REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAA1 | Serum amyloid A-1 protein | [1] | -16.29[2] | -16.16[3] | -11.12[4] | -14.85[5] | -5.95[6] | -0.80[7] |
2 | HSPA8 | Heat shock cognate 71 kDa protein | [8] | 2.54[9] | 2.71[10] | 2.30[11] | 2.67[12] | 2.44[13] | 0.97[14] |
3 | LBP | Lipopolysaccharide-binding protein | [15] | -8.80[16] | -11.66[17] | -3.79[18] | -10.43[19] | -15.55[20] | 2.11[21] |
4 | HSP90B1 | Endoplasmin | [22] | 1.57[23] | 3.38[24] | 2.62[25] | 1.84[26] | 1.83[27] | 2.01[28] |
5 | HSP90AA1 | Heat shock protein HSP 90-alpha | [29] | 2.21[30] | 3.35[31] | 2.87[32] | 2.80[33] | 2.55[34] | 0.79[35] |
6 | FN1 | Fibronectin | [36] | 6.35[37] | 5.99[38] | 6.17[39] | 5.63[40] | 5.90[41] | 4.34[42] |
7 | ITGB1 | Integrin beta-1 | [43] | 3.09[44] | 3.28[45] | 3.70[46] | 4.17[47] | 4.32[48] | 2.21[49] |
8 | TIMP1 | Metalloproteinase inhibitor 1 | [50] | 0.63[51] | -0.83[52] | -7.71[53] | 0.74[54] | 2.39[55] | 2.00[56] |
9 | VIM | Vimentin | [57] | -5.49[58] | -5.76[59] | 0.18[60] | 5.31[61] | 4.79[62] | 0.80[63] |
10 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | [64] | 2.71[65] | 2.82[66] | 3.30[67] | 2.86[68] | 3.42[69] | 2.13[70] |
11 | CEBPD | CCAAT/enhancer-binding protein delta | [71] | -1.62[72] | 1.02[73] | 1.97[74] | -0.91[75] | 0.09[76] | 0.16[77] |
12 | HMOX1 | Heme oxygenase 1 | [78] | 2.38[79] | 1.62[80] | 0.79[81] | 1.11[82] | 0.94[83] | -0.04[84] |
13 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [85] | 3.70[86] | 2.47[87] | 0.07[88] | 0.72[89] | 3.34[90] | 0.21[91] |
14 | FOS | Proto-oncogene c-Fos | [92] | -3.15[93] | -1.72[94] | -2.10[95] | -3.46[96] | -2.33[97] | 0.74[98] |
15 | JUNB | Transcription factor jun-B | [99] | 0.90[100] | 0.21[101] | 1.20[102] | 0.54[103] | 1.45[104] | 0.66[105] |
16 | AKT1 | RAC-alpha serine/threonine-protein kinase | [106] | 2.94[107] | 2.87[108] | 2.08[109] | 2.66[110] | 2.75[111] | 1.80[112] |
17 | LCN2 | Neutrophil gelatinase-associated lipocalin | [113] | -1.94[114] | 1.64[115] | -4.57[116] | -5.67[117] | -3.34[118] | -0.90[119] |
18 | STAT3 | Signal transducer and activator of transcription 3 | [120] | 3.41[121] | 2.08[122] | 3.10[123] | 2.95[124] | 2.29[125] | 4.45[126] |
19 | MYC | Myc proto-oncogene protein | [127] | 3.29[128] | 3.12[129] | 1.38[130] | -0.08[131] | 2.36[132] | 0.05[133] |
20 | BCL2L1 | Bcl-2-like protein 1 | [134] | 5.00[135] | 4.55[136] | 5.80[137] | 2.09[138] | 2.55[139] | 1.23[140] |
21 | HIF1A | Hypoxia-inducible factor 1-alpha | [141] | 2.70[142] | 2.54[143] | 3.62[144] | 5.00[145] | 5.44[146] | 1.24[147] |
22 | IL13RA1 | Interleukin-13 receptor subunit alpha-1 | [148] | 4.08[149] | 3.63[150] | 4.07[151] | 3.05[152] | 2.56[153] | 3.26[154] |
