REACTOME_INTERLEUKIN_37_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.17[2] -1.30[3] -0.57[4] -0.55[5] -1.40[6] 1.11[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] 0.07[9] 0.53[10] 0.47[11] 0.10[12] 0.61[13] -0.03[14]
3 SIGIRR Single Ig IL-1-related receptor [15] -6.78[16] -5.11[17] -3.48[18] -4.10[19] -5.74[20] -1.88[21]
4 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 [22] 0.41[23] 0.82[24] -0.23[25] 0.97[26] -0.08[27] -1.75[28]
5 PTPN2 Tyrosine-protein phosphatase non-receptor type 2 [29] -1.23[30] 0.11[31] 0.48[32] -1.34[33] -1.33[34] -1.55[35]
6 TBK1 Serine/threonine-protein kinase TBK1 [36] -1.01[37] 0.69[38] -0.17[39] -0.30[40] -0.34[41] -0.82[42]
7 SMAD3 Mothers against decapentaplegic homolog 3 [43] 1.55[44] 0.98[45] 1.19[46] 1.01[47] 1.76[48] -1.08[49]
8 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [50] -0.84[51] -0.62[52] -0.05[53] -7.93[54] -3.04[55] -1.47[56]
9 PTPN18 Tyrosine-protein phosphatase non-receptor type 18 [57] -0.40[58] 0.15[59] -1.25[60] -2.87[61] -0.71[62] -0.82[63]
10 CASP1 Caspase-1 [64] -3.41[65] -6.78[66] -5.26[67] -0.71[68] -0.68[69] -2.03[70]
11 PTPN9 Tyrosine-protein phosphatase non-receptor type 9 [71] 0.59[72] 0.55[73] -0.15[74] 0.86[75] 0.72[76] -0.41[77]
12 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 [78] 1.88[79] 1.36[80] 2.32[81] 0.94[82] 1.11[83] 0.22[84]
13 IL18BP Interleukin-18-binding protein [85] -1.51[86] -0.06[87] -1.01[88] -1.14[89] -1.44[90] -1.32[91]
14 IL18R1 Interleukin-18 receptor 1 [92] -7.28[93] -7.45[94] -7.64[95] -4.83[96] 2.19[97] 0.91[98]
15 PTPN4 Tyrosine-protein phosphatase non-receptor type 4 [99] 0.98[100] 2.56[101] 1.66[102] 1.60[103] 0.91[104] 1.95[105]
16 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 [106] 3.71[107] 2.84[108] 3.53[109] 5.59[110] 5.13[111] 2.07[112]
17 IL37 Interleukin-37 [113] -5.65[114] -3.19[115] -5.90[116] -8.63[117] -4.02[118] [119]
18 PTPN7 Tyrosine-protein phosphatase non-receptor type 7 [120] -2.25[121] [122] [123] -4.34[124] [125] 1.32[126]
19 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 [127] -3.61[128] [129] -4.24[130] 5.77[131] 5.14[132] 3.36[133]
20 PTPN5 Tyrosine-protein phosphatase non-receptor type 5 [134] -0.70[135] -0.33[136] -2.46[137] -2.74[138] [139] [140]
21 PTPN20 Tyrosine-protein phosphatase non-receptor type 20 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte SIGIRR
Mean 15.9
Standard deviation 12
Values 0.21 11 11 27 30
[16]
HepG2 SIGIRR
Mean 0.415
Standard deviation 0.029
Values 0.44 0.39
[17]
HepG2.C3A SIGIRR
Mean 1.15
Standard deviation 0.32
Values 1.4 0.92
[18]
HuH.7 SIGIRR
Mean 3.46
Standard deviation 0.43
Values 3 3.7 3.8
[19]
SNU475 SIGIRR
Mean 2.95
Standard deviation 0.46
Values 3.3 2.6
[20]
THLE SIGIRR
Mean 1.16
Standard deviation 0.56
Values 0.76 1.6
[21]
liver SIGIRR
Mean 15
Standard deviation 12
Values 30 4.5 19 6.4
[22]
ref_hepatocyte PTPN12
Mean 9.2
Standard deviation 4.5
Values 11 14 12 5.3 3.4
[23]
HepG2 PTPN12
Mean 35
Standard deviation 1.2
Values 34 36
[24]
HepG2.C3A PTPN12
Mean 40.5
Standard deviation 2.5
Values 42 39
[25]
HuH.7 PTPN12
Mean 18.9
Standard deviation 1.1
Values 19 18 20
[26]
SNU475 PTPN12
Mean 57
Standard deviation 14
Values 47 67
[27]
THLE PTPN12
Mean 33.7
Standard deviation 3.5
Values 36 31
[28]
liver PTPN12
Mean 9.55
Standard deviation 3.7
Values 15 9.1 6.7 7.5
[29]
ref_hepatocyte PTPN2
Mean 8.27
Standard deviation 3
Values 5 6 9.1 13 8.8
[30]
HepG2 PTPN2
Mean 10.1
Standard deviation 2.9
Values 8 12
[31]
HepG2.C3A PTPN2
Mean 22.3
Standard deviation 0.11
Values 22 22
[32]
HuH.7 PTPN2
Mean 28
Standard deviation 2.9
Values 28 25 31
[33]
SNU475 PTPN2
Mean 10.3
Standard deviation 2
Values 8.9 12
[34]
THLE PTPN2
Mean 12.7
Standard deviation 0.75
Values 12 13
[35]
liver PTPN2
