REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] -0.60[2] -1.80[3] -0.68[4] -1.08[5] -1.82[6] 0.19[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] -0.70[9] 0.02[10] 0.36[11] -0.44[12] 0.18[13] -0.96[14]
3 STAT1 Signal transducer and activator of transcription 1-alpha/beta [15] -1.22[16] -1.85[17] -0.35[18] 1.20[19] -1.08[20] -1.27[21]
4 IL6ST Interleukin-6 receptor subunit beta [22] -0.89[23] 0.65[24] 0.56[25] 0.40[26] 1.56[27] 1.56[28]
5 JAK1 Tyrosine-protein kinase JAK1 [29] -0.63[30] -0.86[31] -0.29[32] -0.70[33] -0.07[34] -0.69[35]
6 SOCS3 Suppressor of cytokine signaling 3 [36] -5.29[37] -5.41[38] -3.30[39] -2.13[40] -3.21[41] -2.09[42]
7 IL6R Interleukin-6 receptor subunit alpha [43] -1.36[44] -0.75[45] -1.18[46] -2.20[47] -6.31[48] -0.56[49]
8 OSMR Oncostatin-M-specific receptor subunit beta [50] 0.87[51] 0.87[52] -0.14[53] 0.39[54] 1.53[55] -0.72[56]
9 TYK2 Non-receptor tyrosine-protein kinase TYK2 [57] -0.01[58] 0.64[59] 1.16[60] -0.58[61] 0.33[62] -0.23[63]
10 IL11RA Interleukin-11 receptor subunit alpha [64] -3.12[65] -0.55[66] -1.55[67] -2.87[68] -2.99[69] -1.06[70]
11 LIF Leukemia inhibitory factor [71] 1.13[72] 1.26[73] 2.48[74] 0.29[75] 1.29[76] -7.40[77]
12 CNTFR Ciliary neurotrophic factor receptor subunit alpha [78] -7.80[79] [80] -2.88[81] -4.79[82] -7.45[83] -3.44[84]
13 IL6 Interleukin-6 [85] -9.59[86] [87] -5.30[88] -2.18[89] 0.32[90] [91]
14 CRLF1 Cytokine receptor-like factor 1 [92] 5.62[93] 5.14[94] -0.89[95] -4.31[96] -4.27[97] -6.14[98]
15 CLCF1 Cardiotrophin-like cytokine factor 1 [99] -0.90[100] -2.63[101] -0.80[102] 2.96[103] 0.52[104] -4.14[105]
16 JAK2 Tyrosine-protein kinase JAK2 [106] -0.92[107] -0.63[108] -0.69[109] -0.56[110] 0.02[111] 0.49[112]
17 LIFR Leukemia inhibitory factor receptor [113] -0.23[114] 2.76[115] 3.72[116] 2.74[117] 2.22[118] 4.30[119]
18 CBL E3 ubiquitin-protein ligase CBL [120] 3.30[121] 2.54[122] 3.15[123] 3.81[124] 3.28[125] 1.54[126]
19 CTF1 Cardiotrophin-1 [127] 0.55[128] 0.55[129] -1.63[130] -5.17[131] -0.14[132] -4.59[133]
20 OSM Oncostatin-M [134] -6.44[135] -1.59[136] -5.96[137] -6.53[138] -6.49[139] -3.96[140]
21 IL11 Interleukin-11 [141] 5.34[142] 2.00[143] -0.12[144] 1.86[145] 1.77[146] -3.86[147]
22 IL31RA Interleukin-31 receptor subunit alpha [148] -0.47[149] 0.51[150] 0.76[151] 2.57[152] 0.79[153] -2.77[154]
23 CNTF Ciliary neurotrophic factor [155] [156] -2.14[157] -3.80[158] -2.42[159] -4.52[160] -1.50[161]
24 IL31 Interleukin-31 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[16]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[17]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[18]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[19]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[20]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[21]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[22]
ref_hepatocyte IL6ST
Mean 16.5
Standard deviation 5.8
Values 24 18 9.5 12 19
[23]
HepG2 IL6ST
Mean 43.6
Standard deviation 25
Values 26 61
[24]
HepG2.C3A IL6ST
Mean 92.3
Standard deviation 8.3
Values 86 98
[25]
HuH.7 IL6ST
Mean 63.5
Standard deviation 38
Values 50 1.1e+02 35
[26]
SNU475 IL6ST
Mean 100
Standard deviation 15
Values 90 1.1e+02
[27]