23 | CCND1 | G1/S-specific cyclin-D1 | [155] | 5.91[156] | 3.57[157] | 4.69[158] | 4.59[159] | 3.18[160] | 3.10[161] |
24 | MAOA | Amine oxidase [flavin-containing] A | [162] | -0.34[163] | 0.61[164] | 3.16[165] | -1.94[166] | 3.32[167] | 3.55[168] |
25 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [169] | 2.78[170] | 2.03[171] | 3.43[172] | 5.24[173] | 3.04[174] | 2.99[175] |
26 | VEGFA | Vascular endothelial growth factor A | [176] | 4.08[177] | 5.58[178] | 4.47[179] | 3.15[180] | 3.92[181] | 2.82[182] |
27 | STAT6 | Signal transducer and activator of transcription 6 | [183] | 3.21[184] | 3.62[185] | 2.82[186] | 3.55[187] | 3.52[188] | 2.74[189] |
28 | JAK1 | Tyrosine-protein kinase JAK1 | [190] | 3.37[191] | 3.02[192] | 3.49[193] | 3.34[194] | 4.05[195] | 3.57[196] |
29 | IL18 | Interleukin-18 | [197] | 1.99[198] | -1.67[199] | 2.75[200] | 1.53[201] | 0.94[202] | -2.12[203] |
30 | ICAM1 | Intercellular adhesion molecule 1 | [204] | 4.76[205] | 4.30[206] | 5.00[207] | 2.90[208] | 5.14[209] | 1.63[210] |
31 | IL4R | Interleukin-4 receptor subunit alpha | [211] | 3.47[212] | 3.03[213] | 2.66[214] | 1.51[215] | 1.94[216] | 2.67[217] |
32 | SOCS3 | Suppressor of cytokine signaling 3 | [218] | -1.28[219] | -1.53[220] | 0.48[221] | 1.91[222] | 0.90[223] | 2.18[224] |
33 | ANXA1 | Annexin A1 | [225] | -1.54[226] | -3.22[227] | -1.89[228] | 7.32[229] | 5.83[230] | 0.03[231] |
34 | IL6R | Interleukin-6 receptor subunit alpha | [232] | 2.64[233] | 3.13[234] | 2.60[235] | 1.84[236] | -2.20[237] | 3.70[238] |
35 | CCL2 | C-C motif chemokine 2 | [239] | -10.54[240] | [241] | -9.51[242] | -1.41[243] | 0.82[244] | -1.65[245] |
36 | MMP1 | Interstitial collagenase | [246] | -2.31[247] | -5.91[248] | [249] | 0.96[250] | 0.57[251] | -10.09[252] |
37 | PIM1 | Serine/threonine-protein kinase pim-1 | [253] | 3.05[254] | 2.99[255] | 2.64[256] | 3.09[257] | 2.14[258] | 0.92[259] |
38 | MMP3 | Stromelysin-1 | [260] | -1.65[261] | -6.40[262] | -8.49[263] | 0.96[264] | -2.02[265] | -6.28[266] |
39 | RORC | Nuclear receptor ROR-gamma | [267] | 1.53[268] | 2.39[269] | -7.33[270] | -1.79[271] | -3.73[272] | 2.25[273] |
40 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [274] | 2.39[275] | 2.67[276] | 4.05[277] | 4.77[278] | 4.34[279] | 5.05[280] |
41 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [281] | 4.43[282] | 5.05[283] | 5.29[284] | 3.39[285] | 4.29[286] | -0.27[287] |
42 | BCL6 | B-cell lymphoma 6 protein | [288] | 1.96[289] | 4.38[290] | 3.14[291] | 2.16[292] | 2.97[293] | 2.07[294] |
43 | FSCN1 | Fascin | [295] | 7.22[296] | 3.49[297] | 4.80[298] | 5.34[299] | 4.06[300] | 1.76[301] |
