REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | STAT3 | Signal transducer and activator of transcription 3 | [1] | -0.17[2] | -1.63[3] | -0.99[4] | -1.18[5] | -1.32[6] | 0.96[7] |
2 | GRB2 | Growth factor receptor-bound protein 2 | [8] | 0.47[9] | 0.35[10] | 0.37[11] | -0.87[12] | -0.37[13] | -1.15[14] |
3 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [15] | -0.80[16] | -1.67[17] | -0.67[18] | 1.11[19] | -0.57[20] | -0.50[21] |
4 | SHC1 | SHC-transforming protein 1 | [22] | 0.44[23] | 0.70[24] | 0.68[25] | 1.23[26] | 1.30[27] | -0.67[28] |
5 | JAK1 | Tyrosine-protein kinase JAK1 | [29] | -0.21[30] | -0.68[31] | -0.60[32] | -0.80[33] | 0.44[34] | 0.08[35] |
6 | IL15RA | Interleukin-15 receptor subunit alpha | [36] | -6.62[37] | -9.27[38] | -9.32[39] | -2.89[40] | -2.34[41] | -2.82[42] |
7 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [43] | -1.20[44] | -1.03[45] | -0.04[46] | 0.64[47] | 0.73[48] | 1.55[49] |
8 | SOS1 | Son of sevenless homolog 1 | [50] | -0.82[51] | 0.75[52] | 0.16[53] | -0.58[54] | -0.76[55] | -0.91[56] |
9 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [57] | -1.19[58] | -0.95[59] | -0.48[60] | -8.56[61] | -2.96[62] | -1.63[63] |
10 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [64] | 1.15[65] | 1.42[66] | 1.92[67] | -0.72[68] | 0.43[69] | -1.74[70] |
11 | STAT5B | Signal transducer and activator of transcription 5B | [71] | 0.63[72] | 0.30[73] | 0.90[74] | 0.13[75] | -0.14[76] | 0.17[77] |
12 | INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | [78] | 1.41[79] | 0.72[80] | 1.37[81] | 1.90[82] | 1.77[83] | -0.49[84] |
13 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.49[85] | 1.04[86] | 1.10[87] | -0.37[88] | 0.37[89] | -0.29[90] | |
14 | SOS2 | Son of sevenless homolog 2 | [91] | -0.75[92] | 0.42[93] | -0.45[94] | 0.27[95] | 0.72[96] | 0.39[97] |
15 | STAT5A | Signal transducer and activator of transcription 5A | [98] | -2.67[99] | -1.45[100] | -2.49[101] | -2.27[102] | -0.92[103] | -1.21[104] |
16 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.10[105] | 0.58[106] | 0.66[107] | -0.29[108] | 0.50[109] | 0.47[110] | |
17 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.16[111] | 2.29[112] | -1.62[113] | -1.14[114] | 0.21[115] | -1.15[116] | |
18 | PTK2B | Protein-tyrosine kinase 2-beta | [117] | -1.53[118] | -0.13[119] | 0.73[120] | -3.20[121] | 0.01[122] | 0.32[123] |
19 | GAB2 | GRB2-associated-binding protein 2 | [124] | 0.84[125] | 0.67[126] | 0.82[127] | -0.50[128] | 0.17[129] | -0.90[130] |
20 | IL15 | Interleukin-15 | [131] | -2.73[132] | -2.55[133] | -0.59[134] | -3.58[135] | -1.34[136] | -2.34[137] |
21 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [138] | 3.13[139] | 3.56[140] | -6.73[141] | -7.09[142] | -3.55[143] | -0.17[144] |
22 | HAVCR2 | Hepatitis A virus cellular receptor 2 | [145] | -4.34[146] | -3.68[147] | -3.59[148] | -5.19[149] | -5.46[150] | -0.99[151] |
23 | IL2RG | Cytokine receptor common subunit gamma | [152] | -2.37[153] | -4.22[154] | -3.67[155] | -5.02[156] | [157] | -1.56[158] |
24 | LGALS9 | Galectin-9 | [159] | -3.34[160] | -3.06[161] | -9.40[162] | -0.95[163] | -5.00[164] | -0.41[165] |
25 | STAT4 | Signal transducer and activator of transcription 4 | [166] | -5.56[167] | -4.45[168] | -4.03[169] | 0.21[170] | -0.39[171] | -0.42[172] |
26 | JAK2 | Tyrosine-protein kinase JAK2 | [173] | -0.50[174] | -0.46[175] | -1.00[176] | -0.66[177] | 0.52[178] | 1.26[179] |
27 | CSF2RA | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | [180] | [181] | [182] | [183] | [184] | -7.91[185] | |
28 | IL2RB | Interleukin-2 receptor subunit beta | [186] | -5.49[187] | -6.01[188] | -7.08[189] | -4.24[190] | -6.07[191] | 0.09[192] |
29 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [193] | 1.00[194] | 1.05[195] | 1.80[196] | 1.74[197] | 1.35[198] | 1.23[199] |
30 | LCK | Tyrosine-protein kinase Lck | [200] | 2.05[201] | 2.18[202] | -7.92[203] | -6.51[204] | -6.12[205] | -0.21[206] |
31 | SYK | Tyrosine-protein kinase SYK | [207] | -8.89[208] | -2.97[209] | -6.09[210] | -1.32[211] | -4.25[212] | 1.91[213] |
32 | IL3RA | Interleukin-3 receptor subunit alpha | [214] | [215] | [216] | [217] | [218] | [219] | [220] |
33 | JAK3 | Tyrosine-protein kinase JAK3 | [221] | 1.52[222] | 3.84[223] | -2.27[224] | -2.06[225] | -0.74[226] | 1.65[227] |
34 | CSF2RB | Cytokine receptor common subunit beta | [228] | [229] | [230] | [231] | -7.57[232] | -4.67[233] | 1.42[234] |
35 | IL2RA | Interleukin-2 receptor subunit alpha | [235] | [236] | -6.27[237] | [238] | -6.03[239] | -7.35[240] | -0.91[241] |
36 | IL21R | Interleukin-21 receptor | [242] | -1.21[243] | 0.51[244] | -4.17[245] | -3.89[246] | -0.91[247] | -0.11[248] |
37 | IL9R | Interleukin-9 receptor | [249] | [250] | [251] | [252] | [253] | [254] | [255] |
38 | CSF2 | Granulocyte-macrophage colony-stimulating factor | [256] | -0.26[257] | -4.17[258] | -3.63[259] | -3.14[260] | 5.35[261] | -2.93[262] |
39 | IL5RA | Interleukin-5 receptor subunit alpha | [263] | [264] | [265] | [266] | -2.01[267] | -1.33[268] | 0.88[269] |
40 | IL2 | Interleukin-2 | [270] | [271] | [272] | [273] | [274] | [275] | [276] |
41 | IL9 | Interleukin-9 | [277] | [278] | [279] | [280] | [281] | [282] | [283] |
42 | IL3 | Interleukin-3 | [284] | [285] | [286] | [287] | [288] | [289] | [290] |
43 | IL21 | Interleukin-21 | [291] | [292] | [293] | [294] | [295] | [296] | [297] |
44 | IL5 | Interleukin-5 | [298] | [299] | [300] | [301] | [302] | [303] | [304] |