REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GRB2 | Growth factor receptor-bound protein 2 | [1] | 0.13[2] | -0.21[3] | -0.05[4] | -0.96[5] | -0.82[6] | -0.91[7] |
2 | SHC1 | SHC-transforming protein 1 | [8] | 0.10[9] | 0.14[10] | 0.25[11] | 1.14[12] | 0.85[13] | -0.43[14] |
3 | JAK1 | Tyrosine-protein kinase JAK1 | [15] | -0.55[16] | -1.24[17] | -1.03[18] | -0.88[19] | -0.01[20] | 0.32[21] |
4 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [22] | -1.54[23] | -1.60[24] | -0.47[25] | 0.55[26] | 0.28[27] | 1.79[28] |
5 | SOS1 | Son of sevenless homolog 1 | [29] | -1.16[30] | 0.19[31] | -0.27[32] | -0.67[33] | -1.21[34] | -0.67[35] |
6 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [36] | -1.53[37] | -1.51[38] | -0.90[39] | -8.65[40] | -3.41[41] | -1.39[42] |
7 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [43] | 0.81[44] | 0.86[45] | 1.50[46] | -0.80[47] | -0.02[48] | -1.50[49] |
8 | INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | [50] | 1.07[51] | 0.15[52] | 0.95[53] | 1.81[54] | 1.32[55] | -0.25[56] |
9 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.15[57] | 0.48[58] | 0.67[59] | -0.46[60] | -0.08[61] | -0.05[62] | |
10 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.44[63] | 0.02[64] | 0.24[65] | -0.38[66] | 0.05[67] | 0.71[68] | |
11 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 0.82[69] | 1.73[70] | -2.04[71] | -1.23[72] | -0.24[73] | -0.91[74] | |
12 | GAB2 | GRB2-associated-binding protein 2 | [75] | 0.50[76] | 0.11[77] | 0.39[78] | -0.59[79] | -0.27[80] | -0.66[81] |
13 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [82] | 2.79[83] | 3.00[84] | -7.15[85] | -7.18[86] | -4.00[87] | 0.07[88] |
14 | IL2RG | Cytokine receptor common subunit gamma | [89] | -2.71[90] | -4.78[91] | -4.10[92] | -5.11[93] | [94] | -1.32[95] |
15 | JAK2 | Tyrosine-protein kinase JAK2 | [96] | -0.84[97] | -1.02[98] | -1.43[99] | -0.75[100] | 0.07[101] | 1.50[102] |
16 | CSF2RA | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | [103] | [104] | [105] | [106] | [107] | -7.67[108] | |
17 | IL2RB | Interleukin-2 receptor subunit beta | [109] | -5.83[110] | -6.57[111] | -7.51[112] | -4.33[113] | -6.52[114] | 0.34[115] |
18 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [116] | 0.66[117] | 0.49[118] | 1.37[119] | 1.65[120] | 0.90[121] | 1.47[122] |
19 | IL3RA | Interleukin-3 receptor subunit alpha | [123] | [124] | [125] | [126] | [127] | [128] | [129] |
20 | JAK3 | Tyrosine-protein kinase JAK3 | [130] | 1.18[131] | 3.28[132] | -2.70[133] | -2.15[134] | -1.18[135] | 1.89[136] |
21 | CSF2RB | Cytokine receptor common subunit beta | [137] | [138] | [139] | [140] | -7.66[141] | -5.12[142] | 1.66[143] |
22 | IL2RA | Interleukin-2 receptor subunit alpha | [144] | [145] | -6.83[146] | [147] | -6.12[148] | -7.80[149] | -0.67[150] |
23 | CSF2 | Granulocyte-macrophage colony-stimulating factor | [151] | -0.60[152] | -4.73[153] | -4.06[154] | -3.23[155] | 4.90[156] | -2.68[157] |
24 | IL5RA | Interleukin-5 receptor subunit alpha | [158] | [159] | [160] | [161] | -2.10[162] | -1.78[163] | 1.12[164] |
25 | IL3 | Interleukin-3 | [165] | [166] | [167] | [168] | [169] | [170] | [171] |
26 | IL5 | Interleukin-5 | [172] | [173] | [174] | [175] | [176] | [177] | [178] |
27 | IL2 | Interleukin-2 | [179] | [180] | [181] | [182] | [183] | [184] | [185] |