44 | RHOU | Rho-related GTP-binding protein RhoU | [302] | 3.60[303] | 1.95[304] | 5.32[305] | -0.74[306] | 3.51[307] | 2.53[308] |
45 | TP53 | Cellular tumor antigen p53 | [309] | 4.49[310] | 4.23[311] | 5.27[312] | 4.00[313] | 3.73[314] | 2.00[315] |
46 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [316] | 4.00[317] | 4.52[318] | 4.94[319] | 3.45[320] | 4.45[321] | 4.03[322] |
47 | FGF2 | Fibroblast growth factor 2 | [323] | -3.83[324] | -3.41[325] | 1.03[326] | 3.64[327] | 5.29[328] | 0.38[329] |
48 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | [330] | 0.73[331] | -3.21[332] | -3.59[333] | -0.67[334] | 1.05[335] | 3.50[336] |
49 | ITGB2 | Integrin beta-2 | [337] | 4.15[338] | 5.71[339] | -2.29[340] | -2.48[341] | -4.40[342] | 3.36[343] |
50 | IL1B | Interleukin-1 beta | [344] | -5.84[345] | -5.54[346] | -0.93[347] | -0.88[348] | 4.77[349] | -3.16[350] |
51 | FOXO3 | Forkhead box protein O3 | [351] | 3.31[352] | 3.57[353] | 4.49[354] | 3.11[355] | 4.41[356] | 4.38[357] |
52 | S1PR1 | Sphingosine 1-phosphate receptor 1 | [358] | -5.54[359] | [360] | -0.02[361] | 0.16[362] | 1.87[363] | 3.07[364] |
53 | LAMA5 | Laminin subunit alpha-5 | [365] | 7.78[366] | 7.15[367] | 7.06[368] | 8.71[369] | 6.32[370] | 4.80[371] |
54 | SOCS5 | Suppressor of cytokine signaling 5 | [372] | 3.65[373] | 4.99[374] | 4.76[375] | 4.99[376] | 4.42[377] | 3.13[378] |
55 | TGFB1 | Transforming growth factor beta-1 | [379] | 6.33[380] | 5.46[381] | 3.00[382] | 6.54[383] | 5.84[384] | 0.81[385] |
56 | SOCS1 | Suppressor of cytokine signaling 1 | [386] | 1.41[387] | 2.44[388] | 3.00[389] | 0.91[390] | -0.40[391] | 0.58[392] |
57 | ZEB1 | Zinc finger E-box-binding homeobox 1 | [393] | 2.54[394] | 4.03[395] | 5.19[396] | 6.03[397] | 4.77[398] | 3.88[399] |
58 | FOXO1 | Forkhead box protein O1 | [400] | 4.55[401] | 4.38[402] | 4.81[403] | 3.88[404] | 5.97[405] | 5.13[406] |
59 | CD36 | Platelet glycoprotein 4 | [407] | 4.19[408] | 3.68[409] | -1.11[410] | 5.89[411] | -3.04[412] | 5.13[413] |
60 | RORA | Nuclear receptor ROR-alpha | [414] | 3.15[415] | 5.50[416] | 3.99[417] | -0.49[418] | 0.97[419] | 6.39[420] |
61 | LIF | Leukemia inhibitory factor | [421] | 5.14[422] | 5.14[423] | 6.26[424] | 4.32[425] | 5.41[426] | -3.14[427] |
62 | IL6 | Interleukin-6 | [428] | -5.58[429] | [430] | -1.52[431] | 1.85[432] | 4.44[433] | [434] |
63 | IL23A | Interleukin-23 subunit alpha | [435] | 0.71[436] | 0.99[437] | -0.47[438] | -2.23[439] | -1.09[440] | -1.75[441] |
64 | BATF | Basic leucine zipper transcriptional factor ATF-like | [442] | 2.58[443] | 1.75[444] | -5.30[445] | -7.05[446] | [447] | -0.97[448] |
