REACTOME_IRAK4_DEFICIENCY_TLR2_4 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FGG Fibrinogen gamma chain [1] -0.60[2] -0.35[3] -0.61[4] -6.43[5] -7.97[6] -0.66[7]
2 FGA Fibrinogen alpha chain [8] -0.26[9] -0.60[10] -0.50[11] -5.64[12] -7.99[13] 0.01[14]
3 FGB Fibrinogen beta chain [15] -1.47[16] -1.37[17] 0.49[18] -3.76[19] -6.62[20] 0.79[21]
4 CD14 Monocyte differentiation antigen CD14 [22] -2.35[23] -3.13[24] -0.84[25] 2.05[26] 1.21[27] -0.61[28]
5 HMGB1 High mobility group protein B1 [29] 5.69[30] 5.72[31] 4.94[32] 7.31[33] 7.14[34] -0.65[35]
6 S100A1 Protein S100-A1 [36] 4.05[37] 4.58[38] -1.83[39] -1.41[40] -2.23[41] -10.37[42]
7 S100A9 Protein S100-A9 [43] -0.19[44] -3.37[45] -1.93[46] -1.87[47] -2.05[48] -2.05[49]
8 MYD88 Myeloid differentiation primary response protein MyD88 [50] 5.80[51] 5.15[52] 4.06[53] 5.82[54] 6.46[55] 0.70[56]
9 S100A8 Protein S100-A8 [57] [58] [59] [60] -2.62[61] [62] -0.05[63]
10 LY96 Lymphocyte antigen 96 [64] 3.34[65] 2.23[66] -4.70[67] 5.49[68] 2.22[69] -1.46[70]
11 TIRAP Toll/interleukin-1 receptor domain-containing adapter protein [71] 5.85[72] 5.10[73] 4.69[74] 7.13[75] 6.31[76] 0.17[77]
12 CD36 Platelet glycoprotein 4 [78] 7.33[79] 5.93[80] 0.33[81] 10.03[82] 1.38[83] 2.98[84]
13 TLR2 Toll-like receptor 2 [85] 2.45[86] 3.15[87] -4.37[88] 1.88[89] 8.99[90] 1.14[91]
14 IRAK4 Interleukin-1 receptor-associated kinase 4 [92] 6.25[93] 6.90[94] 6.66[95] 8.27[96] 8.38[97] 1.68[98]
15 TLR4 Toll-like receptor 4 [99] 6.26[100] 0.40[101] -1.01[102] 1.76[103] 12.52[104] 4.37[105]
16 TLR1 Toll-like receptor 1 [106] 2.62[107] [108] -2.26[109] 6.46[110] 7.99[111] 1.97[112]
17 BTK Tyrosine-protein kinase BTK [113] -1.39[114] [115] 4.22[116] 3.84[117] 1.96[118] 1.73[119]
18 TLR6 Toll-like receptor 6 [120] 6.78[121] 6.17[122] 4.89[123] 9.16[124] 9.59[125] 2.64[126]
[1]
ref_hepatocyte FGG
Mean 8.49e+03
Standard deviation 1.1e+04
Values 1.5e+03 1.1e+02 9e+02 2.5e+04 1.5e+04
[2]
HepG2 FGG
Mean 194
Standard deviation 1.5e+02
Values 91 3e+02
[3]
HepG2.C3A FGG
Mean 338
Standard deviation 15
Values 3.3e+02 3.5e+02
[4]
HuH.7 FGG
Mean 389
Standard deviation 3e+02
Values 2.1e+02 7.3e+02 2.3e+02
[5]
SNU475 FGG
Mean 1.56
Standard deviation 0.22
Values 1.4 1.7
[6]
THLE FGG
Mean 0.473
Standard deviation 0.016
Values 0.46 0.48
[7]
liver FGG
Mean 8.17e+03
Standard deviation 4.2e+03
Values 5.8e+03 7.5e+03 1.4e+04 5.1e+03
[8]
ref_hepatocyte FGA
Mean 6.91e+03
Standard deviation 9.4e+03
Values 4.5e+02 63 4.3e+02 2.1e+04 1.3e+04
[9]
HepG2 FGA
Mean 200
Standard deviation 1.3e+02
Values 1.1e+02 2.9e+02
[10]
HepG2.C3A FGA
Mean 232
Standard deviation 52
Values 2.7e+02 2e+02
[11]
HuH.7 FGA
Mean 342
Standard deviation 2.4e+02
Values 2e+02 6.2e+02 2e+02
[12]
SNU475 FGA
Mean 2.2
