REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAE | 14-3-3 protein epsilon | [1] | -1.10[2] | -0.84[3] | -0.59[4] | -0.99[5] | -0.51[6] | -0.87[7] |
2 | YWHAZ | 14-3-3 protein zeta/delta | [8] | -0.43[9] | -0.43[10] | -0.21[11] | 0.78[12] | -0.20[13] | -0.96[14] |
3 | DYNLL1 | Dynein light chain 1, cytoplasmic | [15] | -1.24[16] | -1.05[17] | -1.37[18] | -1.75[19] | -1.58[20] | -1.42[21] |
4 | C1QBP | Complement component 1 Q subcomponent-binding protein, mitochondrial | -0.90[22] | -0.95[23] | -1.16[24] | -2.15[25] | -1.77[26] | -1.16[27] | |
5 | YWHAH | 14-3-3 protein eta | [28] | -1.22[29] | -1.49[30] | -1.62[31] | -1.32[32] | -1.28[33] | -1.27[34] |
6 | YWHAQ | 14-3-3 protein theta | [35] | 0.41[36] | 0.37[37] | -0.02[38] | 1.23[39] | 0.99[40] | 0.09[41] |
7 | SFN | 14-3-3 protein sigma | [42] | -2.22[43] | -2.42[44] | -2.13[45] | -7.96[46] | -8.45[47] | -9.41[48] |
8 | YWHAG | 14-3-3 protein gamma | [49] | 0.35[50] | -0.04[51] | -0.08[52] | 0.59[53] | 0.34[54] | -0.66[55] |
9 | YWHAB | 14-3-3 protein beta/alpha | [56] | 1.18[57] | 1.04[58] | 0.22[59] | 1.17[60] | 1.05[61] | 0.59[62] |
10 | AKT1 | RAC-alpha serine/threonine-protein kinase | [63] | 0.22[64] | 0.14[65] | -1.04[66] | -0.18[67] | 0.28[68] | 0.44[69] |
11 | DYNLL2 | Dynein light chain 2, cytoplasmic | [70] | -0.82[71] | -1.23[72] | -1.10[73] | -2.99[74] | -0.98[75] | -2.26[76] |
12 | STAT3 | Signal transducer and activator of transcription 3 | [77] | 0.69[78] | -0.65[79] | -0.02[80] | 0.11[81] | -0.17[82] | 3.09[83] |
13 | BCL2L1 | Bcl-2-like protein 1 | [84] | 2.28[85] | 1.82[86] | 2.68[87] | -0.74[88] | 0.09[89] | -0.13[90] |
14 | BAX | Apoptosis regulator BAX | [91] | 0.47[92] | -0.17[93] | -0.74[94] | -1.73[95] | -0.91[96] | -3.27[97] |
15 | GSDMD | Gasdermin-D | [98] | -1.78[99] | -0.81[100] | -1.58[101] | -1.39[102] | -2.02[103] | 0.03[104] |
16 | BAD | Bcl2-associated agonist of cell death | [105] | -1.53[106] | -1.25[107] | -2.30[108] | -1.19[109] | -0.35[110] | -0.73[111] |
17 | DIABLO | Diablo homolog, mitochondrial | [112] | -0.01[113] | 0.41[114] | 0.00[115] | -0.46[116] | -0.26[117] | -0.05[118] |
18 | NMT1 | Glycylpeptide N-tetradecanoyltransferase 1 | [119] | 1.62[120] | 1.62[121] | 1.78[122] | 0.64[123] | 1.24[124] | 1.11[125] |
19 | CYCS | Cytochrome c | [126] | 1.48[127] | 1.82[128] | 1.80[129] | 1.20[130] | 2.05[131] | 2.00[132] |
20 | TFDP1 | Transcription factor Dp-1 | [133] | 0.81[134] | 0.29[135] | 0.26[136] | 0.48[137] | 1.49[138] | -0.46[139] |
21 | APIP | Methylthioribulose-1-phosphate dehydratase | [140] | -1.53[141] | -0.65[142] | -0.54[143] | -1.66[144] | -1.75[145] | -0.54[146] |
22 | PPP3R1 | Calcineurin subunit B type 1 | [147] | 0.33[148] | 0.66[149] | 0.47[150] | 0.58[151] | 0.78[152] | -0.46[153] |
23 | CASP3 | Caspase-3 | [154] | 0.28[155] | 1.10[156] | -1.54[157] | -1.02[158] | 0.41[159] | -0.12[160] |
24 | BID | BH3-interacting domain death agonist | [161] | -0.13[162] | 0.13[163] | -0.35[164] | -0.42[165] | -0.51[166] | 0.86[167] |
25 | MAPK1 | Mitogen-activated protein kinase 1 | [168] | 1.85[169] | 2.14[170] | 1.87[171] | 1.72[172] | 1.81[173] | 2.46[174] |
26 | AKT2 | RAC-beta serine/threonine-protein kinase | [175] | 1.10[176] | 1.53[177] | 1.56[178] | 0.73[179] | 0.96[180] | 1.82[181] |
27 | CASP7 | Caspase-7 | [182] | -0.17[183] | -0.38[184] | -0.04[185] | -1.02[186] | -0.38[187] | 0.20[188] |