65 | VCAM1 | Vascular cell adhesion protein 1 | [449] | -4.16[450] | [451] | -0.47[452] | 3.23[453] | 6.69[454] | 5.58[455] |
66 | IL2RG | Cytokine receptor common subunit gamma | [456] | 1.21[457] | -0.51[458] | 0.42[459] | -0.89[460] | [461] | 1.94[462] |
67 | POMC | Pro-opiomelanocortin | [463] | [464] | -5.34[465] | [466] | [467] | -4.34[468] | -0.15[469] |
68 | IL13RA2 | Interleukin-13 receptor subunit alpha-2 | [470] | [471] | [472] | [473] | -0.83[474] | 1.91[475] | 1.38[476] |
69 | MMP9 | Matrix metalloproteinase-9 | [477] | 0.14[478] | -0.74[479] | -2.85[480] | 1.28[481] | -1.22[482] | 1.90[483] |
70 | JAK2 | Tyrosine-protein kinase JAK2 | [484] | 3.09[485] | 3.25[486] | 3.09[487] | 3.47[488] | 4.13[489] | 4.75[490] |
71 | NOS2 | Nitric oxide synthase, inducible | [491] | 2.88[492] | [493] | -2.91[494] | -2.15[495] | -2.97[496] | -5.27[497] |
72 | IL10 | Interleukin-10 | [498] | 0.99[499] | 0.91[500] | 1.37[501] | 0.72[502] | 0.33[503] | 0.45[504] |
73 | POU2F1 | POU domain, class 2, transcription factor 1 | [505] | 5.96[506] | 6.93[507] | 7.94[508] | 6.83[509] | 5.96[510] | 6.16[511] |
74 | IRF4 | Interferon regulatory factor 4 | [512] | -1.97[513] | -1.47[514] | -1.80[515] | -1.60[516] | -2.64[517] | 2.66[518] |
75 | ITGAM | Integrin alpha-M | [519] | 0.46[520] | -1.92[521] | -0.42[522] | 0.12[523] | -2.24[524] | 4.95[525] |
76 | ALOX5 | Arachidonate 5-lipoxygenase | [526] | 1.99[527] | -3.19[528] | -2.83[529] | -4.42[530] | -3.10[531] | 4.86[532] |
77 | NANOG | Homeobox protein NANOG | [533] | 3.27[534] | 2.60[535] | 1.42[536] | 0.43[537] | -0.42[538] | 1.96[539] |
78 | COL1A2 | Collagen alpha-2(I) chain | [540] | -3.29[541] | -3.05[542] | -0.28[543] | 7.68[544] | 7.79[545] | 8.47[546] |
79 | ITGAX | Integrin alpha-X | [547] | 2.39[548] | 3.20[549] | 1.46[550] | 1.46[551] | 1.91[552] | 4.34[553] |
80 | F13A1 | Coagulation factor XIII A chain | [554] | -4.85[555] | -3.62[556] | [557] | [558] | -3.36[559] | 5.53[560] |
81 | CCL22 | C-C motif chemokine 22 | [561] | 1.48[562] | 1.81[563] | 0.76[564] | 0.55[565] | 0.55[566] | -0.64[567] |
82 | JAK3 | Tyrosine-protein kinase JAK3 | [568] | 5.10[569] | 7.54[570] | 1.82[571] | 2.07[572] | 2.88[573] | 5.14[574] |
83 | MUC1 | Mucin-1 | [575] | -0.93[576] | 0.14[577] | 4.63[578] | 7.15[579] | 5.21[580] | -0.34[581] |
84 | SOX2 | Transcription factor SOX-2 | [582] | 0.52[583] | [584] | 3.50[585] | 5.65[586] | -3.26[587] | -2.62[588] |
85 | NDN | Necdin | [589] | -0.86[590] | -0.43[591] | 0.33[592] | 9.65[593] | 7.01[594] | 5.04[595] |
86 | MMP2 | 72 kDa type IV collagenase | [596] | 6.29[597] | -0.53[598] | 1.04[599] | 10.15[600] | 9.77[601] | 5.98[602] |