Standard deviation 0.085
Values 2.3 2.1
[13]
THLE FGA
Mean 0.381
Standard deviation 0.064
Values 0.43 0.34
[14]
liver FGA
Mean 1.06e+04
Standard deviation 2.8e+03
Values 7.3e+03 1.4e+04 1e+04 1.1e+04
[15]
ref_hepatocyte FGB
Mean 4.4e+03
Standard deviation 5.7e+03
Values 3.6e+02 3.3e+02 3.9e+02 1.2e+04 8.4e+03
[16]
HepG2 FGB
Mean 55
Standard deviation 32
Values 33 77
[17]
HepG2.C3A FGB
Mean 86.5
Standard deviation 3.3
Values 84 89
[18]
HuH.7 FGB
Mean 431
Standard deviation 3.8e+02
Values 1.9e+02 8.7e+02 2.3e+02
[19]
SNU475 FGB
Mean 5.14
Standard deviation 3.4
Values 2.7 7.6
[20]
THLE FGB
Mean 0.624
Standard deviation 0.0046
Values 0.62 0.63
[21]
liver FGB
Mean 1.16e+04
Standard deviation 4.8e+03
Values 9.6e+03 1.1e+04 1.8e+04 7.3e+03
[22]
ref_hepatocyte CD14
Mean 148
Standard deviation 1.9e+02
Values 0.7 1.6 16 3.4e+02 3.8e+02
[23]
HepG2 CD14
Mean 1.01
Standard deviation 0.084
Values 1.1 0.95
[24]
HepG2.C3A CD14
Mean 0.856
Standard deviation 0.32
Values 1.1 0.63
[25]
HuH.7 CD14
Mean 5.78
Standard deviation 1.1
Values 5.8 4.7 6.9
[26]
SNU475 CD14
Mean 9.74
Standard deviation 1.9
Values 8.4 11
[27]
THLE CD14
Mean 4.8
Standard deviation 0.97
Values 5.5 4.1
[28]
liver CD14
Mean 148
Standard deviation 88
Values 2.1e+02 68 2.4e+02 77
[29]
ref_hepatocyte HMGB1
Mean 96.9
Standard deviation 78
Values 1.5e+02 2.1e+02 24 42 63
[30]
HepG2 HMGB1
Mean 174
Standard deviation 48
Values 1.4e+02 2.1e+02
[31]
HepG2.C3A HMGB1
Mean 259
Standard deviation 1.5e+02
Values 1.5e+02 3.7e+02
[32]
HuH.7 HMGB1
Mean 207
Standard deviation 1.1e+02
Values 2.5e+02 85 2.9e+02
[33]
SNU475 HMGB1
Mean 245
Standard deviation 23
Values 2.6e+02 2.3e+02
[34]
THLE HMGB1
Mean 191
Standard deviation 52
Values 1.5e+02 2.3e+02
[35]
liver HMGB1
Mean 93.7
Standard deviation 62
Values 1.7e+02 50 1.3e+02 34
[36]
ref_hepatocyte S100A1
Mean 52.6
Standard deviation 1.2e+02
Values 2.6e+02 0 0.83 0.49 0.99
[37]
HepG2 S100A1
Mean 30.2
Standard deviation 8.9
Values 24 36
[38]
HepG2.C3A S100A1
Mean 63.9
Standard deviation 1.9
Values 65 63
[39]
HuH.7 S100A1
Mean 1.03
Standard deviation 0.38
Values 0.71 1.4 0.95
[40]
SNU475 S100A1
Mean 0.315
Standard deviation 0.15
Values 0.42 0.21
[41]
THLE S100A1
Mean 0.157
Standard deviation 0.0041
Values 0.15 0.16
[42]
liver S100A1
Mean 0.0607
Standard deviation 0.044
Values 0.024 0.11 0.026 0.079
[43]
ref_hepatocyte S100A9
Mean 27.8
Standard deviation 27
Values 0 0.21 61 46 32
[44]
HepG2 S100A9
Mean 0.849
Standard deviation 0.92
Values 1.5 0.2
[45]
HepG2.C3A S100A9
Mean 0.136
Standard deviation 0.11
Values 0.058 0.21
[46]
HuH.7 S100A9
Mean 0.51
Standard deviation 0.36
Values 0.57 0.12 0.84
[47]
SNU475 S100A9
Mean 0.121
Standard deviation 0.15
Values 0.014 0.23
[48]
THLE S100A9
Mean 0.0943
Standard deviation 0.051
