REACTOME_INTERLEUKIN_7_SIGNALING			Return to index
Order	Gene	Description	ref_hepatocyte	HepG2	HepG2.C3A	HuH.7	SNU475	THLE	liver
1	STAT3	Signal transducer and activator of transcription 3	[1]	-0.21[2]	-1.26[3]	-1.14[4]	-0.65[5]	-1.38[6]	0.37[7]
2	JAK1	Tyrosine-protein kinase JAK1	[8]	-0.25[9]	-0.31[10]	-0.75[11]	-0.26[12]	0.38[13]	-0.51[14]
3	SMARCA4	Transcription activator BRG1	[15]	1.63[16]	0.90[17]	1.40[18]	0.50[19]	0.94[20]	-1.51[21]
4	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	[22]	-1.23[23]	-0.67[24]	-0.19[25]	1.18[26]	0.68[27]	0.96[28]
5	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta	[29]	1.11[30]	1.78[31]	1.78[32]	-0.18[33]	0.37[34]	-2.33[35]
6	CISH	Cytokine-inducible SH2-containing protein	[36]	-3.67[37]	-3.03[38]	-3.44[39]	-3.54[40]	-4.98[41]	-0.94[42]
7	STAT5B	Signal transducer and activator of transcription 5B	[43]	0.60[44]	0.67[45]	0.76[46]	0.66[47]	-0.20[48]	-0.42[49]
8	BRWD1	Bromodomain and WD repeat-containing protein 1	[50]	-0.09[51]	1.90[52]	1.15[53]	0.88[54]	0.60[55]	1.46[56]
9	TSLP	Thymic stromal lymphopoietin	[57]	-9.19[58]	[59]	-10.60[60]	-6.72[61]	-3.55[62]	-4.71[63]
10	SOCS2	Suppressor of cytokine signaling 2	[64]	-1.57[65]	-3.66[66]	-6.03[67]	-0.24[68]	-5.96[69]	-0.39[70]
11	IRS1	Insulin receptor substrate 1	[71]	1.33[72]	1.22[73]	2.03[74]	0.82[75]	0.39[76]	0.08[77]
12	STAT5A	Signal transducer and activator of transcription 5A	[78]	-2.71[79]	-1.09[80]	-2.63[81]	-1.74[82]	-0.98[83]	-1.80[84]
13	IRS2	Insulin receptor substrate 2	[85]	-6.41[86]	[87]	-3.72[88]	-1.56[89]	2.27[90]	0.35[91]
14	SOCS1	Suppressor of cytokine signaling 1	[92]	-2.21[93]	-0.89[94]	-1.24[95]	-2.68[96]	-4.07[97]	-3.50[98]
15	IL7	Interleukin-7	[99]	-3.41[100]	-1.50[101]	-7.72[102]	-6.69[103]	-3.07[104]	-0.74[105]
16	IL2RG	Cytokine receptor common subunit gamma	[106]	-2.41[107]	-3.85[108]	-3.82[109]	-4.49[110]	[111]	-2.15[112]
17	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma	[113]	0.96[114]	1.42[115]	1.65[116]	2.28[117]	1.29[118]	0.64[119]
18	IL7R	Interleukin-7 receptor subunit alpha	[120]	-5.00[121]	-5.14[122]	-5.85[123]	4.35[124]	4.26[125]	0.18[126]
19	JAK3	Tyrosine-protein kinase JAK3	[127]	1.48[128]	4.20[129]	-2.42[130]	-1.52[131]	-0.79[132]	1.06[133]
20	RAG1	V(D)J recombination-activating protein 1	[134]	-0.84[135]	-0.15[136]	1.45[137]	2.06[138]	-0.20[139]	0.58[140]
21	RAG2	V(D)J recombination-activating protein 2	[141]	-1.80[142]	-2.84[143]	-2.78[144]	-1.55[145]	-1.21[146]	-2.10[147]
22	HGF	Hepatocyte growth factor	[148]	[149]	[150]	-2.58[151]	3.70[152]	0.73[153]	6.86[154]
23	H3C11		[155]	[156]	[157]	[158]	[159]	[160]	[161]
24	H3C4		[162]	[163]	[164]	[165]	[166]	[167]	[168]
25	H3C8		[169]	[170]	[171]	[172]	[173]	[174]	[175]
26	H3C10		[176]	[177]	[178]	[179]	[180]	[181]	[182]
27	H3C13		[183]	[184]	[185]	[186]	[187]	[188]	[189]
28	H3C12		[190]	[191]	[192]	[193]	[194]	[195]	[196]
29	H3C3		[197]	[198]	[199]	[200]	[201]	[202]	[203]
30	H3C2		[204]	[205]	[206]	[207]	[208]	[209]	[210]
31	H3C7		[211]	[212]	[213]	[214]	[215]	[216]	[217]
32	H3C15		[218]	[219]	[220]	[221]	[222]	[223]	[224]
33	H3C1		[225]	[226]	[227]	[228]	[229]	[230]	[231]
34	CRLF2	Cytokine receptor-like factor 2	[232]	[233]	[234]	[235]	[236]	[237]	[238]
35	H3C14		[239]	[240]	[241]	[242]	[243]	[244]	[245]
36	H3C6		[246]	[247]	[248]	[249]	[250]	[251]	[252]

ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36

HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02

HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27

HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35

SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57

THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49

liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02

ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10

HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56

HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29

HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29

SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39

THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80

liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62

ref_hepatocyte SMARCA4
Mean 7.57
Standard deviation 3.6
Values 11 11 8 4.5 3.3

HepG2 SMARCA4
Mean 87.8
Standard deviation 16
Values 99 76

HepG2.C3A SMARCA4
Mean 34.6
Standard deviation 2
Values 36 33

HuH.7 SMARCA4
Mean 71.6
Standard deviation 30
Values 1e+02 43 70

SNU475 SMARCA4
Mean 36.4
Standard deviation 0.56
Values 37 36

THLE SMARCA4
Mean 55.3
Standard deviation 15
Values 45 66

liver SMARCA4
Mean 15.5
Standard deviation 2.3
Values 17 15 13 18

ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14

HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14

HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13

HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15

SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35

THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47

liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02

ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8

HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41

HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35

HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64

SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13

THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28

liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9

ref_hepatocyte CISH
Mean 4.68
Standard deviation 5.7
Values 0.89 0.45 3 14 4.7

HepG2 CISH
Mean 1.38
Standard deviation 0.087
Values 1.3 1.4

HepG2.C3A CISH
Mean 1.4
Standard deviation 0.43
Values 1.7 1.1

HuH.7 CISH
Mean 1.55
Standard deviation 0.25
Values 1.7 1.7 1.3

SNU475 CISH
Mean 1.37
Standard deviation 0.36
Values 1.6 1.1

THLE CISH
Mean 0.567
Standard deviation 0.027
Values 0.59 0.55

liver CISH
Mean 14.3
Standard deviation 12
Values 31 1.8 13 11

ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6

HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18

HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13

HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26

SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19

THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13

liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22

ref_hepatocyte BRWD1
Mean 3.74
Standard deviation 2.5
Values 5.6 2 1.8 2.1 7.2

HepG2 BRWD1
Mean 13.1
Standard deviation 0.32
Values 13 13

HepG2.C3A BRWD1
Mean 34.2
Standard deviation 4.8
Values 38 31

HuH.7 BRWD1
Mean 29.7
Standard deviation 7.8
Values 31 37 21

SNU475 BRWD1
Mean 23.4
Standard deviation 4.1
Values 26 20

THLE BRWD1
Mean 21.6
Standard deviation 6.1
Values 26 17

liver BRWD1
Mean 59.8
Standard deviation 30
Values 38 90 30 81

ref_hepatocyte TSLP
Mean 3.7
Standard deviation 4.3
Values 0 3.4 11 1.8 2.3

HepG2 TSLP
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013

HepG2.C3A TSLP
Mean 0
Standard deviation 0
Values 0 0

HuH.7 TSLP
Mean 0.00856
Standard deviation 0.015
Values 0 0.026 0

SNU475 TSLP
Mean 0.119
Standard deviation 0.1
Values 0.046 0.19

THLE TSLP
Mean 1.21
Standard deviation 0.56
Values 1.6 0.81

liver TSLP
Mean 0.821
Standard deviation 0.77
Values 1.6 0.23 1.4 0.093

ref_hepatocyte SOCS2
Mean 3.66
Standard deviation 2
Values 3.6 6.7 2.3 4.2 1.5

HepG2 SOCS2
Mean 4.62
Standard deviation 2.2
Values 3.1 6.2

