REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SERPINC1 Antithrombin-III [1] -4.45[2] -3.45[3] -2.10[4] -7.86[5] -8.52[6] -0.47[7]
2 SERPING1 Plasma protease C1 inhibitor [8] -4.97[9] -14.69[10] -5.24[11] -4.85[12] -0.10[13] -0.61[14]
3 F2 Prothrombin [15] -0.09[16] -0.41[17] 1.10[18] -4.63[19] -5.58[20] -0.05[21]
4 KNG1 Kininogen-1 [22] -5.44[23] -6.79[24] -0.03[25] -6.96[26] -6.74[27] -0.46[28]
5 A2M Alpha-2-macroglobulin [29] 2.16[30] 2.50[31] 0.95[32] -2.84[33] -4.25[34] 1.59[35]
6 F12 Coagulation factor XII [36] -5.07[37] -3.38[38] -2.02[39] -7.72[40] -3.66[41] -0.78[42]
7 SERPIND1 Heparin cofactor 2 [43] 0.89[44] 1.05[45] 1.31[46] -3.58[47] -3.39[48] -0.85[49]
8 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 1.12[50] 0.11[51] 1.13[52] 3.90[53] 3.23[54] -2.21[55]
9 PROC Vitamin K-dependent protein C [56] 0.11[57] 0.71[58] -0.19[59] -1.07[60] -5.87[61] -0.52[62]
10 SERPINA5 Plasma serine protease inhibitor [63] 2.65[64] 2.17[65] 0.71[66] -0.42[67] -3.07[68] -1.45[69]
11 F9 Coagulation factor IX [70] -10.94[71] [72] -12.28[73] [74] [75] 0.90[76]
12 PROS1 Vitamin K-dependent protein S [77] 0.45[78] 0.26[79] 3.28[80] 1.45[81] 3.06[82] 0.95[83]
13 F10 Coagulation factor X [84] 0.42[85] 0.56[86] 0.23[87] -1.61[88] -4.68[89] -0.29[90]
14 PRCP Lysosomal Pro-X carboxypeptidase [91] 1.93[92] 0.74[93] 1.44[94] 5.33[95] 5.04[96] -0.57[97]
15 KLKB1 Plasma kallikrein [98] -6.49[99] -4.41[100] -4.29[101] -6.26[102] -5.50[103] -0.05[104]
16 F11 Coagulation factor XI [105] -0.50[106] 1.00[107] -1.97[108] -8.06[109] -7.47[110] 0.96[111]
17 F8 Coagulation factor VIII [112] -0.58[113] -1.21[114] 0.23[115] 4.38[116] 3.60[117] 3.35[118]
18 SERPINE2 Glia-derived nexin [119] 6.99[120] 0.71[121] 2.87[122] 8.84[123] 8.51[124] -1.14[125]
19 GP1BA Platelet glycoprotein Ib alpha chain [126] 0.22[127] -0.31[128] 4.02[129] 5.34[130] 4.97[131] 0.70[132]
20 GP1BB Platelet glycoprotein Ib beta chain [133] [134] [135] [136] [137] [138] [139]
21 VWF von Willebrand factor [140] 3.14[141] 0.17[142] -1.09[143] 6.07[144] 2.89[145] 5.34[146]
22 GP5 Platelet glycoprotein V [147] -1.23[148] -0.33[149] -3.20[150] 0.52[151] 3.05[152] 1.05[153]
23 GP9 Platelet glycoprotein IX [154] [155] [156] [157] [158] [159] [160]
[1]
ref_hepatocyte SERPINC1
Mean 879
Standard deviation 1.2e+03
Values 68 6.8 63 1.8e+03 2.5e+03
[2]
HepG2 SERPINC1
Mean 19.9
Standard deviation 0.44
Values 20 20
[3]
HepG2.C3A SERPINC1
Mean 61.9
Standard deviation 15
Values 72 52
[4]
HuH.7 SERPINC1
Mean 69.4
Standard deviation 14
Values 62 86 61
[5]
SNU475 SERPINC1
Mean 0.115
Standard deviation 0.031
Values 0.093 0.14
[6]
THLE SERPINC1
Mean 0.124
Standard deviation 0.017
Values 0.14 0.11
[7]
liver SERPINC1
Mean 1.17e+03
Standard deviation 5.9e+02