THLE IL6ST
Mean 252
Standard deviation 68
Values 3e+02 2e+02
[28]
liver IL6ST
Mean 321
Standard deviation 1.1e+02
Values 2.5e+02 4.2e+02 2.1e+02 4.1e+02
[29]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[30]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[31]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[32]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[33]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[34]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[35]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[36]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[37]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[38]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[39]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[40]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[41]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[42]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[43]
ref_hepatocyte IL6R
Mean 10.5
Standard deviation 4.3
Values 6.9 11 17 6.6 11
[44]
HepG2 IL6R
Mean 20
Standard deviation 0.31
Values 20 20
[45]
HepG2.C3A IL6R
Mean 22.3
Standard deviation 0.4
Values 22 23
[46]
HuH.7 IL6R
Mean 12.1
Standard deviation 3.9
Values 10 17 9.4
[47]
SNU475 IL6R
Mean 10.6
Standard deviation 4
Values 13 7.7
[48]
THLE IL6R
Mean 0.69
Standard deviation 0.095
Values 0.76 0.62
[49]
liver IL6R
Mean 47.1
Standard deviation 10
Values 49 49 33 57
[50]
ref_hepatocyte OSMR
Mean 5.91
Standard deviation 3.2
Values 5 6.1 11 4.8 2.6
[51]
HepG2 OSMR
Mean 52.7
Standard deviation 9
Values 46 59
[52]
HepG2.C3A OSMR
Mean 38.5
Standard deviation 3.3
Values 41 36
[53]
HuH.7 OSMR
Mean 14
Standard deviation 8.7
Values 11 24 7.5
[54]
SNU475 OSMR
Mean 35.7
Standard deviation 8.4
Values 30 42
[55]
THLE OSMR
Mean 88.8
Standard deviation 9.2
Values 95 82
[56]
liver OSMR
Mean 23.7
Standard deviation 9.9
Values 11 34 21 29
[57]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[58]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[59]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[60]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[61]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[62]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[63]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[64]
ref_hepatocyte IL11RA
Mean 2.14
Standard deviation 2.3
Values 1.1 0.21 0.14 4.7 4.6
[65]
HepG2 IL11RA
Mean 1.2
Standard deviation 0.66
Values 1.7 0.73
[66]
HepG2.C3A IL11RA
Mean 5.21
Standard deviation 2.1
Values 6.7 3.7
[67]
HuH.7 IL11RA
Mean 1.91
Standard deviation 0.76
Values 1.1 2.7 1.9
[68]
SNU475 IL11RA
Mean 1.35
Standard deviation 0.4
Values 1.6 1.1
[69]
THLE IL11RA
Mean 1.4
Standard deviation 0.38
Values 1.7 1.1
[70]
liver IL11RA
Mean 6.78
Standard deviation 2.4
Values 8.8 3.5 6.2 8.5
[71]
ref_hepatocyte LIF
Mean 1.54
Standard deviation 2
Values 0.49 2.4 4.6 0.078 0.041
[72]
HepG2 LIF
Mean 16.5
Standard deviation 6.4
Values 21 12
[73]
HepG2.C3A LIF
Mean 13.1
Standard deviation 6.5
Values 18 8.6
[74]
HuH.7 LIF
Mean 22.4
Standard deviation 16
Values 12 41 14
[75]
SNU475 LIF
Mean 8.67
Standard deviation 1.2
Values 7.8 9.5
[76]
THLE LIF
Mean 19.6
Standard deviation 9.5
Values 13 26
[77]
liver LIF