HepG2.C3A SOCS2
Mean 0.708
Standard deviation 0.27
Values 0.52 0.9

HuH.7 SOCS2
Mean 0.201
Standard deviation 0.17
Values 0.14 0.4 0.066

SNU475 SOCS2
Mean 10.6
Standard deviation 6.9
Values 15 5.7

THLE SOCS2
Mean 0.224
Standard deviation 0.00099
Values 0.22 0.22

liver SOCS2
Mean 16.3
Standard deviation 15
Values 36 4.4 5.7 19

ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7

HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23

HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13

HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37

SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22

THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15

liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22

ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95

HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3

HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9

HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2

SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3

THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4

liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2

ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9

HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043

HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0

HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17

SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8

THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43

liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17

ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.1 0 1.3 4.7 3.4

HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.8 1.6

HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 3.7 1.9

HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 3.3 1 5.3

SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 1.3 0.95

THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43

liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 1.1 0.27 0.8 2.2

ref_hepatocyte IL7
Mean 1.1
Standard deviation 0.7
Values 1 0.18 1.1 1.1 2.2

HepG2 IL7
Mean 0.386
Standard deviation 0.18
Values 0.26 0.51

HepG2.C3A IL7
Mean 0.954
Standard deviation 0.44
Values 0.64 1.3

HuH.7 IL7
Mean 0.0187
Standard deviation 0.017
Values 0.0082 0.039 0.0094

SNU475 IL7
Mean 0.0363
Standard deviation 0.0011
Values 0.037 0.035

THLE IL7
Mean 0.502
Standard deviation 0.13
Values 0.41 0.6

liver IL7
Mean 3.86
Standard deviation 1.5
Values 4.9 2.8 2.4 5.3

ref_hepatocyte IL2RG
Mean 1.04
Standard deviation 1.2
Values 0 0 0.89 1.3 3

HepG2 IL2RG
Mean 0.733
Standard deviation 0.88
Values 1.4 0.11

HepG2.C3A IL2RG
Mean 0.176
Standard deviation 0.067
Values 0.22 0.13

HuH.7 IL2RG
Mean 0.264
Standard deviation 0.039
Values 0.25 0.24 0.31

SNU475 IL2RG
Mean 0.158
Standard deviation 0.092
Values 0.093 0.22

THLE IL2RG
Mean 0
Standard deviation 0
Values 0 0

liver IL2RG
Mean 1.37
Standard deviation 1.1
Values 2.4 0.51 2.2 0.41

ref_hepatocyte PIK3R3
Mean 0.405
Standard deviation 0.3
Values 0.52 0.81 0.47 0.078 0.15

HepG2 PIK3R3
Mean 2.95
Standard deviation 2.5
Values 1.2 4.7

HepG2.C3A PIK3R3
Mean 2.65
Standard deviation 1.6
Values 1.5 3.8

HuH.7 PIK3R3
Mean 4.56
Standard deviation 1.3
Values 5.7 3.1 5

SNU475 PIK3R3
Mean 6.68
Standard deviation 0.22
Values 6.5 6.8

THLE PIK3R3
Mean 3.8
Standard deviation 0.9
Values 3.2 4.4

liver PIK3R3
Mean 3.68
Standard deviation 0.27
Values 3.7 3.8 3.3 4

ref_hepatocyte IL7R
Mean 0.372
Standard deviation 0.35
Values 0 0.52 0.72 0 0.62

HepG2 IL7R
Mean 0.0437
Standard deviation 0.044
Values 0.074 0.013

HepG2.C3A IL7R
Mean 0.0258
Standard deviation 0.009
Values 0.019 0.032

HuH.7 IL7R
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037

SNU475 IL7R
Mean 25.9
Standard deviation 8
Values 20 32

THLE IL7R
Mean 27.3
Standard deviation 0.78
Values 27 28

liver IL7R
Mean 2.45
Standard deviation 1
Values 2.8 1.8 1.4 3.7

ref_hepatocyte JAK3
Mean 0.235
Standard deviation 0.23
Values 0.61 0.026 0.15 0.078 0.31