Values 0.13 0.059
[49]
liver S100A9
Mean 10.3
Standard deviation 5.8
Values 7.9 4.3 18 11
[50]
ref_hepatocyte MYD88
Mean 12.3
Standard deviation 6.2
Values 5.4 6 14 19 17
[51]
HepG2 MYD88
Mean 23.8
Standard deviation 12
Values 16 32
[52]
HepG2.C3A MYD88
Mean 22.1
Standard deviation 5.1
Values 18 26
[53]
HuH.7 MYD88
Mean 14.3
Standard deviation 1.1
Values 15 13 15
[54]
SNU475 MYD88
Mean 11
Standard deviation 1.1
Values 12 10
[55]
THLE MYD88
Mean 15.1
Standard deviation 1.7
Values 14 16
[56]
liver MYD88
Mean 30.3
Standard deviation 21
Values 47 9.8 51 14
[57]
ref_hepatocyte S100A8
Mean 3.94
Standard deviation 5.3
Values 0 0 0.42 8.5 11
[58]
HepG2 S100A8
Mean 0
Standard deviation 0
Values 0 0
[59]
HepG2.C3A S100A8
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 S100A8
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 S100A8
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[62]
THLE S100A8
Mean 0
Standard deviation 0
Values 0 0
[63]
liver S100A8
Mean 5.79
Standard deviation 5.5
Values 9.2 0.63 12 1.6
[64]
ref_hepatocyte LY96
Mean 2.98
Standard deviation 1.7
Values 3 4.2 0 4 3.7
[65]
HepG2 LY96
Mean 1.05
Standard deviation 0.03
Values 1 1.1
[66]
HepG2.C3A LY96
Mean 0.711
Standard deviation 0.08
Values 0.77 0.65
[67]
HuH.7 LY96
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[68]
SNU475 LY96
Mean 2.13
Standard deviation 0.56
Values 2.5 1.7
[69]
THLE LY96
Mean 0.194
Standard deviation 0.13
Values 0.1 0.29
[70]
liver LY96
Mean 1.65
Standard deviation 1.4
Values 2.6 0.6 3 0.34
[71]
ref_hepatocyte TIRAP
Mean 2.11
Standard deviation 1.4
Values 1.4 2.2 4.4 1.2 1.3
[72]
HepG2 TIRAP
Mean 4.23
Standard deviation 0.35
Values 4 4.5
[73]
HepG2.C3A TIRAP
Mean 3.68
Standard deviation 1.4
Values 2.7 4.7
[74]
HuH.7 TIRAP
Mean 3.8
Standard deviation 0.83
Values 4.6 3.9 2.9
[75]
SNU475 TIRAP
Mean 4.7
Standard deviation 0.82
Values 5.3 4.1
[76]
THLE TIRAP
Mean 2.33
Standard deviation 0.23
Values 2.2 2.5
[77]
liver TIRAP
Mean 3.61
Standard deviation 0.57
Values 3.2 3.2 4.4 3.6
[78]
ref_hepatocyte CD36
Mean 1.74
Standard deviation 1.4
Values 3.5 0.39 0.28 1.9 2.6
[79]
HepG2 CD36
Mean 9.69
Standard deviation 5.6
Values 5.8 14
[80]
HepG2.C3A CD36
Mean 5.39
Standard deviation 3.6
Values 2.8 8
[81]
HuH.7 CD36
Mean 0.152
Standard deviation 0.061
Values 0.098 0.22 0.14
[82]
SNU475 CD36
Mean 28.9
Standard deviation 5.9
Values 25 33
[83]
THLE CD36
Mean 0.0633
Standard deviation 0.044
Values 0.095 0.032
[84]
liver CD36
Mean 20.9
Standard deviation 5.9
Values 22 24 25 12
[85]
ref_hepatocyte TLR2
Mean 1.56
Standard deviation 1.2
Values 0 0.96 2.3 3.1 1.4
[86]
HepG2 TLR2
Mean 0.296
Standard deviation 0.084
Values 0.36 0.24
[87]
HepG2.C3A TLR2
Mean 0.704
Standard deviation 0.0056
Values 0.7 0.71
[88]
HuH.7 TLR2
Mean 0.00526