Mean 0.0602
Standard deviation 0.032
Values 0.024 0.1 0.051 0.066
[78]
ref_hepatocyte CNTFR
Mean 1.43
Standard deviation 1.9
Values 0 0.55 4.8 1.4 0.46
[79]
HepG2 CNTFR
Mean 0.0315
Standard deviation 0.045
Values 0.063 0
[80]
HepG2.C3A CNTFR
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 CNTFR
Mean 0.507
Standard deviation 0.38
Values 0.66 0.077 0.79
[82]
SNU475 CNTFR
Mean 0.239
Standard deviation 0.049
Values 0.2 0.27
[83]
THLE CNTFR
Mean 0.0426
Standard deviation 0.015
Values 0.053 0.032
[84]
liver CNTFR
Mean 0.871
Standard deviation 0.67
Values 1.6 0.19 0.46 1.2
[85]
ref_hepatocyte IL6
Mean 1.35
Standard deviation 2.5
Values 0 0 5.9 0.6 0.28
[86]
HepG2 IL6
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[87]
HepG2.C3A IL6
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 IL6
Mean 0.0895
Standard deviation 0.012
Values 0.082 0.083 0.1
[89]
SNU475 IL6
Mean 1.37
Standard deviation 1.7
Values 0.15 2.6
[90]
THLE IL6
Mean 8.81
Standard deviation 1.5
Values 7.7 9.9
[91]
liver IL6
Mean 0
Standard deviation 0
Values 0 0 0 0
[92]
ref_hepatocyte CRLF1
Mean 1.05
Standard deviation 2.3
Values 5.2 0 0 0 0.041
[93]
HepG2 CRLF1
Mean 254
Standard deviation 1.2e+02
Values 3.4e+02 1.7e+02
[94]
HepG2.C3A CRLF1
Mean 132
Standard deviation 17
Values 1.4e+02 1.2e+02
[95]
HuH.7 CRLF1
Mean 1.48
Standard deviation 0.28
Values 1.6 1.2 1.7
[96]
SNU475 CRLF1
Mean 0.245
Standard deviation 0.06
Values 0.29 0.2
[97]
THLE CRLF1
Mean 0.285
Standard deviation 0.16
Values 0.17 0.4
[98]
liver CRLF1
Mean 0.0989
Standard deviation 0.15
Values 0.024 0.029 0.026 0.32
[99]
ref_hepatocyte CLCF1
Mean 0.92
Standard deviation 1.2
Values 0 1.5 2.7 0.4 0.041
[100]
HepG2 CLCF1
Mean 2.41
Standard deviation 1.5
Values 3.4 1.4
[101]
HepG2.C3A CLCF1
Mean 0.529
Standard deviation 0.4
Values 0.24 0.82
[102]
HuH.7 CLCF1
Mean 1.38
Standard deviation 0.079
Values 1.3 1.3 1.5
[103]
SNU475 CLCF1
Mean 33
Standard deviation 1.4
Values 34 32
[104]
THLE CLCF1
Mean 6.85
Standard deviation 0.81
Values 6.3 7.4
[105]
liver CLCF1
Mean 0.345
Standard deviation 0.26
Values 0.12 0.37 0.69 0.2
[106]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[107]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[108]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[109]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[110]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[111]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[112]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[113]
ref_hepatocyte LIFR
Mean 0.724
Standard deviation 1
Values 2.6 0.25 0.18 0.2 0.41
[114]
HepG2 LIFR
Mean 3.03
Standard deviation 1.3
Values 2.1 3.9
[115]
HepG2.C3A LIFR
Mean 17.4
Standard deviation 0.87
Values 18 17
[116]
HuH.7 LIFR
Mean 24.9
Standard deviation 7.5
Values 27 31 17
[117]
SNU475 LIFR
Mean 22.3
Standard deviation 5.6
Values 18 26
[118]
THLE LIFR
Mean 17.5
Standard deviation 6.4
Values 22 13
[119]
liver LIFR
Mean 94.5
Standard deviation 28
Values 84 1.1e+02 59 1.2e+02
[120]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[121]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[122]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[123]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[124]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[125]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[126]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14
