
9 IFI16 Gamma-interferon-inducible protein 16 [57] -6.02[58] -7.17[59] -6.57[60] 3.54[61] 3.21[62] 1.02[63]
10 NLRC3 NLR family CARD domain-containing protein 3 [64] -0.55[65] 0.50[66] -0.13[67] 0.05[68] 0.11[69] 3.57[70]
11 STING1 [71] [72] [73] [74] [75] [76] [77]
12 MRE11 Double-strand break repair protein MRE11 [78] [79] [80] [81] [82] [83] [84]
13 NLRP4 NACHT, LRR and PYD domains-containing protein 4 [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte XRCC6
Mean 131
Standard deviation 74
Values 1.7e+02 2.4e+02 1.2e+02 73 58
[2]
HepG2 XRCC6
Mean 289
Standard deviation 39
Values 2.6e+02 3.2e+02
[3]
HepG2.C3A XRCC6
Mean 200
Standard deviation 42
Values 1.7e+02 2.3e+02
[4]
HuH.7 XRCC6
Mean 220
Standard deviation 54
Values 2.6e+02 1.6e+02 2.4e+02
[5]
SNU475 XRCC6
Mean 132
Standard deviation 1.1
Values 1.3e+02 1.3e+02
[6]
THLE XRCC6
Mean 176
Standard deviation 61
Values 1.3e+02 2.2e+02
[7]
liver XRCC6
Mean 67.3
Standard deviation 21
Values 80 58 89 42
[8]
ref_hepatocyte XRCC5
Mean 49.2
Standard deviation 25
Values 80 72 28 35 31
[9]
HepG2 XRCC5
Mean 227
Standard deviation 47
Values 1.9e+02 2.6e+02
[10]
HepG2.C3A XRCC5
Mean 218
Standard deviation 87
Values 1.6e+02 2.8e+02
[11]
HuH.7 XRCC5
Mean 192
Standard deviation 57
Values 2.4e+02 1.3e+02 2.1e+02
[12]
SNU475 XRCC5
Mean 160
Standard deviation 1.4
Values 1.6e+02 1.6e+02
[13]
THLE XRCC5
Mean 209
Standard deviation 38
Values 1.8e+02 2.4e+02
[14]
liver XRCC5
Mean 77.5
Standard deviation 10
Values 78 81 87 63
[15]
ref_hepatocyte DDX41
Mean 15.7
Standard deviation 5.8
Values 13 26 15 15 10
[16]
HepG2 DDX41
Mean 35.1
Standard deviation 6.6
Values 30 40
[17]
HepG2.C3A DDX41
Mean 28.2
Standard deviation 3.5
Values 26 31
[18]
HuH.7 DDX41
Mean 44.4
Standard deviation 14
Values 51 28 54
[19]
SNU475 DDX41
Mean 22.5
Standard deviation 3.1
Values 25 20
[20]
THLE DDX41
Mean 23.1
Standard deviation 1.2
Values 22 24
[21]
liver DDX41
Mean 11.5
Standard deviation 2.3
Values 12 9.7 14 9.6
[22]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[23]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[24]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[25]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[26]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[27]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[28]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[29]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[30]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[31]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[32]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[33]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[34]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[35]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[36]
ref_hepatocyte PRKDC
Mean 3.34
Standard deviation 1.6
Values 5.3 5 1.9 2.2 2.4
[37]
HepG2 PRKDC
Mean 137
Standard deviation 25
Values 1.2e+02 1.5e+02
[38]
HepG2.C3A PRKDC
Mean 84.1
Standard deviation 23
Values 68 1e+02
[39]
HuH.7 PRKDC
Mean 299
Standard deviation 1.8e+02
Values 5e+02 1.6e+02 2.4e+02
[40]