Standard deviation 0.0048
Values 0 0.0064 0.0094
[89]
SNU475 TLR2
Mean 0.0914
Standard deviation 0.057
Values 0.051 0.13
[90]
THLE TLR2
Mean 11.1
Standard deviation 4.3
Values 14 8.1
[91]
liver TLR2
Mean 5.26
Standard deviation 1.6
Values 3.2 6.8 5.1 5.9
[92]
ref_hepatocyte IRAK4
Mean 1.45
Standard deviation 0.56
Values 1.6 0.94 0.79 2.1 1.9
[93]
HepG2 IRAK4
Mean 3.82
Standard deviation 0.94
Values 3.2 4.5
[94]
HepG2.C3A IRAK4
Mean 8.76
Standard deviation 1.5
Values 7.7 9.8
[95]
HuH.7 IRAK4
Mean 10.2
Standard deviation 0.57
Values 9.9 11 9.8
[96]
SNU475 IRAK4
Mean 7.11
Standard deviation 2.2
Values 8.7 5.5
[97]
THLE IRAK4
Mean 6.73
Standard deviation 0.64
Values 6.3 7.2
[98]
liver IRAK4
Mean 7.06
Standard deviation 1.8
Values 5.4 9.3 6 7.5
[99]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0 1.1 0.33 0.64 0.66
[100]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 0.82 2.1
[101]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[102]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0 0.019 0.037
[103]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[104]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[105]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 13 19 11 25
[106]
ref_hepatocyte TLR1
Mean 0.481
Standard deviation 0.24
Values 0.12 0.52 0.38 0.69 0.7
[107]
HepG2 TLR1
Mean 0.103
Standard deviation 0.024
Values 0.12 0.086
[108]
HepG2.C3A TLR1
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 TLR1
Mean 0.00701
Standard deviation 0.0065
Values 0.0082 0.013 0
[110]
SNU475 TLR1
Mean 0.672
Standard deviation 0.026
Values 0.69 0.65
[111]
THLE TLR1
Mean 1.71
Standard deviation 0.1
Values 1.8 1.6
[112]
liver TLR1
Mean 2.86
Standard deviation 1.1
Values 2 4.4 2.1 3
[113]
ref_hepatocyte BTK
Mean 0.217
Standard deviation 0.34
Values 0 0 0 0.32 0.76
[114]
HepG2 BTK
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[115]
HepG2.C3A BTK
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 BTK
Mean 0.281
Standard deviation 0.027
Values 0.31 0.27 0.26
[117]
SNU475 BTK
Mean 0.0494
Standard deviation 0.031
Values 0.028 0.071
[118]
THLE BTK
Mean 0.0118
Standard deviation 0.017
Values 0.024 0
[119]
liver BTK
Mean 1.09
Standard deviation 0.53
Values 0.66 1.8 0.74 1.1
[120]
ref_hepatocyte TLR6
Mean 0.179
Standard deviation 0.1
Values 0.23 0.34 0.082 0.12 0.13
[121]
HepG2 TLR6
Mean 0.681
Standard deviation 0.059
Values 0.72 0.64
[122]
HepG2.C3A TLR6
Mean 0.655
Standard deviation 0.06
Values 0.61 0.7
[123]
HuH.7 TLR6
Mean 0.369
Standard deviation 0.13
Values 0.46 0.42 0.22
[124]
SNU475 TLR6
Mean 1.62
Standard deviation 0.2
Values 1.5 1.8
[125]
THLE TLR6
Mean 1.93
Standard deviation 0.11
Values 2 1.9
[126]
liver TLR6
Mean 1.7
Standard deviation 1
Values 0.63 2.6 1.1 2.5