Mean 9.84
Standard deviation 1.6
Values 11 8.1 12 8.9
[36]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[37]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[38]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[39]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[40]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[41]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[42]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[43]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[44]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[45]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[46]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[47]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[48]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[49]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[50]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 2.2 3.1 4.4 7.6 9.3
[51]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.5 8.6
[52]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.6 8.8
[53]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 13 10 14
[54]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.088 0.051
[55]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[56]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 7.5 4.8 9.1 5.4
[57]
ref_hepatocyte PTPN18
Mean 5.24
Standard deviation 1.6
Values 5.5 3 7.6 5.3 4.8
[58]
HepG2 PTPN18
Mean 11.4
Standard deviation 0.65
Values 11 12
[59]
HepG2.C3A PTPN18
Mean 14.5
Standard deviation 3.1
Values 17 12
[60]
HuH.7 PTPN18
Mean 5.35
Standard deviation 1.2
Values 6.5 4 5.5
[61]
SNU475 PTPN18
Mean 2.27
Standard deviation 0.32
Values 2.5 2
[62]
THLE PTPN18
Mean 12.4
Standard deviation 2.2
Values 11 14
[63]
liver PTPN18
Mean 10.4
Standard deviation 2.7
Values 13 7.9 13 8.1
[64]
ref_hepatocyte CASP1
Mean 3.66
Standard deviation 3.7
Values 0.5 9.1 0.076 3.7 4.9
[65]
HepG2 CASP1
Mean 0.987
Standard deviation 0.74
Values 0.46 1.5
[66]
HepG2.C3A CASP1
Mean 0.0833
Standard deviation 0.049
Values 0.049 0.12
[67]
HuH.7 CASP1
Mean 0.231
Standard deviation 0.041
Values 0.19 0.27 0.23
[68]
SNU475 CASP1
Mean 7.12
Standard deviation 0.23
Values 7.3 6.9
[69]
THLE CASP1
Mean 8.87
Standard deviation 1.2
Values 9.7 8
[70]
liver CASP1
Mean 3.13
Standard deviation 0.99
Values 3.7 2.6 4.2 2
[71]
ref_hepatocyte PTPN9
Mean 3.35
Standard deviation 0.8
Values 3.3 2.3 4.6 3.3 3.3
[72]
HepG2 PTPN9
Mean 14.4
Standard deviation 0.6
Values 15 14
[73]
HepG2.C3A PTPN9
Mean 12.3
Standard deviation 0.96
Values 13 12
[74]
HuH.7 PTPN9
Mean 7.3
Standard deviation 0.78
Values 8.1 7.2 6.6
[75]
SNU475 PTPN9
Mean 19.3
Standard deviation 0.4
Values 20 19
[76]
THLE PTPN9
Mean 21.4
Standard deviation 3.5
Values 19 24
[77]
liver PTPN9
Mean 8.78
Standard deviation 1.9
Values 9.2 8.3 6.5 11
[78]
ref_hepatocyte PTPN23
Mean 2.74
Standard deviation 1.4
Values 1.9 1.2 4.6 3.7 2.2
[79]
HepG2 PTPN23
Mean 29
Standard deviation 1.7
Values 30 28
[80]
HepG2.C3A PTPN23
Mean 17.6
Standard deviation 3.4
Values 20 15
[81]
HuH.7 PTPN23
Mean 33.2
Standard deviation 8.3
Values 43 28 28
[82]
SNU475 PTPN23
Mean 16.7
Standard deviation 3.1
Values 19 15
[83]
THLE PTPN23
Mean 23
Standard deviation 3.3
Values 21 25
[84]
liver PTPN23
Mean 11.1
Standard deviation 2.2
Values 8.9 11 11 14
[85]
ref_hepatocyte IL18BP
Mean 1.96
Standard deviation 2.5
Values 0.61 0.26 1.8 6.4 0.8
[86]
HepG2 IL18BP
Mean 1.98
Standard deviation 0.25
Values 1.8 2.2
[87]
HepG2.C3A IL18BP
Mean 4.73
Standard deviation 1.3
Values 5.7 3.8
[88]
HuH.7 IL18BP
Mean 2.36
Standard deviation 0.82
Values 1.8 3.3 1.9
[89]
SNU475 IL18BP
Mean 2.82
Standard deviation 1.2
Values 3.7 2
[90]
THLE IL18BP
Mean 2.8
Standard deviation 0.81
Values 3.4 2.2
[91]
liver IL18BP
Mean 2.73
