REACTOME_IRE1ALPHA_ACTIVATES_CHAPERONES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSPA5 | 78 kDa glucose-regulated protein | [1] | -0.36[2] | -0.33[3] | -0.98[4] | -1.05[5] | -0.74[6] | -0.72[7] |
2 | PDIA6 | Protein disulfide-isomerase A6 | [8] | -0.46[9] | -0.57[10] | -1.29[11] | -0.90[12] | -1.45[13] | -1.04[14] |
3 | XBP1 | X-box-binding protein 1 | [15] | -1.46[16] | -1.22[17] | 0.56[18] | -2.64[19] | -2.70[20] | -0.01[21] |
4 | ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | [22] | -1.19[23] | -0.50[24] | -1.27[25] | -1.36[26] | -0.56[27] | 0.64[28] |
5 | HDGF | Hepatoma-derived growth factor | [29] | -0.59[30] | -0.52[31] | 0.05[32] | -0.13[33] | 0.07[34] | -2.85[35] |
6 | LMNA | Prelamin-A/C | [36] | -0.05[37] | -0.64[38] | -1.91[39] | 0.78[40] | 0.22[41] | -1.35[42] |
7 | DNAJB11 | DnaJ homolog subfamily B member 11 | [43] | -1.43[44] | -1.36[45] | -1.42[46] | -2.14[47] | -1.12[48] | -1.70[49] |
8 | HYOU1 | Hypoxia up-regulated protein 1 | [50] | 0.64[51] | -0.15[52] | -0.18[53] | 0.23[54] | 0.01[55] | 0.76[56] |
9 | SERP1 | Stress-associated endoplasmic reticulum protein 1 | [57] | -0.60[58] | 0.42[59] | 0.12[60] | -0.68[61] | -0.35[62] | 0.47[63] |
10 | YIF1A | Protein YIF1A | [64] | -0.67[65] | -0.76[66] | 0.61[67] | -1.16[68] | -1.70[69] | -1.03[70] |
11 | SRPRB | Signal recognition particle receptor subunit beta | [71] | -0.81[72] | -0.81[73] | -1.18[74] | -1.51[75] | -0.61[76] | -0.06[77] |
12 | DNAJB9 | DnaJ homolog subfamily B member 9 | [78] | -2.35[79] | -1.02[80] | -0.95[81] | -2.18[82] | -2.02[83] | 0.13[84] |
13 | PREB | Prolactin regulatory element-binding protein | [85] | 0.26[86] | 0.84[87] | -0.30[88] | -0.69[89] | -0.52[90] | -0.20[91] |
14 | PDIA5 | Protein disulfide-isomerase A5 | [92] | -0.50[93] | -0.61[94] | -1.05[95] | -2.18[96] | -1.90[97] | -0.49[98] |
15 | ATP6V0D1 | V-type proton ATPase subunit d 1 | [99] | -0.18[100] | -0.70[101] | -0.21[102] | 0.20[103] | 0.24[104] | -0.37[105] |
16 | SYVN1 | E3 ubiquitin-protein ligase synoviolin | [106] | -0.88[107] | -0.59[108] | -0.89[109] | -1.14[110] | -0.80[111] | 0.03[112] |
17 | KLHDC3 | Kelch domain-containing protein 3 | [113] | 0.30[114] | 0.94[115] | 0.61[116] | 0.81[117] | 0.51[118] | -0.54[119] |
18 | ADD1 | Alpha-adducin | [120] | 1.17[121] | 0.25[122] | 1.06[123] | 2.25[124] | 1.08[125] | 0.21[126] |
19 | SEC31A | Protein transport protein Sec31A | [127] | 1.88[128] | 1.82[129] | 2.00[130] | 1.29[131] | 1.45[132] | 1.28[133] |
20 | TPP1 | Tripeptidyl-peptidase 1 | [134] | 1.24[135] | 0.14[136] | 1.01[137] | 0.65[138] | 0.92[139] | 0.81[140] |
21 | SHC1 | SHC-transforming protein 1 | [141] | 1.25[142] | 1.43[143] | 1.61[144] | 2.91[145] | 2.61[146] | 0.39[147] |
22 | ARFGAP1 | ADP-ribosylation factor GTPase-activating protein 1 | [148] | 1.22[149] | 1.44[150] | 0.77[151] | 0.61[152] | 0.22[153] | -1.49[154] |
23 | DCTN1 | Dynactin subunit 1 | [155] | 1.95[156] | 1.07[157] | 0.52[158] | 1.69[159] | 1.91[160] | 0.17[161] |
24 | GOSR2 | Golgi SNAP receptor complex member 2 | [162] | 0.56[163] | 0.54[164] | -0.43[165] | 0.52[166] | 0.19[167] | 0.17[168] |
25 | DNAJC3 | DnaJ homolog subfamily C member 3 | [169] | -0.62[170] | 0.30[171] | -0.87[172] | 0.33[173] | 0.21[174] | 2.35[175] |