SNU475 PRKDC
Mean 182
Standard deviation 16
Values 1.7e+02 1.9e+02
[41]
THLE PRKDC
Mean 216
Standard deviation 37
Values 1.9e+02 2.4e+02
[42]
liver PRKDC
Mean 89.5
Standard deviation 54
Values 43 1.5e+02 47 1.1e+02
[43]
ref_hepatocyte DTX4
Mean 2.52
Standard deviation 1.8
Values 0.67 1.7 1.6 4.9 3.8
[44]
HepG2 DTX4
Mean 10.3
Standard deviation 1.7
Values 9.1 12
[45]
HepG2.C3A DTX4
Mean 9.29
Standard deviation 0.13
Values 9.2 9.4
[46]
HuH.7 DTX4
Mean 20.7
Standard deviation 3.3
Values 23 22 17
[47]
SNU475 DTX4
Mean 7.93
Standard deviation 2.6
Values 9.8 6.1
[48]
THLE DTX4
Mean 0.804
Standard deviation 0.22
Values 0.64 0.96
[49]
liver DTX4
Mean 18.7
Standard deviation 4.9
Values 17 25 14 19
[50]
ref_hepatocyte TREX1
Mean 2.46
Standard deviation 2.5
Values 0 0.24 6.1 3.3 2.6
[51]
HepG2 TREX1
Mean 0.463
Standard deviation 0.066
Values 0.51 0.42
[52]
HepG2.C3A TREX1
Mean 1.01
Standard deviation 0.32
Values 1.2 0.78
[53]
HuH.7 TREX1
Mean 1.86
Standard deviation 0.62
Values 1.9 1.2 2.5
[54]
SNU475 TREX1
Mean 1.36
Standard deviation 0.25
Values 1.2 1.5
[55]
THLE TREX1
Mean 8.25
Standard deviation 0.64
Values 8.7 7.8
[56]
liver TREX1
Mean 1.98
Standard deviation 1.2
Values 2.6 0.88 3.3 1.1
[57]
ref_hepatocyte IFI16
Mean 1.91
Standard deviation 1.6
Values 0 0.6 3.7 2.4 2.8
[58]
HepG2 IFI16
Mean 0.0974
Standard deviation 0.089
Values 0.16 0.034
[59]
HepG2.C3A IFI16
Mean 0.0355
Standard deviation 0.0047
Values 0.039 0.032
[60]
HuH.7 IFI16
Mean 0.0756
Standard deviation 0.025
Values 0.09 0.09 0.047
[61]
SNU475 IFI16
Mean 60.5
Standard deviation 9.4
Values 54 67
[62]
THLE IFI16
Mean 58.4
Standard deviation 2.9
Values 56 60
[63]
liver IFI16
Mean 5.12
Standard deviation 1.4
Values 5.6 5 6.6 3.2
[64]
ref_hepatocyte NLRC3
Mean 0.13
Standard deviation 0.18
Values 0.019 0.018 0.17 0.0086 0.43
[65]
HepG2 NLRC3
Mean 0.293
Standard deviation 0.063
Values 0.34 0.25
[66]
HepG2.C3A NLRC3
Mean 0.492
Standard deviation 0.23
Values 0.65 0.33
[67]
HuH.7 NLRC3
Mean 0.447
Standard deviation 0.13
Values 0.33 0.59 0.42
[68]
SNU475 NLRC3
Mean 0.368
Standard deviation 0.074
Values 0.32 0.42
[69]
THLE NLRC3
Mean 0.462
Standard deviation 0.082
Values 0.52 0.4
[70]
liver NLRC3
Mean 2.04
Standard deviation 1.2
Values 1 2.6 1.1 3.5
[71]
ref_hepatocyte STING1
Missing
[72]
HepG2 STING1
Missing
[73]
HepG2.C3A STING1
Missing
[74]
HuH.7 STING1
Missing
[75]
SNU475 STING1
Missing
[76]
THLE STING1
Missing
[77]
liver STING1
Missing
[78]
ref_hepatocyte MRE11
Missing
[79]
HepG2 MRE11
Missing
[80]
HepG2.C3A MRE11
Missing
[81]
HuH.7 MRE11
Missing
[82]
SNU475 MRE11
Missing
[83]
THLE MRE11
Missing
[84]
liver MRE11
Missing
[85]
ref_hepatocyte NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 NLRP4
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A NLRP4
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 NLRP4
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[89]
SNU475 NLRP4
Mean 0.0327
Standard deviation 0.04
Values 0.0046 0.061
[90]
THLE NLRP4
Mean 0
Standard deviation 0
Values 0 0
[91]
liver NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0