Values 1.8e+03 7e+02 1.6e+03 6.1e+02
[8]
ref_hepatocyte SERPING1
Mean 849
Standard deviation 1e+03
Values 1.7 21 2.9e+02 1.9e+03 2e+03
[9]
HepG2 SERPING1
Mean 13.3
Standard deviation 11
Values 21 5.7
[10]
HepG2.C3A SERPING1
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[11]
HuH.7 SERPING1
Mean 7.6
Standard deviation 3.9
Values 5.6 12 5.1
[12]
SNU475 SERPING1
Mean 0.892
Standard deviation 0.73
Values 0.38 1.4
[13]
THLE SERPING1
Mean 40.8
Standard deviation 6.5
Values 45 36
[14]
liver SERPING1
Mean 1.02e+03
Standard deviation 1.1e+03
Values 2e+03 99 1.8e+03 1.1e+02
[15]
ref_hepatocyte F2
Mean 442
Standard deviation 5.2e+02
Values 40 79 98 8.2e+02 1.2e+03
[16]
HepG2 F2
Mean 204
Standard deviation 81
Values 2.6e+02 1.5e+02
[17]
HepG2.C3A F2
Mean 256
Standard deviation 95
Values 3.2e+02 1.9e+02
[18]
HuH.7 F2
Mean 321
Standard deviation 18
Values 3.1e+02 3.1e+02 3.4e+02
[19]
SNU475 F2
Mean 0.54
Standard deviation 0.16
Values 0.65 0.43
[20]
THLE F2
Mean 0.475
Standard deviation 0.27
Values 0.66 0.29
[21]
liver F2
Mean 785
Standard deviation 2.9e+02
Values 1e+03 5.3e+02 1e+03 5.3e+02
[22]
ref_hepatocyte KNG1
Mean 402
Standard deviation 5.4e+02
Values 13 3.1 56 7.5e+02 1.2e+03
[23]
HepG2 KNG1
Mean 4.56
Standard deviation 1.2
Values 3.7 5.4
[24]
HepG2.C3A KNG1
Mean 2.8
Standard deviation 1.5
Values 3.9 1.7
[25]
HuH.7 KNG1
Mean 134
Standard deviation 1.2e+02
Values 61 2.7e+02 69
[26]
SNU475 KNG1
Mean 0.0979
Standard deviation 0.045
Values 0.13 0.066
[27]
THLE KNG1
Mean 0.194
Standard deviation 0.026
Values 0.21 0.18
[28]
liver KNG1
Mean 537
Standard deviation 95
Values 6.4e+02 5.5e+02 5.5e+02 4.1e+02
[29]
ref_hepatocyte A2M
Mean 399
Standard deviation 4e+02
Values 5.1e+02 4.6 10 5.4e+02 9.3e+02
[30]
HepG2 A2M
Mean 881
Standard deviation 98
Values 8.1e+02 9.5e+02
[31]
HepG2.C3A A2M
Mean 1.74e+03
Standard deviation 8.5e+02
Values 2.3e+03 1.1e+03
[32]
HuH.7 A2M
Mean 261
Standard deviation 88
Values 2.2e+02 3.6e+02 2e+02
[33]
SNU475 A2M
Mean 1.69
Standard deviation 0.52
Values 2.1 1.3
[34]
THLE A2M
Mean 1.08
Standard deviation 0.16
Values 1.2 0.97
[35]
liver A2M
Mean 2.2e+03
Standard deviation 3.1e+02
Values 1.8e+03 2.4e+03 2.5e+03 2.1e+03
[36]
ref_hepatocyte F12
Mean 152
Standard deviation 2.1e+02
Values 1.8 1.8 22 2.7e+02 4.6e+02
[37]
HepG2 F12
Mean 2.23
Standard deviation 0.82
Values 2.8 1.6
[38]
HepG2.C3A F12
Mean 11.3
Standard deviation 4.2
Values 14 8.4
[39]
HuH.7 F12
Mean 12.8
Standard deviation 2.7
Values 10 15 13
[40]
SNU475 F12
Mean 0.0219
Standard deviation 0.0048
Values 0.019 0.025
[41]
THLE F12
Mean 0.623
Standard deviation 0.023
Values 0.64 0.61
[42]
liver F12
Mean 163
Standard deviation 1e+02
Values 2.7e+02 50 2.3e+02 1e+02
[43]
ref_hepatocyte SERPIND1
Mean 121
