REACTOME_INTERLEUKIN_6_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.22[2] -1.21[3] -0.55[4] -0.99[5] -1.68[6] 0.24[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] 0.12[9] 0.61[10] 0.50[11] -0.34[12] 0.32[13] -0.91[14]
3 STAT1 Signal transducer and activator of transcription 1-alpha/beta [15] -0.40[16] -1.26[17] -0.22[18] 1.30[19] -0.94[20] -1.21[21]
4 IL6ST Interleukin-6 receptor subunit beta [22] -0.07[23] 1.24[24] 0.70[25] 0.50[26] 1.70[27] 1.61[28]
5 JAK1 Tyrosine-protein kinase JAK1 [29] 0.18[30] -0.27[31] -0.15[32] -0.60[33] 0.07[34] -0.63[35]
6 SOCS3 Suppressor of cytokine signaling 3 [36] -4.47[37] -4.82[38] -3.17[39] -2.03[40] -3.07[41] -2.03[42]
7 IL6R Interleukin-6 receptor subunit alpha [43] -0.55[44] -0.16[45] -1.05[46] -2.10[47] -6.17[48] -0.51[49]
8 TYK2 Non-receptor tyrosine-protein kinase TYK2 [50] 0.81[51] 1.23[52] 1.29[53] -0.48[54] 0.47[55] -0.18[56]
9 IL6 Interleukin-6 [57] -8.77[58] [59] -5.17[60] -2.08[61] 0.46[62] [63]
10 JAK2 Tyrosine-protein kinase JAK2 [64] -0.10[65] -0.04[66] -0.56[67] -0.47[68] 0.16[69] 0.54[70]
11 CBL E3 ubiquitin-protein ligase CBL [71] 4.12[72] 3.13[73] 3.28[74] 3.91[75] 3.42[76] 1.59[77]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[16]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[17]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[18]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[19]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[20]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[21]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[22]
ref_hepatocyte IL6ST
Mean 16.5
Standard deviation 5.8
Values 24 18 9.5 12 19
[23]
HepG2 IL6ST
Mean 43.6
Standard deviation 25
Values 26 61
[24]
HepG2.C3A IL6ST
Mean 92.3
Standard deviation 8.3
Values 86 98
[25]
HuH.7 IL6ST
Mean 63.5
Standard deviation 38
Values 50 1.1e+02 35
[26]
SNU475 IL6ST
Mean 100
Standard deviation 15
Values 90 1.1e+02
[27]
THLE IL6ST
Mean 252
Standard deviation 68
Values 3e+02 2e+02
[28]
liver IL6ST
Mean 321
Standard deviation 1.1e+02
Values 2.5e+02 4.2e+02 2.1e+02 4.1e+02
[29]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[30]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[31]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[32]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[33]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[34]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[35]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[36]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[37]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[38]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[39]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[40]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[41]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[42]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[43]
ref_hepatocyte IL6R
Mean 10.5
Standard deviation 4.3
Values 6.9 11 17 6.6 11
[44]
HepG2 IL6R
Mean 20
Standard deviation 0.31
Values 20 20
[45]
HepG2.C3A IL6R
Mean 22.3
Standard deviation 0.4
Values 22 23
[46]
HuH.7 IL6R
Mean 12.1
Standard deviation 3.9
Values 10 17 9.4
[47]
SNU475 IL6R
Mean 10.6
Standard deviation 4
Values 13 7.7
[48]
THLE IL6R
Mean 0.69
Standard deviation 0.095
Values 0.76 0.62
[49]
liver IL6R
Mean 47.1
Standard deviation 10
Values 49 49 33 57
[50]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[51]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[52]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[53]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[54]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[55]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[56]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[57]
ref_hepatocyte IL6
Mean 1.35
Standard deviation 2.5
Values 0 0 5.9 0.6 0.28
[58]
HepG2 IL6
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[59]
HepG2.C3A IL6
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 IL6
Mean 0.0895
Standard deviation 0.012
Values 0.082 0.083 0.1
[61]
SNU475 IL6
Mean 1.37
Standard deviation 1.7
Values 0.15 2.6
[62]
THLE IL6
Mean 8.81
Standard deviation 1.5
Values 7.7 9.9
[63]
liver IL6
Mean 0
Standard deviation 0
Values 0 0 0 0
[64]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[65]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[66]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[67]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[68]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[69]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[70]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[71]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[72]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[73]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[74]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[75]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[76]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[77]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14