Standard deviation 1.1
Values 1.9 2.3 4.4 2.2
[92]
ref_hepatocyte IL18R1
Mean 1.13
Standard deviation 0.78
Values 0 1.5 0.63 1.9 1.6
[93]
HepG2 IL18R1
Mean 0.0208
Standard deviation 0.011
Values 0.029 0.013
[94]
HepG2.C3A IL18R1
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[95]
HuH.7 IL18R1
Mean 0.0137
Standard deviation 0.014
Values 0 0.013 0.028
[96]
SNU475 IL18R1
Mean 0.125
Standard deviation 0.14
Values 0.028 0.22
[97]
THLE IL18R1
Mean 19.9
Standard deviation 8.6
Values 26 14
[98]
liver IL18R1
Mean 7.38
Standard deviation 1.2
Values 8.9 6 6.8 7.8
[99]
ref_hepatocyte PTPN4
Mean 0.856
Standard deviation 0.2
Values 1 1.1 0.64 0.68 0.85
[100]
HepG2 PTPN4
Mean 4.83
Standard deviation 2.1
Values 3.3 6.3
[101]
HepG2.C3A PTPN4
Mean 12.7
Standard deviation 0.71
Values 12 13
[102]
HuH.7 PTPN4
Mean 6.55
Standard deviation 0.84
Values 7.5 6 6.1
[103]
SNU475 PTPN4
Mean 8.25
Standard deviation 1.2
Values 9.1 7.4
[104]
THLE PTPN4
Mean 6.24
Standard deviation 1.7
Values 7.4 5
[105]
liver PTPN4
Mean 11.5
Standard deviation 6.1
Values 7.4 17 5.3 16
[106]
ref_hepatocyte PTPN14
Mean 0.362
Standard deviation 0.38
Values 0.86 0.67 0.18 0.069 0.041
[107]
HepG2 PTPN14
Mean 13.6
Standard deviation 2.5
Values 12 15
[108]
HepG2.C3A PTPN14
Mean 6.5
Standard deviation 0.18
Values 6.4 6.6
[109]
HuH.7 PTPN14
Mean 10.1
Standard deviation 3.1
Values 13 10 7
[110]
SNU475 PTPN14
Mean 55.4
Standard deviation 11
Values 63 48
[111]
THLE PTPN14
Mean 49.3
Standard deviation 4.8
Values 46 53
[112]
liver PTPN14
Mean 5.3
Standard deviation 2.4
Values 3.1 6.5 3.5 8.1
[113]
ref_hepatocyte IL37
Mean 0.289
Standard deviation 0.65
Values 1.4 0 0 0 0
[114]
HepG2 IL37
Mean 0.0165
Standard deviation 0.0071
Values 0.011 0.021
[115]
HepG2.C3A IL37
Mean 0.0793
Standard deviation 0.067
Values 0.13 0.032
[116]
HuH.7 IL37
Mean 0.0117
Standard deviation 0.013
Values 0 0.026 0.0094
[117]
SNU475 IL37
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[118]
THLE IL37
Mean 0.0689
Standard deviation 0.045
Values 0.1 0.037
[119]
liver IL37
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte PTPN7
Mean 0.0927
Standard deviation 0.21
Values 0 0 0 0 0.46
[121]
HepG2 PTPN7
Mean 0.0558
Standard deviation 0.018
Values 0.069 0.043
[122]
HepG2.C3A PTPN7
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 PTPN7
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 PTPN7
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[125]
THLE PTPN7
Mean 0
Standard deviation 0
Values 0 0
[126]
liver PTPN7
Mean 0.805
Standard deviation 0.34
Values 0.85 0.41 1.2 0.73
[127]
ref_hepatocyte PTPN13
Mean 0.0761
Standard deviation 0.11
Values 0.012 0.016 0.27 0 0.081
[128]
HepG2 PTPN13
Mean 0.0179
Standard deviation 0.0071
Values 0.023 0.013
[129]
HepG2.C3A PTPN13
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 PTPN13
Mean 0.00975
Standard deviation 0.0086
Values 0.016 0.013 0
[131]
SNU475 PTPN13
Mean 13.2
Standard deviation 0.96
Values 14 13
[132]
THLE PTPN13
Mean 10.4
Standard deviation 0.59
Values 11 10
[133]
liver PTPN13
Mean 2.72
Standard deviation 1.8
Values 1 4.5 1.3 4
[134]
ref_hepatocyte PTPN5
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[135]
HepG2 PTPN5
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[136]
HepG2.C3A PTPN5
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[137]
HuH.7 PTPN5
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[138]
SNU475 PTPN5
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[139]
THLE PTPN5
Mean 0
Standard deviation 0
Values 0 0
[140]
liver PTPN5
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte PTPN20
Missing
[142]
HepG2 PTPN20
Missing
[143]
HepG2.C3A PTPN20
Missing
[144]
HuH.7 PTPN20
Missing
[145]
SNU475 PTPN20
Missing
[146]
THLE PTPN20
Missing
[147]
liver PTPN20
Missing