26 | SSR1 | Translocon-associated protein subunit alpha | [176] | 2.22[177] | 2.82[178] | 2.18[179] | 2.55[180] | 2.18[181] | 2.75[182] |
27 | TLN1 | Talin-1 | [183] | 3.08[184] | 1.67[185] | 2.55[186] | 3.37[187] | 3.60[188] | 2.97[189] |
28 | SULT1A3 | Sulfotransferase 1A3 | [190] | [191] | [192] | [193] | [194] | [195] | [196] |
29 | GSK3A | Glycogen synthase kinase-3 alpha | [197] | 0.71[198] | 0.41[199] | 0.61[200] | 0.34[201] | 1.31[202] | -2.22[203] |
30 | WIPI1 | WD repeat domain phosphoinositide-interacting protein 1 | [204] | 0.19[205] | 1.02[206] | 0.19[207] | -0.97[208] | -0.04[209] | -0.33[210] |
31 | GFPT1 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | [211] | 1.51[212] | 2.49[213] | 2.38[214] | 1.52[215] | 1.56[216] | 2.22[217] |
32 | CTDSP2 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 | 1.68[218] | 1.90[219] | 2.29[220] | 2.68[221] | 2.28[222] | 1.36[223] | |
33 | EDEM1 | ER degradation-enhancing alpha-mannosidase-like protein 1 | [224] | 1.07[225] | 1.25[226] | 1.49[227] | 0.38[228] | 1.95[229] | 2.78[230] |
34 | CXXC1 | CXXC-type zinc finger protein 1 | [231] | 0.28[232] | 0.25[233] | 0.23[234] | -0.48[235] | 0.60[236] | -0.18[237] |
35 | TSPYL2 | Testis-specific Y-encoded-like protein 2 | [238] | -0.96[239] | -0.17[240] | -1.00[241] | -0.87[242] | 0.91[243] | -1.62[244] |
36 | WFS1 | Wolframin | [245] | 2.23[246] | 1.45[247] | 1.26[248] | 2.78[249] | 0.62[250] | 0.33[251] |
37 | TATDN2 | Putative deoxyribonuclease TATDN2 | [252] | 1.72[253] | 1.56[254] | 1.91[255] | 1.19[256] | 2.36[257] | 0.41[258] |
38 | KDELR3 | ER lumen protein-retaining receptor 3 | [259] | 2.14[260] | 1.53[261] | 2.47[262] | 0.97[263] | 0.76[264] | -0.34[265] |
39 | ZBTB17 | Zinc finger and BTB domain-containing protein 17 | [266] | 0.74[267] | 1.33[268] | 0.65[269] | 0.93[270] | 0.97[271] | -0.25[272] |
40 | DDX11 | ATP-dependent DNA helicase DDX11 | [273] | 0.32[274] | 0.80[275] | 1.34[276] | 2.16[277] | 1.45[278] | -0.35[279] |
41 | EXTL3 | Exostosin-like 3 | [280] | 2.80[281] | 1.86[282] | 2.96[283] | 2.44[284] | 2.71[285] | 1.74[286] |
42 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | 0.87[287] | 0.59[288] | 0.05[289] | 0.55[290] | 1.93[291] | -0.29[292] | |
43 | FKBP14 | Peptidyl-prolyl cis-trans isomerase FKBP14 | [293] | 1.63[294] | 2.47[295] | 2.26[296] | 2.50[297] | 2.45[298] | 0.14[299] |
44 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | [300] | -0.09[301] | 0.46[302] | 0.56[303] | -0.72[304] | 0.83[305] | 1.78[306] |
45 | CUL7 | Cullin-7 | [307] | 3.80[308] | 4.00[309] | 2.49[310] | 3.61[311] | 2.06[312] | 1.38[313] |
46 | EXTL2 | Exostosin-like 2 | [314] | 1.30[315] | 2.50[316] | 2.84[317] | 2.18[318] | 3.34[319] | 0.46[320] |
47 | PLA2G4B | Cytosolic phospholipase A2 beta | [321] | -6.47[322] | -7.53[323] | -4.84[324] | -4.39[325] | -4.51[326] | [327] |
48 | EXTL1 | Exostosin-like 1 | [328] | 0.11[329] | 2.36[330] | -0.74[331] | -0.36[332] | 0.46[333] | -2.44[334] |
49 | MYDGF | Myeloid-derived growth factor | [335] | [336] | [337] | [338] | [339] | [340] | [341] |
50 | SRPRA | Signal recognition particle receptor subunit alpha | [342] | [343] | [344] | [345] | [346] | [347] | [348] |