Standard deviation 1.4e+02
Values 66 3.4 31 1.5e+02 3.6e+02
[44]
HepG2 SERPIND1
Mean 111
Standard deviation 5.1
Values 1.1e+02 1.1e+02
[45]
HepG2.C3A SERPIND1
Mean 192
Standard deviation 88
Values 2.6e+02 1.3e+02
[46]
HuH.7 SERPIND1
Mean 102
Standard deviation 43
Values 82 1.5e+02 72
[47]
SNU475 SERPIND1
Mean 0.307
Standard deviation 0.2
Values 0.16 0.45
[48]
THLE SERPIND1
Mean 0.595
Standard deviation 0.18
Values 0.47 0.72
[49]
liver SERPIND1
Mean 124
Standard deviation 75
Values 2e+02 65 1.8e+02 53
[50]
ref_hepatocyte C1QBP
Mean 101
Standard deviation 47
Values 85 1.2e+02 1.7e+02 84 44
[51]
HepG2 C1QBP
Mean 108
Standard deviation 11
Values 1.2e+02 1e+02
[52]
HepG2.C3A C1QBP
Mean 83.6
Standard deviation 25
Values 66 1e+02
[53]
HuH.7 C1QBP
Mean 74.6
Standard deviation 24
Values 79 49 96
[54]
SNU475 C1QBP
Mean 45.6
Standard deviation 3
Values 44 48
[55]
THLE C1QBP
Mean 48.9
Standard deviation 16
Values 37 60
[56]
liver C1QBP
Mean 40
Standard deviation 24
Values 55 22 66 17
[57]
ref_hepatocyte PROC
Mean 84.1
Standard deviation 95
Values 27 18 9.2 1.4e+02 2.2e+02
[58]
HepG2 PROC
Mean 44.6
Standard deviation 8.7
Values 51 39
[59]
HepG2.C3A PROC
Mean 106
Standard deviation 50
Values 1.4e+02 70
[60]
HuH.7 PROC
Mean 24.9
Standard deviation 5.4
Values 20 24 31
[61]
SNU475 PROC
Mean 1.22
Standard deviation 0.38
Values 1.5 0.95
[62]
THLE PROC
Mean 0.0742
Standard deviation 0.037
Values 0.1 0.048
[63]
liver PROC
Mean 107
Standard deviation 53
Values 1.7e+02 61 1.4e+02 64
[64]
ref_hepatocyte SERPINA5
Mean 77.8
Standard deviation 77
Values 95 2.5 2.4 1.1e+02 1.8e+02
[65]
HepG2 SERPINA5
Mean 240
Standard deviation 1.2e+02
Values 1.6e+02 3.2e+02
[66]
HepG2.C3A SERPINA5
Mean 269
Standard deviation 80
Values 3.3e+02 2.1e+02
[67]
HuH.7 SERPINA5
Mean 43.2
Standard deviation 5.8
Values 39 50 40
[68]
SNU475 SERPINA5
Mean 1.77
Standard deviation 0.22
Values 1.9 1.6
[69]
THLE SERPINA5
Mean 0.477
Standard deviation 0.028
Values 0.5 0.46
[70]
liver SERPINA5
Mean 52.4
Standard deviation 43
Values 1.2e+02 26 36 32
[71]
ref_hepatocyte F9
Mean 71.3
Standard deviation 94
Values 0 0.79 8.1 1.7e+02 1.8e+02
[72]
HepG2 F9
Mean 0.0179
Standard deviation 0.0071
Values 0.023 0.013
[73]
HepG2.C3A F9
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 F9
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[75]
SNU475 F9
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE F9
Mean 0
Standard deviation 0
Values 0 0
[77]
liver F9
Mean 245
Standard deviation 1.2e+02
Values 1.6e+02 3.8e+02 1.3e+02 3.1e+02
[78]
ref_hepatocyte PROS1
Mean 52
Standard deviation 41
Values 32 38 3 80 1.1e+02
[79]
HepG2 PROS1
Mean 34.9
Standard deviation 18
Values 22 47
[80]
HepG2.C3A PROS1
Mean 48.1
Standard deviation 13
Values 39 57
[81]
HuH.7 PROS1