[127]
ref_hepatocyte CTF1
Mean 0.176
Standard deviation 0.17
Values 0 0 0.28 0.24 0.36
[128]
HepG2 CTF1
Mean 1.26
Standard deviation 0.65
Values 1.7 0.81
[129]
HepG2.C3A CTF1
Mean 0.921
Standard deviation 0.64
Values 1.4 0.47
[130]
HuH.7 CTF1
Mean 0.148
Standard deviation 0.0013
Values 0.15 0.15 0.15
[131]
SNU475 CTF1
Mean 0.0226
Standard deviation 0.025
Values 0.0046 0.041
[132]
THLE CTF1
Mean 0.832
Standard deviation 0.078
Values 0.89 0.78
[133]
liver CTF1
Mean 0.0486
Standard deviation 0.062
Values 0.14 0.014 0.026 0.013
[134]
ref_hepatocyte OSM
Mean 0.102
Standard deviation 0.17
Values 0 0 0 0.38 0.13
[135]
HepG2 OSM
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[136]
HepG2.C3A OSM
Mean 0.12
Standard deviation 0.064
Values 0.17 0.075
[137]
HuH.7 OSM
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[138]
SNU475 OSM
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[139]
THLE OSM
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[140]
liver OSM
Mean 0.0435
Standard deviation 0.033
Values 0 0.057 0.077 0.04
[141]
ref_hepatocyte IL11
Mean 0.101
Standard deviation 0.16
Values 0.38 0 0.095 0 0.033
[142]
HepG2 IL11
Mean 20
Standard deviation 20
Values 34 5.8
[143]
HepG2.C3A IL11
Mean 1.43
Standard deviation 0.25
Values 1.3 1.6
[144]
HuH.7 IL11
Mean 0.242
Standard deviation 0.062
Values 0.25 0.3 0.18
[145]
SNU475 IL11
Mean 1.68
Standard deviation 2
Values 0.26 3.1
[146]
THLE IL11
Mean 1.79
Standard deviation 0.084
Values 1.7 1.8
[147]
liver IL11
Mean 0.0459
Standard deviation 0.075
Values 0 0.16 0 0.026
[148]
ref_hepatocyte IL31RA
Mean 0.0641
Standard deviation 0.056
Values 0 0.057 0.15 0.052 0.057
[149]
HepG2 IL31RA
Mean 0.226
Standard deviation 0.053
Values 0.26 0.19
[150]
HepG2.C3A IL31RA
Mean 0.324
Standard deviation 0.087
Values 0.26 0.39
[151]
HuH.7 IL31RA
Mean 0.282
Standard deviation 0.1
Values 0.21 0.4 0.24
[152]
SNU475 IL31RA
Mean 1.75
Standard deviation 0.66
Values 1.3 2.2
[153]
THLE IL31RA
Mean 0.578
Standard deviation 0.095
Values 0.64 0.51
[154]
liver IL31RA
Mean 0.062
Standard deviation 0.067
Values 0 0.16 0.051 0.04
[155]
ref_hepatocyte CNTF
Mean 0.026
Standard deviation 0.058
Values 0 0 0 0 0.13
[156]
HepG2 CNTF
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A CNTF
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[158]
HuH.7 CNTF
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[159]
SNU475 CNTF
Mean 0.0224
Standard deviation 0.019
Values 0.0093 0.035
[160]
THLE CNTF
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[161]
liver CNTF
Mean 0.0609
Standard deviation 0.058
Values 0.024 0.11 0 0.11
[162]
ref_hepatocyte IL31
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 IL31
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A IL31
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 IL31
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[166]
SNU475 IL31
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[167]
THLE IL31
Mean 0
Standard deviation 0
Values 0 0
[168]
liver IL31
Mean 0
Standard deviation 0
Values 0 0 0 0