28 | CASP8 | Caspase-8 | [189] | 0.16[190] | 0.88[191] | -0.05[192] | -0.21[193] | -0.51[194] | -0.73[195] |
29 | MAPK8 | Mitogen-activated protein kinase 8 | [196] | -1.30[197] | 0.26[198] | -0.97[199] | -1.03[200] | -0.73[201] | 0.17[202] |
30 | TP53BP2 | Apoptosis-stimulating of p53 protein 2 | [203] | -0.46[204] | 0.02[205] | 1.50[206] | 1.13[207] | 0.86[208] | 0.74[209] |
31 | BAK1 | Bcl-2 homologous antagonist/killer | [210] | 1.03[211] | 0.73[212] | 0.59[213] | 1.06[214] | 0.98[215] | -1.10[216] |
32 | AVEN | Cell death regulator Aven | [217] | -0.84[218] | -0.95[219] | -3.13[220] | -1.18[221] | -0.65[222] | -0.52[223] |
33 | TP53 | Cellular tumor antigen p53 | [224] | 1.78[225] | 1.49[226] | 2.15[227] | 1.17[228] | 1.27[229] | 0.64[230] |
34 | MAPK3 | Mitogen-activated protein kinase 3 | [231] | 1.99[232] | 2.19[233] | 2.13[234] | 0.30[235] | 0.76[236] | -0.35[237] |
35 | BBC3 | Bcl-2-binding component 3 | [238] | 0.88[239] | 0.92[240] | 0.31[241] | -2.93[242] | -1.73[243] | -3.65[244] |
36 | PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | -0.56[245] | -0.27[246] | -0.77[247] | -1.21[248] | 0.14[249] | 0.74[250] | |
37 | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats | [251] | -0.16[252] | 2.20[253] | 2.16[254] | 2.75[255] | 1.86[256] | 2.46[257] |
38 | BMF | Bcl-2-modifying factor | [258] | 0.96[259] | 1.48[260] | 2.44[261] | 3.51[262] | -1.41[263] | -0.11[264] |
39 | XIAP | E3 ubiquitin-protein ligase XIAP | [265] | 1.66[266] | 2.40[267] | 2.75[268] | 2.47[269] | 2.33[270] | 3.37[271] |
40 | CASP9 | Caspase-9 | [272] | 0.30[273] | 1.41[274] | 0.43[275] | 0.12[276] | -0.13[277] | 0.15[278] |
41 | E2F1 | Transcription factor E2F1 | [279] | 2.09[280] | 2.10[281] | 2.12[282] | 1.74[283] | 2.62[284] | -2.93[285] |
42 | CARD8 | Caspase recruitment domain-containing protein 8 | [286] | -0.05[287] | 0.91[288] | 1.94[289] | 0.58[290] | 1.04[291] | 2.11[292] |
43 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [293] | 0.19[294] | -3.02[295] | 0.43[296] | 2.16[297] | 1.82[298] | -3.61[299] |
44 | TFDP2 | Transcription factor Dp-2 | [300] | 2.05[301] | 2.89[302] | 2.81[303] | 2.26[304] | 2.93[305] | 3.04[306] |
45 | PPP1R13B | Apoptosis-stimulating of p53 protein 1 | [307] | 1.69[308] | 1.14[309] | 0.12[310] | 0.82[311] | 1.12[312] | 1.67[313] |
46 | BCL2L11 | Bcl-2-like protein 11 | [314] | 1.65[315] | 1.81[316] | 2.03[317] | 1.74[318] | 1.15[319] | 2.67[320] |
47 | APAF1 | Apoptotic protease-activating factor 1 | [321] | 1.80[322] | 2.38[323] | 2.53[324] | 2.50[325] | 2.04[326] | 2.17[327] |
48 | AKT3 | RAC-gamma serine/threonine-protein kinase | [328] | -1.70[329] | -4.11[330] | -3.52[331] | 5.71[332] | 5.11[333] | 4.29[334] |
49 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [335] | 4.23[336] | 2.14[337] | 5.45[338] | 5.08[339] | 7.30[340] | -1.47[341] |
50 | GZMB | Granzyme B | [342] | -4.47[343] | [344] | [345] | [346] | [347] | -0.02[348] |
51 | TP73 | Tumor protein p73 | [349] | 0.87[350] | 3.57[351] | 2.39[352] | 0.55[353] | 2.12[354] | 1.34[355] |
52 | BCL2 | Apoptosis regulator Bcl-2 | [356] | -2.71[357] | 2.85[358] | -4.66[359] | 1.65[360] | 1.80[361] | 3.92[362] |
53 | TP63 | Tumor protein 63 | [363] | [364] | [365] | -1.88[366] | -1.50[367] | -4.64[368] | -0.79[369] |
54 | SEPTIN4 | [370] | [371] | [372] | [373] | [374] | [375] | [376] | |
55 | GSDME | Gasdermin-E | [377] | [378] | [379] | [380] | [381] | [382] | [383] |