87 | IL12A | Interleukin-12 subunit alpha | [603] | 1.45[604] | [605] | 3.40[606] | 1.16[607] | 3.03[608] | -1.13[609] |
88 | TNF | Tumor necrosis factor | [610] | 3.96[611] | 1.99[612] | -2.32[613] | 0.49[614] | -2.67[615] | 0.15[616] |
89 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | [617] | -1.33[618] | [619] | 6.03[620] | 4.02[621] | 4.21[622] | 3.26[623] |
90 | IL23R | Interleukin-23 receptor | [624] | 0.80[625] | 2.15[626] | 4.32[627] | -0.22[628] | -0.41[629] | 0.53[630] |
91 | OSM | Oncostatin-M | [631] | -2.44[632] | 2.29[633] | -2.18[634] | -2.50[635] | -2.37[636] | 0.31[637] |
92 | BCL2 | Apoptosis regulator Bcl-2 | [638] | 0.00[639] | 5.58[640] | -1.54[641] | 4.48[642] | 4.26[643] | 5.27[644] |
93 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [645] | -0.95[646] | 1.09[647] | -2.60[648] | [649] | [650] | 2.63[651] |
94 | FCER2 | Low affinity immunoglobulin epsilon Fc receptor | [652] | [653] | [654] | [655] | [656] | [657] | 1.61[658] |
95 | IL1A | Interleukin-1 alpha | [659] | 2.43[660] | 2.20[661] | 1.31[662] | 2.07[663] | 8.89[664] | 0.46[665] |
96 | PTGS2 | Prostaglandin G/H synthase 2 | [666] | [667] | 0.40[668] | 0.94[669] | 5.57[670] | 11.46[671] | 4.88[672] |
97 | ALOX15 | Arachidonate 15-lipoxygenase | [673] | 4.47[674] | 0.57[675] | 5.44[676] | 0.95[677] | 1.46[678] | 1.10[679] |
98 | HGF | Hepatocyte growth factor | [680] | [681] | [682] | 1.66[683] | 7.30[684] | 4.40[685] | 10.94[686] |
99 | IL17A | Interleukin-17A | [687] | [688] | [689] | [690] | [691] | [692] | [693] |
100 | OPRM1 | Mu-type opioid receptor | [694] | [695] | 0.63[696] | [697] | [698] | -0.40[699] | -0.44[700] |
101 | IL4 | Interleukin-4 | [701] | [702] | [703] | [704] | [705] | [706] | [707] |
102 | IL13 | Interleukin-13 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |
103 | TWIST1 | Twist-related protein 1 | [715] | [716] | [717] | [718] | [719] | [720] | [721] |
104 | CCL11 | Eotaxin | [722] | [723] | [724] | [725] | [726] | [727] | [728] |
105 | IGHG1 | Immunoglobulin heavy constant gamma 1 | [729] | [730] | [731] | [732] | [733] | [734] | [735] |
106 | CXCL8 | Interleukin-8 | [736] | [737] | [738] | [739] | [740] | [741] | [742] |
107 | IGHG4 | Immunoglobulin heavy constant gamma 4 | [743] | [744] | [745] | [746] | [747] | [748] | [749] |
108 | IGHE | Immunoglobulin heavy constant epsilon | [750] | [751] | [752] | [753] | [754] | [755] | [756] |
109 | OPRD1 | Delta-type opioid receptor | [757] | [758] | [759] | [760] | [761] | [762] | [763] |
110 | IL17F | Interleukin-17F | [764] | [765] | [766] | [767] | [768] | [769] | [770] |
111 | IL12B | Interleukin-12 subunit beta | [771] | [772] | [773] | [774] | [775] | [776] | [777] |