REACTOME_ION_HOMEOSTASIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FXYD1 | Phospholemman | [1] | -7.02[2] | -5.15[3] | -13.16[4] | -15.91[5] | -13.50[6] | -3.73[7] |
2 | ASPH | Aspartyl/asparaginyl beta-hydroxylase | [8] | -0.23[9] | -1.23[10] | -0.75[11] | 0.84[12] | -0.61[13] | -1.15[14] |
3 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | [15] | 1.52[16] | 1.08[17] | 1.08[18] | -0.66[19] | 0.26[20] | -0.59[21] |
4 | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | [22] | -1.16[23] | -0.26[24] | -0.46[25] | -1.58[26] | -2.36[27] | -1.41[28] |
5 | CALM1 | Calmodulin-1 | [29] | -0.77[30] | -0.26[31] | -0.02[32] | 0.68[33] | 0.45[34] | 0.98[35] |
6 | AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 | [36] | -0.60[37] | -0.04[38] | 0.31[39] | 0.10[40] | 0.47[41] | -0.34[42] |
7 | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | [43] | 0.74[44] | 1.07[45] | 1.15[46] | 1.90[47] | 1.34[48] | 1.10[49] |
8 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [50] | -1.01[51] | -0.71[52] | -0.93[53] | -1.38[54] | -0.29[55] | -1.42[56] |
9 | SRI | Sorcin | [57] | -7.75[58] | -8.73[59] | -1.85[60] | -1.39[61] | -0.90[62] | -1.52[63] |
10 | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 | [64] | 0.12[65] | -0.14[66] | -0.19[67] | -0.10[68] | 1.08[69] | -2.66[70] |
11 | STIM1 | Stromal interaction molecule 1 | [71] | 0.00[72] | 0.45[73] | -0.17[74] | -0.02[75] | -0.61[76] | 0.57[77] |
12 | ORAI1 | Calcium release-activated calcium channel protein 1 | [78] | -1.16[79] | -1.22[80] | -1.91[81] | -2.12[82] | -1.43[83] | -2.22[84] |
13 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [85] | -0.71[86] | 0.07[87] | 1.37[88] | -0.23[89] | -0.54[90] | 0.77[91] |
14 | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 | [92] | 0.07[93] | 1.99[94] | 0.24[95] | -0.90[96] | -0.27[97] | 3.23[98] |
15 | ABCC9 | ATP-binding cassette sub-family C member 9 | [99] | -3.72[100] | -2.05[101] | -1.12[102] | -1.23[103] | -2.52[104] | 3.31[105] |
16 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | [106] | -0.67[107] | -1.96[108] | 0.89[109] | 2.52[110] | 3.39[111] | 3.02[112] |
17 | FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B | [113] | -0.10[114] | 0.90[115] | -1.33[116] | -4.36[117] | -1.80[118] | -1.40[119] |
18 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | -0.07[120] | 1.61[121] | 1.01[122] | 0.78[123] | 0.84[124] | 0.31[125] | |
19 | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | [126] | 0.36[127] | 2.48[128] | 3.23[129] | 2.24[130] | 2.67[131] | 2.28[132] |
20 | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 | [133] | 4.45[134] | 3.77[135] | 2.04[136] | 1.44[137] | 4.12[138] | -0.41[139] |
21 | ATP2B2 | Plasma membrane calcium-transporting ATPase 2 | [140] | -0.92[141] | 0.38[142] | 3.49[143] | -6.03[144] | -5.23[145] | 3.33[146] |
22 | DMPK | Myotonin-protein kinase | [147] | 0.66[148] | 0.91[149] | 0.65[150] | 2.77[151] | 2.05[152] | -0.09[153] |
23 | FXYD2 | Sodium/potassium-transporting ATPase subunit gamma | [154] | -1.42[155] | -2.86[156] | [157] | [158] | [159] | -0.81[160] |
24 | FXYD6 | FXYD domain-containing ion transport regulator 6 | [161] | -8.86[162] | [163] | [164] | -3.96[165] | -8.43[166] | 2.08[167] |
25 | ORAI2 | Protein orai-2 | [168] | 2.60[169] | 1.98[170] | 0.97[171] | 3.54[172] | 3.32[173] | 1.18[174] |
26 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [175] | -3.38[176] | -4.23[177] | -7.41[178] | -3.77[179] | -2.63[180] | 0.51[181] |