Mean 171
Standard deviation 49
Values 1.5e+02 2.3e+02 1.4e+02
[82]
SNU475 PROS1
Mean 4.31
Standard deviation 0.37
Values 4 4.6
[83]
THLE PROS1
Mean 22.4
Standard deviation 4.5
Values 19 26
[84]
liver PROS1
Mean 185
Standard deviation 47
Values 1.5e+02 1.9e+02 2.5e+02 1.5e+02
[85]
ref_hepatocyte F10
Mean 43.2
Standard deviation 44
Values 25 4.4 6.8 82 98
[86]
HepG2 F10
Mean 28.5
Standard deviation 7.1
Values 34 24
[87]
HepG2.C3A F10
Mean 49.1
Standard deviation 38
Values 76 22
[88]
HuH.7 F10
Mean 17.2
Standard deviation 3.7
Values 14 21 16
[89]
SNU475 F10
Mean 0.43
Standard deviation 0.042
Values 0.46 0.4
[90]
THLE F10
Mean 0.0869
Standard deviation 0.0026
Values 0.089 0.085
[91]
liver F10
Mean 64.8
Standard deviation 49
Values 1.3e+02 29 70 28
[92]
ref_hepatocyte PRCP
Mean 28.3
Standard deviation 18
Values 54 18 6.9 30 32
[93]
HepG2 PRCP
Mean 53.1
Standard deviation 3.7
Values 51 56
[94]
HepG2.C3A PRCP
Mean 36.3
Standard deviation 1.5
Values 35 37
[95]
HuH.7 PRCP
Mean 26.1
Standard deviation 1.5
Values 25 28 26
[96]
SNU475 PRCP
Mean 34.5
Standard deviation 0.73
Values 35 34
[97]
THLE PRCP
Mean 48
Standard deviation 3.4
Values 46 50
[98]
liver PRCP
Mean 35.1
Standard deviation 18
Values 44 29 54 12
[99]
ref_hepatocyte KLKB1
Mean 25.1
Standard deviation 35
Values 0.73 2.3 2.2 41 79
[100]
HepG2 KLKB1
Mean 0.137
Standard deviation 0.048
Values 0.1 0.17
[101]
HepG2.C3A KLKB1
Mean 0.913
Standard deviation 0.0015
Values 0.91 0.91
[102]
HuH.7 KLKB1
Mean 0.434
Standard deviation 0.48
Values 0.11 0.98 0.21
[103]
SNU475 KLKB1
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[104]
THLE KLKB1
Mean 0.0287
Standard deviation 0.018
Values 0.041 0.016
[105]
liver KLKB1
Mean 44.5
Standard deviation 24
Values 80 28 37 33
[106]
ref_hepatocyte F11
Mean 20.4
Standard deviation 18
Values 25 1.9 1.7 30 44
[107]
HepG2 F11
Mean 7.11
Standard deviation 4.7
Values 3.8 10
[108]
HepG2.C3A F11
Mean 31.5
Standard deviation 4.6
Values 28 35
[109]
HuH.7 F11
Mean 1.76
Standard deviation 1.5
Values 0.93 3.4 0.91
[110]
SNU475 F11
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[111]
THLE F11
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[112]
liver F11
Mean 73
Standard deviation 13
Values 67 91 72 62
[113]
ref_hepatocyte F8
Mean 1.68
Standard deviation 1.5
Values 0.18 0.85 0.94 3.6 2.8
[114]
HepG2 F8
Mean 0.551
Standard deviation 0.063
Values 0.6 0.51
[115]
HepG2.C3A F8
Mean 0.558
Standard deviation 0.077
Values 0.61 0.5
[116]
HuH.7 F8
Mean 0.668
Standard deviation 0.14
Values 0.71 0.78 0.52
[117]
SNU475 F8
Mean 1.06
Standard deviation 0.33
Values 1.3 0.83
[118]
THLE F8
Mean 1.05
Standard deviation 0.19
Values 1.2 0.91
[119]
liver F8
Mean 31.4
Standard deviation 10
Values 27 46 22 30
[120]
ref_hepatocyte SERPINE2