HepG2 JAK3
Mean 2.46
Standard deviation 0.35
Values 2.7 2.2

HepG2.C3A JAK3
Mean 10.6
Standard deviation 4.3
Values 14 7.6

HuH.7 JAK3
Mean 0.158
Standard deviation 0.069
Values 0.11 0.24 0.12

SNU475 JAK3
Mean 0.279
Standard deviation 0.0072
Values 0.27 0.28

THLE JAK3
Mean 0.519
Standard deviation 0.094
Values 0.59 0.45

liver JAK3
Mean 2.86
Standard deviation 0.73
Values 2.8 2.2 2.5 3.9

ref_hepatocyte RAG1
Mean 0.0958
Standard deviation 0.094
Values 0 0.2 0 0.1 0.18

HepG2 RAG1
Mean 0.2
Standard deviation 0.056
Values 0.16 0.24

HepG2.C3A RAG1
Mean 0.21
Standard deviation 0.036
Values 0.18 0.24

HuH.7 RAG1
Mean 0.938
Standard deviation 0.29
Values 1.1 1.1 0.61

SNU475 RAG1
Mean 1.36
Standard deviation 0.28
Values 1.6 1.2

THLE RAG1
Mean 0.319
Standard deviation 0.068
Values 0.37 0.27

liver RAG1
Mean 0.835
Standard deviation 0.56
Values 0.31 1.6 0.49 0.99

ref_hepatocyte RAG2
Mean 0.0299
Standard deviation 0.051
Values 0 0 0.12 0 0.033

HepG2 RAG2
Mean 0.0322
Standard deviation 0.021
Values 0.017 0.047

HepG2.C3A RAG2
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011

HuH.7 RAG2
Mean 0.0156
Standard deviation 0.02
Values 0.0082 0.039 0

SNU475 RAG2
Mean 0.0346
Standard deviation 0.023
Values 0.019 0.051

THLE RAG2
Mean 0.0494
Standard deviation 0.028
Values 0.03 0.069

liver RAG2
Mean 0.0407
Standard deviation 0.051
Values 0 0.057 0 0.11

ref_hepatocyte HGF
Mean 0.0217
Standard deviation 0.03
Values 0 0 0 0.052 0.057

HepG2 HGF
Mean 0
Standard deviation 0
Values 0 0

HepG2.C3A HGF
Mean 0
Standard deviation 0
Values 0 0

HuH.7 HGF
Mean 0.0131
Standard deviation 0.017
Values 0.033 0.0064 0

SNU475 HGF
Mean 0.963
Standard deviation 0.42
Values 1.3 0.67

THLE HGF
Mean 0.138
Standard deviation 0.061
Values 0.095 0.18

liver HGF
Mean 14.7
Standard deviation 7.2
Values 9.2 24 9.5 16

ref_hepatocyte H3C11
Missing

HepG2 H3C11
Missing

HepG2.C3A H3C11
Missing

HuH.7 H3C11
Missing

SNU475 H3C11
Missing

THLE H3C11
Missing

liver H3C11
Missing

ref_hepatocyte H3C4
Missing

HepG2 H3C4
Missing

HepG2.C3A H3C4
Missing

HuH.7 H3C4
Missing

SNU475 H3C4
Missing

THLE H3C4
Missing

liver H3C4
Missing

ref_hepatocyte H3C8
Missing

HepG2 H3C8
Missing

HepG2.C3A H3C8
Missing

HuH.7 H3C8
Missing

SNU475 H3C8
Missing

THLE H3C8
Missing

liver H3C8
Missing

ref_hepatocyte H3C10
Missing

HepG2 H3C10
Missing

HepG2.C3A H3C10
Missing

HuH.7 H3C10
Missing

SNU475 H3C10
Missing

THLE H3C10
Missing

liver H3C10
Missing

ref_hepatocyte H3C13
Missing

HepG2 H3C13
Missing

HepG2.C3A H3C13
Missing

HuH.7 H3C13
Missing

SNU475 H3C13
Missing

THLE H3C13
Missing

liver H3C13
Missing

ref_hepatocyte H3C12
Missing

HepG2 H3C12
Missing

HepG2.C3A H3C12
Missing

HuH.7 H3C12
Missing

SNU475 H3C12
Missing

THLE H3C12
Missing

liver H3C12
Missing

ref_hepatocyte H3C3
Missing

HepG2 H3C3
Missing

HepG2.C3A H3C3
Missing

HuH.7 H3C3
Missing

SNU475 H3C3
Missing

THLE H3C3
Missing

liver H3C3
Missing

ref_hepatocyte H3C2
Missing

HepG2 H3C2
Missing

HepG2.C3A H3C2
Missing

HuH.7 H3C2
Missing

SNU475 H3C2
Missing

THLE H3C2
Missing

liver H3C2
Missing

ref_hepatocyte H3C7
Missing

HepG2 H3C7
Missing

HepG2.C3A H3C7
Missing

HuH.7 H3C7
Missing

SNU475 H3C7
Missing

THLE H3C7
Missing

liver H3C7
Missing

ref_hepatocyte H3C15
Missing

HepG2 H3C15
Missing

HepG2.C3A H3C15
Missing

HuH.7 H3C15
Missing

SNU475 H3C15
Missing

THLE H3C15
Missing

liver H3C15
Missing

ref_hepatocyte H3C1
Missing

HepG2 H3C1
Missing

HepG2.C3A H3C1
Missing

HuH.7 H3C1
Missing

SNU475 H3C1
Missing

THLE H3C1
Missing

liver H3C1
Missing

ref_hepatocyte CRLF2
Mean 0
Standard deviation 0
Values 0 0 0 0 0

HepG2 CRLF2
Missing

HepG2.C3A CRLF2
Missing

HuH.7 CRLF2
Missing

SNU475 CRLF2
Missing

THLE CRLF2
Missing

liver CRLF2
Missing

ref_hepatocyte H3C14
Missing

HepG2 H3C14
Missing

HepG2.C3A H3C14
Missing

HuH.7 H3C14
Missing

SNU475 H3C14
Missing

THLE H3C14
Missing

liver H3C14
Missing

ref_hepatocyte H3C6
Missing

HepG2 H3C6
Missing

HepG2.C3A H3C6
Missing

HuH.7 H3C6
Missing

SNU475 H3C6
Missing

THLE H3C6
Missing

liver H3C6
Missing