27 | KCNJ11 | ATP-sensitive inward rectifier potassium channel 11 | [182] | -0.54[183] | -0.57[184] | -1.36[185] | -2.12[186] | -2.35[187] | -1.09[188] |
28 | TRPC1 | Short transient receptor potential channel 1 | [189] | 1.23[190] | 3.02[191] | 2.98[192] | 2.14[193] | 2.66[194] | -0.70[195] |
29 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | [196] | 2.30[197] | 2.65[198] | 3.59[199] | 1.94[200] | 3.31[201] | 4.01[202] |
30 | CLIC2 | Chloride intracellular channel protein 2 | [203] | -4.95[204] | -3.80[205] | -2.11[206] | 1.62[207] | -4.42[208] | 1.42[209] |
31 | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2 | [210] | -3.19[211] | -1.98[212] | -0.98[213] | -1.59[214] | -1.94[215] | 1.17[216] |
32 | ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | [217] | 1.28[218] | -2.74[219] | 0.87[220] | 0.21[221] | 0.32[222] | 2.02[223] |
33 | TNNI3 | Troponin I, cardiac muscle | [224] | 1.90[225] | 0.02[226] | -6.03[227] | -1.93[228] | 0.68[229] | -5.88[230] |
34 | ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | [231] | 0.00[232] | [233] | -4.80[234] | -1.66[235] | -1.33[236] | -1.86[237] |
35 | CASQ1 | Calsequestrin-1 | [238] | -1.96[239] | [240] | -4.88[241] | 0.42[242] | -3.55[243] | -2.83[244] |
36 | TRDN | Triadin | [245] | -5.77[246] | -5.23[247] | 1.42[248] | 3.37[249] | -5.18[250] | -3.12[251] |
37 | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | [252] | 1.65[253] | 0.60[254] | -0.45[255] | 1.51[256] | -0.17[257] | 1.84[258] |
38 | NOS1 | Nitric oxide synthase, brain | [259] | -2.40[260] | 0.04[261] | -1.75[262] | -1.58[263] | -1.18[264] | 0.05[265] |
39 | FXYD3 | FXYD domain-containing ion transport regulator 3 | [266] | 2.56[267] | 7.06[268] | 3.02[269] | -3.68[270] | -5.06[271] | -0.43[272] |
40 | ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | [273] | 3.71[274] | 6.12[275] | 2.33[276] | 1.37[277] | 2.30[278] | 0.96[279] |
41 | SLC8A1 | Sodium/calcium exchanger 1 | [280] | 0.70[281] | [282] | [283] | 3.85[284] | 2.31[285] | 6.96[286] |
42 | SLC8A3 | Sodium/calcium exchanger 3 | [287] | -1.39[288] | -2.87[289] | -3.93[290] | [291] | -2.91[292] | -0.01[293] |
43 | PLN | Cardiac phospholamban | [294] | [295] | [296] | [297] | 1.25[298] | -2.11[299] | 3.32[300] |
44 | RYR1 | Ryanodine receptor 1 | [301] | 0.64[302] | -2.95[303] | -0.97[304] | 2.50[305] | 1.61[306] | 4.26[307] |
45 | SLC8A2 | Sodium/calcium exchanger 2 | [308] | 0.17[309] | 0.00[310] | -0.57[311] | 0.12[312] | -0.86[313] | -0.63[314] |
46 | RYR3 | Ryanodine receptor 3 | [315] | 3.14[316] | 4.65[317] | 2.28[318] | 5.18[319] | 4.56[320] | 6.12[321] |
47 | RYR2 | Ryanodine receptor 2 | [322] | 2.00[323] | 0.23[324] | 2.48[325] | 3.94[326] | 2.14[327] | 8.27[328] |
48 | SLN | Sarcolipin | [329] | [330] | [331] | [332] | [333] | [334] | [335] |
49 | FXYD7 | FXYD domain-containing ion transport regulator 7 | [336] | [337] | [338] | [339] | [340] | [341] | [342] |
50 | ATP2B3 | Plasma membrane calcium-transporting ATPase 3 | [343] | [344] | [345] | [346] | [347] | [348] | [349] |
51 | CASQ2 | Calsequestrin-2 | [350] | [351] | [352] | [353] | [354] | [355] | [356] |
52 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [357] | [358] | [359] | [360] | [361] | [362] | [363] |
53 | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | [364] | [365] | [366] | [367] | [368] | [369] | [370] |
54 | FXYD4 | FXYD domain-containing ion transport regulator 4 | [371] | [372] | [373] | [374] | [375] | [376] | [377] |