Mean 1.5
Standard deviation 2.2
Values 5.4 0.83 0.9 0.13 0.19
[121]
HepG2 SERPINE2
Mean 93.9
Standard deviation 48
Values 1.3e+02 60
[122]
HepG2.C3A SERPINE2
Mean 1.89
Standard deviation 0.81
Values 1.3 2.5
[123]
HuH.7 SERPINE2
Mean 3.72
Standard deviation 2
Values 2.6 6 2.6
[124]
SNU475 SERPINE2
Mean 20.8
Standard deviation 9.8
Values 14 28
[125]
THLE SERPINE2
Mean 28.2
Standard deviation 8.6
Values 22 34
[126]
liver SERPINE2
Mean 1.25
Standard deviation 0.95
Values 2.4 0.53 1.7 0.38
[127]
ref_hepatocyte GP1BA
Mean 0.18
Standard deviation 0.32
Values 0 0 0.75 0 0.15
[128]
HepG2 GP1BA
Mean 0.104
Standard deviation 0.032
Values 0.13 0.082
[129]
HepG2.C3A GP1BA
Mean 0.112
Standard deviation 0.0078
Values 0.11 0.12
[130]
HuH.7 GP1BA
Mean 0.99
Standard deviation 0.51
Values 1 1.5 0.46
[131]
SNU475 GP1BA
Mean 0.222
Standard deviation 0.17
Values 0.34 0.1
[132]
THLE GP1BA
Mean 0.291
Standard deviation 0.018
Values 0.28 0.3
[133]
liver GP1BA
Mean 0.538
Standard deviation 0.38
Values 0.24 0.47 0.36 1.1
[134]
ref_hepatocyte GP1BB
Mean 0.139
Standard deviation 0.19
Values 0 0.12 0.11 0.46 0
[135]
HepG2 GP1BB
Missing
[136]
HepG2.C3A GP1BB
Missing
[137]
HuH.7 GP1BB
Missing
[138]
SNU475 GP1BB
Missing
[139]
THLE GP1BB
Missing
[140]
liver GP1BB
Missing
[141]
ref_hepatocyte VWF
Mean 0.138
Standard deviation 0.13
Values 0.14 0.026 0 0.32 0.2
[142]
HepG2 VWF
Mean 0.599
Standard deviation 0.15
Values 0.7 0.49
[143]
HepG2.C3A VWF
Mean 0.12
Standard deviation 0.078
Values 0.17 0.064
[144]
HuH.7 VWF
Mean 0.022
Standard deviation 0.031
Values 0.0082 0.058 0
[145]
SNU475 VWF
Mean 0.283
Standard deviation 0.027
Values 0.3 0.26
[146]
THLE VWF
Mean 0.0529
Standard deviation 0.0079
Values 0.047 0.059
[147]
liver VWF
Mean 10.3
Standard deviation 3.3
Values 8.3 10 7.8 15
[148]
ref_hepatocyte GP5
Mean 0.0581
Standard deviation 0.064
Values 0 0.1 0 0.043 0.15
[149]
HepG2 GP5
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[150]
HepG2.C3A GP5
Mean 0.0355
Standard deviation 0.0047
Values 0.039 0.032
[151]
HuH.7 GP5
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[152]
SNU475 GP5
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[153]
THLE GP5
Mean 0.0248
Standard deviation 0.01
Values 0.018 0.032
[154]
liver GP5
Mean 0.22
Standard deviation 0.043
Values 0.26 0.26 0.18 0.19
[155]
ref_hepatocyte GP9
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 GP9
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A GP9
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GP9
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 GP9
Mean 0
Standard deviation 0
Values 0 0
[160]
THLE GP9
Mean 0
Standard deviation 0
Values 0 0
[161]
liver GP9
Mean 0.0284
Standard deviation 0.034
Values 0.024 0 0.077 0.013